269 results about "Ginsenoside-Re" patented technology

Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine; 2-amino-6-methyl-mercaptopurine; 1-methyl xanthine; 2-aminopurine; theophylline; theobromine; adenine; adenosine; kinetin; p-chlorophenoxyacetic acid; 2,4-dichlorophenoxyacetic acid; indole-3-butyric acid; indole-3-acetic acid methyl ester; beta-naphthoxyacetic acid; 2,3,5-triiodobenzoic acid; adenine hemisulfate; n-benzyl-9-(2-tetrahydropyranyl)adenine; 1,3-diphenylurea; 1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea; zeatin; indole-3-acetic acid; 6-benzylaminopurine; alpha-napthaleneacetic acid; 6-2-furoylaminopurine; green tea extract; white tea extract; menthol; tea tree oil; ginsenoside-RB1; ginsenoside-RB3; ginsenoside-RC; ginsenoside-RD; ginsenoside-RE; ginsenoside-RG1; ginseng root extract; ginseng flower extract; pomegranate extract, extracts from Ajuga turkestanica; extracts from viola tricolor and combinations thereof; an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.

A method for promoting angiogenesis in a patient comprising providing crosslinkable biological solution to the target tissue, wherein the crosslinkable biological solution is loaded with at least one angiogenic agent. In one embodiment, the at least one angiogenic agent is a non-protein factor selected from a group consisting of ginsenoside Rg₁, ginsenoside Re, combination thereof and the like. In another embodiment, the crosslinkable biological solution of the present invention is broadly defined in a form or phase of solution, paste, gel, suspension, colloid or plasma that may be solidifiable thereafter.

The invention relates to a composite of active ingredients of Chinese herb medicine used for preventing the damage of cerebral ischemia and relevant diseases, in particular to a preparation which is prepared by the active ingredients of the Chinese herb medicine; the preparation is prepared by the active ingredients of the Chinese herb medicine and the conventional preparation technique which is used by carriers permitted by pharmacy, and comprises the following components with the parts by weight: 2 to 10 parts of ginsenoside Rb, 2 to 10 parts of ginsenoside Rg1, 1 to 5 parts of ginsenoside Rd, 1 to 5 parts of ginsenoside Re, 2 to 10 parts of stilbene glycoside, 1 to 5 parts of ginkgolide and 1 to 5 parts of flavonoid mixture which consists of kaempferol and quercetin with the weight rate to be 1:1. The invention has the advantages that the defects that in the traditional compounded Chinese medicine, the composition is complex, the product quality is not controlled effectively and the curative effect is not stable are overcome, has clear ingredients, definite effect, stable quality and obvious control effect on ischemic stroke, sequela, cerebral arteriosclerosis and vascular dementia, can improve the functions of motor nerve, and learning and memory of the patients, has low toxicity and simple preparation method without obvious side effect and is suitable for industrial mass production.

The invention discloses a preparation method of ginseng composite fruit-vegetable enzyme and a product, and belongs to the field of the preparation of fruit-vegetable enzyme. The preparation method of the ginseng composite fruit-vegetable enzyme comprises the following steps: (1) washing ginseng, fruits and vegetables, and air drying the ginseng, fruits and vegetables; (2) slicing or crushing the ginseng and fruits, cutting the vegetables into segments or crushing the vegetables into pieces, uniformly mixing, charging honey, and uniformly mixing to obtain a mixed raw material; (4) inoculating yeast into the mixed raw material, and fermenting to obtain mash; (5) inoculating acetic bacteria into the mash obtained in the step (4), and fermenting to obtain fermented mash; (6) inoculating lactobacillus into the fermented mash obtained in the step (5), fermenting, aging and filtering to obtain the ginseng composite fruit-vegetable enzyme. The prepared ginseng composite fruit-vegetable enzyme is moderate in sweet and sour taste, contains carbohydrate, folic acid, panaxoside and various trace elements and nutrients necessary for a human body, is easy to digest by the human body and capable of effectively improving the utilization rate of various natural fruit and vegetable nutritional value of Changbai Moutain.

The invention provides a radix notoginseng extract which contains 5-10% of notoginsenoside R1, 25-36% of ginsenoside Rg1, 2.5-5% of ginsenoside Re, 30-39% of ginsenoside Rb1, 5-10% of ginsenoside Rd and at least 2% of ginsenoside Rf, ginsenoside Rh1, ginsenoside Rc, ginsenoside Rb2 and ginsenoside Rg3, wherein the ginsenoside R1, the ginsenoside Rg1, the ginsenoside Re, the ginsenoside Rb1 and the ginsenoside Rd account for 75-95% of the total weight. The invention also provides a preparation method of the radix notoginseng extract. The radix notoginseng extract prepared by the method has little impurities, the purity of the component of total saponin is higher, and especially, the components of the ginsenoside Rf, the ginsenoside Rh1, the ginsenoside Rc, the ginsenoside Rb2, the ginsenoside Rg3 and the like with very low content are purified. The medicinal preparation prepared by the radix notoginseng extract has better curative effect and higher safety.

The present invention relates to Chinese medicine and its extracting and processing technology, and is especially the effective part extracted from American ginseng leaf and ginseng leaf and its preparation process. The extracted effective part contains six kinds of ginsenoside substances, including ginsenoside Re, ginsenoside Rb1, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rc and ginsenoside Rd. Its preparation process includes water extracting American ginseng leaf and ginseng leaf in the weight ratio of 1 to 0.3, macroporous resin adsorption of the water extract liquid, water eluting to eliminate impurity, further eluting with two kinds of elutents, collecting the eluted liquid, and refining the total solid matter to reach purity up to 63.45 %. The extracted effective part has less side effects, and may be used widely in compound medicine preparation and functional food and for separating ginsenoside substance.

The invention discloses a composition for treating cardiovascular diseases and a preparation method thereof. The composition comprises (by weight part) Radix Ginseng Rubra saponin 2-20, Ophiopogon japonicus saponin 0.2-3, and Ophiopogon japonicus flavone 0.02-3; wherein the Radix Ginseng Rubra saponin extract contains (by dry weight) ginsenoside Rg1 not less than 9.0%, ginsenoside Re not less than 3.0%, ginsenoside Rb1 not less than 12.0%, and Panax ginseng total saponins not less than 80%; the Ophiopogon japonicus saponin extract contains (by dry weight) ophiopogonin D not less than 6.0%, ophiopogonin D' not less than 6.0%, and Ophiopogon japonicus total saponins not less than 80%; and the Ophiopogon japonicus flavone extract contains (by dry weight) methylophiopogonone A and methylophiopogonone B in total not less than 80%. Animal experiments showed that the composition has good therapeutic action on myocardial ischemia and has better anti-shock effect.

The invention discloses an Rg2 group and an Rh1 group of red ginseng saponin and a preparation method as well as applications in preparing cosmetics preventing skin aging. Extracts which are extracted from ginseng roots, do not contain saponin, and contain saponin enzyme of ginseng and other water-soluble matters react with ginsenoside Re to obtain red ginseng mixed saponin Rg2 group consisting of red ginseng rare saponin 20(S)-Rg2, 20(R)-Rg2, Rg4 and Rg6, and the extracts react with ginsenoside Rg1 to obtain the red ginseng mixed saponin Rh1 group consisting of red ginseng rare saponin 20(S)-Rh1, 20(R)-Rh1, Rh4 and Rk3. Compared with a saponin Rg2 monomer and a saponin Rh1 monomer, the function of the Rg2 group and Rh1 group of red ginseng mixed saponin for promoting skin fibroblast collagen synthesis is improved obviously, the Rg2 group and Rh1 group of red ginseng mixed saponin are more safe to skin and human bodies, and have less side effects.

The invention relates to panax notoginseng saponins medicine combination and the application thereof, which are characterized in that the active ingredient is composed of panax notoginseng saponins which contains notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, ginsenoside Rd, ginsenoside Rb3 and ginsenoside Rb2; the combination with different contents and ingredients of saponins are prepared; the combinations have different treatment effects.

The invention provides a medicinal composition, which comprises the following components: ginsenoside Rb1, ginsenoside Rg1, notoginsenoside R1, ginsenoside Rd, ginsenoside Re, ginsenoside Rf, ginsenoside Rc, ginsenoside Rh1, ginsenoside Rb2 and ginsenoside Rg3. The invention also provides a preparation method for the medicinal composition. The medicinal composition has definite components; compared with the total notoginsenoside in the prior art, the medicinal composition has stable quality and good controllability; and results of experiments of acute toxicity, undue toxicity, hemolysis and the like show that the medicinal composition has higher safety and wide clinical application prospect.

The invention relates to a detection method of compound danshen dripping pills, comprising the following contents of: observation of characters, discrimination of contents, inspection of contents, comparison of finger prints and assaying of contained components. The detection method provided by the invention comprises a discriminating method of the medicinal component panax notoginseng, the discriminating method adopts thin-layer chromatography, the reference materials adopt a panax notoginseng reference medicinal material, a ginsenoside Rg1 reference substance, a ginsenoside Re reference substance, a ginsenoside Rb1 reference substance and a panax notoginseng saponin R1 reference substance. The detection method provided by the invention also comprises a discriminating method and an assaying method of the medicinal component danshen, wherein the discriminating method adopts a sub-2 mu m liquid chromatography technology to perform chromatographic fingerprint discrimination, and adopts sodium danshensu as a reference material; and the assaying method adopts a sub-2 mu m liquid chromatography technology to perform assaying on the components such as danshensu, panax notoginseng saponin R1, ginsenoside Rg1 and ginsenoside Rb1 in the danshen.

The invention discloses a method for extracting and separating total saponins of panax ginseng from american ginseng. The method employs a series of high-efficiency extraction, separation and purification technical measures of alcohol-backflow extracting, water precipitating, purifying by a macroporous adsorption resin, decolorizing with an ion exchange resin, etc. The obtained total saponins of panax ginseng are white powder and comprise ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, ginsenoside Rc and ginsenoside Rd, wherein the total purity of ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 is more than 74.0%. The production process is simple and practical, has no pollution, and is suitable for large-scale production.

The present invention discloses a UPLC-MS quantitative method for the contents of twelve components in a traditional Chinese medicine composition preparation, specifically determination of the contents of calycosin-7-O-beta-D-glucoside (1), isoquercitrin (2), narirutin (3), hesperidin (4), ginsenoside Re (5), ginsenoside Rg1(6), periplocoside (7), ginsenoside Rf (8), ginsenoside Rb1 (9), astragaloside (10), ginsenoside Rd (11) and periplocin H1 (12) in the traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicine composition preparation component detection. The determining method of the present invention has characteristics of short period, good reproducibility and high sensitivity.

The present invention relates to a series of dicarboxylic acid ester derivatives of ginsenosides such as succinate and glutarate derivatives of 20-O-β-D-glucopyranosyl-protopanaxadiol (compound K, abbreviated as CK), preparation thereof and pharmaceutical uses thereof. The dicarboxylic acid ester derivatives of ginsenosides of the present invention can be used to form pharmaceutical acceptable salts thereof having a high water solubility or can be directly dissolved in an aqueous solution of metal salt, and retain the pharmaceutical activities of ginsenosides such as tumor growth inhibition and cancer preventive cytotoxicity. The dicarboxylic acid ester derivatives of ginsenosides of the present invention are thus suitable for use in the manufactures of various pharmaceutically and cosmetically acceptable dosage forms of preparations, such as peripheral, oral, and topical dosage forms.

The invention discloses a traditional Chinese medicine preparation lumbus-strengthening kidney-tonifying pill detection method, according to the method, rehmannia glutinosa, yam, tuckahoe, schisandra, chrysanthemum and astragalus in a lumbus-strengthening kidney-tonifying pill can be microscopically identified, a radix angelicae sinensis referenee crude herb, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, dipsacus asper saponin VI, astragaloside and deoxyschizandrin are used as reference substances, whether the lumbus-strengthening kidney-tonifying pill contains the radix angelicae sinensis ,ginseng, dipsacus asper, astragalus and schisandra can be identified by thin-layer chromatography; the dipsacus asper saponin VI content in the lumbus-strengthening kidney-tonifying pill preparation can be detected by HPLC, according to the detection method, the quantitative index is that the dipsacus asper saponin VI (C47H76O18) content in every 1g of the traditional Chinese medicine preparation lumbus-strengthening kidney-tonifying pill may not be less than 0.60mg, the controllability of quality standards of the traditional Chinese medicine preparation lumbus-strengthening kidney-tonifying pill can be improved to further ensure the product intrinsic quality and effect, so that the quality standard is more perfect, and the drug quality control level is improved.

The invention relates to a pharmaceutical composition and a preparation method thereof. The pharmaceutical composition contains ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Re, wherein the weight ratio of ginsenoside Rg1: ginsenoside Rb1: ginsenoside Re is 1:0.7:1.2. The composition provided by the invention has notable effects and high safety, can alleviate apoplexy symptoms, obviously shortens the course of disease, improves depression of patients with apoplexy sequelae, and the like.

The invention relates to the technical field of biological medicine, and discloses an NMN (Beta-Nicotinamide Mononucleotide) beneficial bacterium health composition and a preparation method and application thereof. The composition comprises in parts by weight: 20 to 40 parts of NMN, 10 to 15 parts of beneficial bacterium powder, 0 to 8 parts of betaine, 0 to 5 parts of grape seed extract, 0 to 5 parts of baicalein, 0 to 5 parts of apigenin, 0 to 8 parts of astaxanthin, 0 to 8 parts of ginsenoside, and 0 to 8 parts of ganoderma lucidum polysaccharide (GLP); beneficial bacteria in the NMN beneficial bacterium health composition prepared by the invention can effectively improve the microecology of intestinal floras of a user, not only can improve the metabolic syndrome caused by the intestinal floras of the user, but also can improve the intestinal absorption efficiency, and is beneficial to the absorption of the NMN in the intestinal tract; the ginsenoside and the GLP are mainly matchedto improve the immunity of the user, so that the user can better adapt to various changes of the metabolic pathway level, which are caused by the case that the NAD + level is improved after the NMN enters the human body, and the organism has higher buffering capacity on the changes; and AMPK activators (the betaine, the baicalein and the apigenin) have a synergistic effect with the NMN, so that the NMN beneficial bacterium health composition is better in effect and has no side effects.

The invention discloses a quality detecting method of medicine for curing diabetes, belonging to the field of Chinese herbal medicine quality detection, comprising steps such as the discriminating and checking of the medicine for curing diabetes and the detecting of extracts and content. The quality detecting method realizes the discrimination of astragaloside, puerarin, sarsasapogenin, American ginseng, ginsenoside Rb1 and Rg1 through thin layer chromatography, and at the same time adopts the dual-wavelength scanning method to accurately detect the content of ginsenoside Re; at least 0.10mg American ginseng should be contained in each grain calculated by ginsenoside Re (C48H82O18). The quality detecting method has the advantages of easy operation, accurate and advanced performance and good linear relationship, reproducibility, precision, stability and recovery rate, can effectively control the quality of the product and can ensure the therapeutic effects of the product.

The invention provides a method for controlling the quality of a Chinese traditional throat medicine. The method comprises the steps: (1) discriminating ginseng, radix trichosanthis and liquorice contained in the Chinese traditional throat medicine by the microscope discrimination method; (2) detecting vitriol in natrii sulfas exsiccatus by the barium chloride reagent precipitation method; (3) detecting natural indigo in the Chinese traditional throat medicine by the thin-layer chromatography, and comparing the natural indigo with indigotin and indirubin; (4) detecting borneol and menthol by the thin-layer chromatography; (5) detecting ginseng contained in the Chinese traditional throat medicine by the thin-layer chromatography, and comparing the Chinese traditional throat medicine with ginseng, ginseng saponin Rb1, ginsenoside Re and ginsenoside Rg1; (6) detecting liquorice contained in the Chinese traditional throat medicine by the thin-layer chromatography; and (7) detecting the content of andrographolide and dehydrolyzed andrographolide contained in the Chinese traditional throat medicine. The method used for controlling the quality of the Chinese traditional medicine overcomes the defects of the prior discrimination method that the specificity is not enough; the thin-layer chromatography is used for detecting natural indigo, borneol and menthol simultaneously, the sampling amount is difficult to grasp, and excellent separating effect is difficult to reach, the thin-layer chromatography can just detect limited ingredients, i.e. natural indigo, borneol and menthol, thus failing to effectively discriminate the Chinese traditional throat medicine; the prior discrimination method fails to measure the content of effective ingredients, and can not effectively control the defects of product quality. The method improves the specialty and the quality stability, and ensures security and effective use of the medicine by users.

The invention discloses an application of ginsenoside-Re in protecting nerve cells, and belongs to the technology field of medicines. According to the invention, the ginsenoside-Re has the effect of protecting cerebral ischemia, cerebral ischemia reperfusion injury, Parkinson disease, Alzheimer disease and PC12 cells; and can be used for preparing new drugs for preventing and treating neurological diseases such as Parkinson disease, Alzheimer disease, cerebral apoplexy and cerebral ischemia. For a mouse model, the dose of ginsenoside-Re is 8-26mg/kg; for a rat model, the dose of ginsenoside-Re is 5-26mg/kg, and for cell experiments, the dose is 10<-5>-10<-8>mol/L.

The invention is suitable for the field of medicines and provides a drug composition for preventing and treating related diseases of ischemic stroke. The drug composition comprises the following components in parts: 1.0-3.5 parts of notoginsenoside R1, 4.0-7.5 parts of ginsenoside Rg1, 3.5-7.5 parts of ginsenoside Rb1, 1.0-3.0 parts of ginsenoside Re, 0.03-0.15 part of astragaloside, 0.02-0.010 part of calycosin-7-O-beta-D-glucopyranoside, 0.01-0.10 part of harpagoside, 0.002-0.010 part of cinnamic acid, 0.45-1.5 parts of salvianolic acid B, 0.02-0.10 part of cryptotanshinone and 0.02-0.10 part of tanshinone IIA. The drug composition provided by the invention has the functions of promoting blood circulation and removing blood stasis, supplementing qi and nourishing yin, can be used for preventing and treating the related diseases of the ischemic stroke and is capable of overcoming the shortcomings of component complexity and the like of traditional compound traditional Chinese medicine preparations.

The invention relates to a method for extracting and preparing high-purity ginsenoside Re from herminium by high speed counter current chromatography, which is characterized by comprising the following steps: soaking fruit residues of the herminium in 70 percent ethanol solution through overnight; performing ultrasonic extraction for 30 minutes for three times repeatedly and concentrating extract liquid after filtration to obtain herminium coarse extract; and selecting ethyl acetate 0.5-2, butanol 4-7 and water 6-9 according to a volume ratio to form a solvent system and separating at a room temperature of from 16 to 28 by using a high speed counter current chromatographic instrument. The method for preparing and separating ginsenoside Re in large scale avoids the use of solid filler as well as irreversible adsorption, sample loss and pollution, and is high in efficiency, quick and low in cost. The obtained ginsenoside Re has a purity of more than 98 percent, and the method is suitable for separating and preparing the insenoside Re from herminium coarse extracts prepared under various process conditions.