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Drug sustained-release material and preparation method thereof

A sustained-release material and drug technology, applied in the direction of non-active ingredients of polymer compounds, inorganic non-active ingredients, organic non-active ingredients, etc., can solve problems such as reduction, increase of drug level, and insufficient therapeutic effect, and achieve hydrophilicity Good performance, high encapsulation rate, and good drug sustained release effect

Inactive Publication Date: 2018-06-15
FOSHAN RUISHENGTONG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Through the traditional way of administration, most of the drug ingredients are released very quickly, causing the drug level in the body to rise rapidly, reach the peak and then decrease rapidly
For drugs, their effects are closely related to the concentration of the drug in the serum, and the drastic fluctuations often cause unacceptable side effects at the peak, and then insufficient therapeutic effect due to the low concentration of the drug in the serum

Method used

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  • Drug sustained-release material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A drug slow-release material, prepared from the following ingredients in parts by weight: 0.5 parts of silk fibroin peptide, 1 part of polycaprolactone, 1 part of bovine serum albumin, 1 part of glycolic acid, 2 parts of garlic oil, sodium tripolyphosphate 0.5 parts, 1 part of aloe polysaccharide, 3 parts of low molecular weight chitosan, 2 parts of polyanionic cellulose, 1 part of N,N'-dioleoyl ethylenediamine diethanesulfonate, 5 parts of polyethylene glycol, 2 parts of dialdehyde, 50 parts of deionized water.

[0019] The preparation method of above-mentioned drug sustained-release material is:

[0020] (1) Mix and stir low molecular weight chitosan, polyanionic cellulose, silk fibroin peptide, polycaprolactone, bovine serum albumin, glycolic acid, aloe polysaccharide and deionized water for 20 minutes to obtain component A;

[0021] (2) Mix and stir garlic oil, N,N'-dioleoyl ethylenediamine diethanesulfonate sodium and polyethylene glycol for 10 minutes to obtain c...

Embodiment 2

[0027] A drug slow-release material, prepared from the following ingredients in parts by weight: 0.8 parts of silk fibroin peptide, 1.5 parts of polycaprolactone, 1.5 parts of bovine serum albumin, 1.5 parts of glycolic acid, 2.5 parts of garlic oil, sodium tripolyphosphate 0.7 parts, 1.5 parts of aloe polysaccharide, 4 parts of low molecular weight chitosan, 2.5 parts of polyanionic cellulose, 2 parts of N,N'-dioleoyl ethylenediamine diethanesulfonate, 6 parts of polyethylene glycol, 2.5 parts of dialdehyde, 55 parts of deionized water.

[0028] The preparation method of above-mentioned drug sustained-release material is:

[0029] (1) Mix and stir low molecular weight chitosan, polyanionic cellulose, silk fibroin peptide, polycaprolactone, bovine serum albumin, glycolic acid, aloe polysaccharide and deionized water for 25 minutes to obtain component A;

[0030] (2) Mix garlic oil, sodium N,N'-dioleoyl ethylenediamine diethanesulfonate and polyethylene glycol for 15 minutes t...

Embodiment 3

[0036] A drug slow-release material, prepared from the following ingredients in parts by weight: 1 part of silk fibroin peptide, 1.5 parts of polycaprolactone, 2 parts of bovine serum albumin, 1.5 parts of glycolic acid, 3 parts of garlic oil, sodium tripolyphosphate 0.8 parts, 1.5 parts of aloe polysaccharide, 4.5 parts of low molecular weight chitosan, 2.5 parts of polyanionic cellulose, 2 parts of N,N'-dioleoyl ethylenediamine diethanesulfonate, 6 parts of polyethylene glycol, 3 parts of dialdehyde, 60 parts of deionized water.

[0037] The preparation method of above-mentioned drug sustained-release material is:

[0038] (1) Mix and stir low molecular weight chitosan, polyanionic cellulose, silk fibroin peptide, polycaprolactone, bovine serum albumin, glycolic acid, aloe polysaccharide and deionized water for 25 minutes to obtain component A;

[0039] (2) Mix garlic oil, sodium N,N'-dioleoyl ethylenediamine diethanesulfonate and polyethylene glycol for 15 minutes to obtai...

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Abstract

The invention provides a drug sustained-release material and a preparation method of the drug sustained-release material. The preparation method of the drug sustained-release material is as follows: (1) mixing and stirring low molecular weight chitosan, polyanionic cellulose, silk fibroin peptide, polycaprolactone, bovine serum albumin, glycollic acid, aloe polysaccharide and deionized water to obtain a component A; (2) mixing and stirring garlic oil, N,N'-bioleoyl ethidene diamine diethyl sodium sulfonate and polyethylene glycol to obtain a component B; (3) mixing the component A with the component B, and conducting ultrasonic shearing; (4) adding sodium tripolyphosphate and glutaraldehyde, heating and stirring; (5) standing and separating to obtain an aqueous phase, regulating the pH value to 8, centrifuging at the low speed to remove larger particles; (6) regulating the pH value of a suspension to neutral, centrifuging, abandoning a solvent, and drying. The drug sustained-release material is higher in water absorption, good in hydrophily and high in encapsulation efficiency, has an excellent drug sustained-release effect at the same time, and is most suitable for a drug taking 1dose per 24h.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a drug slow-release material and a preparation method thereof. Background technique [0002] Through the traditional way of administration, most of the drug ingredients are released very quickly, causing the drug level in the body to rise rapidly, reach a peak and then decrease rapidly. As for the drug, its effect is closely related to the concentration of the drug in the serum, and violent fluctuations often cause unacceptable side effects at the peak, and then insufficient therapeutic effect due to the low concentration of the drug in the serum. In order to maintain the necessary drug concentration in the body, the drug can only be taken or injected several times a day at regular intervals. Even if the dosage and time interval of the drug are arranged, the blood drug concentration in the body is still in a state of fluctuation. The drug controlled release system appeared in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/34A61K47/44A61K47/36A61K47/38A61K47/20A61K47/10A61K47/08A61K47/02
CPCA61K47/42A61K47/02A61K47/08A61K47/10A61K47/20A61K47/34A61K47/36A61K47/38A61K47/44
Inventor 王金英
Owner FOSHAN RUISHENGTONG TECH CO LTD
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