48 results about "Labdane" patented technology

Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.

The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone, chemically diagrammed asinhibits the synthesis of pro-inflammatory cytokines, activates the PPAR-gamma receptor and diminishes nuclear factor kappa B.The compound is useful to treat auto-immune diseases, for organ and tissue transplantation, and to treat immunodeficiency (e.g., AIDS).

The invention relates to the field of algistats, in particular to a nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative as well as a preparation method and application in algaeinhibition. The structure of the nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative is shown in formula (I). The preparation method of the derivative comprises the followingsteps: inoculating seaweed endophytic fungus trichoderma asperellum A-YMD-9-2 into a fungal culture medium for fermentation culture, and separating and purifying a fermentation product to obtain the nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative represented by formula (I). A microalgae inhibition experiment of the nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative disclosed by the invention shows that the median inhibitory concentration of the compound for microalgae can reach 1.1 [mu]g / ml.

The invention relates to a method for extracting and separating labdane diterpenes from Himalayan mayapple fruit and application thereof. The method effectively solves problems of extraction of labdane diterpenes from Himalayan mayapple fruit, purity determination and application of the labdane diterpenes in preparing drugs for resisting mammary cancer and liver cancer. The method comprises the following steps: extracting Himalayan mayapple fruit with ethanol, suspending the ethanol extract in distilled water, extracting sequentially with petroleum ether and dichloromethane, passing the dichloromethane extraction part through a silica gel column, eluting with petroleum ether-acetone, collecting 215 fractions, and merging the 1st-50th fractions, 51st-134th fractions, 135th-178th fractions and 179th-215th fractions to obtain components Fr.1-Fr.4; passing the component Fr.4 through a Sephadex LH-20 column, eluting with methanol, collecting 22 fractions, and merging the 1st-4th fractions and 5th-22nd fractions to obtain sub-components Fr.4-1 and Fr.4-2; and carrying out open ODS (octadecylsilyl) column chromatography on the sub-component Fr.4-2, eluting with methanol-water, collecting 45 fractions, carrying out detection and analysis by silica gel thin-layer chromatography, and respectively merging the fractions containing labda-7, 13-diene-3, 15-diol (I) and 14,15-dinor-3beta-hydroxy-7-labden-13-one (II). The method is stable and reliable, is easy to operate, and can be effectively used for preparing drugs for resisting mammary cancer and liver cancer.

The present invention addresses the problem of providing a novel base resin for a soldering flux, said novel base resin being capable of improving the fluidity of a flux, the viscosity stability and tackiness of a solder paste, and the color tone and crack resistance of a flux residue. This novel base resin comprises a rosin (A) containing: at least 15wt% of a pimarane-type resin acid (a-1); at least 1wt% of a labdane-type resin acid (a-2); and at least 50wt% of an abietane-type resin acid (a-3) that does not have any conjugated double bond.

Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.

The present invention relates to novel compositions based on hydrated lipidic lamellar phases or liposomal compositions, prepared by combining different lipid molecules, synthetic and / or from natural sources, said compositions comprising at least one of a) labd-13-ene-8α, 15-diol and / or derivatives thereof; b) labd-14-ene-8, 13-diol or derivatives thereof; c) 3β-hydroxy-labd-14-ene-8, 13-epoxy and / or derivatives thereof, d) a plant extract containing the aforementioned labdanes or derivatives thereof. The compositions of the invention exhibit cytotoxicity against cancerous cells and are utilized for the treatment of tumors and leukemias.

The invention describes methods of preparation of isoforskolin extract, deacetylforskolin extract and related compounds from a natural source. Compositions and human and veterinary applications of such extracts in weight management through promoting lean body mass and in topical preparations for cellulite control, are also described. The compositions of the invention could be administered in a variety of dosage forms, including but not limited to ready-to-serve beverages, dry mixes for food products and beverages, oral preparations, injectables, emulsions, liniments or oils, to humans or animals.

The present invention discloses eight new diterpenoids, i.e. Dysongensins A to H, extracted from the leaves and twigs of Dysoxylum hongkongense, wherein AMBROX® which is applicable in the perfume industry is prepared from Dysongensin A via a series of chemical reactions, and the cytotoxicity of Dysongensins A to H against human cancer cell lines and their antiviral and anti-inflammatory activities are determined. Therefore, in the present invention, AMBROX® prepared from Dysongensin A is a new idea for application as an odorous compound in the perfume industry, and the novel diterpenoids can be prepared as a pharmaceutical compositions and / or a drug having antiviral, anti-inflammatory and / or anti-cancer activities.

The invention belongs to the field of traditional Chinese medicine preparation and relates to a novel use of Andrographis paniculata enantio-labdane-type diterpene compounds in preparation of anti-complement drugs. Through the modern chemistry and pharmacology research method, the anti-complement active substances of the whole plant of Andrographis paniculata from Acanthaceae are researched. Through activity guiding separation, nine enantio-labdane-type diterpene compounds are obtained from an ethyl acetate extract part of 95% ethanol extract and it is proved that the enantio-labdane-type diterpene compounds have strong inhibition effects on a complement system classical pathway and an alternative pathway. A result shows that inhibitory effect (CH50) of the compounds on the classical pathway is 0.023-0.172mg / ml and the inhibitory effect (AP50) on the alternative pathway is 0.054-0.296mg / ml. The compounds can be used to prepare anti-complement drugs.

A nutritional supplement for increasing cognitive functioning. The supplement includes a flavonoid such as luteolin and a labdane diterpene such as forskolin. The supplement can also include one or any combination of L-phenylalanine, L-carnitine, acetyl-L-carnitine, and vitamin B6. Artichoke extract can be used as a source of luteolin. Methods of using the nutritional supplements to increase cognitive functioning are also included.

The invention discloses a compound represented by a formula A, or pharmaceutically acceptable salts thereof. In the formula, R1 is selected from H, -OH, -OAc, -OMe, or -OEt; R2 is selected from H, -Ac, -Me, or -Et; R3 is selected from H, -OMe, -OEt, -OH or null; R4 is selected from H, -OMe, -OEt, -OH or null; R5 is selected from H or =O; X and Y are independently selected from O or C; and X and Y are different elements. As a research result, bis-spiro labdane diterpene separated from motherwort herb has a certain inhibition effect against platelet aggregation.

This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from Leucas stelligera, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same.