Sargassum fusiforme polypeptide with wound healing promoting effect and application thereof

A hijiri polysaccharide and wound healing technology, applied in the field of biomedicine, can solve problems such as few reports, and achieve the effects of promoting migration, skin wound healing, and wound healing.

Pending Publication Date: 2019-05-21
WENZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Hijiki polysaccharide is a water-soluble polysaccharide extracted from the whole algae Hijiki, which has a variety of biological activities, such

Method used

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  • Sargassum fusiforme polypeptide with wound healing promoting effect and application thereof
  • Sargassum fusiforme polypeptide with wound healing promoting effect and application thereof
  • Sargassum fusiforme polypeptide with wound healing promoting effect and application thereof

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Embodiment Construction

[0022] The specific implementation manners of the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0023] (1) Cold water extraction to prepare the crude extract of hijiki polysaccharides

[0024] (1) Dry Hijiki at 50°C, pulverize into powder, and pass through a 100-mesh sieve;

[0025] (2) Weigh 15 g of the hijiki algae powder obtained in step (1) and fully mix it with 95% ethanol, reflux and degrease 3 times at 70° C. for 2 hours each time, fully remove the lipid and pigment in the hijiki powder;

[0026] (3) Recover the algae powder after degreasing in step (2), add distilled water according to the ratio of material to liquid 1:10 (m:v), fully stir and mix and soak for 12 hours, filter with two layers of gauze, collect the filtrate for the first time, and add Add th...

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Abstract

The invention discloses a sargassum fusiforme polypeptide with a wound healing promoting effect and application thereof. The sargassum fusiforme polypeptide has the sugar content of 68-83.5%, the protein content of 1.5-12.3% and the uronic acid content of 6.4-22%. The application of the sargassum fusiforme polypeptide refers to the application in preparing medicines and functional cosmetics with the wound healing promoting effect, the proliferation of human keratinocytes can be promoted, the polypeptide has an important effect of reconstructing the after-skin-wound skin barrier function, the migration of the human keratinocytes can be promoted, and the polypeptide has the effects of accelerating the re-epithelization process and promoting the skin wound healing.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a hijiki polysaccharide capable of promoting wound healing and an application thereof. Background technique [0002] Excessive wound damage, varicose veins of the lower extremities, diabetes, decubitus and other reasons may cause chronic and difficult-to-heal wounds. Wound healing is a complex pathophysiological process completed with the participation of epidermal keratinocytes, fibroblasts and other cells and cytokines. process. Among them, the re-epithelialization process is a key link in wound healing and plays a vital role in the recovery of the epidermal barrier function. [0003] The re-epithelialization process refers to the process in which keratinocytes at the wound edge migrate to the center of the wound, then proliferate and differentiate, cover the wound, and re-form a complete skin barrier. Therefore, the proliferation and migration of keratinocytes play a key role in ...

Claims

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Application Information

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IPC IPC(8): A61K36/03A61P17/02
Inventor 高艺恬王妍胡振林张旭何丹吴明江
Owner WENZHOU UNIVERSITY
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