The application provides application of linear
dipeptide Ala-Leu in prevention and treatment of nematodes. The linear
dipeptide Ala-Leu from plants has the activity of killing various nematodes, including
common root knot nematodes, pine nematodes and other
plant nematodes and free-living nematodes such as
Caenorhabditis elegans, and can obviously kill insects at a
low dose;
potting experiments prove that the linear
dipeptide can prevent and treat
plant diseases caused by nematodes. Moreover, the linear dipeptide Ala-Leu has the advantages of small molecular weight, simple structure, low cost, good
heat resistance and stability, and is easy to be degraded in animal cells, is safe for humans and other animals, has no activity of inhibiting the growth of
bacteria and fungi, is safe for non-target organisms, does not affect the soil bacterial
community structure, and has high application value in development of an environmentally-friendly, safe and efficient new type of nematocide and a new type of agent for preventing and treating
plant nematode diseases.