4 results about "Nimesulide" patented technology

1. Name of the product in this design: Packaging Box (Nimesulide Granules). 2. Purpose of this design: For product packaging. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a nimesulide tablet and a preparation method thereof. The nimesulide tablet comprises nimesulide, a filler, an adhesive, a disintegrating agent, a lubricant and a compound stabilizer, and optionally comprises a coating material, the compound stabilizer comprises beta-cyclodextrin, lysine and lac acid, and the preparation method comprises the following steps: preparing composite powder, granulating, drying and finishing granules, totally mixing and tabletting, and optionally coating. Through the synergistic effect of the compound stabilizer and the optimized preparation process, the problems of low dissolution speed, low bioavailability and insufficient stability of the traditional nimesulide tablet are solved, meanwhile, the process is simplified, parameters are easy to control, the nimesulide tablet is suitable for large-scale industrial production, the drug effect can be quickly exerted, and the long-term effectiveness and safety of the drug can be guaranteed.

The application discloses application of nimesulide or a pharmaceutical salt thereof combined with an azole antifungal drug or a propenylamine antifungal drug in preparation of an antifungal drug. The application proves through in-vivo and in-vitro experiments that nimesulide combined with fluconazole shows clear synergistic antifungal effect. Nimesulide combined with fluconazole can improve the survival rate of animals infected with fungi, and has low toxicity to wax moth larvae and mammal cells.

The application discloses a kind of organic total synthesis methods of nimesulide derivatives, it is obtained by the reaction of phenol derivative and nitration test, first intermediate;First intermediate and esterification reagent are esterified, and second intermediate is obtained;Second intermediate and nucleophilic reagent are substituted, and third intermediate is obtained;Third intermediate and phenol derivative are coupled, and fourth intermediate is obtained;Fourth intermediate and reducing agent are reduced, and fifth intermediate is obtained;Fifth intermediate and sulfonylation reagent are sulfonylated, and sixth intermediate is obtained;Sixth intermediate and nitration reagent are nitrified, and nimesulide derivative is obtained.The application selects more easily preserved, cheap and easily obtained and higher safety substrate and reagent, process is simple, reaction condition requirement is low, green environmental protection, safety performance is good, product yield is high, easy to scale production.