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Method for promoting conversion of ginsenoside by paenibacillus polymyxa through Cu<2+> ions

A technology of polymyx spore-like and ginsenoside, which is applied in the biological field and can solve the problems of low ginsenoside monomer content and the like

Inactive Publication Date: 2018-02-06
JILIN AGRICULTURAL UNIV
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  • Claims
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Problems solved by technology

[0003] In view of the low content of ginsenoside monomers in ginseng, the object of the present invention is to provide a Cu 2+ A method for ions to promote the transformation of ginsenosides by Paenibacillus polymyxa, to more efficiently produce rare saponins or increase the yield of ginsenosides, thereby improving the medicinal value of ginseng

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  • Method for promoting conversion of ginsenoside by paenibacillus polymyxa through Cu&lt;2+&gt; ions

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example 1

[0004] Example 1 a kind of Cu 2+ Ions promote the method of Paenibacillus polymyxa transforming ginsenoside

[0005] The invention relates to the field of biotechnology, and is a kind of Cu 2+ Ion-promoted method for transformation of ginsenosides by Paenibacillus polymyxa. The ginseng endogenous Paenibacillus polymyxa of the present invention is preserved in the General Microorganism Center of China Microbiological Culture Collection Management Committee, and the preservation number is CGMCC 7250. The method increases the content of ginsenoside monomers Rg1, Re, Rf, Rb1, Rg2, Rb2, Rb3, Rd, Rh4, Rg3, protopanaxatriol, Compound K, Rg5, Rh2 and protopanaxadiol. The method is simple, low in cost, and conducive to industrialized large-scale production. The specific scheme is as follows:

[0006] 1. a Cu 2+ The method that ion promotes Paenibacillus polymyxa to transform ginsenoside is characterized in that it is completed by the following steps:

[0007] (1) Paenibacillus po...

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Abstract

The invention provides a method for promoting conversion of ginsenoside by paenibacillus polymyxa through Cu<2+> ions. The content of ginsenoside monomers Rg1, Re, Rf, Rb1, Rg2, Rb2, Rb3, Rd, Rh4, Rg3, protopanaxatriol, Compound K, Rg5, Rh2 and protopanoxadiol in ginseng products converted by the paenibacillus polymyxa is increased. The efficient production of ginsenoside monomers is facilitated;further, the medicinal value of the ginseng is improved. The method is simple and convenient; the cost is low; the industrialized large-scale production is facilitated.

Description

technical field [0001] The invention relates to the field of biotechnology, and is a kind of Cu 2+ Ion-promoted method for transformation of ginsenosides by Paenibacillus polymyxa. Background technique [0002] Ginsenosides are the medicinal ingredients of ginseng, but the content of ginseng is relatively low, especially the content of rare ginsenosides. In addition, after oral administration, ginsenosides can hardly be decomposed by human gastrointestinal digestive enzymes, but can only be absorbed and utilized by the human body after being metabolized by the unique microorganisms in the intestinal tract, so as to play a pharmacological role. The possible transformation of panaxadiol saponins is mainly through the enzymes produced by microorganisms to hydrolyze the β-(1-6)-glucosidic bond on C20 and the β-(1-2)-glucosidic bond on C3, and then generate Rd, Rd Further hydrolysis generates F2 or Rg3, F2 is then hydrolyzed into C-K, Rg3 can be converted into Rh2, and finally ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P33/20C12R1/01
CPCC12P33/20
Inventor 郜玉钢臧埔肖茹雪赵岩何忠梅祝洪艳李新殿杨鹤赵露刘双利陈长卿蔡恩博王玉珍毛欣欣张连学
Owner JILIN AGRICULTURAL UNIV
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