169 results about "Skin transplantation" patented technology

Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.

Silver-containing, sol-gel derived bioactive glass compositions and methods of preparation and use thereof are disclosed. The compositions can be in the form of particles, fibers and/or coatings, among other possible forms, and can be used, for example, for treating wounds, improving the success of skin grafts, reducing the inflammatory response and providing anti-bacterial treatments to a patient in need thereof. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating the compositions into or onto the implanted materials. The compositions can also be used to prepare devices used for in vitro and ex vivo cell culture.

The present invention provides skin grafting and devices that comprise a systematic approach to the process of skin grafting, i.e., harvesting, post-excision processing and application of donor skin and pre and post-graft treatment of the recipient site.

A method and device for inducing or promoting growth and proliferation of skin cells or tissue or for controlling bacterial skin infection is described. The skin cells are irradiated with a low-intensity broad spectrum light at a wavelength of between about 340 to 3,000 nm. The increase in rate of cultivated cells is useful for example to obtain skin-like tissue needed for skin grafts or for promoting healing of skin wounds or lesions. Light-induced skin bacteria control is useful for example in the treatment of bacterial infections of the skin.

The present invention relates to a dermal substitute comprising the biodegradable polymer such as collagen and the biomaterial such as amnion, the preparation method and the use thereof. Specifically, the present invention provides with an amnion-collagen sponge complex structure prepared by attaching, inserting or incorporating an amnion obtained from placenta to/in collagen. Inventive dermal substitute can be applied to surgery and wound requiring skin graft, for example, severe burns such as second-degree burn, without rejection by immune system. Further, inventive dermal substitute with amnion instead of silicone membrane has several advantages, such as better biocompatibility, anti-inflammatory activity and promoting activity of wound healing and commercial utilization as basement membrane. Also, inventive complex structure can be used as the basic matrix of bio-artificial skin for culturing cells and the biodegradable basic matrix for preparing artificial organs.

Improvements are made to a novel media that replace the requirement for all protein growth factors by the addition to the medium of physiological concentrations of retinyl acetate. The media are serum-free, companion cell or feeder layer-free and organotypic, matrix free solutions for the cultivation of clonally competent basal keratinocytes. The media and methods are useful in the production of epidermal epithelial tissue that is suitable for skin grafting.

Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.

A dermatome assembly is operable to harvest a skin graft and includes an ultrasonic dermatome and a power supply. The ultrasonic dermatome includes a body and an ultrasonic blade assembly mounted in the body. The blade assembly includes a frequency generator and a cutting horn powered by the frequency generator. The cutting horn is spaced apart from the body so that the body is restricted from damping vibrational movement of the cutting horn. The dermatome assembly is operable to precisely control the thickness of the cut skin graft and also restrict the cutting horn from overheating.

A skin graft preparing system includes a surgical device having a housing with a front end defining a forward direction and a rear end defining a rear direction for moving along skin in the forward direction. Cutting structure is moveably coupled to the housing for separating skin from the body where the cutting structure has a cutting portion. The cutting portion cyclically translates in the forward and rear direction without lateral movement. The skin graft preparing system also includes a skin graft preparing device having a base structure, one or more skin feeding structures, one or more skin preparing structures, and one or more skin collecting structures coupled to the base structure. The skin supporting structure from the surgical device provides the skin feeding structure of the skin graft preparing device.

Hand-held appliance for preparation of an excised skin graft, that is placed upon a plane surface, by tangential excision of tissue below the epidermis to produce a trimmed skin graft of desired remaining tissue layers and thickness with a blade that is held between two holding rods, that can be placed on a plane surface and that is held in a height-adjustable axis parallel to the surface. The end regions of the rods are shaped so that the distance between the axis and the contact surface of the edge of the end regions to the surface changes at least by sections, while the minimal distance and the maximal distance define the lowest and the highest cutting plane, respectively, so that the distance of the cutting plane is defined by the operating angle between the plane of the rods and the surface.

The invention relates to a preparation method of tissue engineering skin containing hair follicles. In the invention, tissue engineering hair follicles are evenly inoculated in a tissue engineering dermal layer formed by compounding a bracket material and cells, then the tissue engineering dermal layer is covered by epidermal cells, and the tissue engineering skin containing the hair follicles is formed after culture; the invention overcomes the defects of little number of the hair follicles in the skin, no uniformity and uncontrollable quantity of the hair follicles caused by mixed injection formerly, and the prepared tissue engineering skin contains an epidermis, dermis and hair follicle type tissue structure, wherein the number of the hair follicles approaches to the natural number, the hair follicles are evenly distributed in artificial pores and develop continuously after in-vitro culture and transplantation, a multi-layer concentric circle structure is formed, an inner layer is hair papilla cells wrapt by micro-capsule membranes, and an outer layer is epithelium class cells; and the skin cultured in vitro or transplanted in vivo finally forms functional skin containing a hair follicle accessory structure, and the regeneration of the hair follicles after skin transplantation can be realized.

Constructs including a tubular biodegradable polyglycolic acid scaffold may be coated with extracellular matrix proteins and are substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, an arterial graft, a venous graft, a duct graft, a skin graft, or a urinary graft or conduit.

The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.

The present invention is directed to methods for readily propagating somatic hair follicle stem cells or melanocyte stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods. For example, the resulting cultured somatic hair follicle stem cells can be used for a variety of applications including cell replacement therapies such as hair transplants, gene therapies, and tissue engineering applications, such as the generation of artificial skin and skin regeneration strategies including skin grafts.

The invention discloses artificial skin based on liquid metal sensing. The artificial skin comprises a cross-linking polymer layer, a liquid metal circuit and a central processing unit. The artificial skin can convert pressure sensed from the outside, elasticity and other tactile senses into deformation of the cross-linking polymer layer; the liquid metal circuit is closely attached to the cross-linking polymer layer, so resistance and capacity of the circuit are changed; then the central processing unit can convert changes of circuit electric signals into neural signals capable of being recognized by human bodies to be transmitted to a nervous system, and accordingly the skin can sense different pressures, elasticity and the like. Flexibility of liquid metal is used, electric properties of the liquid metal circuit are changed through deformation of a substrate, and accordingly the artificial skin has the function of a tactile sensor. Due to the advantages that the artificial skin has the sensitive tactile sensing function and is free of individual difference and convenient to store and transport and the like, the artificial skin can be widely used in skin transplantation and robot bionic skin.

The present invention refers to an Integrated Implant System constituted as a gel-matrix-cells integrated system, that allows providing implants in a brief time period, for covering a great skin extension to be treated, with a successful acceptance in patients with burns, chronic damage or wound skin, needing of a skin grafting.

The present invention provides one kind of double-layered artificial skin implant comprising one hypodermal layer containing polyglycollic acid and other biodegradable material, fibroblast and matrix protein; and one epidermal layer on the hypodermal layer. The artificial skin has continuous epidermal cell growing on the surface of the fibroblast-PGA composite, well cell differentiation and obvious lamination. The slice shows the artificial skin has the tissue structure characteristic similar to that of normal body skin. The preparation process and use of the artificial skin is also provided.

The present invention relates to fibrin cell supports for cell cultures formed by the mixture of plasma proteins including fibrinogen and thrombin. The fibrin cell supports are preferably used for preparing a culture of cells such as keratinocytes, recovering the culture in the form of a reconstituted tissue, and transporting same. The reconstituted tissue is particularly suitable for use as a skin graft.