7 results about "Nimesulide" patented technology

Disclosed herein are hyaluronic acid (HA)-nimesulide conjugates having one or two disaccharide units.

1. Name of the product in this design: Packaging Box (Nimesulide Granules). 2. Purpose of this design: For product packaging. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color.

The present invention relates to the field of medicine, and in particular to a pretreatment method of a nimesulide bulk drug and a composition thereof. The present invention provides a nimesulide bulk drug with a special particle size distribution, and the bulk drug with the particle size distribution is used to prepare a nimesulide product, which can improve the solubility and uniform dissolution of the nimesulide product. The present invention also provides a pretreatment method of a nimesulide raw material, which uses airflow pulverization to pulverize the poorly soluble drug nimesulide, and utilizes the collision of the material's own particles to prepare micronized poorly soluble drug nimesulide of a certain particle size. By controlling airflow pulverization parameters, optimal feed amount, and discharging method, the loss is reduced; the bulk drug after airflow pulverization is properly treated to reduce the degradation of the excellent properties of the powder caused by the re-agglomeration of the material after airflow pulverization; the particle size of the bulk drug obtained under the airflow pulverization parameters is monitored, and a nimesulide composition is prepared, and the optimal particle size range is screened by the dissolution curve.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a nimesulide tablet and a preparation method thereof. The nimesulide tablet comprises nimesulide, a filler, an adhesive, a disintegrating agent, a lubricant and a compound stabilizer, and optionally comprises a coating material, the compound stabilizer comprises beta-cyclodextrin, lysine and lac acid, and the preparation method comprises the following steps: preparing composite powder, granulating, drying and finishing granules, totally mixing and tabletting, and optionally coating. Through the synergistic effect of the compound stabilizer and the optimized preparation process, the problems of low dissolution speed, low bioavailability and insufficient stability of the traditional nimesulide tablet are solved, meanwhile, the process is simplified, parameters are easy to control, the nimesulide tablet is suitable for large-scale industrial production, the drug effect can be quickly exerted, and the long-term effectiveness and safety of the drug can be guaranteed.

The invention relates to the field of medicine, in particular to a nimesulide raw material medicine pretreatment method and a nimesulide raw material medicine composition. According to the nimesulide raw material medicine with the special particle size distribution, the dissolution rate of the nimesulide product can be increased by preparing the nimesulide product from the raw material medicine with the special particle size distribution, and dissolution is uniform. The invention also provides a pretreatment method of the nimesulide raw material, the indissolvable drug nimesulide is crushed by adopting an airflow crushing mode, and the micronized indissolvable drug nimesulide with a certain granularity is prepared by utilizing particle collision of the material. Loss is reduced by controlling airflow crushing parameters, the optimal feeding amount and the discharging mode; the raw material medicines subjected to airflow crushing are properly treated, so that the deterioration of excellent characteristics of the powder caused by re-agglomeration of the materials subjected to airflow crushing is reduced; monitoring the particle size of the raw material medicine obtained under jet milling parameters, preparing the nimesulide composition, and screening the optimal particle size range through a dissolution curve.

The application discloses application of nimesulide or a pharmaceutical salt thereof combined with an azole antifungal drug or a propenylamine antifungal drug in preparation of an antifungal drug. The application proves through in-vivo and in-vitro experiments that nimesulide combined with fluconazole shows clear synergistic antifungal effect. Nimesulide combined with fluconazole can improve the survival rate of animals infected with fungi, and has low toxicity to wax moth larvae and mammal cells.

The application discloses a kind of organic total synthesis methods of nimesulide derivatives, it is obtained by the reaction of phenol derivative and nitration test, first intermediate;First intermediate and esterification reagent are esterified, and second intermediate is obtained;Second intermediate and nucleophilic reagent are substituted, and third intermediate is obtained;Third intermediate and phenol derivative are coupled, and fourth intermediate is obtained;Fourth intermediate and reducing agent are reduced, and fifth intermediate is obtained;Fifth intermediate and sulfonylation reagent are sulfonylated, and sixth intermediate is obtained;Sixth intermediate and nitration reagent are nitrified, and nimesulide derivative is obtained.The application selects more easily preserved, cheap and easily obtained and higher safety substrate and reagent, process is simple, reaction condition requirement is low, green environmental protection, safety performance is good, product yield is high, easy to scale production.