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28 results about "Ginsenoside-Re" patented technology

Pediococcus acidilactici TH903 and application of pediococcus acidilactici TH903 in directional preparation of rare ginsenoside Rg4 by fermenting ginseng berries

The invention discloses pediococcus acidilactici TH903 and application thereof in directional preparation of rare ginsenoside Rg4 by fermenting ginseng berries, and belongs to the field of fermentation engineering, the pediococcus acidilactici TH903 is preserved in the China Center for Type Culture Collection on September 29, 2025, the preservation number is CCTCC NO: M20252155, and the preservation unit is the China Center for Type Culture Collection. The Pediococcus acidilactici TH903 is utilized to successfully and directionally convert ginsenoside Re in the ginseng berry extract into rare ginsenoside Rg4, the rare ginsenoside Rg4 is mainly used as a fermentation product, the main target product, namely the rare ginsenoside Rg4, is accurately prepared, and the Pediococcus acidilactici TH903 has relatively high specificity, and can be used for preparing the rare ginsenoside Rg4. Meanwhile, the method has the advantages of high conversion efficiency and high conversion product content, and a cheap and efficient preparation process is established for the rare ginsenoside Rg4.
Owner:TONGHUA CHENGCHENG PHARM CO LTD

Fermented lactobacillus mucus GB705 and application thereof in directional preparation of rare ginsenoside F4 by fermenting ginseng flower buds

The invention discloses lactobacillus mucus GB705 and application thereof in directional preparation of rare ginsenoside F4 by fermenting ginseng flower buds, and belongs to the field of fermentation engineering, and the preservation number of the lactobacillus mucus GB705 is CCTCC (China Center for Type Culture Collection) NO: M20252089. According to the invention, the lactobacillus mucus GB705 bacterial suspension is utilized to ferment the ginseng flower bud extract to prepare the rare ginsenoside F4, ginsenoside Re in the ginseng flower bud extract can be efficiently and directionally converted into the rare ginsenoside F4 only through one-step standing fermentation, multi-step reaction is not needed, the preparation process is simplified, the process complexity is reduced, and the method is suitable for industrial production. The raw material conversion rate and the yield of the rare ginsenoside F4 are improved. Meanwhile, in the standing fermentation process, the content of by-products is low, the solvent consumption is small, the conditions are mild, and large-scale and low-cost production of the rare ginsenoside F4 can be achieved.
Owner:JILIN ACAD OF AGRI SCI

Phytobacterium plantarum BT810 and application thereof in preparing rare ginsenoside by fermenting ginseng flower buds

The invention discloses plant lactobacillus BT810 and application thereof in preparing rare ginsenoside by fermenting ginseng flower buds, and belongs to the field of fermentation engineering. The lactobacillus plantarum BT810 is preserved in the China Center for Type Culture Collection on August 18, 2025, and the preservation number of the lactobacillus plantarum BT810 is CCTCC (China Center for Type Culture Collection) NO: M20251845. According to the method, a ginseng flower bud aqueous extract is taken as a fermentation substrate and inoculated with phytobacterium plantarum BT810 for standing fermentation, and ginsenoside Re in the ginseng flower bud aqueous extract is selectively hydrolyzed by beta-glucosidase secreted by the BT810 and is directionally converted into Rg2 and Rg4. The method has the advantages of extremely low by-products, high conversion rate, mild reaction conditions, low preparation cost and easiness in expanded production, and a convenient way is provided for large-scale, low-cost and efficient co-preparation of the rare ginsenosides Rg2 and Rg4.
Owner:JILIN ZHONGHUI BIOTECHNOLOGY CO LTD

A ginsenoside pharmaceutical composition having tyrosinase inhibitory activity and use thereof

PendingCN122097179ACosmetic preparationsToilet preparationsTyrosineGinsenoside Rd
The present application relates to a ginsenoside composition for inhibiting tyrosinase activity, which comprises any two or any three of ginsenoside Rd, ginsenoside Re or ginsenoside Rf. Ginsenoside Rf can be used as a synergistic molecule of ginsenoside Rd and Re, and can significantly enhance the inhibitory ability of tyrosinase activity through synergistic effect, thereby reducing the synthesis and secretion of melanin.
Owner:YANBIAN UNIV

Pdrn participates in the preparation method of a kind of body

This invention discloses a PDRN ginsenoside system and its preparation method, belonging to the field of cosmetics and topical skin preparations. Addressing the shortcomings of existing skincare products containing PDRN and ginsenosides, such as easy inactivation of active ingredients, low co-encapsulation rate of the two components, poor transdermal absorption efficiency, insufficient system stability and compatibility, and lack of synergistic effects, this invention designs a ginsenoside system composed of a phase A lipid carrier, a phase B aqueous matrix, and a phase C functional adjuvant. The proportions of each component are optimized, and a corresponding preparation process is provided. This invention achieves efficient co-loading of water-soluble PDRN and lipid-soluble ginsenosides, improving system stability and transdermal bioavailability of active ingredients, while also providing synergistic repair and anti-aging effects. It is gentle and non-irritating, and the preparation process is suitable for large-scale industrial production, making it widely applicable in various skincare formulations.
Owner:ZHEJIANG RUIYAN NEW MATERIAL TECH CO LTD

Ginsenoside composition gel liquid soap for double residence on skin and preparation method thereof

The invention relates to the technical field of skin care compositions, in particular to a ginsenoside composition gel soap liquid capable of doubly residing on skin. The composition does not contain a surfactant and a foaming agent, takes a panaxoside composition in a specific proportion as a core active component, and cooperates with a licorice extract, hyaluronic acid, a rapeseed extract, a bearberry leaf extract and a willow bark extract to form a stable gel system. The composition replaces traditional surfactants and foaming agents, solves the problems that traditional components damage skin barriers and cannot stay for a long time, has dual functions of deep cleaning and skin care, and has two characteristics of cleaning type non-staying products and cream type staying products at the same time. Experiments prove that the composition has excellent effects of resisting oxidation, whitening, deodorizing and removing cutin scales, is high in safety, does not contain harmful ingredients such as hormones and antibiotics, and can stay on the skin for a long time to play a continuous role.
Owner:潘东凯

Use of glycosyltransferase bs-yji c in bacillus subtilis 168

The application discloses application of a glycosyltransferase Bs-YjiC in Bacillus subtilis 168 and comprises the following steps: catalyzing reaction of ginsenoside Rg2, the glycosyltransferase Bs-YjiC and uridine diphosphate glucose, so as to glycosylate C 20 hydroxyl group of the ginsenoside Rg2 to generate ginsenoside Re; or catalyzing reaction of notoginsenoside R2, the glycosyltransferase Bs-YjiC and uridine diphosphate glucose, so as to glycosylate C 20 hydroxyl group of the notoginsenoside R2 to generate notoginsenoside R1; the application utilizes the glycosyltransferase Bs-YjiC of microbial origin to catalyze C 20 hydroxyl group glycosylation of the ginsenoside Rg2 or the notoginsenoside R2, and since the ginsenoside Re and the notoginsenoside R1 have important pharmacological effects, the glycosyltransferase Bs-YjiC of microbial origin can be utilized to catalyze synthesis of the ginsenoside Re and the notoginsenoside R1 beneficial to human health.
Owner:WENZHOU SAFETY (EMERGENCY) RES INST TIANJIN UNIV

A composition for alleviating, repairing testicular damage caused by heat stress and use thereof

ActiveCN119345212Brepair damagepromote recoveryLycoperseneChitosan nanoparticles
The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.
Owner:NANJING BIODE CO LTD

A beta-glucosidase ge000505 for saponin conversion and a preparation method and application thereof

The application discloses a kind of β-glucosidase GE000505 for saponin conversion and its preparation method and application, belong to biotechnology field, the amino acid sequence of the β-glucosidase GE000505 as shown in SEQ ID NO.1, it is encoded by the gene with nucleotide sequence as shown in SEQ ID NO.2.This β-glucosidase GE000505 of the application can convert high content ginseng and sanchi saponin into rare saponin R2, Rg3, Rg2 and Rh1, can convert sanchi saponin R1 into R2 entirely, convert ginsenoside Rd into Rg3 entirely, convert ginsenoside Re into Rg2 entirely, convert ginsenoside Rg1 into Rh1 entirely, convert ginsenoside F1 into aPPT entirely, convert ginsenoside F2 into aPPD entirely, solve the problem that existing β-glucosidase is not resistant to alcohol in the conversion of ginsenoside.
Owner:KUNMING MEDICAL UNIVERSITY +1

Pseudo-ginseng oral liquid as well as preparation method and application thereof

The invention relates to the technical field of health-care food, in particular to a pseudo-ginseng oral liquid and a preparation method and application thereof, and the pseudo-ginseng oral liquid comprises the following components in percentage by weight: 20-40% of pseudo-ginseng root extract, 3-8% of pseudo-ginseng stem and leaf extract, 0.5-2% of pseudo-ginseng flower extract and the balance of purified water. The total saponin is not less than 1200 mg / 100 mL in terms of ginsenoside Re, the ginsenoside Rb1 is not less than 30 wt%, the ginsenoside Rg1 is not less than 25 wt%, and the notoginsenoside R1 is not less than 5 wt%. The pH value of the product is 4.5-7.5, the product meets strict physicochemical and microbial standards, the product is packaged by a sodium-calcium glass bottle, and the shelf life is 24 months. The preparation method comprises the following steps: exclusively extracting, purifying, preparing, sterilizing and the like, and realizing quality controllability through an HPLC (High Performance Liquid Chromatography) characteristic chromatogram. The preparation is reasonable in dosage form, the problems of moisture absorption, low bioavailability and the like of a solid preparation are solved, and the active components are easy to absorb and convenient to take. Through research, the health-care tea has the health-care functions of improving hypoxia tolerance and relieving physical fatigue, and is suitable for people with related requirements.
Owner:YUNNAN NAN PHARMACEUTICAL CO LTD

Application of zinc-ginsenoside coordination nano-enzyme in treatment of diabetic nephropathy

The invention relates to the technical field of biological medicine, in particular to application of zinc-ginsenoside coordination nano-enzyme in treatment of diabetic nephropathy. The Zn (at) Gs-Re nano-enzyme provided by the invention not only enhances the stability and biological activity of ginsenoside Re, but also endows the ginsenoside Re with novel similar SOD / CAT enzyme activity, realizes multiple synergistic effects of resisting oxidation, resisting inflammation, resisting apoptosis, protecting mitochondria and improving renal functions, and shows remarkable superiority in the aspect of treating diabetic nephropathy and related complications.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL +1

A method for quality analysis of ginseng medicinal materials

The present application relates to the technical field of compound analysis, and in particular to a quality analysis method of ginseng medicinal materials, comprising the following steps: S100, preparation of a control solution: taking ginsenoside Rg1 control product, ginsenoside Re control product, ginsenoside Rf control product, ginsenoside Rb1 control product, ginsenoside Rc control product, ginsenoside Rb2 control product, ginsenoside Rd control product, 3-O-feruloylquinic acid control product, 4-coumaric acid control product, 8-O-4 / 8-O-4 dehydrogenated tri-ferulic acid control product, and adding methanol to prepare a mixed solution, and shaking to obtain the control solution. The present application synchronously monitors two components of saponins and phenolic acids under one detection method, monitors ten component contents of seven saponin components and three polyphenol components, obtains characteristic spectra of saponin components and polyphenol components, and the monitoring quality is more comprehensive and efficient.
Owner:HUNAN TIANJIN PHARMA

Multi-component quantitative analysis method for anti-aging tablets

The application provides a multi-component quantitative analysis method of anti-aging tablets, acetonitrile-0.1% formic acid aqueous solution is used as a mobile phase, an HSS T3 chromatographic column is used for target compound separation, and 13 active components in the anti-aging tablets are simultaneously determined in an MRM mode by using an electrospray ionization triple quadrupole mass spectrometer, the linear range of the 13 active components is 0.4-100 ng / mL, the linear range of ginsenoside Rb1, ginsenoside Rb2, ginsenoside Rc, ginsenoside Rd, ginsenoside Re, ginsenoside Rf and ginsenoside Rg1 is 4-1000 ng / mL, the method has high sensitivity, strong specificity and good reproducibility, and realizes simultaneous quantitative analysis of the 13 active components in the anti-aging tablets.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE +1

Compositions that protect cells from oxidative and mitochondrial stress

PendingUS20260090969A1Organic active ingredientsCosmetic preparationsAcacetinLuteolinidin
There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACTI peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).
Owner:NUCHIDO LTD

Method for detecting saponin components in ginseng and preparation thereof

PendingCN121231664AComponent separationMass spectrometry detectorElectro spray
The invention discloses a method for detecting saponin components in ginseng and a preparation thereof. Relates to the field of medicinal material detection. The method for detecting the saponin components in the ginseng and the ginseng preparation comprises the following steps: S1, taking a ginseng sample or a ginseng-containing preparation, adding an extraction solvent, and extracting to obtain a test solution; s2, the test solution is injected into a liquid chromatograph, a chromatographic column is adopted for gradient elution, and octadecylsilane chemically bonded silica is adopted as a filling agent of the chromatographic column; s3, detecting pseudo-ginsenoside F11, ginsenoside Rf, ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Re by adopting an electrospray ionization source negative ion mode and a multi-reaction monitoring mode of a mass spectrometry detector; a mobile phase used for gradient elution is selected from acetonitrile-water, an acetonitrile-ammonium acetate solution, acetonitrile-ammonium formate, methanol-formic acid or an acetonitrile-tetrahydrofuran-ammonium formate solution. By combining C18 chromatographic column gradient elution with a mass spectrum multi-reaction monitoring (MRM) mode and providing a mobile phase system, the problems of narrow applicability, isomeride interference, strong matrix effect and the like of a method for detecting saponin components of ginseng and preparations thereof in the prior art are effectively solved.
Owner:GUANGDONG INST FOR DRUG CONTROL (GUANGDONG INST FOR DRUG QUALITY GUANGDONG PORT DRUG CONTROL INST)

Method for detecting content of effective components of pseudo-ginseng and dragon's blood capsules

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly relates to a method for detecting the content of effective components of pseudo-ginseng and dragon's blood capsules. The invention provides a method for detecting the content of effective components in a pseudo-ginseng and dragon's blood capsule, which comprises the following steps: a, preparing a test solution: weighing pseudo-ginseng and dragon's blood capsule powder, adding methanol, performing ultrasonic treatment, and filtering to obtain the test solution; b, preparation of a reference substance solution: precisely weighing a ginsenoside Re reference substance, and adding methanol to dissolve the ginsenoside Re reference substance; the preparation method comprises the following steps: precisely weighing a proper amount of reference substances such as resveratrol, 4, 4-dihydroxy-2, 6-dimethoxy dihydrochalcone, loureirin A, loureirin B, loureirin C and loureirin D, and adding methanol for dissolving, thereby obtaining the resveratrol, 4, 4-dihydroxy-2, 6-dimethoxy dihydrochalcone and loureirin A; c, preparation of a reference substance solution: weighing the panax notoginseng total saponin reference extract, and adding methanol to dissolve the panax notoginseng total saponin reference extract to obtain the reference substance solution; and d, measuring and calculating the content. The method disclosed by the invention is high in accuracy, good in linearity, high in precision, good in separation degree and relatively good in repeatability.
Owner:YUNNAN SHENGKE PHARM CO LTD

Ginseng composition beverage capable of promoting gastrointestinal absorption as well as preparation method and application of ginseng composition beverage

The invention discloses a ginseng composition beverage capable of promoting gastrointestinal absorption and a preparation method and application thereof, and belongs to the technical field of foods.The ginseng composition beverage capable of promoting gastrointestinal absorption is prepared from ginsenoside extract, phospholipid substances and cyclodextrin; the ginsenoside extract comprises ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1; the ginsenoside extract and the phospholipid substance are combined through a hydrogen bond to form a hydrogen bond conjugate system; the hydrogen bond conjugate system and cyclodextrin form an inclusion compound through an inclusion effect. The functional components ginsenoside Rg1, Re and Rb1 in the ginseng are taken as indexes, the solubility, fat solubility and stability of the three kinds of ginsenoside are improved at the same time at a time, gastrointestinal absorption of the ginseng can be promoted, the ginseng can be better utilized, and the efficacy of the ginseng can be better exerted.
Owner:JILIN WEITE BIOENGINEERING CO LTD +1

A composition for treating ischemic heart disease and use thereof

This invention belongs to the field of biomedical technology, specifically relating to a composition for treating ischemic heart disease and its application. This invention combines two or more of ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, and notoginsenoside R1, which can significantly downregulate the levels of myocardial enzymes, aspartate aminotransferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) in myocardial coronary effusion, with an inhibitory effect significantly higher than that of a single saponin component and the positive control drug verapamil. Simultaneously, the composition exhibits better recovery capabilities for coronary flow (CF), left ventricular developmental pressure (LVDP), maximum rate of decrease in left ventricular pressure (-dp / dtmax), and heart rate (HR) in myocardial coronary effusion. Therefore, the composition can alleviate and treat myocardial ischemia-reperfusion injury through multiple targets and mechanisms, fundamentally inhibiting the development of ischemic heart disease.
Owner:HUAQIAO UNIVERSITY

Pharmaceutical composition for treating drug-induced liver injury and preparation method thereof

The invention relates to the technical field of biological medicine, and discloses a pharmaceutical composition for treating drug-induced liver injury and a preparation method thereof, active ingredients are ginsenoside Re and betaine, and the active ingredients are matched with pharmaceutically acceptable auxiliary materials such as microcrystalline cellulose to prepare dispersible tablets. The processes of gradient drying, precise tabletting and the like are adopted for preparation, and the component mixing and dissolution efficiency is optimized. The composition can significantly reduce transaminase and repair liver injury through the synergistic effect of oxidation resistance, inflammation resistance and hepatocyte repair, has the effect superior to that of a pharmaceutical composition with a single active component, and is fast in disintegration, high in dissolution rate, good in safety, controllable in quality and suitable for industrial production.
Owner:YANBIAN UNIV AFFILIATED HOSPITAL (YANBIAN HOSPITAL)

Ginseng adventitious root cell strain CCUM-Re-7 as well as extract, preparation method and application thereof

The invention discloses a ginseng adventitious root cell strain CCUM-Re-7 as well as an extract, a preparation method and application thereof. A construction method of the cell strain CCUM-Re-7 comprises the following steps: performing double disinfection and sterilization on ginseng, performing culture amplification after slicing, and separating into layered stem cells; inducing the separated cambium stem cells to generate ginseng adventitious roots; culturing the induced ginseng adventitious roots, and screening a cell strain CCUM-Re-7 from the induced adventitious roots; and carrying out large-scale culture on the cell strain to extract and prepare the ginseng adventitious root extract rich in saponin, and taking the ginseng adventitious root extract as an effective component to prepare the anti-aging and whitening composition. The invention belongs to the technical field of biology, and particularly provides a method for extracting an extract rich in ginsenoside Re from ginseng adventitious roots induced by ginseng cambium stem cells and application of the extract in anti-aging and skin whitening.
Owner:CHANGCHUN UNIV OF CHINESE MEDICINE

Cistanche deserticola and ginseng essence health wine preparation method based on multi-process synergy and product

The invention discloses a desert cistanche and ginseng essence health-preserving wine preparation method based on multi-process synergy and a product, belongs to the field of health-preserving wine preparation, and aims to solve the problems that the existing preparation process has obvious defects, and the production efficiency, active ingredient retention and product quality are difficult to balance. The problems of the traditional brewing method are particularly prominent as follows: the production period is extremely long and usually exceeds 6 months, and the production efficiency is seriously influenced; the extraction rate of the key active ingredient echinacoside in cistanche is lower than 55%, so that the health-preserving effect of the product is insufficient; and pectin in Chinese wolfberry can make the wine turbid, the light transmittance is lower than 80%, and the appearance of the product is influenced. A single modern process has the same shortages that although ultrasonic extraction can shorten the extraction time to be within 72 hours, when the temperature exceeds 60 DEG C, the degradation rate of ginsenoside Re in ginseng can exceed 30%, and the product value is reduced. The preparation method of the desert cistanche and ginseng essence health wine based on multi-process synergy has remarkable advantages in the aspects of active ingredient extraction, wine body stability, energy consumption and the like.
Owner:GUANGXI JIUZHUANGTANG LIQUOR CO LTD

Ginsenoside aerosol inhalation solution as well as preparation method and application thereof

The invention discloses a ginsenoside aerosol inhalation solution as well as a preparation method and application thereof, and belongs to the technical field of medicines. The ginsenoside solution for aerosol inhalation is prepared from the following raw materials in parts by weight: 0.1 to 3 parts of ginsenoside Re, 1 to 8 parts of hydroxypropyl-beta-cyclodextrin, 0.1 to 3.5 parts of sodium chloride, 1 to 5 parts of polyethylene glycol, 0.05 to 0.15 part of ascorbic acid, 0.1 to 0.8 part of chitosan and a pH (Potential of Hydrogen) regulator. Experiments prove that the ginsenoside aerosol inhalation solution prepared from the raw materials is high in atomization efficiency, high in bioavailability and good in stability, has a balanced slow-release effect and is small in side effect.
Owner:ZHEJIANG UNIVERSITY OF CHINESE MEDICINE FUYANG RESEARCH INSTITUTE

A method for identifying panax quinquefolium and its application

ActiveCN116794213Baccurate identificationThe average test time is shortComponent separationMedicinal herbsPseudoginsenoside F11
This invention belongs to the field of thin-layer chromatography (TLC) identification technology for traditional Chinese medicine, and specifically relates to a rapid TLC identification method and application for American ginseng and ginseng. The TLC identification method includes the following steps: taking a test sample, adding a solvent, sonicating, and taking the supernatant as the test solution; taking American ginseng and ginseng reference materials, adding solvents respectively, sonicating, and taking the supernatant as American ginseng reference material solutions and ginseng reference material solutions; taking ginsenoside Rg1, ginsenoside Rf, ginsenoside Re, ginsenoside Rd, and pseudoginsenoside F11 reference standards, adding solvents, mixing, and obtaining reference solution; finally, performing TLC analysis and result determination on the test solution, reference material solution, and reference solution. This invention is simple to operate, highly efficient and rapid, has good repeatability and high accuracy, and is low in toxicity and durable, and can simultaneously detect adulteration, substitution, and confusion in American ginseng and ginseng.
Owner:GUANGDONG INST FOR DRUG CONTROL (GUANGDONG INST FOR DRUG QUALITY GUANGDONG PORT DRUG CONTROL INST)

Content detection method and quality control method of Shendan brain-dredging dropping pill

The invention relates to a content detection method and a quality control method in a Shendan brain-dredging dropping pill, the content detection method comprises the content determination of ginsenoside Rb1, ginsenoside Rg1 and ginsenoside Re, and comprises the following steps: preparation of a test solution, preparation of a reference solution, and high performance liquid chromatography determination. In the content determination of ginsenoside Rb1, ginsenoside Rg1 and ginsenoside Re, acetonitrile is used as a mobile phase A and water is used as a mobile phase B in the high performance liquid chromatography. According to the method provided by the invention, the content detection of the effective components in the Shendan brain-dredging dropping pill can be effectively realized, so that the quality of the Shendan brain-dredging dropping pill is comprehensively detected and monitored, and the clinical medication safety and curative effect are ensured.
Owner:BEIJING INCREASEPHARM CORP LTD

Application of ginsenoside Re in preparation of medicine for inhibiting senescence of cerebrovascular endothelial cells

PendingCN121129872AOrganic active ingredientsNervous disorderAutophagy-Related ProteinsVascular endothelium
The invention relates to application of ginsenoside Re in preparation of drugs for inhibiting aging of cerebrovascular endothelial cells, and belongs to the technical field of biological medicines. Cell experiments find that GRe can inhibit D-gal induced primary cerebrovascular endothelial cell senescence and reduce the number of senescent cells, and also has the effects of degrading autophagy related protein P62 and increasing the ratio of LC3II / LC3I, so that cerebrovascular endothelial cell senescence is inhibited; animal experiments also find that the GRe can significantly increase the cerebrovascular skeleton density, reduce the expression level of senescence-related proteins P21 and P16 and improve the cognitive function.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE

Fingerprint spectrum detection method of heart-stabilizing traditional Chinese medicine composition

The invention provides a fingerprint spectrum detection method of a heart-stabilizing traditional Chinese medicine composition, the detection method comprises a fingerprint spectrum and an effective index component determination method, a characteristic spectrum is established by adopting a high performance liquid chromatography-mass spectrometry method, and meanwhile, the effective index component determination method is used for determining the effective index component of the heart-stabilizing traditional Chinese medicine composition. Chemical characteristic index components in rhizoma nardostachyos, pseudo-ginseng, codonopsis pilosula and rhizoma polygonati medicinal materials in the heart-stabilizing granules are determined. According to the present invention, 22 batches of the heart stabilizing particles are determined, 8 index components such as polygonatum sibiricum alkali A, lobetyolin, desoxynardostinol A, notoginsenoside R1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and ginsenoside Rd are identified, and the detection method has characteristics of rapid detection (detection time is less than 18 min), relatively comprehensive qualitative detection index relative components, high sensitivity, high accuracy, and the like. The internal quality of the compound traditional Chinese medicine composition can be objectively represented.
Owner:SHANDONG BUCHANG PHARMA

Method for determining contents of multiple components in Aidi preparation

The invention provides a method for determining the content of multiple components in an Aidi preparation, and belongs to the technical field of medicines. The Aidi preparation is prepared from traditional Chinese medicinal materials including ginseng, cantharides, astragalus membranaceus and acanthopanax. The content determination method comprises the following steps: simultaneously determining cantharidin, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rd, isofraxidin, syringin, formononetin, astragaloside, chlorogenic acid, eleutheroside E, calycosin-7-glucoside, astragaloside II, neochlorogenic acid, cryptochlorogenic acid and eleutheroside E1 in the Aidi preparation by adopting liquid chromatography-mass spectrometry; the composition is prepared from effective components such as ginsenoside F3, ginsenoside Rg2, azelaic acid and the like. Compared with the prior art, the method has the advantages that the contents of the 20 effective components in the Aidi preparation are simultaneously measured under the same chromatographic condition through liquid chromatography-mass spectrometry, the method is convenient and rapid, the requirement for product quality detection is greatly improved, the method is more suitable for quality control of drugs in the future, and the drug quality and the clinical drug effect are guaranteed.
Owner:GUIZHOU YIBAI PHARMA CO LTD

A method for detecting the content of kaixin san ingredients

This invention discloses a method for detecting the content of components in Kaixin San (a traditional Chinese medicine formula). Based on high-performance liquid chromatography (HPLC), a method for detecting the content of components in Kaixin San is constructed. By adopting a suitable gradient elution program, especially by strictly controlling the initial mobile phase ratio of the gradient elution program, and by combining the selection of chromatographic column and mobile phase, the method can rapidly and comprehensively determine the content of six chemical components in Kaixin San under dual-wavelength conditions: polygalactosidone III, 3,6-disinyl sucrose, ginsenoside Re, ginsenoside Rb1, β-asarone, and α-asarone. The method has high sensitivity, good specificity, accurate results, and good reproducibility.
Owner:BENGBU FENGYUAN TUSHAN PHARM CO LTD