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35 results about "Ginkgolides" patented technology
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DITERPENES with three LACTONES and a unique tert-butyl group, which are found in GINKGO plants along with BILOBALIDES.
Ganoderma ginkgo ginkgo rice wine, preparation method and efficacy thereof
ActiveCN102277255ASuppress high blood pressureAlcoholic beverage preparationMicroorganism based processesBiotechnologyGinkgo nut
The invention discloses lucid ganoderma-gingko wine, relating to the technical field of biological engineering. According to the wine provided by the invention, the alcoholic strength is 8-16%, the content of general flavone is 1-5 mg / L, the content of gingko lactone is 1-6 mg / L, the content of general terpenes compound is 30-800 mg / L, the content of protein is 60-200 mg / L, the content of ganoderic acid is 10-17 mg / L, the content of soluble sugar is 0-2.0%, the content of gingko phenolic acid is 0-5 ppm and the content of hydrocyanic acid is 0-0.1 microgram / liter. According to the preparationmethod provided by the invention, the gingko is hydrolyzed by utilizing a double-enzyme method to obtain a gingko hydrolyzing solution and the gingko hydrolyzing solution contains active compounds including gingko flavone, terpenes compounds, amino acid, peptides and starch and the like, wherein the content of the amino acid and the peptides is not less than 1% and the content of the starch is not less than 2%; the hydrolyzing solution is converted through lucid ganoderma strains and a rice mold culture is added to ferment to obtain fermentation liquor; the fermentation liquor is filtered andblended to obtain the lucid ganoderma-gingko wine. The wine provided by the invention contains the active components of the gingko and the lucid ganoderma and has the functions of preventing hypertension, resisting oxidization and the like.
Owner:JIANGSU UNIV
Superficial venules dredging preparation for treating cerebral arteriosclerosis
InactiveCN1628683AInhibition formationPrevent proliferationOrganic active ingredientsPowder deliveryThird generationCerebral arteriosclerosis
Disclosed is a superficial venules dredging preparation for treating cerebral arteriosclerosis which comprises the constituents (by weight portion) of quercetin 2-6.35 g, kaempferide 1.5-4.6 g, isorhamnetin 0.35-1g, ginkgolides 1-3g, ginseng saponin 0.6-2g, and right amount of auxiliary materials.
Owner:湖南恒伟药业股份有限公司
Method for producing instant health care ginkgo powder
The invention relates to a method for producing instant health care ginkgo powder, which belongs to the technical field of ginkgo processing. The technical proposal of the invention comprises that the method for producing the instant health care ginkgo powder produces the ginkgo powder by taking a production process of 'a method for producing and eating instant ginkgo powder (application number: 200910094025.1)' as a reference. The method comprises the following steps: adding components of ginkgo leaf extract, cane sugar finemeal, accelerated solvent, substances with various flavors and the like which are embedded by beta-cyclodextrin into instant ginkgo powder in proportion, and then through the processes of granulation, subpackage and the like, preparing the instant health care ginkgo powder with strengthened health care function, significantly-reduced bitter tastes of ginkgetin and ginkgolide, and various tastes.
Owner:李奇峰 +1
Ginkgolide composition and application thereof
InactiveCN103263411AOvercoming Quality Control FlawsEasy to separateOrganic active ingredientsCardiovascular disorderVascular diseaseMedicine
The present invention discloses a Ginkgolide composition and a method for the preparation thereof. The composition includes two active components, Ginkgolide A and Ginkgolide B, and the weight ratio of Ginkgolide A to Ginkgolide B is 1: (2-9). A strong synergistic effect is found between Ginkgolide A and Ginkgolide B, which has a remarkable application effect on the treatment of cardio-cerebral vascular disease. The invention realizes simultaneous determination for the component content of the Ginkgolides preparation. Experiments show that the Ginkgolide A and Ginkgolide B have the advantages of good separating degree with better linear relation, reproducibility, precision, stability, and recovery rate. The dosage form of the preparations provided by the present invention is beneficial for improving the bioavailability in vivo and drug efficacy.
Owner:JIANGSU KANION PHARMA CO LTD +1
Ginkgo leaf composition and application thereof for preparing ginkgo biloba leaf extract injection
ActiveCN106420850AEfficient removalImprove stabilityMetabolism disorderPharmaceutical delivery mechanismAnaphylactoid reactionsSolubility
The invention relates to a ginkgo leaf composition, in particular to a ginkgo leaf composition and application thereof for preparing a ginkgo biloba leaf extract injection. The ginkgo leaf composition is prepared from 25-43% of total flavonol glycosides, 6.5-17% of ginkgolides, 3-5% of bilobalide and smaller than 3 ppm of ginkgoic acid. According to the preparation method of the ginkgo leaf composition, two kinds of resin of DM130 and AB-8 are adopted for adsorption, the harmful ingredient total ginkgolic acid is effectively removed, and anaphylactoid reaction occurrences are reduced; meanwhile, various extracting methods and composite extracting agent repeated extraction are adopted, the target component content is high, the purity is good, and the product quality is improved. The obtained ginkgo biloba leaf extract injection is clear in compositional ratio, good in stability, good in solubility and stable in curative effect and contains few impurities.
Owner:HEILONGJIANG ZBD PHARMA +1
Preparation method and quality detection method for medicine composition drop-pills
The invention discloses a ginkgolides dripping pill and a preparation method and a quality detection method thereof. During the preparation process, the ginkgolides and various substrates are evenly mixed and heated according to proportion, stirred and suspended and finally prepared into the dripping pill in a gradient way; one or a plurality of distinguishing or content detecting methods are adopted to carry out quality detection. The preparation formulation of the dripping pill selected by the ginkgolides dripping pill is the typical preparation formulation of the oral administration in themodern traditional Chinese medicines, and is characterized by high medicament stability, hard hydration and oxidation, quick effect, high bioavailability as well as convenient use and carrying. The ginkgolides is a medicament which is hardly dissolved in water, is dispersed into the substrates and prepared into the dripping pill; moreover, the solubility, the stripping speed and the bioavailability thereof are improved.
Owner:JIANGSU KANION PHARMA CO LTD
Ginkgo leaf debitterizing method
The invention discloses a ginkgo leaf debitterizing method, which consists of: mixing a ginkgo leaf concentrated solution with a Momordica grosvenori concentrated solution in a mass ratio of 1:0.5-1, heating the mixture at 40-100DEG C for 2-4h, and then conducting spray drying. By mixing a ginkgo leaf extract with a Momordica grosvenori extract and carrying out heating, the bitter taste of ginkgoleaves can be removed. Test reports show that debitterized ginkgo leaves no longer contain ginkgo flavone and ginkgolides. Taste tests of the product provided in the invention show that: debitterizedginkgo leaves have a unique flavor, a good taste, as well as a faint yellow color, and are very popular with consumers.
Owner:徐光策
Production process of gingko leaf beverage
The invention relates to a production process of a gingko leaf beverage and belongs to the machining of a food beverage. The invention aims to provide a production process of a gingko leaf beverage enriched with ginkgo lactone and polysaccharide, which is safe and efficient, is scientific and concise and can produce in a large scale. Ginkgolic acid harmful to a human body is removed and the original taste and flavor of ginkgos can be effectively kept; and a healthy beverage enriched with beneficial components including natural ginkgo lactone, flavone and the like can be produced. The production process disclosed by the invention takes natural and high-quality ginkgo leaves as main raw materials, and Vc, fructo-oligose, potassium sorbate and the like are added to prepare one gingko beverage which is fresh and thirst-quenching and is beneficial to improving the health of blood capillary circulation of a human body and improving the immunity.
Owner:镇江市丹徒区南山溪园茶叶专业合作社
Production process of gingko oral solution
The invention relates to a production process of a ginkgo flavone and lactone oral solution and belongs to the processing of health-care products. The invention aims to develop a production process of a ginkgo leaf beverage containing ginkgo lactone and polysaccharide, which is safe and efficient, is scientific and concise and can produce in a large scale. The original taste and flavor of ginkgos can be effectively kept after harmful substances of a ginkgolic acid in ginkgo leaves are removed and the original taste and flavor of the ginkgos are kept; and the healthy beverage is enriched with beneficial components including natural ginkgo lactone, flavone and the like. The production process disclosed by the invention takes the natural and high-quality ginkgo leaves as main raw materials to prepare the ginkgo oral solution through steps of: preparing a ginkgo leaf raw solution, disacidifying the ginkgo leaf raw solution, adjusting flavor and filing, and adding Vc, potassium sorbate and the like. After being taken, the ginkgo flavone and lactone oral solution is beneficial for improving the health of blood capillary circulation of a human body and improving the immunity.
Owner:镇江市丹徒区南山溪园茶叶专业合作社
Ganoderma lucidum-ginkgo functional food and preparation method thereof
InactiveCN103689557AHas the function of protecting the liverCultivating equipmentsFood preparationBiotechnologyGinkgo nut
The invention discloses a ganoderma lucidum-ginkgo functional food and a preparation method thereof, and the process relates to the field of biological engineering technology. With ginkgo as main raw material and by adopting strain liquid deep culture and solid fermentation technologies, the ganoderma lucidum-ginkgo functional food is obtained. The preparation method comprises the steps: cutting ginkgo into small lumps with the size of 3-5 mm, inoculating with a 5-30% ganoderma lucidum seed liquid after sterilization, carrying out sealed fermentation with a preservative film, and after drying and smashing the fermentation product, thus obtaining the ganoderma lucidum-ginkgo functional food. The product contains 0.3-2 mg / g of total flavonoids, 0.2-1.5 mg / g of ginkgolides, 0.8-3.9 mg / g of ganoderma trierponoides, 0.9-8 mg / g of proteins, less than 0.5% of soluble sugar, 1-15 mg / g of polysaccharide, less than 5 [mu]g / g of ginkgolic acid, and less than 0.1 [mu]g / g of hydrocyanic acid. Because of containing the flavonoid compounds, terpenoids, ganoderma triterpenes and other active ingredients, the product has the efficacies of inhibiting tumor cell reproduction and reducing oxidative stress in a body.
Owner:JIANGSU UNIV +1
Method for simultaneous preparing high-purity total flavonol glycosides and ginkgolides
ActiveCN107375356ALow in Total FlavonolsGinkgolide content requirements are lowOrganic chemistryGinkgophyta medical ingredientsFlavonolsSolvent
A method for simultaneous separating total flavonol glycosides and ginkgolides from ginkgo biloba extract is provided. The method is characterized in that the ginkgo biloba extract is taken as a raw material, column chromatography enrichment and purification through polyamide and macroporous resin are conducted, after eluent is concentrated, ester solution is added for extraction, an organic phase part is washed with water, standing is conducted for stratification, an aqueous phase and an organic phase are combined correspondingly, an solvent is recovered, drying and smashing are conducted, and then the high-purity total flavonol glycosides and the ginkgolides are obtained. According to the method for simultaneous separating the total flavonol glycosides and the ginkgolides from the ginkgo biloba extract, it is guaranteed that the purity of the total flavonol glycosides simultaneously separated from the ginkgo biloba extract reaches 90% or more, the transfer rate is not less than 65%, the purity of the total of the sum of ginkgolides A, ginkgolides B and ginkgolides C is more than 85% or more, the transfer rate of the sum of the ginkgolides is not less than 55%, and total ginkgolic acid contained is less than 1mg / kg; organic extraction is combined with water washing so that the high-purity total flavonol glycosides and the ginkgolides can be simultaneously obtained with rapid speed and low cost, residue organic solvents is low, and sensitization substance is less or few.
Owner:SHINEWAY PHARMA GRP LTD +1
The method for preparing ginkgolide B by using the thallus thale as a catalyst
Owner:BEIJING LYUKE TIANCHENG BIO TECH
Ganoderma lucidum-ginkgo fruit wine and preparation method thereof
InactiveCN103695225AHas the function of protecting the liverProtect the liverAlcoholic beverage preparationBiotechnologyGinkgo nut
The invention discloses a ganoderma lucidum-ginkgo fruit wine and a preparation method thereof, and the process relates to the field of biological engineering technology. The ganoderma lucidum-ginkgo fruit wine is prepared by taking ginkgo as main raw material and by adopting a solid fermentation technology and a wine-brewing process. The preparation method comprises the steps: cutting ginkgo into small lumps with the size of 3-5 mm, introducing a 5-30% ganoderma lucidum seed liquid after sterilization, carrying out sealed fermentation with a preservative film, adding cooked rice cooked from rice having the weight of 30-70% of the ganoderma lucidum fermentation product weight, distiller yeasts with the weight of 1-5% of the rice weight and water with the amount being 2-5 times the rice weight, and after fermenting at the temperature of 10-30 DEG C for 10-50 days, filtering and blending the fermentation liquid to obtain the ganoderma lucidum-ginkgo fruit wine. The alcoholic strength of the wine is 8-30%, the total flavone content is 1-15 mg / L, the ginkgolides content is 10-150 mg / L, the ganoderma triterpenes content is 50-500 mg / L, the protein content is 60-500 mg / L, the soluble sugar content is less than 2.0%, the polysaccharide content is 100-800 mg / L, and the saponin content is 20-500 mg / L. The wine has anti-oxidation and liver-protecting efficacies.
Owner:JIANGSU UNIV +1
Chinese medicinal composition for treating depression
InactiveCN102266380AAvoid toxicity and side effectsNervous disorderPlant ingredientsSide effectBakuchiol
The invention relates to a traditional Chinese medicine composition for treating depression, which consists of 2-10 ginkgo biloba extracts and 2-20 psoraleae extracts in parts by weight. Ginkgo biloba extract is water or ethanol extract of ginkgo biloba, and psoraleae extract is water or ethanol extract. The Ginkgo biloba extract is a standard Ginkgo biloba extract or an extract of total ginkgo lactones. The said psoralen extract is psoralen extract or bakuchiol extract. The composition is aimed at each link of the onset of depression, exerts pharmacological effects on multiple targets, avoids the toxicity and side effects of chemical drugs, and is a therapeutic and preventive drug for depression with broad market prospects.
Owner:TIANJIN TAIYANG PHARMA
Process for removing pesticides from ginkgo biloba extracts, and extracts obtainable by said process
Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps:a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides;b. crystallisation from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%;c. crystallisation from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%;d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).
Owner:INDENA SPA
Preparation method of nontoxic high-purity ginkgo total lactones and monomers thereof
ActiveCN105061458ASave the long process of recrystallizationImprove developmentOrganic chemistryBulk chemical productionSolventSilica gel
The invention relates to a preparation method of nontoxic high-purity ginkgo total lactones and monomers thereof, which adopts a solvent extraction+precipitation+compound filled column chromatography+supercritical CO2 back extraction crystallization combined technique to prepare the high-purity ginkgo total lactones and monomers thereof. The extraction solvent is propyl formate, the precipitation solvent adopts petroleum ether, and the total lactone purity is up to 98%. The neutral aluminum oxide / normal-phase silica gel compound filled column chromatography is performed, and the supercritical CO2 back extraction crystallization is performed to obtain the ginkgo lactone monomers A, B and C with the purity of 97% or above; and no toxic ginkgolic acid is detected. The separation purification technique has the advantages of simple method and high product purity, and can be easily used in practical production.
Owner:HEFEI UNIV OF TECH
Pharmaceutical composition for treating myocardial ischemia as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition
InactiveCN107569505ALow priceThe composition is clearOrganic active ingredientsConfectioneryReflux extractionCurative effect
The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition for treating myocardial ischemia as well as an application of the pharmaceutical composition and an injection prepared and formed by the pharmaceutical composition. The pharmaceutical composition consists of quercetin-3-O-[beta]-D-glucosyl (1-2)-[alpha]-L-rhamnoside, narcissoside, kaempferol-3-O-[beta]-D-glucosyl (1-2)-[alpha]-L-rhamnoside and ginkgolides A, B and C. The pharmaceutical composition is clear in ingredients and controllable in mass; the various components are mutually cooperated under specific proportions; and the pharmaceutical composition can be clinically applied to myocardial ischemia, with a curative effect obviously better than that of a ginkgo biloba extract, which is unclear in components, provided by the prior art. The invention also provides a preparation method of pharmaceutical composition; by conducting reflux extraction with 93-96% ethanol, and by implementing porous resin adsorption treatment, the components can be effectively separated; and the preparation method is simple in process and applicable to industrial production.
Owner:朗致集团江西医药有限公司
Ginkgolides K and compound thereof as well as preparation method and use thereof
ActiveCN102002052BSolve technical problemsMaintain natural structureOrganic active ingredientsNervous disorderSolubilityFully developed
The invention discloses a compound of ginkgolides K of which a general formula is shown in (I), and a composition is prepared by mixing the ginkgolides K compound and pharmaceutically-acceptable medicine carrier, wherein G is alkaline substances. The invention also discloses a preparation method of the compound and treatment use thereof. In the invention, the ginkgolides K compound changes the physical property of the ginkgolides K, thereby the invention has the advantages of good stability, and the ginkgolides K compound has good water-solubility and higher stability. In the compound, a natural structure of the ginkgolides K can be kept, and when the compound is used as an effective component to enter the human body, the activity of the ginkgolides K can be fully developed to achieve theaim of treating an illness.
Owner:JIANGSU KANION PHARMA CO LTD
Bilobalide B extraction device
PendingCN114159832AImprove leaching effectImprove the purification effectOrganic chemistrySolid solvent extractionPhysical chemistryEnvironmental engineering
The invention discloses a bilobalide B extraction device which comprises a feeding mechanism and an extraction mechanism, the extraction mechanism comprises a filter cartridge, the bottom end of the filter cartridge is of an arc-shaped structure, a liquid discharge pipe is arranged at the bottom end of the filter cartridge, the liquid discharge pipe is connected with a return pipe and a collection pipe through a shunt pipe, and the other end of the return pipe is connected with a circulating water pump; a heating box is arranged on one side of the circulating water pump. Ginkgo leaves accumulated in the feeding box are extruded by pushing the extrusion rod, so that the ginkgo leaves can smoothly enter the crushing cylinder to be processed, and the operation is simple and convenient; according to the invention, cell walls of ginkgo leaves are crushed and extracted through ultrasonic waves, the interior of the filter cartridge can be heated through the electric heating layer outside the filter cartridge, and the extracted filtrate is further heated by the heating box, so that the yield can be effectively increased, and the leaching effect and the purification effect of ginkgolide are also improved; therefore, the purity of the final product is improved.
Owner:SHANGHAI SINE PROMOD PHARMA
A method for separating and purifying ginkgolide a and ginkgolide b
ActiveCN106496246BHigh purityWide range of disease managementOrganic chemistryPurification methodsHot melt
Owner:孙焱辉 +1
Detoxification and bitter-covering treatment method for whole ginkgo fruits
The invention discloses a detoxification and bitter-covering treatment method for whole ginkgo fruits, and the method comprises the following steps: removing crude peel, performing shelling, detoxifying and neutralizing, performing high static pressure treatment, performing enzymolysis, dipping, draining, coating and frying, and preparing detoxified and bitter-covering crisp ginkgo fruits, or preparing preserved ginkgo fruits after wet preservative treatment. According to the detoxification and bitterness-covering treatment method for the whole ginkgo, unique detoxification, extraction, enzymolysis and frying methods are adopted, so that the ginkgo is completely unshelled, detoxified and bitterness-covered, toxins are thoroughly removed, and substances such as ginkgo flavone, ginkgolide, amino acids, vitamins, minerals and the like which are beneficial to a human body in the ginkgo are reserved as much as possible; Nutrient substances such as vitamins, citric acid and lecithin are artificially added, so that balanced nutrition required by a human body is ensured, the optimal crisp taste is ensured by a low-oil and low-temperature baking and frying technology, excessive energy intake is avoided, and the innovative preserved white fruit provides a soft and appropriate taste for consumers.
Owner:BEIJING DAYOU SHENGCUI BIOTECH CO LTD
Ginkgo long-chain non-coding RNA and application thereof to bilobalide biosynthesis
PendingCN113817738AVector-based foreign material introductionAngiosperms/flowering plantsMolecular biologyGinkgolides
The invention belongs to the technical field of plant molecular biology, and particularly relates to ginkgo long-chain non-coding RNA and an application thereof to bilobalide biosynthesis, and the sequence of the ginkgo long-chain non-coding RNA is shown as SEQ ID NO.1. The ginkgo long-chain non-coding RNA can effectively increase the content of bilobalide.
Owner:HUNAN UNIV OF SCI & ENG
Composition for preventing or treating sexual dysfunction and use of composition
InactiveCN110694005AImprove efficacyImprove erectile functionOrganic active ingredientsAntinoxious agentsSexual functioningDendrobium candidum
The invention discloses a composition containing ginkgolides and dendrobium candidum, use of the composition containing ginkgolides and dendrobium candidum to preparation of medical compositions, health-care products and foods for preventing and / or treating sexual dysfunction, and use of the composition containing ginkgolides and dendrobium candidum to preparation of compositions, health-care products and foods for enhancing immunity and resisting weariness, and belongs to the technical field of traditional Chinese medicine compositions. Specifically, according to the composition disclosed bythe invention, the weight ratio of the ginkgolides to the dendrobium candidum is (1-20) to (5-200), wherein the dendrobium candidum is measured by the weight of dry product crude medicines. The invention further discloses a medicinal preparation containing the composition. Animal experiments and clinical observation results indicate that the composition disclosed by the invention has the efficacyof preventing, or treating or relieving the sexual dysfunction, and besides, has the effects of adjusting immunity and resisting weariness.
Owner:CHENGDU BAIYU PHARMA CO LTD
Determination method for total ginkgolic acid in ginkgolide composition
The invention relates to the field of phytoextraction and in particular relates to a determination method for total ginkgolic acid in ginkgolide composition. By adopting the ginkgolide extraction separation method provided by the invention, ginkgolid composition with fixed components can be obtained. In the determination method for the total ginkgolic acid, 20mul of each of a test solution, a reference substance solution and a contrast solution for locating is precisely sucked and injected into a liquid chromatograph, the total peak area of a chromatographic peak corresponding to a total ginkgolic acid reference substance in the test solution is calculated, and the content of the total ginkgolic acid is calculated by adopting a ginkgo new acid reference substance external standard method.
Owner:CHENGDU BAIYU PHARMA CO LTD
Process for removing pesticides from ginkgo biloba extracts, and extracts obtainable by said process
InactiveUS20170042952A1Crystallization separationAntinoxious agentsGinkgo Biloba Leaf ExtractMedicinal chemistry
Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps:a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides;b. crystallisation from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%;c. crystallisation from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%;d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).
Owner:INDENA SPA
A pharmaceutical composition containing ginkgolide b and non-peptide thrombin inhibitors and its preparation method and application
ActiveCN105560236BPromote anticoagulant functionReduce doseOrganic active ingredientsBlood disorderSide effectMechanism of action
The invention provides a pharmaceutical composition containing ginkgolide B. The pharmaceutical composition comprises the ginkgolide B and pseudo-peptide thrombin inhibitor. The invention further provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages that the ginkgolide B and the pseudo-peptide thrombin inhibitor are combined to achieve a synergic effect, and the pharmaceutical composition is excellent in anticoagulation effect, low in side effect and promising in clinical application prospect; the pharmaceutical composition is novel in prescription, simple in component, clear in action mechanism, evident in curative effect, less prone to tolerance generating and capable of achieving large-scale industrial production.
Owner:CHENGDU BAIYU PHARMA CO LTD
Method of identifying a plant extract
InactiveCN1185354CMicrobiological testing/measurementRecombinant DNA-technologyGinkgo bilobaGinkgo leaf extract
The present invention is directed to a method of establishing an identity of Ginkgo biloba leaves or isolated ginkgolide B (GKB) or another component of the extract of Ginkgo biloba leaves, by obtaining a gene regulation profile. The invention is also directed to a method of verifying the identity of a Ginkgo biloba extract by comparing the gene regulation profile of a Gingko biloba extract of unknown or questionable origin with the gene regulation pofile of a Gingko biloba extract of known origin. The present invention is further directed to a method of establishing a gene expression profile of Ginkgolide A, Ginkgolide B or any other component isolated from a Ginkgo biloba extract, more particularly, from EGB 7613.
Owner:SOC DE CONSEILS DE RECH & DAPPLICATIONS SCI SAS +1
A kind of pharmaceutical composition containing ginkgolide B and phosphodiesterase inhibitor and its preparation method and application
ActiveCN105560238BPromote anti-platelet aggregation functionReduce doseOrganic active ingredientsBlood disorderSide effectMechanism of action
The invention provides a pharmaceutical composition containing ginkgolide B. The pharmaceutical composition comprises the ginkgolide B and phosphodiesterase inhibitor. The invention further provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages that the ginkgolide B and the phosphodiesterase inhibitor are combined to achieve a synergic effect, and the pharmaceutical composition is excellent in platelet aggregation inhibiting effect, low in side effect and promising in clinical application prospect; the pharmaceutical composition is novel in prescription, simple in component, clear in action mechanism, evident in curative effect, less prone to tolerance generating and capable of achieving large-scale industrial production.
Owner:CHENGDU BAIYU PHARMA CO LTD
Method for enriching ginkgolide in ginkgo fruit juice based on probiotic fermentation
PendingCN111411133ALow costImprove enrichment effectMicroorganism based processesFermentationBiotechnologyAmylase
The invention discloses a method for enriching ginkgolide in ginkgo fruit juice based on probiotic fermentation, and belongs to the technical field of food processing. The method mainly comprises thefollowing steps: (1) mixing ginkgo fruits and water to perform pulping to obtain pulp, adding alpha-amylase and a saccharifying enzyme into the pulp for enzymolysis, and performing centrifuging to obtain ginkgo juice; and (2) sterilizing the ginkgo juice, and inoculating the ginkgo juice with probiotics for fermentation. The content of ginkgolides in the ginkgo juice is obviously improved after the ginkgo fruit juice is fermented by probiotics, and the nutritional health care value is greatly improved. The method is safe and environmentally friendly, has low cost, and is beneficial to industrial production and popularization.
Owner:南京农业大学泰州研究院
Method for preparing high-purity ginkgolides
InactiveCN102491983AEliminates the need for chromatographic separationReduce dehydration loadOrganic chemistryBulk chemical productionAcetic acidEthyl ester
The invention relates to a method for separating and purifying high-purity ginkgo terpene lactones, and the high-purity ginkgo terpene lactones are prepared by adopting a combined process of solvent extraction, recrystallization, supercritical CO2 extraction removal and drying, wherein an extraction solvent is ethyl propionate; anhydrous ethyl acetate is used as a recrystallization solvent; and a supercritical CO2 extraction removal solvent is adopted for drying. The purity of a product can be above 99%. The separation and purification process is simple in method, low in cost and easy for industrial production and application.
Owner:JIANGSU BESCON PHARMA
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