The present application belongs to the technical field of
traditional Chinese medicine extraction, and particularly relates to an extraction method of high-activity
ginseng extract, which is used for improving the conversion and extraction efficiency of rare ginsenosides Rg1, Rg3, Rg5, Rh2 and
Compound K. The extraction method combines microbial
fermentation, electrostatic field wall breaking and supercritical CO2 extraction. The microbial
fermentation treatment is mainly used for promoting the synthesis of ginsenosides, the high-
voltage pulse electric field induces the
electroporation effect of
ginseng cells to increase the permeability of
cell membrane and
cell wall, the supercritical CO2 extraction has
high cell permeability to improve the extraction rate and purity of ginsenosides, and in addition, the catalytic aid added in the extraction process is helpful to the conversion and
catalysis of rare
ginsenoside components.