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Composition of traditional Chinese medicine effective constituent for preventing and treating diseased associated with cerebral ischemia injury

A technology of active ingredients and compositions, applied in the field of compositions for the prevention and treatment of cerebral ischemic injury, can solve problems such as the inability to truly control product quality, affect the stability of clinical efficacy, and difficult effective control of product quality, so as to protect ischemic injury , prevent platelet aggregation, reduce the effect of cerebrovascular resistance

Active Publication Date: 2009-02-04
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although Compound Shenwu Capsules has good anti-cerebral ischemic injury and anti-arteriosclerosis functions and neuroprotective functions and clinical efficacy, but because it is a compound preparation of traditional Chinese medicine, its composition is relatively complicated, and its product quality is difficult to obtain effective control in practical applications. Their quality control method is mainly to carry out the HPLC content determination and TLC inspection of 1 to 2 index components, and leave most of the active ingredients alone, which cannot really control the product quality, and will eventually affect the stability of clinical efficacy

Method used

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  • Composition of traditional Chinese medicine effective constituent for preventing and treating diseased associated with cerebral ischemia injury
  • Composition of traditional Chinese medicine effective constituent for preventing and treating diseased associated with cerebral ischemia injury
  • Composition of traditional Chinese medicine effective constituent for preventing and treating diseased associated with cerebral ischemia injury

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Embodiment 1, tablet

[0147] raw material:

[0148] Ginsenoside Rb 1 (content≥95%), ginsenoside Rd (content≥95%), ginsenoside Re (content≥95%), ginsenoside Rg 1 (content ≥ 95%); the above four ginsenosides were purchased from Jilin Hongjiu Biotechnology Co., Ltd.

[0149] Stilbene glycosides (content ≥ 70%), provided by Tianjin Huilv Technology Co., Ltd.

[0150] Ginkgolides (total lactone content ≥ 95%; ginkgolide B ≥ 40%), provided by Shanghai Autuo Information Technology Co., Ltd.

[0151] Quercetin and kaempferol (content ≥ 95%) were purchased from Shaanxi Huike Plant Development Co., Ltd.

[0152] Ginsenoside Rb 1 10kg, Ginsenoside Rd 1.0kg, Ginsenoside Re 4kg, Ginsenoside Rg 1 10kg, stilbene glycosides 8kg, ginkgolides 4kg, flavonoid mixture 3kg (quercetin 1.5Kg plus kaempferol 1.5Kg), mixed according to equal increment method to make active ingredient mixture (FSWXN5) 40Kg, add starch 25kg, 35 kg of dextrin, mixed evenly, granulated with 75% alcohol, dr...

Embodiment 2

[0155] Embodiment 2, capsule

[0156] Raw material source is with embodiment 1

[0157] Ginsenoside Rb 1 4kg, Ginsenoside Rd 4.0kg, Ginsenoside Re 5kg, Ginsenoside Rg 1 6kg, 2.0kg of stilbene glycosides, 5kg of ginkgolides, 2kg of flavonoid mixture, mixed according to the method of equal increase to make active ingredient mixture (FSWXN2) 28Kg, add 12kg of starch, 10kg of dextrin, mix well, and make Capsule powder 50kg packs No. 3 capsules, and a total of 333,300 capsules are prepared, each 0.15g, containing FSWXN 84mg / grain.

[0158] The content of each active ingredient in the compound Shenwu Xingnao active ingredient (SWXNF2) capsule was determined by HPLC method, and the results are shown in the following table.

[0159]

[0160] Compound Shenwu Xingnao active ingredient composition 2 (FSWXN2) capsule powder obtained by the present invention, its each active ingredient content measured by HPLC method is: ginsenoside Rb 1 7.62%, Ginsenoside Rg 1 11.38%, ginsenos...

Embodiment 3

[0161] Embodiment 3 honey pill

[0162] Raw material source is with embodiment 1

[0163] Ginsenoside Rb 1 2.0kg, Ginsenoside Rd 2.0kg, Ginsenoside Re 3.0kg, Ginsenoside Rg 1 8.0kg, stilbene glycosides 10.0kg, ginkgolides 2kg, flavonoid mixture 2kg, mixed according to the method of equal increase to make compound ginseng root refreshing active ingredient composition 1 (FSWXN1) 29.0kg, add starch 20.5kg, paste Refined 15.kg, mixed evenly, added honey 10kg to make small honeyed pills, dried at 60°C, made into 72.5kg dry pills, filled with No. 0 capsules, and made a total of 241,000 capsules, each 0.30g, containing FSWXN 1 120mg / capsule.

[0164] Oral dosage: 1 capsule each time, 2 times a day.

[0165] The results of the content of each active ingredient in the small honeyed pills in each sachet of capsules are determined in the following table by HPLC method.

[0166] Trial for the clinical treatment of stroke sequelae, 2 times a day, 1 capsule each time, for 60 days,...

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Abstract

The invention relates to a composite of active ingredients of Chinese herb medicine used for preventing the damage of cerebral ischemia and relevant diseases, in particular to a preparation which is prepared by the active ingredients of the Chinese herb medicine; the preparation is prepared by the active ingredients of the Chinese herb medicine and the conventional preparation technique which is used by carriers permitted by pharmacy, and comprises the following components with the parts by weight: 2 to 10 parts of ginsenoside Rb, 2 to 10 parts of ginsenoside Rg1, 1 to 5 parts of ginsenoside Rd, 1 to 5 parts of ginsenoside Re, 2 to 10 parts of stilbene glycoside, 1 to 5 parts of ginkgolide and 1 to 5 parts of flavonoid mixture which consists of kaempferol and quercetin with the weight rate to be 1:1. The invention has the advantages that the defects that in the traditional compounded Chinese medicine, the composition is complex, the product quality is not controlled effectively and the curative effect is not stable are overcome, has clear ingredients, definite effect, stable quality and obvious control effect on ischemic stroke, sequela, cerebral arteriosclerosis and vascular dementia, can improve the functions of motor nerve, and learning and memory of the patients, has low toxicity and simple preparation method without obvious side effect and is suitable for industrial mass production.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition prepared by using active ingredients of traditional Chinese medicines for preventing and treating cerebral ischemia injury. Background technique [0002] Diseases related to cerebral ischemic injury include stroke, sequelae of stroke, vascular dementia and Alzheimer's disease. Ischemic stroke is an important killer that threatens human health. It has a high incidence in middle-aged and elderly people, and the age of onset is getting younger. Senile dementia is a common disease in the elderly, and there are different types such as vascular dementia (Vascular Dementia, VD) and senile dementia (AD). Vascular dementia is an important type of senile dementia and one of the sequelae of ischemic stroke, which seriously affects the quality of life of the elderly. With the gradual aging of my country's population, the number of patients with ischemic cerebrovascular disease is incr...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/7048A61K31/7028A61K31/365A61P9/10
Inventor 贝伟剑郭姣臧林泉胡因铭朴胜华丁金龙
Owner GUANGDONG PHARMA UNIV
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