81 results about "Panaxatriol" patented technology

The invention relates to a preparation method of flavor ginseng; after ginseng is added with nature fruit juice or organic acid for reaction, the content of the precious ginsenoside in products is enhanced, the efficacies of ginseng is improved, while the specific flavor of ginseng is maintained. The main quality characteristics is that: the flavor ginseng includes at least one of the following ingredients: ginsenoside Rg3, ginsenoside Rh1 and ginsenoside 20R-Rh2; wherein, the ratio of the total amount of precious ginsenoside group, ginsenoside Rb1, ginsenoside Rb2, ginsenoside Rd and ginsenoside Rc to the total amount of ginsenoside Re, ginsenoside Rg1 and ginsenoside Rf is more than 2.5; the preparation method can convert part of the component causing internal heat, namely, panaxatriol ginsenoside, into precious ginsenoside.

The invention relates to a brand discoloration wet-process polyurethane resin with good hydrolysis resistance and a preparation method of the brand discoloration wet-process polyurethane resin. The polyurethane resin comprises the following components in percentage by weight: 8-15% of diphenylmethane-4, 4'-diisocyanate, 12-20% of poly(polyol adipate), 1-4% of 1, 4-butanediol, 0.05-1% of ethylene glycol, 0.3-2% of hydroxyl fluorine-silicone oil, 60-77% of N, N-dimethylformamide and 1-4% of polyoxypropylene propylene-panaxatriol. The polyurethane resin has the characteristics of good surface smoothness and good hydrolysis resistance; after the polyurethane resin is processed by using a branding process, the discoloring effects of grains on the surface of the polyurethane resin are remarkable, and the polyurethane resin has a strong stereoscopic impression.

The compound panoxatriol saponin with physiological activity contains panoxatriol saponin, gingko extractive, theanine and supplementary material is prepared into various preparations. The compound panoxatriol saponin can treat cerebral atherosclerosis, senile dementia, etc. by means of the functions of strengthening the activity of cerebral cell and cerebral nerve cell, improving brain's oxygen and blood supplying state, etc.

The invention discloses a preparation method of a panaxadiol saponin and a panaxadiol type saponin monomer. The preparation method comprises the following steps: taking radix notoginseng, ginseng or American ginseng as raw materials, extracting and concentrating the raw materials through low alcohols and filtering through diatomite; then selectively absorbing panaxatriol saponin with macroporous resin with an aperture of 50-70 [mu]m, collecting effluent liquid and drying to obtain a panaxadiol saponin coarse product; dissolving the panaxadiol saponin coarse product through methanol, ethanol, methanol water or ethanol water, adding acetonitrile or ethyl acetate to precipitate, collecting a precipitate to dissolve, putting a panaxadiol saponin aqueous solution on a chromatographic resin column, firstly resolving triol impurities with an ethanol solution, and dissolving and resolving by adopting different concentrations of ethanol or methanol solutions to obtain the panaxadiol saponin or the panaxadiol type saponin monomer. The preparation method disclosed by the invention overcomes the defects of low yield, high production cost, low purity, long production period and the like in the prior art, obtains the high-purity panaxadiol saponin or the panaxadiol type saponin monomer and is simple and easy to operate, low in cost, suitable for industrial production, environment-friendly and free of pollution.

The invention belongs to the technical field of medicines, and relates to a panaxatriol supersaturated self-microemulsion and a preparation method thereof. The panaxatriol supersaturated self-microemulsion consists of panaxatriol and a supersaturated self-microemulsion system, wherein the supersaturated self-microemulsion system is composed of an oil phase, an emulsifier, a co-emulsifier and polymers. The panaxatriol supersaturated self-microemulsion specifically consists of the following ingredients in the following percent weight in volume: 0.1-10% of the panaxatriol, 10-50% of the oil phase, 30-70% of the emulsifier, 10-30% of the co-emulsifier, and 0.5-10% of water-soluble cellulose. Compared with conventional self-microemulsions, the panaxatriol supersaturated self-microemulsion is capable of effectively delaying drug precipitation so as to improve emulsion stability; and moreover, the panaxatriol supersaturated self-microemulsion prepared by the preparation method is capable of effectively improving bioavailability of the panaxatriol in vivo. Pharmacokinetic experiments have proven that the bioavailability of the panaxatriol supersaturated self-microemulsion is improved by 2.7 times compared with bulk drugs.

The invention discloses a novel process for producing rare ginsenoside from panaxatriol ginsenoside in ionic liquid through enzyme-catalysis directional transformation and for separating and purifying the rare ginsenoside. Specifically, the method comprises the following steps: dissolving panaxatriol ginsenoside in the ionic liquid and adding the ionic liquid dissolved with the panaxatriol ginsenoside to a reaction kettle, and then adding a complex enzyme preparation in a quantitative mode; conducting the directional transformation under corresponding conditions, so that a great amount of rare ginsenoside is obtained; and collecting a finished product and purifying the product, so that various varieties of rare ginsenoside which are higher than 95% in purity are obtained. The process is high in yield of the rare ginsenoside, environment-friendly, relatively simple in downstream purifying process and conducive to large-scale production.

The invention discloses a panaxatriol saponins composition and application thereof to preparation of drugs for strengthening immunity. The panaxatriol saponins composition at least comprises 5-60% of ginsenoside-Re and 5-60% of ginsenoside-Rg1 by weight percent. The panaxatriol saponins composition has stronger activity than the single ginsenoside in resisting Parkinson's diseases and has high bioavailability, simple preparation method and low price.

The invention discloses a protopanaxatriol derivative as well as a preparation method and application thereof. The structural formula of the protopanaxatriol derivative includes a formula I, a formula II, a formula III, a formula IV and a formula V. According to the invention, protopanaxatriol is successfully subjected to structure modification by utilizing a microbial transformation technology so as to obtain multiple novel compounds, and an in-vitro antitumor cell test proves that the compounds have preferable antitumor activity, can serve as active components of an antitumor drug and have wide application.

This invention relates to a method for preparing protopanaxadiol and protopanaxatriol by co-oxidizing with oxygen and peroxide and alkali-hydrolyzing total notoginsenoside. The method comprises: (1) oxidizing and alkali-hydrolyzing Panax ginseng total saponin extract and Gynostemma pentaphyllum total saponin extract by applying cooperative effect of oxygen and peroxide, and alkali-hydrolyzing using alkoxide in situ formed in alcohol at 80-95 swg..C for 8-24 h, where the Panax ginseng total saponin extract and Gynostemma pentaphyllum total saponin extract / alcohol ratio is 30-150 g / L; (2) purifying by column chromatography to obtain protopanaxadiol and protopanaxatriol. The method adopts cooperative effect of oxygen and peroxide, thus can obtain high-purity protopanaxadiol and protopanaxatriol with high yields at low reaction temperatures and short reaction time. This invention provides a simple, convenient and low-cost method for preparing protopanaxadiol and protopanaxatriol in large amounts, which can satisfy the needs of drugs for treating cardiovascular and cerebrovascular diseases and tumor.

Disclosed are a panaxatriol saponins enteric pellet and a method for preparing same, and a capsule comprising the enteric pellet. The enteric pellet comprises a core having a diameter of 20-24 mesh consisting of panaxatriol saponins and pharmaceutical necessities, and an enteric coating layer over the core, wherein the panaxatriol saponins, the pharmaceutical necessities and the enteric coating layer are in a weight ratio of 100:(165-208):(45-65). Preferred pharmaceutical necessities consist of microcrystalline cellulose, starch and polyvidone K30 in a weight ratio of (80-100):(80-100):(5-6), or consist of microcrystalline cellulose, micronized silica gel and polyvidone K30 in a weight ratio of 100:100:8. Preferred enteric pellet has the following components and weight ratio thereof of panaxatriol saponins : microcrystalline cellulose : starch : polyvidone K30 : enteric coating layer = 100:93:93:5.7:58.3, or panaxatriol saponins : microcrystalline cellulose : micronized silica gel : polyvidone K30 : enteric coating layer = 100:100:100:8:62. The enteric pellet is prepared by fluid-bed method or extrusion-spheronization method.

The invention relates to the process for preparing protopanoxadiol and protopanaxatriol by using general saponin extract from panax ginseng plant leaves and gynostemma pentaphylla extractive as raw material for alkaline hydrolysis reaction in organic solvent through column chromatography and purification.

The invention relates to a stereoselectivity complete synthesis method of panaxytriol. In the method, 5-bromine-1-pentene-4-alkyne-3-alcohol is taken as an intermediate, and a Cadiot-Chodkiewcz alkyne-alkyne coupling reaction is carried out on the intermediate and (4R, 5R)-1-dodecyne-4,5-glycol to synthesize the target product panaxytriol. The method provided by the invention has the advantages of simple and available reaction raw materials, short synthesis route, mild reaction conditions and high reaction overall yield.