18 results about "Cadaverine" patented technology

The invention discloses a coumarin-based bio-based epoxy resin monomer and a preparation method and application thereof, and the structure of the monomer is DPE, DCE and DHE. The monomer takes dihydrocoumarin and biomass amine compounds (including putrescine, cadaverine and 1, 6-hexamethylenediamine) as raw materials, biomass bisphenol DP, DC and DH are prepared through a simple ring-opening reaction, and then the monomer is prepared through a glycidyl reaction. A bisamide structure is innovatively introduced into the epoxy resin monomer, so that the epoxy resin monomer has the advantages of simple and convenient synthesis process, high yield, easily available raw materials, good biological safety and the like, and the performance is superior to that of traditional petroleum-based epoxy resin. The bio-based epoxy resin prepared based on the monomer shows a novel molecular structure and excellent mechanical properties and heat resistance.

This application relates to a method for producing cadaverine dicarboxylate (cadaverine verphosphate or cadaverine azelaate), comprising a first step of culturing L-lysine-producing microorganisms in a medium supplemented with dicarboxylic acid in the form of diammonium dicarboxylate to obtain lysine dicarboxylate, and a second step of converting lysine dicarboxylate to cadaverine dicarboxylate. According to this application, by carrying out the process according to the above procedure, high-purity cadaverine dicarboxylate (cadaverine verphosphate or cadaverine azelaate) can be obtained without ion resin exchange, decarboxylation, and distillation steps.

This application relates to a method for producing cadaverine dicarboxylate (cadaverine sebacate, cadaverine undecane diate, or cadaverine dodecane diate), comprising a first step of culturing L-lysine-producing microorganisms in a medium supplemented with dicarboxylic acid in the form of diammonium dicarboxylate to obtain lysine dicarboxylate, and a second step of converting the lysine dicarboxylate to cadaverine dicarboxylate. According to this application, by carrying out the process according to the above procedure, a high-purity cadaverine dicarboxylate (cadaverine sebacate, cadaverine undecane diate, or cadaverine dodecane diate) can be obtained without ion resin exchange, decarboxylation, or distillation steps.

The present application relates to a method for preparing a cadaverine dicarboxylate (cadaverine suberate or cadaverine azelate), the method comprising: a first step of obtaining a lysine dicarboxylate by culturing an L-lysine producing microorganism in a culture medium to which a dicarboxylic acid in the form of a diammonium dicarboxylate is added; and a second step of converting the lysine dicarboxylate into a cadaverine dicarboxylate. According to the present application, a cadaverine dicarboxylate (cadaverine suberate or cadaverine azelate) of high purity can be obtained without ion resin exchange, a decarboxylation process, and a distillation process by implementing the method according to the above procedure.

The invention relates to the technical field of biologic detection of metabolomics, in particular to an OSAHS metabolism marker, a diagnosis model and application of the OSAHS metabolism marker and the diagnosis model. The metabolic marker comprises a red blood cell metabolite and / or a plasma metabolite; erythrocyte metabolites comprise L-aspartic acid, D-ribose-5-diphosphoric acid, cadaverine, 12, 13-epoxy octadecenoic acid, L-arginine, N-acetylmethionine, 5-hydroxyeicosatetraenoic acid, 13-oxo-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 10-tetrahydroxy-9Z, the component A is one or more of 11E-octadecadienoic acid, inosine monophosphate, nicotinamide, alpha-lactose, sphingosine, hydroxy octadecadienoyl or glyceraldehyde-3-phosphoric acid; the plasma metabolite is prepared from one or more of fumaric acid, cadaverine, L-aspartic acid, malic acid, sphingosine-1-phosphoric acid, L-arginine, cysteine-S-sulfate, thiosulfate, gamma-glutamyl alanine, galacturonic acid or vitamin B2.

The application provides a bacteriostatic and deodorizing composite preparation for pets and application thereof, which comprises 30-40% of enzyme preparation, 20-30% of plant extract, 20-30% of probiotic powder, and 0-10% of inorganic salt and filling aid. The application can efficiently remove ammonia and effectively reduce the ammonia gas yield in excrement; can efficiently inhibit E. coli, Salmonella, MRSA, C. perfringens and the like; can reduce fecal odor and effectively reduce fecal odor substances in pet excrement, such as indole, cadaverine, spermidine, putrescine and skatole and the like; is safe and harmless, avoids the negative influence of chemical synthetic substances on pet health, prevents clumping, and maximally reduces the influence on cat litter clumping, thereby guaranteeing the use effect.

The invention relates to the technical field of metabonomics analysis, in particular to application of a metabolic marker in preparation of a head and neck squamous cell carcinoma diagnostic product, a kit, a screening method of the metabolic marker of the head and neck squamous cell carcinoma, a diagnostic model and a construction method and application of the diagnostic model. The metabolic marker comprises at least one of lactic acid, sphingosine, cadaverine, uridine diphosphate, allantoic acid, hydroxyproline, sphingosine-1-phosphoric acid, indole-3-acetaldehyde, pantothenic acid, fumaric acid, malic acid, prostaglandin or ornithine in red blood cells and / or plasma. The screened red blood cells and plasma metabolism markers can be used for predicting or diagnosing the head and neck squamous cell carcinoma respectively or independently, particularly, the red blood cell metabolism markers can provide more stable tumor microenvironment information, and the metabolism stability is high and is not easily influenced by diet and circadian rhythm.

The invention discloses a salt-tolerant Bacillus velezensis strain capable of efficiently degrading protein and biogenic amine and an application of the salt-tolerant Bacillus velezensis strain. The bacillus velezensis is a strain FJNU-SIO1, is classified and named as bacillus velezensis, is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation date is September 26, 2025, the preservation number is CGMCC No.36086, and the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No. 3, Beichen West Road, Chaoyang District, Beijing. The strain FJNU-SIO1 is wide in growth adaptation range, can tolerate the salt concentration of 1%-10%, and can still efficiently degrade protein and nine common biogenic amines including putrescine, cadaverine, histamine and tyramine under the high salt concentration of 10%, the degradation rate of the protein can reach 47.68%, and the degradation rate of the total biogenic amines can reach 32.77%. The strain FJNU-SIO1 provided by the invention has the outstanding advantages of simplicity and convenience in operation, low cost, wide applicability and the like when being applied to degradation treatment of proteins and biogenic amines, and has an important value for guaranteeing safe production of fermented foods.

This application relates to a method for producing cadaverine adipic acid, comprising a first step of culturing L-lysine-producing microorganisms in a medium supplemented with adipic acid in the form of diammonium adipic acid to obtain lysine adipic acid, and a second step of converting lysine adipic acid to cadaverine adipic acid. According to this application, by carrying out the process according to the above procedure, high-purity cadaverine adipic acid can be obtained without ion resin exchange, decarboxylation, and distillation steps.

The application discloses a nondestructive detection method for biological amine of Spanish mackerel based on Raman spectrum technology, and belongs to the technical field of food nondestructive detection. ‑1 The method first cuts fresh Spanish mackerel into pieces and refrigerates the pieces for different lengths of time to prepare different freshness samples, collects Raman spectra of the samples in the range of 400-2000 cm ‑1 under 532nm laser light, simultaneously determines the histamine, putrescine and cadaverine content in the samples by HPLC, carries out principal component analysis on the spectrum baseline correction and normalization, realizes accurate classification of the freshness of Spanish mackerel by combining LDA, SVM and RF machine learning models, the accuracy of the SVM model reaches 100%, the spectrum characteristic variables are screened by CARS, PLSR and SVR regression models are established, and accurate quantification of the three core biological amine is realized, and the prediction correlation coefficients are all higher than 0.9. The application is nondestructive, rapid and convenient to operate, improves the early warning sensitivity of Spanish mackerel corruption, can effectively avoid the risk of excessive histamine, and also provides technical reference for biological amine detection of similar marine products.

The invention belongs to the technical field of analytical chemistry, and particularly relates to a method for detecting seven biogenic amines by liquid chromatography-mass spectrometry, which comprises the following steps: performing liquid chromatography separation-tandem mass spectrometry detection on a liquid to be detected to obtain the peak area of each biogenic amine; obtaining the content of each biogenic amine in the sample to be detected according to a preset standard curve of each biogenic amine; the preset standard curve of each biogenic amine is a linear relation between the concentration of each biogenic amine and the peak area ratio; the biogenic amine comprises putrescine, phenylethylamine, cadaverine, tryptamine, spermidine, tyramine and histamine. The method solves the problems of incapability of quantification, poor detection stability, inaccurate detection result and the like of the existing biogenic amine detection method.

The application discloses a flavonol fluorescent probe for detecting biological amine, a preparation method thereof and a fluorescent spin coating film application thereof. The application takes 3'-hydroxy-4'-acetyl.[1,1'-biphenyl]-4-carboxylic acid as a starting material, and performs a hydroxy aldehyde condensation reaction with 2,4,6-trimethoxybenzaldehyde to prepare 3'-hydroxy-4'-(3-(2,4,6-trimethoxyphenyl) acryloyloxy)-[1,1'-biphenyl]-4-carboxylic acid (HTC); the HTC is subjected to oxidative cyclization under alkaline conditions to obtain 4-(2-(2,4,6-trimethoxyphenyl)-3-hydroxy-chromone-7-yl) benzoic acid (HTBA); the HTBA is further subjected to esterification with 4-cyanobenzoyl chloride to prepare 4-(2-(2,4,6-trimethoxyphenyl)-3-((4-cyanobenzoyl)oxy)-chromone-7-yl) benzoic acid (CTBA). Under the irradiation of 365nm ultraviolet light, after a DMF / 10mM PBS buffer (v / v=1 / 9) solution of the CTBA is added with biological amine cadaverine, the fluorescence color of the solution changes from light blue to bright yellow, and the detection limit of the biological amine reaches 3.6*10 ‑7 M, and the CTBA has a good application prospect as a fluorescent probe for detecting biological amine.

The invention relates to the technical field of metabolome biologic detection, in particular to a metabolic marker for glaucoma diagnosis, a screening method, a diagnosis model and application of the metabolic marker. The metabolism markers comprise an erythrocyte metabolism marker and a plasma metabolism marker; the red blood cell metabolism marker comprises one or more of phosphate, pyrophosphoric acid, O-decenoyl-L-carnitine, hydroxy octadecadienoyl carnitine, inosine monophosphate, inosine diphosphate, malic acid, fumaric acid, D-erythritol-4-phosphoric acid, indole-3-acetaldehyde, cadaverine, hypoxanthine, ornithine, arginine and tyrosine; the plasma metabolism marker comprises one or more of sphingosine 1 phosphate, pyruvic acid, allantoate, 2-ketoglutaric acid, 5-oxoproline, malic acid, ornithine, fumarate, 5-L-glutamyl-L-glutamine, catechol-3-sulfonic acid, achloroanthocyanidin, L-aspartic acid, spermine, L-arginine or 5-hydroxyisouric acid.

The present application relates to a method for preparing a cadaverine dicarboxylate (cadaverine succinate or cadaverine glutarate), comprising: a first step of obtaining a lysine dicarboxylate by culturing an L-lysine-producing microorganism in a culture medium to which a dicarboxylic acid in the form of a diammonium dicarboxylate is added; and a second step of converting the lysine dicarboxylate into a cadaverine dicarboxylate. According to the present application, by implementing the method according to the above procedure, a cadaverine dicarboxylate (cadaverine succinate or cadaverine glutarate) of high purity can be obtained without ion resin exchange, decarboxylation, and distillation.

The present application relates to a method for preparing a cadaverine dicarboxylate (cadaverine sebacate, cadaverine undecanediate or cadaverine dodecanediate), the method comprising: a first step of obtaining a lysine dicarboxylate by culturing an L-lysine producing microorganism in a culture medium to which a dicarboxylic acid in the form of a diammonium dicarboxylate is added; and a second step of converting the lysine dicarboxylate into a cadaverine dicarboxylate. According to the present application, a cadaverine dicarboxylate (cadaverine sebacate, cadaverine undecanedioate, or cadaverine dodecanedioate) of high purity can be obtained without ion resin exchange, decarburization, and distillation by implementing the method according to the above procedure.

Disclosed herein is a process for the preparation of pentamethylenediamine (PMDA, also referred to as cadaverine or 1, 5-pentanediamine) by reacting pentane-1, 3-pentanediamine containing at least one anion selected from the group consisting of carbonate, sulfate and phosphate to form pentamethylenediamine; contacting the fermented broth comprising one or more 1, 5-diammonium salts with an amount of an oxide or hydroxide salt of a divalent metal selected from magnesium and calcium sufficient to form a broth comprising an amount of one or more precipitated divalent metal salts of one or more anions; removing the one or more precipitated divalent metal salts from the fermented broth to form a broth comprising a lesser amount of the one or more divalent metal salts; and removing PMDA from the bouillon from which the one or more precipitated divalent metal salts have been removed.

The invention belongs to the field of food packaging materials, and provides a preparation method of a fluorescent label for specific detection of putrescine, tyramine and cadaverine, and the preparation method comprises the following steps: dispersing rhodamine B into an ethanol solution to prepare an indicator I; dissolving polymethylacrylic acid and hydroxytetraphenyl ethylene in tetrahydrofuran, and preserving heat to obtain an indicator II; dissolving zein in an ethanol solution, heating and stirring, cooling, and adding a plasticizer to obtain a loaded matrix solution; uniformly mixing the indicator I and the indicator II, slowly adding the loaded matrix solution to obtain a film-forming solution, degassing, casting, spreading, drying, and balancing temperature and humidity to obtain the fluorescent label. The fluorescent label prepared by the invention is wide in concentration response range to putrescine, tyramine and cadaverine solutions, low in detection limit, sensitive in response and high in color discrimination, and can accurately indicate the freshness of fresh chicken.