35 results about "Ginkgolides" patented technology

Disclosed is a superficial venules dredging preparation for treating cerebral arteriosclerosis which comprises the constituents (by weight portion) of quercetin 2-6.35 g, kaempferide 1.5-4.6 g, isorhamnetin 0.35-1g, ginkgolides 1-3g, ginseng saponin 0.6-2g, and right amount of auxiliary materials.

The invention relates to a method for producing instant health care ginkgo powder, which belongs to the technical field of ginkgo processing. The technical proposal of the invention comprises that the method for producing the instant health care ginkgo powder produces the ginkgo powder by taking a production process of 'a method for producing and eating instant ginkgo powder (application number: 200910094025.1)' as a reference. The method comprises the following steps: adding components of ginkgo leaf extract, cane sugar finemeal, accelerated solvent, substances with various flavors and the like which are embedded by beta-cyclodextrin into instant ginkgo powder in proportion, and then through the processes of granulation, subpackage and the like, preparing the instant health care ginkgo powder with strengthened health care function, significantly-reduced bitter tastes of ginkgetin and ginkgolide, and various tastes.

The present invention discloses a Ginkgolide composition and a method for the preparation thereof. The composition includes two active components, Ginkgolide A and Ginkgolide B, and the weight ratio of Ginkgolide A to Ginkgolide B is 1: (2-9). A strong synergistic effect is found between Ginkgolide A and Ginkgolide B, which has a remarkable application effect on the treatment of cardio-cerebral vascular disease. The invention realizes simultaneous determination for the component content of the Ginkgolides preparation. Experiments show that the Ginkgolide A and Ginkgolide B have the advantages of good separating degree with better linear relation, reproducibility, precision, stability, and recovery rate. The dosage form of the preparations provided by the present invention is beneficial for improving the bioavailability in vivo and drug efficacy.

The invention relates to a production process of a ginkgo flavone and lactone oral solution and belongs to the processing of health-care products. The invention aims to develop a production process of a ginkgo leaf beverage containing ginkgo lactone and polysaccharide, which is safe and efficient, is scientific and concise and can produce in a large scale. The original taste and flavor of ginkgos can be effectively kept after harmful substances of a ginkgolic acid in ginkgo leaves are removed and the original taste and flavor of the ginkgos are kept; and the healthy beverage is enriched with beneficial components including natural ginkgo lactone, flavone and the like. The production process disclosed by the invention takes the natural and high-quality ginkgo leaves as main raw materials to prepare the ginkgo oral solution through steps of: preparing a ginkgo leaf raw solution, disacidifying the ginkgo leaf raw solution, adjusting flavor and filing, and adding Vc, potassium sorbate and the like. After being taken, the ginkgo flavone and lactone oral solution is beneficial for improving the health of blood capillary circulation of a human body and improving the immunity.

A method for simultaneous separating total flavonol glycosides and ginkgolides from ginkgo biloba extract is provided. The method is characterized in that the ginkgo biloba extract is taken as a raw material, column chromatography enrichment and purification through polyamide and macroporous resin are conducted, after eluent is concentrated, ester solution is added for extraction, an organic phase part is washed with water, standing is conducted for stratification, an aqueous phase and an organic phase are combined correspondingly, an solvent is recovered, drying and smashing are conducted, and then the high-purity total flavonol glycosides and the ginkgolides are obtained. According to the method for simultaneous separating the total flavonol glycosides and the ginkgolides from the ginkgo biloba extract, it is guaranteed that the purity of the total flavonol glycosides simultaneously separated from the ginkgo biloba extract reaches 90% or more, the transfer rate is not less than 65%, the purity of the total of the sum of ginkgolides A, ginkgolides B and ginkgolides C is more than 85% or more, the transfer rate of the sum of the ginkgolides is not less than 55%, and total ginkgolic acid contained is less than 1mg/kg; organic extraction is combined with water washing so that the high-purity total flavonol glycosides and the ginkgolides can be simultaneously obtained with rapid speed and low cost, residue organic solvents is low, and sensitization substance is less or few.

The invention discloses a ganoderma lucidum-ginkgo fruit wine and a preparation method thereof, and the process relates to the field of biological engineering technology. The ganoderma lucidum-ginkgo fruit wine is prepared by taking ginkgo as main raw material and by adopting a solid fermentation technology and a wine-brewing process. The preparation method comprises the steps: cutting ginkgo into small lumps with the size of 3-5 mm, introducing a 5-30% ganoderma lucidum seed liquid after sterilization, carrying out sealed fermentation with a preservative film, adding cooked rice cooked from rice having the weight of 30-70% of the ganoderma lucidum fermentation product weight, distiller yeasts with the weight of 1-5% of the rice weight and water with the amount being 2-5 times the rice weight, and after fermenting at the temperature of 10-30 DEG C for 10-50 days, filtering and blending the fermentation liquid to obtain the ganoderma lucidum-ginkgo fruit wine. The alcoholic strength of the wine is 8-30%, the total flavone content is 1-15 mg/L, the ginkgolides content is 10-150 mg/L, the ganoderma triterpenes content is 50-500 mg/L, the protein content is 60-500 mg/L, the soluble sugar content is less than 2.0%, the polysaccharide content is 100-800 mg/L, and the saponin content is 20-500 mg/L. The wine has anti-oxidation and liver-protecting efficacies.

The invention relates to a traditional Chinese medicine composition for treating depression, which consists of 2-10 ginkgo biloba extracts and 2-20 psoraleae extracts in parts by weight. Ginkgo biloba extract is water or ethanol extract of ginkgo biloba, and psoraleae extract is water or ethanol extract. The Ginkgo biloba extract is a standard Ginkgo biloba extract or an extract of total ginkgo lactones. The said psoralen extract is psoralen extract or bakuchiol extract. The composition is aimed at each link of the onset of depression, exerts pharmacological effects on multiple targets, avoids the toxicity and side effects of chemical drugs, and is a therapeutic and preventive drug for depression with broad market prospects.

The invention relates to a preparation method of nontoxic high-purity ginkgo total lactones and monomers thereof, which adopts a solvent extraction+precipitation+compound filled column chromatography+supercritical CO2 back extraction crystallization combined technique to prepare the high-purity ginkgo total lactones and monomers thereof. The extraction solvent is propyl formate, the precipitation solvent adopts petroleum ether, and the total lactone purity is up to 98%. The neutral aluminum oxide/normal-phase silica gel compound filled column chromatography is performed, and the supercritical CO2 back extraction crystallization is performed to obtain the ginkgo lactone monomers A, B and C with the purity of 97% or above; and no toxic ginkgolic acid is detected. The separation purification technique has the advantages of simple method and high product purity, and can be easily used in practical production.

The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition for treating myocardial ischemia as well as an application of the pharmaceutical composition and an injection prepared and formed by the pharmaceutical composition. The pharmaceutical composition consists of quercetin-3-O-[beta]-D-glucosyl (1-2)-[alpha]-L-rhamnoside, narcissoside, kaempferol-3-O-[beta]-D-glucosyl (1-2)-[alpha]-L-rhamnoside and ginkgolides A, B and C. The pharmaceutical composition is clear in ingredients and controllable in mass; the various components are mutually cooperated under specific proportions; and the pharmaceutical composition can be clinically applied to myocardial ischemia, with a curative effect obviously better than that of a ginkgo biloba extract, which is unclear in components, provided by the prior art. The invention also provides a preparation method of pharmaceutical composition; by conducting reflux extraction with 93-96% ethanol, and by implementing porous resin adsorption treatment, the components can be effectively separated; and the preparation method is simple in process and applicable to industrial production.

The invention discloses a bilobalide B extraction device which comprises a feeding mechanism and an extraction mechanism, the extraction mechanism comprises a filter cartridge, the bottom end of the filter cartridge is of an arc-shaped structure, a liquid discharge pipe is arranged at the bottom end of the filter cartridge, the liquid discharge pipe is connected with a return pipe and a collection pipe through a shunt pipe, and the other end of the return pipe is connected with a circulating water pump; a heating box is arranged on one side of the circulating water pump. Ginkgo leaves accumulated in the feeding box are extruded by pushing the extrusion rod, so that the ginkgo leaves can smoothly enter the crushing cylinder to be processed, and the operation is simple and convenient; according to the invention, cell walls of ginkgo leaves are crushed and extracted through ultrasonic waves, the interior of the filter cartridge can be heated through the electric heating layer outside the filter cartridge, and the extracted filtrate is further heated by the heating box, so that the yield can be effectively increased, and the leaching effect and the purification effect of ginkgolide are also improved; therefore, the purity of the final product is improved.

The invention discloses a detoxification and bitter-covering treatment method for whole ginkgo fruits, and the method comprises the following steps: removing crude peel, performing shelling, detoxifying and neutralizing, performing high static pressure treatment, performing enzymolysis, dipping, draining, coating and frying, and preparing detoxified and bitter-covering crisp ginkgo fruits, or preparing preserved ginkgo fruits after wet preservative treatment. According to the detoxification and bitterness-covering treatment method for the whole ginkgo, unique detoxification, extraction, enzymolysis and frying methods are adopted, so that the ginkgo is completely unshelled, detoxified and bitterness-covered, toxins are thoroughly removed, and substances such as ginkgo flavone, ginkgolide, amino acids, vitamins, minerals and the like which are beneficial to a human body in the ginkgo are reserved as much as possible; Nutrient substances such as vitamins, citric acid and lecithin are artificially added, so that balanced nutrition required by a human body is ensured, the optimal crisp taste is ensured by a low-oil and low-temperature baking and frying technology, excessive energy intake is avoided, and the innovative preserved white fruit provides a soft and appropriate taste for consumers.

The invention relates to a method for separating and purifying high-purity ginkgo terpene lactones, and the high-purity ginkgo terpene lactones are prepared by adopting a combined process of solvent extraction, recrystallization, supercritical CO2 extraction removal and drying, wherein an extraction solvent is ethyl propionate; anhydrous ethyl acetate is used as a recrystallization solvent; and a supercritical CO2 extraction removal solvent is adopted for drying. The purity of a product can be above 99%. The separation and purification process is simple in method, low in cost and easy for industrial production and application.