48 results about "Labdane" patented technology

The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone, chemically diagrammed as inhibits the synthesis of pro-inflammatory cytokines, activates the PPAR-gamma receptor and diminishes nuclear factor kappa B. The compound is useful to treat auto-immune diseases, for organ and tissue transplantation, and to treat immunodeficiency (e.g., AIDS).

The invention provides a plurality of labdane diterpenoid compounds and derivatives thereof, which can be used for preparing pharmaceutical composition for preventing or treating neurodegenerative diseases. The invention also provides an arborvitae seed extract, the arborvitae seed extract contains one or more labdane diterpenoid compounds and the derivatives, and can be used for preparing pharmaceutical composition for preventing or treating neurodegenerative diseases.

Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.

The invention provides a series of labdane type diterpene derivatives and a preparation method and application thereof. The derivatives are compounds containing structures as shown in general formula I, II or III or addition salts formed from compounds and pharmaceutically acceptable acids or alkalis. R1 is hydrogen, hydroxy or C1-C3 alkyloxy or acyloxy; R2 is C1-C3 saturated or unsaturated alkyl, C1-C3 oxygen-containing alkyl or C1-C3 acid and ester thereof or salt. The derivatives employ Labiatae Phlomis plant Phlomis umbrosa as a raw material, and solvent extraction, column chromatography separation and purification are carried out for preparation. According to the invention, based on separation for preparing the labdane type diterpene derivatives, the compounds have activity for inhibiting alpha-glucosidase is verified, so that lead compounds for developing oral medicaments for reducing blood glucose are provided, and the preparation method has important meanings for exploring new purposes of natural products and botanical drugs.

The invention relates to the field of medical technology and provides an application of labdane diterpene glycoside compounds in rubus chingii Hu in preparing a medicine for preventing or treating chronic nephritis, kidney-yang deficiency, osteoporosis and prostatitis. The general formula of the chemical structure of the labdane diterpene glycosides in rubus chingii Hu is shown by the formula (I) in the specification. According to in-vivo animal experiments, the compounds provided by the invention have activity in preventing and treating chronic nephritis, kidney-yang deficiency, osteoporosis and prostatitis, wherein the curative effect of raspberry glycoside-F1-7 is better.

The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone, chemically diagrammed asinhibits the synthesis of pro-inflammatory cytokines, activates the PPAR-gamma receptor and diminishes nuclear factor kappa B.The compound is useful to treat auto-immune diseases, for organ and tissue transplantation, and to treat immunodeficiency (e.g., AIDS).

The invention discloses a labdane-type diterpene compound. The labdane-type diterpene compound has a chemical structure shown in the following description. The invention relates to the field of natural drugs and concretely relates to the novel labdane-type diterpene compound in motherwort, a preparation method of the compound and a medical use of the compound in preparation of antitumor drugs. An external test proves that the novel labdane-type diterpene compound has effects of resisting cervical carcinoma, leukemia and breast cancer and can be used for preparing drugs for resisting cervical carcinoma, leukemia and breast cancer.

A composition based on labdane-diterpenoids that provides better photo protection against both UV A and UV B radiations in the HaCaT human keratinocyte cell lines is disclosed. The composition comprises 8,13-epoxy-1α,6β,7β,9α-tetrahydroxylabd-14-en-11-one alone and in combination with 6β-acetoxy-8,13-epoxy-1α,7β,9α-trihydroxylabd-14-en-11-one and / or 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one. The composition protects the cells of the skin from harmful UV A and UV B rays through synergistic mechanisms with utility as a safe long-term cosmetic solution for preventing UV-induced skin damage and to induce sunless tanning. Additionally, the composition enhances melanogenesis in B16F1 mouse melanoma cells acting as tanning inducers / accelerators both in the presence or absence of sunlight. Elevation of melanogenesis confers additional protection against UV-induced skin damage.

The invention relates to the field of algistats, in particular to a nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative as well as a preparation method and application in algaeinhibition. The structure of the nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative is shown in formula (I). The preparation method of the derivative comprises the followingsteps: inoculating seaweed endophytic fungus trichoderma asperellum A-YMD-9-2 into a fungal culture medium for fermentation culture, and separating and purifying a fermentation product to obtain the nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative represented by formula (I). A microalgae inhibition experiment of the nitrogen-containing cyclic flores aurantii labdane sesquiterpene derivative disclosed by the invention shows that the median inhibitory concentration of the compound for microalgae can reach 1.1 [mu]g / ml.

The invention relates to the field of natural medicaments, and particularly relates to application of labdane-type diterpene Leoleorin H in preparation of an anti-tumor medicament. A research on the pharmacological activity of Leoleorin H shows that Leoleorin H has suppression activity to various tumors, is the best in the suppression effect on the cervical cancer, the breast cancer and leukemia cells and does not have toxicity reaction on normal cells, so that Leoleorin H can be used for preparing the anti-tumor medicament, particularly cervical cancer, breast cancer and leukemia cell resistant medicaments.

A nutritional supplement for increasing cognitive functioning. The supplement includes a flavonoid such as luteolin and a labdane diterpene such as forskolin. The supplement can also include one or any combination of L-phenylalanine, L-carnitine, acetyl-L-carnitine, and vitamin B6. Artichoke extract can be used as a source of luteolin. Methods of using the nutritional supplements to increase cognitive functioning are also included.

The invention belongs to the field of quality analysis for natural medicine, relates to a method for measuring labdane diterpenoidal in coleus forskohlii, and particularly relates to a method for measuring labdane diterpenoidal in coleus forskohlii by adopting a matrix solid-phase dispersion technology. The method disclosed by the invention comprises the following steps of: extracting diterpenoidal ingredients in coleus forskohlii by adopting a matrix solid-phase dispersion technology, and removing polar and nonpolar interferents; and then qualitatively and quantitatively analysing five labdane diterpenoidal such as isoforskolin by adopting a high-performance liquid chromatography method. According to the method disclosed by the invention, the complex process of sample pre-treatment is simplified, the time is saved, the consumption of an organic solvent is reduced, and the emulsion phenomenon caused by liquid-liquid extraction is eliminated; the detection method is accurate and sensitive; and a rapid and effective quality evaluation method is provided for coleus forskohlii.

The invention relates to a method for extracting and separating labdane diterpenes from Himalayan mayapple fruit and application thereof. The method effectively solves problems of extraction of labdane diterpenes from Himalayan mayapple fruit, purity determination and application of the labdane diterpenes in preparing drugs for resisting mammary cancer and liver cancer. The method comprises the following steps: extracting Himalayan mayapple fruit with ethanol, suspending the ethanol extract in distilled water, extracting sequentially with petroleum ether and dichloromethane, passing the dichloromethane extraction part through a silica gel column, eluting with petroleum ether-acetone, collecting 215 fractions, and merging the 1st-50th fractions, 51st-134th fractions, 135th-178th fractions and 179th-215th fractions to obtain components Fr.1-Fr.4; passing the component Fr.4 through a Sephadex LH-20 column, eluting with methanol, collecting 22 fractions, and merging the 1st-4th fractions and 5th-22nd fractions to obtain sub-components Fr.4-1 and Fr.4-2; and carrying out open ODS (octadecylsilyl) column chromatography on the sub-component Fr.4-2, eluting with methanol-water, collecting 45 fractions, carrying out detection and analysis by silica gel thin-layer chromatography, and respectively merging the fractions containing labda-7, 13-diene-3, 15-diol (I) and 14,15-dinor-3beta-hydroxy-7-labden-13-one (II). The method is stable and reliable, is easy to operate, and can be effectively used for preparing drugs for resisting mammary cancer and liver cancer.

The invention provides a novel ladanum type diterpene derivative and a preparation method and application thereof. The invention provides a novel compound, an extraction, the preparation method and application thereof. The compound employs Labiatae Phlomis plant Phlomis umbrosa as a raw material, and solvent extraction, extraction, column chromatography separation and purification are carried out for preparation. According to the invention, based on separation for preparing the novel labdane type diterpene, the compound has an activity for inhibiting alpha-glucosidase is verified, so that lead compounds for developing oral medicaments for reducing blood glucose are provided, and the preparation method has important meanings for exploring new purposes of natural products and botanical drugs.

The invention discloses a novel labdane-type diterpenoid compound. The compound is reported for the first time and is a labdane-type diterpenoid compound with a novel structure. The compound can be prepared from the dry above-ground part of callicarpa nudiflora through extraction, separation and purification. In vitro tests show that the compound has a remarkable proliferation inhibition effect on human pancreatic carcinoma MiaPaCa-2 cells under an anaerobic culture condition, the inhibition effect is more remarkable with increase of the concentration of the compound and the prolonging of acting time, that is, time-dosage dependency exists within a certain concentration range, and the compound can be further developed into a drug for treating pancreatic carcinoma.

The invention discloses a compound represented by a formula A, or pharmaceutically acceptable salts thereof. In the formula, R1 is selected from H, -OH, -OAc, -OMe, or -OEt; R2 is selected from H, -Ac, -Me, or -Et; R3 is selected from H, -OMe, -OEt, -OH or null; R4 is selected from H, -OMe, -OEt, -OH or null; R5 is selected from H or =O; X and Y are independently selected from O or C; and X and Y are different elements. As a research result, bis-spiro labdane diterpene separated from motherwort herb has a certain inhibition effect against platelet aggregation.

The invention belongs to the field of biochemical medicines, and discloses two labdane diterpenoids, and an extraction method and application thereof. The structures of the two labdane diterpenoids are shown in the specification. The labdane diterpenoids are extracted and separated from scoparia dulcis l. Cell experiments prove that the labdane diterpenoids can remarkably resist pancreas islet cell apoptosis.

The present invention relates to novel compositions based on hydrated lipidic lamellar phases or liposomal compositions, prepared by combining different lipid molecules, synthetic and / or from natural sources, said compositions comprising at least one of a) labd-13-ene-8α, 15-diol and / or derivatives thereof; b) labd-14-ene-8, 13-diol or derivatives thereof; c) 3β-hydroxy-labd-14-ene-8, 13-epoxy and / or derivatives thereof, d) a plant extract containing the aforementioned labdanes or derivatives thereof. The compositions of the invention exhibit cytotoxicity against cancerous cells and are utilized for the treatment of tumors and leukemias.

The invention describes methods of preparation of isoforskolin extract, deacetylforskolin extract and related compounds from a natural source. Compositions and human and veterinary applications of such extracts in weight management through promoting lean body mass and in topical preparations for cellulite control, are also described. The compositions of the invention could be administered in a variety of dosage forms, including but not limited to ready-to-serve beverages, dry mixes for food products and beverages, oral preparations, injectables, emulsions, liniments or oils, to humans or animals.

The object of the present invention is to provide a soldering-flux-oriented novel base resin that enhances the fluidity of a soldering flux and both the visco-stability and adhesion of a solder paste, while improving the color tone and anti-crack property of the flux residue. The present invention is directed to a base resin for a soldering flux, the base resin comprising a rosin (A) containing at least 15 wt % of a pimarane-type resin acid (a-1), at least 1 wt % of a labdane-type resin acid (a-2), and at least 50 wt % of an abietane-type resin acid that has no conjugated double bond (a-3).

The invention belongs to the field of traditional Chinese medicine preparation and relates to a novel use of Andrographis paniculata enantio-labdane-type diterpene compounds in preparation of anti-complement drugs. Through the modern chemistry and pharmacology research method, the anti-complement active substances of the whole plant of Andrographis paniculata from Acanthaceae are researched. Through activity guiding separation, nine enantio-labdane-type diterpene compounds are obtained from an ethyl acetate extract part of 95% ethanol extract and it is proved that the enantio-labdane-type diterpene compounds have strong inhibition effects on a complement system classical pathway and an alternative pathway. A result shows that inhibitory effect (CH50) of the compounds on the classical pathway is 0.023-0.172mg / ml and the inhibitory effect (AP50) on the alternative pathway is 0.054-0.296mg / ml. The compounds can be used to prepare anti-complement drugs.

A nutritional supplement for increasing cognitive functioning. The supplement includes a flavonoid such as luteolin and a labdane diterpene such as forskolin. The supplement can also include one or any combination of L-phenylalanine, L-carnitine, acetyl-L-carnitine, and vitamin B6. Artichoke extract can be used as a source of luteolin. Methods of using the nutritional supplements to increase cognitive functioning are also included.

The invention belongs to the technical field of medicines, and relates to a 90% methanol extract prepared from branches and leaves of Pseudotsuga sinensis, labdane and abietane diterpenoid compounds separated from the methanol extract, a preparation method of the compounds and application of the compounds in pharmacy. A biological activity test shows that the compound remarkably inhibits ATP-citrate lyase (ACL); the compound can be used for preparing medicines or lead compounds of the medicines for preventing or treating ACL-mediated glycolipid metabolism disorder related diseases, such as hyperlipemia, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes mellitus and obesity.

The invention belongs to the technical field of phytochemistry, and discloses an oxidized labdane diterpenoid compound as well as a separation method and application thereof, and the C-3 site of the A ring of the compound is oxidized. The compound I and the compound II are obtained through multi-stage separation steps of water extraction, polar solvent extraction, organic solvent gradient elution, liquid chromatography separation and the like. A pharmaceutical activity experiment shows that the compound has obvious anti-inflammatory activity, and shows that the compound has a good application prospect in the aspect of preparing the medicine for preventing or treating inflammation.

The invention discloses labdane diterpene derivatives as well as a pharmaceutical composition and application thereof, and belongs to the technical field of medicine. In the invention, based on the isolation of the labdane diterpene derivatives, it is confirmed that any one of the labdane diterpene derivatives having structural formulas I-XII as shown in the specification can be used as an inhibitor of a nuclear factor-kappaB (NF-kappaB) signal pathway, and can inhibit the NF-kappaB signal pathway and treat NF-kappaB-mediated diseases.

The invention discloses a compound represented by a formula A, or pharmaceutically acceptable salts thereof. In the formula, R1 is selected from H, -OH, -OAc, -OMe, or -OEt; R2 is selected from H, -Ac, -Me, or -Et; R3 is selected from H, -OMe, -OEt, -OH or null; R4 is selected from H, -OMe, -OEt, -OH or null; R5 is selected from H or =O; X and Y are independently selected from O or C; and X and Y are different elements. As a research result, bis-spiro labdane diterpene separated from motherwort herb has a certain inhibition effect against platelet aggregation.

This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from Leucas stelligera, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same.