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79 results about "Human keratinocyte" patented technology
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The keratinocyte is the major cell type of the epidermis, making up about 90% of epidermal cells. Human Epidermal Keratinocytes (HEK) perform a barrier function in the skin and mouth, protecting against invasion of bacteria and foreign particles.
Method and compositions for treating skin
A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
Owner:ELC MANAGEMENT LLC
Protein-free defined media for the growth of normal human keratinocytes
Improvements are made to a novel media that replace the requirement for all protein growth factors by the addition to the medium of physiological concentrations of retinyl acetate. The media are serum-free, companion cell or feeder layer-free and organotypic, matrix free solutions for the cultivation of clonally competent basal keratinocytes. The media and methods are useful in the production of epidermal epithelial tissue that is suitable for skin grafting.
Owner:BIOPLAST MEDICAL
Keratinocyte stem cells
InactiveUS6485971B1Increase capacityHigh purityEpidermal cells/skin cellsArtificial cell constructsEpitheliumMedicine
Enrichment for human Keratinocyte Stem Cells KSCs to a high degree of purity can be successfully achieved on the basis of a cell surface component whose expression is proliferation-related in conjunction with an integrin such as the alpha6beta4 integrin. Transferrin receptor may be used as the cell surface component that is proliferation related. Enrichment of Transit amplifying cells can also be achieved by use of a variation of this method. The enrichment follows on from harvesting of cells from an epithelium, preferably rich in stem cells.
Owner:PETER MACCALLUM CANCER INST
Non-viable keratinocyte cell composition or lysate for promoting wound healing
Cultures of keratinocyte cells are provided which are free from nonautologous fibroblasts and organ extracts, and which have a high speed of cell amplification for a minimum seeding density. The cultures can be cryopreserved in a buffered isotonic medium containing serum and a cryoprotectant. The cultures are produced by a process that does not involve the use of a feeder layer and organ extracts. A culture medium which can be used contains Medium 199, serum, epidermal growth factor, cholera toxin and / or hydrocortisone, and optionally insulin. A substance for wound healing and for cosmetic applications is derived from cultured human keratinocytes. A non-viable total keratinocyte lysate for use in promoting wound healing is produced by growing keratinocyte cells on a support, detaching the cells from the support, and lysing the detached cells to obtain the lysate which may be frozen and lyophilized. The cells may be grown without using a support to produce the lysate, or to produce a non-viable keratinocyte cell culture lyophilisate or spray dried non-viable keratinocyte cell composition for use in healing wounds.
Owner:CELLTRAN LTD
Vascularized human skin equivalent
InactiveUS20070207125A1Accelerated rate of vascularizationImprove clinical utilityBiocideEpidermal cells/skin cellsSkin equivalentIn vivo
Clinical performance of currently available human skin equivalents is limited by failure to develop perfusion. To address this problem we have developed a method of endothelial cell transplantation that promotes vascularization of human skin equivalents in vivo. Living skin equivalents were constructed by sequentially seeding the apical and basal surfaces of acellular dermis with cultured human keratinocytes and Bcl-2 transduced HUVEC or umbilical cord cells sequentially. After orthotopic implantation of grafts comprising cultured human keratinocytes and Bcl-2 transduced HUVEC cells onto mice, the grafts displayed both a differentiated human epidermis and perfusion through the HUVEC-lined microvessels. These vessels, which showed evidence of progressive maturation, accelerated the rate of graft vascularization. Successful transplantation of such vascularized human skin equivalents should enhance clinical utility, especially in recipients with impaired angiogenesis.
Owner:YALE UNIV
Method and compositions for treating skin
Owner:ELC MANAGEMENT LLC
Methods for preparing human skin substitutes from human pluripotent stem cells
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)
Epidermal differentiation microRNA signature and uses thereof
ActiveCN102625853AHas moisturizing functionCosmetic preparationsMicrobiological testing/measurementEpitheliumCuticle
The present invention relates to a method for determining the state of epidermal differentiation of a human keratinocyte in a human epithelium sample, said method including determining the level of expression of at least one microRNA selected from among hsa-miR-455-3p, hsa-miR-141, hsa-miR-148a, hsa-miR-182, hsa-miR-224, hsa-miR-26a, hsa-miR-26b, hsa-miR-361-5p, hsa-miR-425, hsa-miR-92b, hsa-let-7i, hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-29a, hsa-miR-29b, hsa-miR-663, hsa-miR-30a, and hsa-miR-30c within said keratinocyte, and comparing the level of expression of the microRNA(s) selected at the mean level of expression of the microRNA(s) selected in the undifferentiated keratinocytes or in differentiated epidermal keratinocytes, preferably from the same strain or the same population. The present invention also relates to various uses of the method for determining the state of epidermal differentiation, as well as to pharmaceutical or cosmetic compositions.
Owner:LOREAL SA
Anti-oxidation, anti-glycation and anti-aging skin care composition and application thereof
ActiveCN111437237APromote hydrationInhibition releaseCosmetic preparationsToilet preparationsInflammatory factorsHuman keratinocyte
The invention belongs to the technical field of daily cosmetics, and discloses an anti-oxidation, anti-glycation and anti-aging skin care composition and an application thereof. The composition mainlycomprises carnosine, ultra-low molecular weight dendrobium officinale polysaccharide extract and bifida ferment lysate, and also can comprise a solvent and a preservative. By golden proportioning andcombined use of three components including the carnosine, the ultra-low molecular weight dendrobium officinale polysaccharide extract and the bifida ferment lysate, the synergistic effect is achieved, so that the composition has the effects of resisting oxidation, resisting glycosylation, inhibiting release of inflammatory factors by human keratinocytes after photodamage, promoting expression ofbarrier repair genes and promoting synthesis of collagen, and takes the comprehensive anti-ageing effect. In addition, the anti-oxidation, anti-glycation and anti-aging skin care composition is simplein component type and easy to prepare and easy to mix with other components in the cosmetics, and has the obvious advantage of being easy to add in various types of formulas.
Owner:东莞巨微新材料科技有限公司
Method and composition for skin grafts
A chimeric skin comprising immortalized human keratinocyte cells cocultured with donor keratinocytes is disclosed.
Owner:WISCONSIN ALUMNI RES FOUND
Method for preparing relaxing and face-cleansing cosmetics and application
ActiveCN102379838ACosmetic preparationsAntipyreticRecombinant Human Keratinocyte Growth FactorVitamin C
The invention relates to a method for preparing relaxing and face-cleansing cosmetics and application. The cosmetics comprises the following components in percentage by mass: 0.00001 to 0.001 percent of recombinant human keratinocyte growth factors, 0.00001 to 0.001 percent of recombinant human interleukin-1 receptor antagonist, 0.1 to 0.5 percent of low-molecular sodium heparin, 5 to 25 percent of stabilizer, 0.02 to 0.3 percent of hyaluronic acid, 0.5 to 8 percent of vitamin C sodium phosphate, 0.5 to 5 percent of methyl propanediol, 0.3 to 0.7 percent of 1,2 hexanediol, 0.5 to 3.5 percent of lactobacillus / mung bean fermentation liquor, 0.5 to 5 percent of dissolved protease and the balance of water. The relaxing and face-cleansing cosmetics are applied to sensitive skin, can be stored for a long time, and is suitable for long-term use.
Owner:广州泰润合投资有限公司
Cosmetic composition comprising a meteorite extract, and use of the extract as cosmetic agent suitable for stimulating the differentiation of human keratinocytes
The present invention relates to a cosmetic composition comprising a meteorite extract. The present invention also relates to methods of using the extract as a cosmetic agent suitable for stimulating the differentiation of human keratinocytes.
Owner:GATTEFOSSE SA
Methods for Preparing Human Skin Substitutes from Human Pluripotent Stem Cells
InactiveUS20110165130A1Enhance stratification and differentiationBiocideEpidermal cells/skin cellsGerm layerCuticle
The present invention relates to an ex vivo method for obtaining a population of human keratinocytes derived from human pluripotent stem cells comprising a step of co-culturing human pluripotent stem cells with cells that support ectodermal differentiation in presence of an agent that stimulates epidermal induction and a agent that stimulates terminal differentiation of keratinocytes. A further object of the invention relates to a method for preparing a human skin substitute comprising a step of providing an organotypic culture of the substantially pure homogenous population of human keratinocytes derived from human pluripotent stem cells obtained according to the method of the invention.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)
Ginseng flower composite fermentation product, preparation method and application thereof
ActiveCN109481356ASmall molecular weightReduce contentCosmetic preparationsToilet preparationsPreparing skinSkin repair
The invention relates to the field of daily chemicals and plant extracts, in particular to a ginseng flower composite fermentation product and an application thereof. A ginseng flower extract is fermented by yeast and lactic acid bacteria successively, and the contents of rare ginsenosides s-Rg2, R-Rg2, S-Rg3, R-Rg3, PPT, F4, Rh4, Rg5 and Compound K in the ginseng flower composite fermentation product contained in a supernatant of the fermentation product are all increased. The ginseng flower composite fermentation product can promote human keratinocyte proliferation, inhibit tyrosinase activity, limit melanin generation, improve skin pigmentation, and has whitening effect. Therefore, the ginseng flower composite fermentation product can be used for preparing skin external preparations, and can be used as an active ingredient for skin repair, improvement of pigmentation or whitening.
Owner:JALA GROUP CORPORATION
Growth factor mediated cosmeceuticals and use thereof to enhance skin quality
InactiveUS20080234194A1Promote migrationReduce wrinklesCosmetic preparationsVirusesDiseaseWrinkle skin
It has been discovered that vascular endothelial growth factor (“VEGF”) promotes migration of activated (but not differentiating) keratinocytes to skin. This growth factor specifically increases migration of keratinocytes of the “wounded skin” phenotype but does not have significant effects upon differentiated keratinocytes. It also increases collagen deposition and reduces wrinkles, enhances skin quality, and increases skin thickness to normal levels in individuals where skin has thinned due to age or disorder such as diabetes. It is particularly well suited for use as cosmeceuticals when applied in purified form and in known amounts. The data presented in the examples demonstrate efficacy and specificity of VEGF in enhancing migration of normal human keratinocytes as well as formation of new granulation tissue including collagen formation. VEGF induces keratinocyte and fibroblast migration, formation of new tissue, and not only induces deposition of collagen but improves alignment of the collagen fibers. Accordingly, this growth factor is highly suitable for use as a cosmeceutical, especially for skin resurfacing and reduction in wrinkles.
Owner:NEW YORK UNIV
150 KDA TGF-B1 accessory receptor acts a negative modulator of TGF-B signaling
Owner:9406 2668 QUEBEC INC
Methods for Culturing Keratinocytes from Human Embryonic Stem Cells
InactiveUS20070274963A1Fast harvestBiocideMicrobiological testing/measurementPure cultureHuman keratinocyte
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
Quick construction preparation method of human epidermal tissues
InactiveCN103721294AHigh transplantabilityImprove production efficiencyProsthesisSkin graftingHuman skin
The invention relates to a quick construction preparation method of human epidermal tissues. In terms of the structure characteristics of human epidermal tissues, chitosan, gelatin and human keratinocyte are adopted for cell culture, and are subjected to film shaping, nutrient solution immersion and tissue construction to generate human epidermal tissues of the human keratinocyte under a high-pressure sterile state. The preparation method is advanced in process, the preparation efficiency and speed of human epidermal tissues can be effectively improved due to construction and use of a gas pressure device, and the human epidermal tissue can be used for skin-grafting treatment of burnt patients, and the effect of skin grafting can be improved, so that the quick construction preparation method of human epidermal tissues is perfect.
Owner:RES INST OF NANJING RUNNAN MEDICAL ELECTRONICS CO LTD
Compositions and methods to effect enhanced photoprotection against UV A and UV B induced damage of human skin
InactiveUS20080226571A1Improve toleranceImprove securityCosmetic preparationsBiocideEpoxyUltraviolet
A composition based on labdane-diterpenoids that provides better photo protection against both UV A and UV B radiations in the HaCaT human keratinocyte cell lines is disclosed. The composition comprises 8,13-epoxy-1α,6β,7β,9α-tetrahydroxylabd-14-en-11-one alone and in combination with 6β-acetoxy-8,13-epoxy-1α,7β,9α-trihydroxylabd-14-en-11-one and / or 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one. The composition protects the cells of the skin from harmful UV A and UV B rays through synergistic mechanisms with utility as a safe long-term cosmetic solution for preventing UV-induced skin damage and to induce sunless tanning. Additionally, the composition enhances melanogenesis in B16F1 mouse melanoma cells acting as tanning inducers / accelerators both in the presence or absence of sunlight. Elevation of melanogenesis confers additional protection against UV-induced skin damage.
Owner:MAJEED MUHAMMED
Sargassum fusiforme polypeptide with wound healing promoting effect and application thereof
PendingCN109771449APromote proliferationPromote migrationAlgae medical ingredientsDermatological disorderSkin barrier functionSARGASSUM FUSIFORME
The invention discloses a sargassum fusiforme polypeptide with a wound healing promoting effect and application thereof. The sargassum fusiforme polypeptide has the sugar content of 68-83.5%, the protein content of 1.5-12.3% and the uronic acid content of 6.4-22%. The application of the sargassum fusiforme polypeptide refers to the application in preparing medicines and functional cosmetics with the wound healing promoting effect, the proliferation of human keratinocytes can be promoted, the polypeptide has an important effect of reconstructing the after-skin-wound skin barrier function, the migration of the human keratinocytes can be promoted, and the polypeptide has the effects of accelerating the re-epithelization process and promoting the skin wound healing.
Owner:WENZHOU UNIVERSITY
Phellinus igniarius polysaccharide extract, preparation method and applications thereof, and skin external application agent containing Phellinus igniarius polysaccharide extract
The invention discloses a Phellinus igniarius polysaccharide extract, a preparation method and applications thereof, and a skin external application agent containing the Phellinus igniarius polysaccharide extract. According to the present invention, the Phellinus igniarius polysaccharide extract can significantly clear free radicals, can promote the proliferation of human fibroblasts and the synthesis of type I collagen, can resist human keratinocyte oxidative damage, and can be used in the fields of cosmetics, health food and medicine, especially in cosmetics.
Owner:JALA GROUP CORPORATION
Water-soluble microemulsion and preparation method thereof
InactiveCN112675077ASimple preparation processStable in natureAntibacterial agentsCosmetic preparationsPropanoic acidHemolysis
The invention discloses a water-soluble microemulsion. The water-soluble microemulsion is characterized in that the microemulsion comprises cannabidiol, a surfactant, a cosurfactant and water, and comprises the following components in percentage by weight of 0.5-5wt% of industrial hemp full-spectrum oil, 2 to 40 wt% of PPG-13-decyl tetradecyl alcohol polyether-24; 2-40 wt% of PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerol, and the balance of water. The microemulsion disclosed by the invention is clear and transparent in color, is uniformly distributed into liquid drops with the particle size of about 10-30nm, is good in thermodynamic stability, and is not layered after being stored for a long time. Meanwhile, the microemulsion can effectively inhibit hyaluronidase activity, inhibit secretion of human keratinocyte IL-8 and promote generation of IL-10, remarkably inhibit growth of staphylococcus aureus and propionibacterium acnes and remove free radicals, and does not generate obvious blood coagulation or hemolysis reaction, so that inflammatory response of skin is relieved, and anti-inflammatory and soothing effects are achieved.
Owner:云南银橙汉普生命科学研究股份有限公司
Preparation method of umbilical cord mesenchymal stem cell liquid for beautifying and maintenance
InactiveCN108753713AGuarantee the safety of useNo allergic reactionCosmetic preparationsToilet preparationsWrinkle skinCuticle
The invention relates to a preparation method of umbilical cord mesenchymal stem cell liquid for beautifying and maintenance, and belongs to the technical field of medical beautifying. The method comprises the following steps of 1, obtaining umbilical cord stem cells; 2, conducting subculture; 3, preparing the umbilical cord stem cell liquid. According to the technical scheme, umbilical cord stemcells can secrete various cell growth factors to provide a good microenvironment for skin epidermal cells, wherein the cell growth factors include the fibroblastoma growth factor, the fibroblast growth factor, the hepatocyte growth factor, the insulin growth factor, angiogenin and the like; the in-vitro proliferation and migration of human keratinocytes can be activated, skin regeneration and skinwound healing are promoted when the factors enter the skin, the maturity of the skin epidermal cells can be promoted, the skin elasticity is improved, the skin is moisturized, wrinkles are eliminated, pigmentation is prevented, and the liquid has a good beautifying effect.
Owner:丁彬彬
Trichophyton rubrum infection model preparation method
PendingCN109971704AOvercome ObscurityEasy to operateMicrobiological testing/measurementEpidermal cells/skin cellsCollagen scaffoldBiology
An embodiment of the invention discloses a trichophyton rubrum infection model preparation method and application. The preparation method includes the steps: separating a corium layer and a cuticularlayer of prepuce tissues, and digesting and culturing the cuticular layer to obtain human keratinocytes; finally, adding the human keratinocytes to a collagen scaffold and culturing the human keratinocytes to form a tissue engineering skin model. The model is simple to operate and easy to observe and solves the problem that a current trichophyton rubrum infection animal model is not easily observed. Seeds of the trichophyton rubrum infection model are the human keratinocytes and closer to the biological state of human skin fungal infection.
Owner:HOSPITAL OF DERMATOLOGY CHINESE ACAD OF MEDICAL SCI
Chemical coupling matter of deletion-recombination human keratinocyte growth factor I type
ActiveCN102633874AProtects against acute liver injuryProtection from damagePeptide/protein ingredientsDigestive systemFactor iiMucosal inflammation
The invention discloses a coupling matter formed by chemical modification of polyethylene glycol of a deletion-recombination human keratinocyte growth factor I type. The coupling matter is characterized in that covalent chemical coupling is performed on activated polyethylene glycol molecules with the molecular weight being 5K to 40K and free sulfhydryl in 79-site cysteine of the deletion-recombination human keratinocyte growth factor I type (delta 23KGF-I) with the deletion of 23-site amino acid at the N terminal, and then column chromatography purification is performed to obtain the pegylation deletion-recombination human keratinocyte growth factor I type. The coupling matter retains the biological effects of human keratinocyte growth factors, changes the internal metabolic dynamics characteristic of the factors and has values of prevention and therapy on digestive tract mucosa damage or ulcerative mucosal inflammation caused by radiotherapy and chemotherapy as well as on acute chemical liver damage.
Owner:CHONGQING PEG BIO BIOTECH CO LTD
Recombinant human keratinocyte factor KGF-2 (keratinocyte growth factor-2) environment-sensitive eye transfer system and application thereof
The invention discloses a recombinant human keratinocyte factor KGF-2 (keratinocyte growth factor-2) environment-sensitive eye transfer system and application thereof, and particularly relates to an environment-sensitive eye transfer system taking KGF-2 silicon plastid as a core and a preparation method and application thereof, and the transfer system comprises the following components by weight: 1.2-3.5 wt% of KFG-2, 1-10wt% of organic - inorganic compound lipid, 6-20wt% of a protective agent and 1-5wt% of substrate gel. The KGF-2 silicon plastid is prepared by thin film hydration ultrasound, and further the environment sensitive eye transfer system is prepared. Compared with the prior art, the product can obviously improve the stability of the KGF-2 and prolong the retention time of the KGF-2 in the eye, is conducive to the absorption and utilization of the KGF-2, has good repairing effects on various corneal ulcers, also can moisten the eyeball and alleviate the dry eye symptoms, has good relieving effects on eye fatigues, and also is suitable for the repairing of other oral mucosas and mucosa trauma and the repairing after skin beauty treatment.
Owner:广州力鑫生物科技有限公司
Immortalized cell line derived from normal human skin tissues
A human keratinocyte cell line immortalized by at least one functional tumor gene of DNA viral origin characterized in that it is: (1) non-tumorigenic, (2) conserves the capacity for differentiation and for the expression of proteins and of enzymes expressed by normal differentiated keratinocytes even after an elevated number of passages in culture; and (3) forms a stratified and polarized epithelium having a stratum corneum ortho-keratinocyte, if cultivated in an organo-typical culture in a medium without serum and without a layer of nourishing cells. An improved process to immortalize human skin cells to obtain immortalized keratinocytes. Also, the use of keratinocytes for immunological, pharmacological, photo- and chemical-toxicological analyzes of skin reaction and for expression of heterologous genes and for the construction of artificial skin.
Owner:NESTEC SA
Method and composition for skin grafts
A chimeric skin comprising immortalized human keratinocyte cells cocultured with donor keratinocytes is disclosed.
Owner:WISCONSIN ALUMNI RES FOUND
Method for detecting biological activity of recombinant human keratinocyte growth factors
ActiveCN106226511APromote proliferationIntuitive and accurate measurementBiological testingRecombinant Human Keratinocyte Growth FactorVolumetric Mass Density
The invention provides a method for detecting recombinant human keratinocyte growth factors (rhKGF-1). The method includes steps of 1), cultivating keratinocytes; 2) inoculating the keratinocytes and controlling the density of the keratinocytes; 3), treating rhKGF-1 samples, carrying gradient dilution on the concentration of the rhKGF-1 samples and adding 5-acetenyl-2'-deoxyuridine (EdU) into the rhKGF-1 samples with various rhKGF-1 concentration dilution degrees to prepare loading samples with the series of rhKGF-1 concentration dilution degrees; 4), washing the keratinocytes in keratinocyte plates obtained at the step 2) and removing cultivation media; 5), loading the loading samples obtained at the step 3) into keratinocyte cultivation plates obtained at the step 4) and cultivating and incubating the keratinocytes; 6), solidifying and permeabilizing the keratinocytes, and then carrying out 'Click-iT' reaction on the EdU; 7), arranging the keratinocytes treated at the step 6) in a multifunctional microplate reader, reading the fluorescence intensity (RFU) and computing the biological activity of the rhKGF-1. The method has the advantages of low detection background, high sensitivity, specificity and accuracy, good repeatability and the like. Besides, the method is particularly applicable to detecting the biological activity of the rhKGF-1 and establishing quality standards.
Owner:信立泰(苏州)药业有限公司
UV based cell viability as an indicator of sun protection factor and methods of measurement thereof
InactiveUS20100075360A1Simple methodEasy to implementMicrobiological testing/measurementMaterial analysisFiberUltraviolet
Disclosed is a simple method of determining SPF based on the staining pattern of viable cells like mouse fibroblasts and human keratinocytes after exposure to ultraviolet radiations. The method provides results comparable to the standard methods of SPF measurement using human subjects.
Owner:SAMI LABS LTD
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