26 results about "Mass spectrometry detector" patented technology

The invention discloses a detection method and a detection system for the cracking gas concentration of a transformer insulating material. The detection method comprises the following steps: performing headspace treatment on to-be-detected insulating oil to realize oil-gas separation in a sample; then the mixed gas is separated through a chromatographic column, the concentration of the dissolved gas is detected and analyzed through a mass spectrometry detector, and the cracking gas comprises at least one of methane, ethane, ethylene, acetylene, hydrogen, carbon monoxide or carbon dioxide. The method specifically comprises the following steps: preparing a to-be-detected insulating oil sample, and treating the to-be-detected insulating oil sample by adopting headspace to realize oil-gas separation in the sample; separating the mixed gas by adopting a chromatographic column, and then detecting and analyzing the dissolved gas by adopting a mass spectrometry detector; preparing a standard gas for dissolving the gas, establishing a calibration curve, and quantitatively calculating the concentration of the cracking gas through the calibration curve. The method can accurately detect methane, ethane, ethylene, acetylene, hydrogen, carbon monoxide and carbon dioxide gases, and has the characteristics of high detection sensitivity, good repeatability, simplicity and convenience and the like.

The present application is applicable to the field of medical devices, and discloses a liquid chromatography-mass spectrometry apparatus and a control method for the liquid chromatography-mass spectrometry apparatus. The liquid chromatography-mass spectrometry apparatus comprises a sample storage device, a pretreatment device, a chromatography device, a mass spectrometry detection device, and a controller. The chromatography device comprises a test solution preparation channel, a test solution transfer assembly, a liquid phase fluid delivery assembly, and a chromatography column. An operating pressure outputted by the liquid phase fluid delivery assembly is less than or equal to 20 MPa. The length of the chromatography column is greater than or equal to 3 mm and less than or equal to 35 mm. A sample comprises a target substance to be measured, and the target substance to be measured comprises at least one of vitamin D, a steroid hormone, and a catecholamine. The present application reduces costs of the liquid chromatography-mass spectrometry apparatus.

This invention relates to the field of medical devices and discloses a liquid chromatography-mass spectrometry (LC-MS) device and a control method for the LC-MS device. The LC-MS device includes a sample storage device, a pretreatment device, a chromatographic element, a mass spectrometry detection device, and a controller. The chromatographic element includes a reagent preparation channel, a reagent transfer assembly, a liquid flow delivery assembly, and a chromatographic column. The liquid flow delivery assembly is used to drive the reagent in the reagent preparation channel through the chromatographic column to adsorb the reagent onto the column, and to drive the liquid flow through the chromatographic column to elute the adsorbed reagent to form the analyte. The pretreatment device uses magnetic separation to pretreatment the sample. The operating pressure of the liquid flow delivery assembly is less than or equal to 20 MPa. This invention reduces the cost of LC-MS devices.

1. Name of the product in this design: Mass Spectrometry Detector (Doping Detector). 2. Purpose of this design: For doping detection. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The application provides a liquid chromatography-mass spectrometry method for detecting phytosterol content in dried blood spots, and belongs to the technical field of detection.The application simplifies a sampling process, uses a disposable blood taking needle and a blood taking card for sampling, replaces traditional serum or plasma samples with obtained dried blood spots, punches a sampling area of the dried blood spot sample through a puncher with a diameter of 3.2 mm, takes three dried blood spot samples, extracts seven kinds of sterol substances contained in the dried blood spot samples through n-hexane, adopts liquid chromatography-mass spectrometry, carries out detection and quantification through chromatographic separation and a mass spectrometry detector, realizes rapid and accurate determination of cholesterols, beta-sitosterols, daidzein, campesterol, dihydrocholesterol, dehydrocholesterol and 7-alkenyl cholestanol, and the method is simple in operation, accurate in quantification, and has a recovery rate of 92.4%-96.7%.

This invention relates to the field of medical devices and discloses a liquid chromatography-mass spectrometry (LC-MS) device. The LC-MS device includes a sample storage device, a pretreatment device, a chromatographic element, a mass spectrometry detection device, and a controller. The chromatographic element includes a reagent preparation channel, a reagent transfer assembly, a liquid flow delivery assembly, and a chromatographic column. The reagent transfer assembly is used to transfer at least a portion of the reagent obtained from the pretreatment device to the reagent preparation channel. The liquid flow delivery assembly is used to drive the reagent in the reagent preparation channel through the chromatographic column to adsorb the reagent onto the column, and to drive the liquid flow through the chromatographic column to elute the adsorbed reagent to form the analyte. The length of the chromatographic column is greater than 0 mm and less than 50 mm. This invention reduces the cost of LC-MS devices.

The invention provides a method for detecting six isomers of trinitrotoluene, a separation method in the detection method is a gas chromatographic method, a quantitative detector in the detection method is a mass spectrometric detector, and a qualitative method in the detection method is standard sample verification. A chromatographic column in the gas chromatography is a capillary column; the temperature rise mode of a column oven in the gas chromatography is a programmed temperature rise mode. The rapid detection method for the six isomers of trinitrotoluene has the characteristics of good peak presentation, high resolution, strong repeatability and simple and rapid operation, can realize separation and content determination of the six isomers of trinitrotoluene in one step, saves the test cost, is convenient to popularize and has wide application prospects. And effective guarantee is provided for synthesis process monitoring and product quality control of TNT.

The invention discloses a method for determining the limit I of aristolochic acid in a cough-relieving and phlegm-reducing pill, which comprises the following steps: performing ultrasonic extraction on the cough-relieving and phlegm-reducing pill by using a 70% methanol solution, performing gradient elution by using acetonitrile as a mobile phase A and a 0.1% formic acid solution containing 1mmol / L ammonium acetate as a mobile phase B, and determining the limit I of aristolochic acid in the cough-relieving and phlegm-reducing pill by using a triple quadrupole mass spectrometry detector, the total limit of aristolochic acid I in the cough-relieving and phlegm-reducing pill is measured by multiple reaction monitoring (MRM) ion pairs in an electrospray positive ion (ESI) mode.

The invention relates to the technical field of petrochemical product analysis, in particular to a method for measuring n-alkane content and carbon number distribution of white oil based on gas chromatography-mass spectrometry, which comprises the following steps: carrying out gas chromatography-mass spectrometry detection on a white oil sample to obtain total ion flow and mass spectrometry data; determining retention time and peak area of n-alkanes with different carbon numbers in the total ion chromatogram according to the total ion current and the mass spectrum data; and according to the retention time and the peak area, obtaining the n-alkane content in the white oil sample, the proportion of each carbon number interval and the carbon number distribution. The separation effect is good, the test result is accurate and reliable, the content and carbon number distribution of the n-alkanes in the C12-C34 carbon number interval can be measured, a mass spectrum detector is used, the carbon number distribution interval defining accuracy is improved, a standard sample is not needed for comparison, the detection process is convenient and rapid, and application and popularization are facilitated.

The invention discloses a method for detecting saponin components in ginseng and a preparation thereof. Relates to the field of medicinal material detection. The method for detecting the saponin components in the ginseng and the ginseng preparation comprises the following steps: S1, taking a ginseng sample or a ginseng-containing preparation, adding an extraction solvent, and extracting to obtain a test solution; s2, the test solution is injected into a liquid chromatograph, a chromatographic column is adopted for gradient elution, and octadecylsilane chemically bonded silica is adopted as a filling agent of the chromatographic column; s3, detecting pseudo-ginsenoside F11, ginsenoside Rf, ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Re by adopting an electrospray ionization source negative ion mode and a multi-reaction monitoring mode of a mass spectrometry detector; a mobile phase used for gradient elution is selected from acetonitrile-water, an acetonitrile-ammonium acetate solution, acetonitrile-ammonium formate, methanol-formic acid or an acetonitrile-tetrahydrofuran-ammonium formate solution. By combining C18 chromatographic column gradient elution with a mass spectrum multi-reaction monitoring (MRM) mode and providing a mobile phase system, the problems of narrow applicability, isomeride interference, strong matrix effect and the like of a method for detecting saponin components of ginseng and preparations thereof in the prior art are effectively solved.

This invention discloses a method and system for measuring volatile organic compounds (VOCs) in exhaust gas from stationary pollution sources. The method includes determining the sampling locations and points for exhaust gas emissions from stationary pollution sources; collecting data on the main product outputs and main raw material or fuel consumption of a pre-defined enterprise and establishing a database; collecting exhaust gas using an exhaust gas sampling device; obtaining exhaust gas chromatography using a mass spectrometer; obtaining low molecular weight components using a flame ionization detector (FID) to obtain VOC components; dividing the low molecular weight components into different concentration series and performing gas chromatography analysis to plot working curves; calculating the correlation coefficients between the low molecular weight components and the response area for different concentration series; analyzing other compounds using a mass spectrometer; calculating the correlation coefficients between other compounds and the response area; calculating the concentration of VOCs; establishing pollution source data based on the database; and performing regression analysis using the database and the VOC concentrations to output the results.

This invention relates to the field of medical devices and discloses a liquid chromatography-mass spectrometry (LC-MS) coupling device. The device includes a sample storage device, a pretreatment device, a chromatographic element, a mass spectrometry detection device, and a controller. The chromatographic element includes a reagent transfer assembly, at least one first liquid chromatography channel, and at least one second liquid chromatography channel. The first liquid chromatography channel is used to elute a first reagent with a liquid fluid driven by a first operating pressure to form a first analyte. The second liquid chromatography channel is used to elute a second reagent with a liquid fluid driven by a second operating pressure to form a second analyte. The first operating pressure is less than or equal to 20 MPa, and the second operating pressure is greater than 20 MPa. This invention reduces the cost of LC-MS coupling devices.

This application relates to the field of mass spectrometry analysis and detection technology, and in particular to a detection method for enhancing ion recognition, comprising the following steps: Step 1, placing an ultrasonic standing wave device within an ion source, the ultrasonic standing wave device including at least two oppositely arranged acoustic transducer units for emitting sound waves of the same frequency and opposite propagation directions to superimpose and form an ultrasonic standing wave field, and also including a triaxial adjustment mechanism; Step 2, the two acoustic transducer units extending into the ion source cavity and located on both sides of the nozzle, adjusting the position of the acoustic transducer units using the triaxial adjustment mechanism so that the acoustic transducer units are close to the rear of the nozzle, and the center height of the acoustic transducer units is lower than the tip of the nozzle; Step 3, adjusting the spacing between the two acoustic transducer units; Step 4, aligning the standing wave node axially with the entrance of the mass spectrometer detector. This method can enhance the focusing of sample ions, thereby improving the ion recognition effect of the mass spectrometer detector, without changing the internal structure of the ion source.

The present invention relates to a vinyl chloride-based polymer, a resin composition comprising same, and a method for preparing same, wherein the vinyl chloride-based polymer has a degree of polymerization of 2800-5000, and has a peak in at least one of a region having a retention time of 1.5 to 2.5 minutes and a region having a retention time of 4 to 6 minutes in a graph obtained as a result of liquid chromatography / quadrupole mass spectrometry analysis performed under the following conditions.

The invention discloses a liquid chromatography-tandem mass spectrometry detection method for di-tert-butyl dicarbonate residue in a bulk drug. The invention relates to the technical field of pharmaceutical analysis, and discloses a BOC (Boron Oxidized Carboxylic Acid) preparation method which comprises the following steps: reacting BOC anhydride with phenylpropionic acid under the heating condition of alkaline tetrahydrofuran by taking a phenylpropionic acid tetrahydrofuran alkaline solution as a deriving agent. The method provided by the invention can effectively detect the residue of BOC anhydride in the bulk drug, and the limit of quantitation reaches 0.2 [mu] g / mL; compared with a direct sample injection test method, the sensitivity is higher, the sample preparation process is simple, the operation is safe and simple, the treatment is convenient and rapid, and the detection efficiency is improved; equipment is easy to obtain, a measured chromatographic baseline is stable and does not drift, interference of a mass spectrometric detector is small, and precision and accuracy of the method are improved; the method is used for residue determination of BOC anhydride, has good sensitivity, linear relation, precision, accuracy and stability, and has important research value in the aspects of bulk drug quality research, impurity analysis and control research and the like.

The invention discloses a method for detecting formic acid, methanol and ethanol based on an automatic headspace gas chromatography-mass spectrometry technology. The detection method comprises the following steps: S1, preparing a mixed standard working solution of formic acid, methanol and ethanol; s2, adding an esterification reagent into the mixed standard working solution or the to-be-detected sample, and sealing the mixed standard working solution or the to-be-detected sample in a headspace bottle; s3, the headspace bottle is placed in an automatic headspace sampler, heating and heat preservation are conducted, formic acid and isopropanol are subjected to an esterification reaction to generate isopropyl formate, and meanwhile the isopropyl formate, methyl alcohol and ethyl alcohol are volatilized to the top space of the headspace bottle; s4, the headspace sample injector automatically extracts gas in the headspace and injects the gas into the gas chromatography system; and S5, carrying out separation through a chromatographic column, carrying out heating, carrying out detection by using a mass spectrometry detector, and carrying out qualitative and quantitative analysis on formic acid, methanol and ethanol in the to-be-detected sample. The detection method provided by the invention realizes rapid, automatic, high-sensitivity and high-specificity synchronous detection of formic acid, methanol and ethanol in a blood sample.

The utility model relates to the technical field of medicine packaging testing, in particular to a packaging system sealing performance testing device based on a helium mass spectrum, which comprises a low-temperature device, a sample testing device arranged in the low-temperature device and a helium mass spectrum detector, the sample testing device comprises an upper part and a lower part which is detachably arranged at the bottom of the upper part, wherein a first cavity is formed in the middle of the bottom of the upper part, first positioning holes are formed in the four corners of the top of the upper part respectively and penetrate through the upper part, first through holes are formed in the side wall of the upper part, and the first through holes communicate with the first cavity; according to the utility model, the sealing performance of the packaging system can be effectively detected in a low-temperature state, and powerful support is provided for medicine packaging quality control.

This invention belongs to the field of mass spectrometry detector technology, and specifically relates to a mass spectrometry detector and its data correction method, apparatus, and storage medium. The method includes: acquiring ion data collected by the mass spectrometry detector in scanning mode based on a preset scan step divided by ion mass; acquiring the actual mass of each group of ions of the same mass in the ion data and recording it as a data acquisition point, with each data acquisition point corresponding to a set acquisition point based on the preset scan step; when the mass difference between a data acquisition point and the corresponding set acquisition point is less than or equal to a preset accuracy range, using the signal intensity of the data acquisition point as the signal intensity of the corresponding set acquisition point; when the mass difference between a data acquisition point and the corresponding set acquisition point is less than or equal to a correction threshold, obtaining the signal intensity of the set acquisition point based on the signal intensities of the two data acquisition points with the closest masses to the corresponding set acquisition point. This improves the precision and accuracy of the acquired ion data.

The invention belongs to the technical field of mass spectrometry, and particularly relates to a method for improving the stability of a mass spectrometry detector, which comprises the following steps: gradually increasing the initial high pressure V0 of the detector, and outputting a reference ion signal and a target ion signal respectively corresponding to the adjusted high pressure by the detector; when the reference ion signal and the target ion signal are utilized to obtain a reference ion final signal IM '' ', the high voltage increasing step length delta V'of the detector is obtained; and obtaining the concentration C of the target substance under the target high pressure by using the reference ion signal, the target ion signal and the signal IM '' '. The device has the advantages of simple adjustment and the like.

The application relates to a square wave driven ion storage-multiple reflection time-of-flight mass spectrometry system and method, which comprises the following steps: applying a direct current voltage DC1 and a direct current voltage DC2 to an inlet electrode and an outlet electrode of an ion trap respectively; applying a square wave radio frequency voltage with an arbitrary frequency and amplitude to a radio frequency electrode; allowing an ion beam with energy to pass through the inlet electrode and enter the region of the radio frequency electrode, so that ion injection is realized; then, under the action of a direct current potential well formed by the inlet electrode and the outlet electrode and a quadrupole potential well formed by the square wave radio frequency, ion storage and cooling in the ion trap are realized; after sufficient cooling, double pulse voltages are applied to the inlet electrode and the outlet electrode, so that the ions in the trap are extracted to a time-of-flight mass spectrometry detector along the axial direction. The application applies a digital square wave to replace a sine wave in ion storage-multiple reflection time-of-flight mass spectrometry. The performance of the IS-MRTOFMS can be improved, a deeper potential well can further improve the resolution of the IS-MRTOFMS, the storage capacity of the storage well is improved, and the sensitivity of the instrument is improved.

The invention belongs to the technical field of drug detection, and discloses an oligonucleotide intermediate impurity detection method of a targeted AGT gene. According to the present invention, the reverse phase ion pair high performance liquid chromatography is adopted, such that the five impurities including the shortened sequence impurity (5 'n-1), the incomplete sulfo sequence impurity and the increased sequence impurity (5' n + Cms, 5 'n + Ufs) in the oligonucleotide drug positive-sense strand and the oligonucleotide drug antisense strand can be simultaneously separated, and the identification detection of the drug intermediate can be achieved when the mass spectrometry detector is combined. In the method, the separation condition of the impurities is good, the method has good applicability to the finished product and the intermediate, and the quality of the finished product and the intermediate of the oligonucleotide medicine can be conveniently controlled.

A detection system and a method for detecting chiral compounds, wherein the multi-mode analytical system is suitable for separating non-chiral and chiral components and for resolving and detecting enantiomers, and the analytical system includes an injection system, a liquid chromatography system as a first dimension chromatograph, a supercritical chromatography system as a second dimension chromatograph, a trap system, a connection system, and a detector, the liquid chromatography system includes a reversed-phase liquid column, the supercritical chromatography system includes one or more chiral columns, the connection system includes a first multi-port valve and a second multi-port valve, and the detector is a mass spectrometry detector.

The invention discloses a method for detecting the content of genotoxic impurity N-nitrosopropafenone in propafenone hydrochloride injection, which is characterized in that a blank solution, a reference solution and a test sample solution are detected by liquid chromatography-mass spectrometry; the parameter conditions of the liquid chromatography are as follows: 0.1% formic acid is taken as a mobile phase A, methanol is taken as a mobile phase B, and gradient elution is performed; the flow velocity is 0.27 ml to 0.33 ml per minute; the column temperature is 36-44 DEG C; the conditions of gradient elution are as follows; the parameter condition of the mass spectrum is as follows: a mass spectrum detector is adopted, and mass-to-charge ratios (m / z) 371.3 and (m / z) 98.0 are used as quantitative ion pairs. The method is simple to operate, high in detection speed, high in sensitivity and good in repeatability.

The application provides a method for determining hydrocarbon compounds in jet fuel by GCxGC-FID-TOFMS, which comprises the following steps: after a jet fuel sample sequentially passes through a one-dimensional column, a modulator and a two-dimensional column, the sample enters a hydrogen flame ionization detector and a mass spectrometer through a micro-flow path shunt three-way joint at the same time, and double-channel detector data software is used for test analysis; the acquisition frequency of the mass spectrometer is 20-100 Hz. According to the application, the retention time of components on the detectors of two different pressure outlets is basically consistent, the double-channel detector data software is used for test analysis, the difficulty of data processing is greatly reduced, and the determination efficiency and accuracy of hydrocarbon compounds in jet fuel are improved.

The invention belongs to the technical field of analysis and detection, and particularly relates to a method for determining adenosine in plasma by two-dimensional column switching high performance liquid chromatography, which solves the problems of insufficient sensitivity, high cost or complex operation in the existing adenosine detection by optimizing sample pretreatment and two-dimensional chromatographic separation processes. The method comprises the following steps: S1, adding a protein precipitator into a to-be-detected sample to obtain a mixed sample solution; s2, centrifuging the mixed sample liquid, collecting supernate, and adding an ammonium acetate solution to obtain a to-be-detected sample; and S3, detecting the to-be-detected sample by adopting a two-dimensional column switching high performance liquid chromatography to obtain the adenosine content in the to-be-detected sample. The method does not need an isotope internal standard and a mass spectrometric detector, is low in cost, simple and convenient to operate, low in sensitivity and good in intraday / interday precision, is suitable for routine detection of adenosine in clinical plasma, and can realize that a sample is detected as soon as possible.