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Two Libadang diterpenoids, their extraction methods and applications

A compound and diterpenoid technology, applied in the field of biochemical medicine, to achieve significant anti-apoptosis effect of islet cells

Active Publication Date: 2022-06-28
HAINAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to good blood sugar control, the use of drugs that can reduce β-cell apoptosis is the new core of modern T2DM treatment. There is no anti-diabetic drug used in clinical practice that directly targets β-cell apoptosis in islet cells.

Method used

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  • Two Libadang diterpenoids, their extraction methods and applications
  • Two Libadang diterpenoids, their extraction methods and applications
  • Two Libadang diterpenoids, their extraction methods and applications

Examples

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Embodiment 1

[0022] Example 1 Preparation of the compound of the present invention

[0023] Get 10kg of rock sugar grass, extract with ethanol or methanol under reflux, after the extract is concentrated, dissolve the extract in water, then extract with petroleum ether, remove the upper organic phase, after the remaining water layer is extracted with dichloromethane, recover the lower organic phase, reduce Concentrate under pressure to obtain the total extract (180g) extracted with dichloromethane.

[0024] Take the obtained total extract and use the silica gel dry method for sample loading, that is, first dissolve the total extract extracted with dichloromethane and add a small amount of organic solvent, then add a small amount of silica gel and mix well. -300 mesh) column chromatography, respectively using petroleum ether-dichloromethane with different volume ratios as eluent to carry out gradient elution, eluting 3 to 10 column volumes until colorless, collecting petroleum ether-dichloro...

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Abstract

The invention belongs to the field of biochemistry and medicine, and discloses two diterpenoids of Labatin, its extraction method and its application. The structures of the two diterpenoid compounds of the present invention are as follows: the compound is extracted and separated from Bingtangcao, and the cell experiment proves that the above compound can significantly resist the apoptosis of islet cells.

Description

technical field [0001] The invention belongs to the field of biochemical medicine, and specifically relates to two labradoroid diterpenoids, an extraction method and application thereof. Background technique [0002] Diabetes is one of the chronic diseases that seriously threatens the health of all human beings. The incidence rate is increasing year by year. Among diabetic patients, more than 90% are type 2 diabetes mellitus (T2DM). In the early stage of T2DM, insulin resistance is predominant. With the prolongation of the course of the disease, the function of pancreatic β cells gradually declines and the disease gradually aggravates. Apoptosis is the final form of pancreatic β-cell functional decline, which in turn leads to insufficient insulin secretion and increased blood glucose. Although commercially available drugs can lower blood sugar in patients, apoptosis is still the main culprit behind the progressive aggravation of diabetes. In addition to controlling blood s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C67/48C07C67/56C07C67/58C07C69/78A61P3/10
CPCC07C67/48C07C67/56C07C67/58A61P3/10C07C2602/28C07B2200/07C07C69/78
Inventor 张彩云张小坡孙万莹张勇邱军强李祎莹陈丽珍张璐
Owner HAINAN MEDICAL UNIV
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