Two labdane diterpenoids, and extraction method and application thereof

A compound, labrador's technology, applied in the field of biochemical medicine

Active Publication Date: 2020-06-16
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to good blood sugar control, the use of drugs that can reduce β-cell apoptosis is the new core of modern T2DM treatment. There is no anti-diabetic drug used in clinical practice that directly targets β-cell apoptosis in islet cells.

Method used

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  • Two labdane diterpenoids, and extraction method and application thereof
  • Two labdane diterpenoids, and extraction method and application thereof
  • Two labdane diterpenoids, and extraction method and application thereof

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Embodiment 1

[0022] The preparation of embodiment 1 compound of the present invention

[0023] Take 10 kg of rock sugar grass, use ethanol or methanol to reflux extract, after the extract is concentrated, dissolve the extract in water, then extract with petroleum ether, remove the upper organic phase, and after the remaining water layer is extracted with dichloromethane, recover the lower organic phase, reduce Concentrate under reduced pressure to obtain the total extract (180 g) extracted with dichloromethane.

[0024] Get the total extract obtained, and use the silica gel dry method to load the sample, that is, first extract the total extract with dichloromethane and add a small amount of organic solvent to dissolve it, then add a small amount of silica gel and mix well, after the organic solvent evaporates to dryness, grind finely, use silica gel (200 -300 mesh) column chromatography, using different volume ratios of petroleum ether-dichloromethane as the eluent for gradient elution, el...

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PUM

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Abstract

The invention belongs to the field of biochemical medicines, and discloses two labdane diterpenoids, and an extraction method and application thereof. The structures of the two labdane diterpenoids are shown in the specification. The labdane diterpenoids are extracted and separated from scoparia dulcis l. Cell experiments prove that the labdane diterpenoids can remarkably resist pancreas islet cell apoptosis.

Description

technical field [0001] The invention belongs to the field of biochemistry and medicine, and in particular relates to two diterpenoids of Libadang, its extraction method and its application. Background technique [0002] Diabetes is one of the chronic diseases that seriously threaten the health of all human beings, and its incidence is increasing year by year. Among diabetic patients, more than 90% are type 2 diabetes mellitus (T2DM). Insulin resistance is the main form of T2DM in the early stage. As the course of the disease prolongs, the function of pancreatic β-cells gradually declines, and the disease gradually worsens. Apoptosis is the final form of islet β-cell function decline, which in turn leads to insufficient insulin secretion and elevated blood sugar. Although commercially available drugs can lower blood sugar in patients, apoptosis is still the main culprit in the gradual exacerbation of diabetes. In addition to good blood sugar control, the use of drugs that c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/48C07C67/56C07C67/58C07C69/78A61P3/10
CPCC07C67/48C07C67/56C07C67/58A61P3/10C07C2602/28C07B2200/07C07C69/78
Inventor 张彩云张小坡孙万莹张勇邱军强李祎莹陈丽珍张璐
Owner HAINAN MEDICAL COLLEGE
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