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Chitosan non-woven fabric and preparation method and application thereof

A technology of chitosan and non-woven fabrics, applied in non-woven fabrics, textiles, papermaking, medical science, etc., can solve the problems of pure chitosan electrospinning difficulties, achieve good structural stability, expand the scope of application, The effect of improving spinnability

Inactive Publication Date: 2016-11-09
SHAOXING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because chitosan is only soluble in acidic solution, and because the chitosan molecular chain contains a large number of amino groups, it is protonated in acidic solution, so that the molecular chains repel each other, and finally the electrospinning of pure chitosan is very difficult.

Method used

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  • Chitosan non-woven fabric and preparation method and application thereof
  • Chitosan non-woven fabric and preparation method and application thereof
  • Chitosan non-woven fabric and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 0.35 g of chitosan with a molecular weight of 200,000, and 0.35 g of polymethacrylic acid with a molecular weight of 80,000, dissolve them in 7.0 g of 65 wt.% acetic acid aqueous solution at 60°C, and then add 1.0 g of N,N-Di Methylformamide solvent, after stirring and dissolving, then add 0.035g salicylic acid to dissolve, stir and dissolve, inject the spinning solution into a 20mL syringe with an inner diameter of 1.2mm flat needle, fix the syringe on the micro-injection pump, A metal receiving screen was placed at a distance of 15 cm from the needle; the needle was connected to a 25 kV high-voltage DC power supply, and a flow rate of 2.0 mL / h was set for electrospinning. After 20 h, the receiving screen collected chitosan ultrafine particles with a diameter of about 187 nm. The fine fibers were then treated in an oven at 180 °C for 2 h to obtain chitosan nonwoven fabrics.

Embodiment 2

[0033] Take 0.35g of chitosan with molecular weight of 200,000, 0.35g of 20,000 polymethacrylic acid, dissolve in 7.0g, 65 wt.% aqueous acetic acid solution at 60°C, then add 1.0g of dimethyl sulfoxide, stir After dissolving, add 0.035 g of salicylic acid to dissolve, and stir to dissolve. Inject the spinning solution into a 20 mL syringe with a flat needle with an inner diameter of 1.2 mm, fix the syringe on a microsyringe pump, and place a metal receiving screen 15 cm away from the needle. Connect the needle to a 25 kV high-voltage DC power supply, set a flow rate of 2.0 mL / h for electrospinning, and collect chitosan microfibers with a diameter of about 457 nm on the receiving screen after 20 h; then place them in an oven at 160 °C After treatment for 2 h, chitosan non-woven fabrics were obtained.

Embodiment 3

[0034] Embodiment 3, the influence of different cross-linking time on sustained-release performance.

[0035] The preparation method is the same as in Example 1, the difference is that the crosslinking time is changed, and crosslinking is carried out at 180° C. for 1, 2, and 6 hours to study its influence on the salicylic acid slow-release performance of the chitosan nonwoven fabric. The test results are as follows: Figure 5 shown. The sustained-release performance experiment is as follows: 20 mg chitosan non-woven fabric was placed in 100 mL PBS solution (pH=7.4), oscillated at a constant temperature of 20 ° C, and the absorption peak of the solution at a wavelength of 295 nm was detected by ultraviolet spectroscopy (salicylic acid UV characteristic absorption peak) changes.

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Abstract

The invention discloses a chitosan non-woven fabric and a preparation method and application thereof. The preparation method is characterized in that polymethylacrylic acid serves as a co-spinning high polymer material, polymethylacrylic acid and chitosan are subjected to electrostatic co-spinning to prepare chitosan superfine fibers, then the chitosan superfine fibers are subjected to high-temperature crosslinking, and the chitosan non-woven fabric is prepared. The chitosan non-woven fabric prepared through the electrostatic spinning technology has the advantages that the fibers are fine, and high porosity and a high specific surface area are achieved; polymethylacrylic acid serves as a co-spinning reagent and a cross-linking reagent at the same time, the spinnability of chitosan is improved, N,N-dimethyl formamide or dimethyl sulfoxide is used as a co-solvent, and the morphology of nano-fibers in the non-woven fabric is improved; the cross-linked chitosan non-woven fabric shows good structural stability, solvent-resistant performance, acid-alkali-resistant performance and drug slow release performance; the drug slow release performance can be adjusted by adjusting cross-linking time and temperature, and therefore the application range of the chitosan non-woven fabric is widened.

Description

Technical field: [0001] The invention relates to a micro-nano non-woven fabric drug-carrying system, in particular to a chitosan non-woven fabric and a preparation method and application thereof. Background technique: [0002] Chitin is a natural polymer extracted from the shells of crustaceans such as shrimps, insects, and crabs. Its production in nature is second only to cellulose, and chitosan is the product of chitin deacetylation. Chitosan has good biocompatibility and biodegradability, and can be degraded into CO in organisms 2 And water, so chitosan has a very wide range of applications in biomedicine, tissue engineering, drug sustained release, immobilization of cells and enzymes, and polymer membrane materials. [0003] Nanomaterials have a large specific surface area, which can make drug components well dispersed and immobilized, and are considered to be drug carrier materials with superior performance. Among them, nano-scale ultrafine fibers prepared by electr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/44D01D5/00D04H1/4382D04H1/728
CPCA61L15/28A61L15/24A61L15/44A61L2300/602D01D5/0069D01D5/0076D01D5/0092D04H1/4382D04H1/728C08L5/08C08L33/02
Inventor 邢桂英
Owner SHAOXING UNIVERSITY
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