27 results about "Streptomyces strain" patented technology

The invention relates to a streptomyces sp. Strain EC15 and an application of the streptomyces sp. Strain EC15. The streptomyces strain EC15 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation address is No.3, yard 1, Beichen West Road, Chaoyang District, Beijing, the preservation date is December 25, 2024, and the preservation number is CGMCC NO.33195. The streptomyces strain EC15 has the advantages that the streptomyces strain EC15 can be used for preparing the streptomyces strain EC15; the strain has the functions of dissolving organic phosphorus, dissolving inorganic phosphorus, producing a biological membrane, producing an iron carrier, producing IAA and producing ACC deaminase. The EC15 bacterial liquid is used for soaking seeds under the stress of 200 mmol / L and 250 mmol / L NaCl, so that the germination potential, the germination rate, the germination index, the radicle length, the germ length and the fresh weight of group seedlings of the alfalfa seeds can be obviously improved. After the EC15 strain is inoculated, under the stress of 200 mmol / L NaCl, the plant height, stem diameter, leaf area and overground part fresh and dry weight of alfalfa plants can be obviously improved.

This invention discloses an engineered Streptomyces strain that produces tacrolimus, its construction method, and its applications. The strain is *Streptomyces tsukuba* (…). Streptomyces tsukubaensis QZ001 was the starting strain, and homologous recombination technology was used to knock out the [specific component] in the starting strain. tdha Genes and tcdh Genes and overexpression tulz Genes were used to construct an engineered Streptomyces strain that produces tacrolimus: Streptomyces tsukuba ( Streptomyces tsukubaensis The invention relates to strain QZ004, and optimizes the fermentation medium for engineered Streptomyces strains. Both the Streptomyces strain and the engineered Streptomyces strain can be used for the production of tacrolimus, tacrolimus derivatives, or anti-rejection drugs. The strain provided by this invention possesses stable genetic characteristics, a simplified fermentation process, and abundant fermentation yield, making it suitable for the large-scale production of tacrolimus.

The invention relates to the technical field of microorganisms, and particularly discloses a streptomyces rust red strain JQ021 and application thereof. The strain is preserved in the China Center for Type Culture Collection on October 9, 2025, and the preservation number of the strain is CCTCC NO: M 20252186. The strain JQ021, a culture of the strain JQ021 and a metabolic extract produced by the strain JQ021 show efficient and broad-spectrum inhibitory activity on various aquatic pathogenic vibrios, especially vibrio parahaemolyticus, vibrio alginolyticus and vibrio Ewana. The invention also relates to a microbial preparation and an antibacterial composition containing the strain or the metabolic extract, and an application of the microbial preparation and the antibacterial composition in preparation of a preparation for preventing and treating aquaculture vibriosis. The strain provides valuable microbial resources for developing safe and efficient antibiotic substitutes.

The invention belongs to the technical field of microbial resources and natural pigment production, and particularly relates to a streptomyces strain for producing purpurin, a streptomyces liquid and application thereof, the streptomyces strain is XS01-03Na, the preservation number is CGMCC No.35420, and the streptomyces strain is preserved in China General Microbiological Culture Collection Center on July 28, 2025. By means of sequencing, multi-site sequence comparison, phylogenetic tree construction and the like, the XS01-03Na disclosed by the invention is found to be a new strain of streptomycete; meanwhile, the XS01-03Na disclosed by the invention has the characteristic of high yield of purpurin, and the produced purpurin has excellent stability and antibacterial activity and can be applied to various fields such as printing and dyeing, food processing, medicine and health care and the like.

The present application relates to the field of microbiological technology, and specifically discloses a strain of Streptomyces rutilocolore JQ021 and its application. The strain has been preserved in the China Center for Type Culture Collection on October 9, 2025, and the preservation number is CCTCC NO: M 20252186. The strain JQ021 and its culture, metabolic extract produced therefrom all exhibit high and broad-spectrum inhibitory activity against various aquatic pathogenic Vibrio, especially Vibrio parahaemolyticus, Vibrio alginolyticus and Vibrio owensii. The present application also relates to a microbial preparation and an antibacterial composition comprising the strain or the metabolic extract, and the application thereof in preparing a preparation for preventing and treating aquatic vibrio disease. The strain provides a valuable microbial resource for developing safe and efficient antibiotic substitutes.

The application discloses a synthetic bacterial flora capable of improving salt tolerance of alfalfa, which is composed of Pseudomonas strain EC5, Agrobacterium strain EC17, Streptomyces strain EC15, Paracoccus strain RH39, Pseudomonas strain RH6, Pseudomonas strain RH37, Sporosarcina strain RH34 and Bacillus strain RH32. The synthetic bacterial flora has the functions of dissolving organic phosphorus, dissolving inorganic phosphorus, dissolving potassium, producing siderophore, producing biofilm, producing IAA and producing ACC deaminase. Seed soaking and germination under the stress of 200 mmol / L and 250 mmol / L NaCl can obviously improve the germination potential, germination rate, germination index, radicle length, plumule length and fresh weight of the group seedling embryo of alfalfa. Under the stress of 200 mmol / L NaCl, seed soaking with the synthetic bacterial flora can significantly improve the plant height, stem diameter, leaf area and fresh and dry weight of the above-ground part of alfalfa.

The invention discloses streptomyces baldness, a fungicide, a slow-release fertilizer as well as a preparation method and application of the streptomyces baldness, the fungicide and the slow-release fertilizer, and belongs to the technical field of microorganisms. The streptomyces calvus strain GX2024L1 is obtained by being separated from soil, and the preservation number of the streptomyces calvus strain GX2024L1 is CGMCC (China General Microbiological Culture Collection Center) No. 32902. The strain and the microbial inoculum thereof can be applied to preparation of slow-release fertilizers. When the slow-release fertilizer is prepared, the silkworm excrement is pretreated and crushed to increase the surface area of the silkworm excrement, then the silkworm excrement is inoculated with the Streptomyces calvus strain GX2024L1 or a microbial inoculum thereof for controllable fermentation, macromolecules such as cellulose, hemicellulose and polysaccharide in the silkworm excrement are moderately degraded through thallus metabolism, and a porous carrier is formed and functional groups are exposed while a structural framework is maintained. The carrier adsorbs and loads urea and a urease inhibitor through hydrogen bonds and coordination, and the slow-release fertilizer is prepared through granulation and coating. The slow-release fertilizer can realize slow release and continuous release of urea within 1-8 months, nitrogen loss is effectively inhibited by using the urease inhibitor, and dual benefits of silkworm excrement recycling and crop full-cycle nutrient accurate supply are realized.

The invention relates to the field of microorganisms, in particular to a novel streptomyces strain capable of producing volatile antibacterial substances and application of the novel streptomyces strain. The streptomyces strain AMJ-169 related to the invention is identified as a new streptomyces strain, and also has obvious inhibitory activity on strawberry anthracnose pathogen, cucumber fusarium wilt pathogen, botrytis cinerea and the like. Volatile organic compounds generated by the strain AMJ-169 have remarkable inhibitory activity on papaya colletotrichum gloeosporioides, mango colletotrichum gloeosporioides, banana colletotrichum gloeosporioides and The volatile organic compounds and the volatile compounds thereof also have inhibitory activity on a variety of plant pathogens. The levorotatory-alpha-pinene can effectively reduce the scab diameter of strawberry anthracnose on strawberry fruits, and has significant inhibitory activity on strawberry anthracnose. The new streptomyces strain and the volatile antibacterial substance generated by the streptomyces strain provide a new way for biological prevention and control of strawberry anthracnose, and have wide development space and development and application prospects.

The invention relates to a Streptomyces rhizosphere strain 14-3, the Streptomyces rhizosphere strain 14-3 is preserved in the Guangdong Microbiological Culture Collection Center, the preservation number is GDMCC No. 63693, and the preservation date is August 3, 2023, the preservation number is CGMCC No. 63693, the preservation number is CGMCC No. 63693, the preservation number is CGMCC No. 63693, the preservation number is CGMCC No. 63693, the preservation number is CGMCC No. 63693, and the preservation number is CGMCC No. 63693, and the preservation number is CGMCC No. 63693. The streptomyces rhizosphere strain 14-3 has a strong antagonistic effect on the main pathogenic bacterium colletotrichum truncatum causing the soybean anthracnose, and the fermentation liquor of the streptomyces rhizosphere strain 14-3 can obviously inhibit the mycelial growth of the colletotrichum truncatum, completely inhibit the germination of conidia and cause the splitting decomposition of spore cells; and the obtained fermentation liquor not only has an excellent prevention and treatment effect on soybean anthracnose, but also has no influence on soybean growth.

The application discloses a kind of streptomyces youssoufiensis strain and the application of its metabolite cis-3-indoleacrylic acid, belongs to the technical field of microbial pesticides.The preservation name of streptomyces youssoufiensis strain is streptomyces youssoufiensis YMF3.862 strain, is preserved in China Microbial Culture Collection Center;Preservation date: May 20, 2024;Preservation number: CGMCC No.30698.The application has the characteristics of low cost, good effect, no residue, safety to human and environment, and the preparation of biological pesticide by YMF3.862 strain and its metabolite cis-3-indoleacrylic acid has more than 60% of the control effect on tobacco root-knot nematode disease, tobacco bacterial wilt and the composite disease caused by the two.

The invention discloses a streptomyces strain WS-15992 and an application of the streptomyces strain WS-15992. The preservation number of the streptomyces mayteni WS-15992 is CCTCC (China Center for Type Culture Collection) M: 2020348, and the preservation number of the streptomyces mayteni WS-15992 is CCTCC M: 2020348. The streptomyces WS-15992 provided by the invention has strong stress resistance, is easy to ferment in a large scale, is suitable for being prepared into a preparation product through spray drying, and has a good field control effect on pear rust.

This invention discloses a strain of Streptomyces SK-2 and its application in the control of white cone rot. The Streptomyces strain of this invention (… Streptomyces SK-2 (sp.) was isolated from the rhizosphere soil of Chinese fir soil. This biocontrol bacterium can significantly inhibit the occurrence area of ​​white cone rot disease under indoor conditions, with a prevention effect of more than 68%, and has potential development and application value.

The invention relates to a streptomyces engineering bacterium with high yield of josamycin as well as a construction method and application of the streptomyces engineering bacterium. The engineering bacterium is a high-yield strain which is obtained by taking Streptomyces nanonensis ATCC17835 as an original strain and carrying out over-expression on regulatory protein genes JosR1 and JosR2 in a genome of the Streptomyces nanonensis ATCC17835, and the engineering bacterium is named as Streptomyces nanonensis CBR18-P001 (the preservation number is CCTCC No. M 2025197). The invention further discloses a preparation method of the engineering bacterium, and a preparation method of the engineering bacterium comprises the following steps: taking the Streptomyces nanonensis ATCC17835 as the original strain, carrying out over-expression on the regulatory protein genes JosR1 and JosR2 in the genome of the engineering bacterium. The fermentation yield of the strain josamycin can reach 7000 mg / L or above, and a fermentation product contains a characteristic impurity O (the molecular formula and molecular weight are 825, the relative retention time of a high performance liquid phase is 0.95, and the mass spectrum characteristic peak m / z is 826 [M + H]) as a biomarker. The invention also provides a construction method of the strain, a fermentation production process and an identification method based on characteristic impurities.

The invention relates to the field of microorganisms, in particular to streptomyces, a microbial preparation and application thereof. The invention provides Streptomyces sp., and the preservation number of the Streptomyces sp. Is GDMCC 67625. The Streptomyces sp. Has the advantages that the preservation number of the Streptomyces sp. Is GDMCC 67625; the invention provides a novel streptomyces strain LE64, a preparation containing the strain and application of the novel streptomyces strain LE64. The bacterial strain can effectively inhibit banana fusarium wilt and greatly promote banana plant growth, and an environment-friendly microbial solution is provided for solving the problem of banana fusarium wilt.

The invention discloses streptomyces LZZY-S40 with broad-spectrum bacteriostatic activity and growth promoting effect and application thereof, and belongs to the technical field of microorganisms. The invention provides streptomyces sp. LZZY-S40 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.30320 in order to solve the problems that in the prior art, streptomyces mostly focuses on single function research, the antibacterial spectrum is relatively narrow, and the agricultural production requirement that various diseases coexist is difficult to meet. The bacterial strain has good broad-spectrum bacteriostatic activity on plant pathogenic fungi, and the bacteriostasis rate of the bacterial strain on plant pathogenic bacteria xanthomonas semitransparent reaches 100%; a spore suspension of the strain has a remarkable promoting effect on wheat root length, bud length and wheat fresh weight; in addition, the streptomyces LZZY-S40 strain can also be applied to preparation of microbial agents for producing extracellular protease, auxin, siderophore, nitrogenase and ACC deaminase.

This invention isolated a Streptomyces strain SCA4-4 with significant cellulose degradation ability from wheat rhizosphere soil samples from the dry-hot valley of the Jinsha River in Sichuan Province. After systematic polyphasic taxonomic identification, this strain was determined to be a new species of the genus Streptomyces and was named *Streptomyces jinshaensis*. Streptomyces jinshaensis The strain SCA4-4 (sp. nov.), with accession number GDMCC No: 63008, possesses biological characteristics such as cellulose degradation and nitrogen fixation capabilities. Furthermore, it can adjust the activity of related enzymes according to different substrates, thereby achieving differentiated degradation of various crop straw materials. This provides a new pathway for the recycling of agricultural waste, reduces the use of chemical fertilizers, and mitigates negative environmental impacts, demonstrating broad application potential in agriculture and the environment.

This invention discloses a Streptomyces strain AB_3, classified as amylase-producing Streptomyces (…). Streptomyces diastatochromogenes The strain is preserved under the CCTCC No. M20252932. This invention also discloses a solid-state fermentation agent of *Streptomyces AB_3*, comprising the aforementioned *Streptomyces AB_3* strain. This invention further discloses the application of *Streptomyces AB_3* strain or the solid-state fermentation agent of *Streptomyces AB_3* in controlling soil-borne bacterial wilt and in promoting crop growth. *Streptomyces AB_3* possesses multiple functions, including disease resistance and growth promotion. This invention utilizes a novel solid-state fermentation method, significantly increasing the amount of *Streptomyces* spores and solving the problem of *Streptomyces* failing to produce spores during liquid culture.

The invention discloses a synthetic flora capable of improving salt tolerance of alfalfa. The synthetic flora consists of a pseudomonas strain EC5, an agrobacterium strain EC17, a streptomyces strain EC15, a paracoccus strain RH39, a pseudomonas strain RH6, a pseudomonas strain RH37, a sporosarcina strain RH34 and a bacillus strain RH32. The synthetic flora provided by the invention has the functions of dissolving organic phosphorus, dissolving inorganic phosphorus, dissolving potassium, producing iron carriers, producing biological membranes, producing IAA and producing ACC deaminase. Seed soaking and germination under the stress of 200 mmol / L and 250 mmol / L NaCl can obviously improve the germination potential, germination rate, germination index, radicle length, germ length and colony seedling embryo fresh weight of alfalfa seeds. Under the stress of 200 mmol / L NaCl, the plant height, stem diameter, leaf area and overground part fresh and dry weight of alfalfa plants can be obviously improved after the seeds are soaked by the synthetic flora.

This invention discloses a Streptomyces strain SZWQ98, its inoculant, and its applications, belonging to the field of microbial technology. The Streptomyces SZWQ98 has the preservation number CGMCC No. 30577. This invention is the first to discover that Streptomyces SZWQ98 can inhibit the growth and disease development of Streptomyces scabii, Rhizoctonia solani, Fusarium oxysporum, and Fusarium solani, with stable antibacterial effects. Furthermore, greenhouse pot experiments and field control trials have verified that Streptomyces SZWQ98 has significant control effects against various soil-borne plant diseases (potato black scurf, potato powdery scab, and peanut fruit rot), and also promotes plant growth, providing a new biocontrol resource for the biological control of soil-borne plant diseases and the promotion of plant growth.

Provided is a Streptomyces and its use in synthesis of phosphatidylserine. A fermentation broth produced by the Streptomyces, using soybean lecithin and L-serine as raw materials, can simultaneously convert phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) in lecithin to efficiently produce phosphatidylserine (PS). The Streptomyces, designated as Streptomyces sp. LN2, is deposited at China General Microbiological Culture Collection Center (CGMCC) on Apr. 1, 2024, with an accession number CGMCC NO. 30230.

The invention belongs to the technical field of microbiology, and discloses a streptomyces strain, a culture, a composition, a microbial agent and application thereof. The bacterial strain is a bacterial strain which is preserved in Guangdong Microbial Culture Collection Center and has a preservation number of GDMCC 64196 or GDMCC 64202, or a bacterial strain of which a 16S rRNA gene sequence has at least 98.65% identity with a sequence as shown in SEQ ID No. 1 or SEQ ID No. 2. The bacterial strain provided by the embodiment of the invention belongs to a new strain, and the bacterial strain or the composition and the microbial agent based on the bacterial strain have good effects of inhibiting pathogenic fungi or pathogenic bacteria, dissolving phosphorus and fixing nitrogen, promoting plant growth, preventing and treating bugs and preventing and treating cucumber rhizoctonia solani.

The invention discloses streptomyces G18 and application thereof, and relates to the technical field of biological control. The streptomycete G18 disclosed by the invention is preserved in the China Center for Type Culture Collection on June 05, 2025, and the preservation number is CCTCC NO: M 20251269. The streptomyces albus is streptomyces albus, the streptomyces albus can be used for preventing and treating the camellia oleifera anthracnose, the inhibition rate of fermentation liquor of the streptomyces albus on a camellia oleifera anthracnose pathogenic bacterium colletotrichum gloeosporioides YC12 strain is as high as 80%, the inhibition rate of n-butyl alcohol extract of the fermentation liquor of the streptomyces albus on the YC12 strain is as high as 97.65%, the growth of the YC12 strain is almost completely inhibited, and the streptomyces albus can be used for preventing and treating the camellia oleifera anthracnose. The streptomyces G18 has a good prevention and treatment effect on the camellia oleifera anthracnose, and can be prepared into a biological agent for biological prevention and treatment on the camellia oleifera anthracnose.

This invention discloses a genetically engineered bacterium producing high levels of oleoflavones, its construction method, and its applications, belonging to the fields of genetic engineering and microbial technology. The genetically engineered bacterium for high oleoflavone production is a Streptomyces strain overexpressing the ORF8022 gene (Seq ID No. 1) and / or the ORF8003 gene (Seq ID No. 2). Its construction method includes the following steps: constructing an overexpression plasmid with a strong promoter element driving the expression of the target gene; and transferring the constructed plasmid to a Streptomyces host producing oleoflavones via conjugation transfer. This invention, through genetic engineering, overexpresses the endogenous genes ORF8022 and ORF8003, which are potentially related to oleoflavone biosynthesis, thereby significantly increasing the yield of oleoflavones.

This invention belongs to the field of microbial fermentation technology, specifically relating to an antibiotic Streptomyces strain, and further disclosing its application in the fermentation production of pentostatin. This invention screened a high-yield pentostatin-producing antibiotic Streptomyces antibioticus FIM-PNT-23-66 using atmospheric pressure, room temperature plasma mutagenesis technology. This strain can ferment pentostatin to a high yield, with a pentostatin potency as high as 651 μg / mL, significantly increasing pentostatin production. Furthermore, it exhibits excellent genetic traits and is suitable for industrial fermentation production.

The invention belongs to the technical field of microbiology, and discloses a streptomyces toxytricini strain, a culture, a composition, a microbial agent and application of the streptomyces toxytricini strain, the culture, the composition and the microbial agent, and the streptomyces toxytricini strain is selected from any one of A1)-A3): A1) a strain preserved in Guangdong Microbial Culture Collection Center with the preservation number of GDMCC No.64201; a2) a strain of which the 16S rRNA gene sequence has at least 98.65%, 99%, 99.5%, 99.6%, 99.7%, 99.8%, 99.9%, 99.99% and 100% identity with the sequence as shown in SEQ ID No.1; and A3) a strain of which the genomic sequence has an average nucleotide consistency of at least 99.6%, 99.7%, 99.8%, 99.9%, 99.99% and 100% with that of A1). The bacterial strain MN215602 provided by the embodiment of the invention shows relatively strong antibacterial activity, has good siderophore producing characteristics, and has relatively high growth speed. The fermentation liquor of the strain MN215602 can obviously weaken the pathogenicity of the ralstonia solanacearum to tomato seedlings.

Disclosed herein is a UV mutagenesis produced new Streptomyces spororaveus strain SC263 that exhibits an increased thermostability of the antibiotic produced, which shows antibiotic activity against bacteria and fungi. Also provided are the antibiotic produced by SC263 and a composition thereof for treatment of bacterial and fungal infections. The antibiotic has a very high molecular weight, which is suitable for topical administration.