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Notoginseng medicine composition for treating cardiac and cerebral vascular diseases

A technology for cardiovascular and cerebrovascular diseases and a composition is applied in the field of active ingredients of Panax notoginseng saponins, and can solve problems such as adverse reactions, severe allergic reactions, complex ingredients and the like

Active Publication Date: 2006-11-08
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Panax notoginseng saponins injection preparation made from Panax notoginseng as the raw material is also very complicated. It is not yet clear which ingredients have the main therapeutic effect, which ingredients are toxic and will cause adverse reactions, and the mechanism of action between the ingredients. No one has done a comprehensive study
In addition to the ingredients of the drug itself, the organic solvents used in the extraction process can cause adverse reactions. In addition, it is difficult to remove impurities during the preparation process, which may also be the cause of adverse reactions
Since the clinical application of Panax notoginseng saponins injection preparations, many adverse reactions have occurred
[0006] The application of Xuesaitong Injection and Xuesaitong for Injection mainly has the following three adverse reactions: 1. Severe allergic reaction, the patient has chills, fever, chest tightness, asthma, etc., and induces acute left heart failure

Method used

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  • Notoginseng medicine composition for treating cardiac and cerebral vascular diseases
  • Notoginseng medicine composition for treating cardiac and cerebral vascular diseases
  • Notoginseng medicine composition for treating cardiac and cerebral vascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Embodiment 1: the preparation of pharmaceutical composition of the present invention

[0102] Take notoginseng and grind it into 1000g of coarse powder, add 8000ml of 60% ethanol to extract for 7 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, gradient elution with different concentrations of ethanol, the ethanol concentration is adjusted from 5% to 95% within 6 hours , flow rate 4.5BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and concentrate To a clear paste with a relative density of 1.13 (60°C) to obtain the active ingredient ...

Embodiment 2

[0104] Embodiment 2: the preparation of pharmaceutical composition of the present invention

[0105]Take notoginseng and grind it into 1000g of coarse powder, add 10000ml of 50% ethanol to extract for 6 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.4g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 5.5 hours ), the flow rate is 5.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.15 (60°C), dry to obta...

Embodiment 3

[0107] Embodiment 3: the preparation of pharmaceutical composition of the present invention

[0108] Take notoginseng and grind it into coarse powder 1000g, add 75% ethanol 7500ml to extract for 8 hours, collect the extract, filter, take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.6g crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 6.5 hours ), the flow rate is 4.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.16 (60°C) to obtain the active ingr...

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PUM

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Abstract

The present invention relates to a kind of total arasaponin composition, which has the active component of total arasaponin comprising arasaponin R1, ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 not less than 55.0 wt% and ginsenoside Rd not more than 2.5 wt%. The total arasaponin composition is prepared into injection, powder for injection, enteric coated tablet, bolus, medicine powder and other preparation forms. The medicine of the present invention has the functions of promoting blood circulation to disperse blood clots and activating collateral flow, and is used in treating blood stasis to block collateral channels, apoplexy, hemiplegia and other cardiac and cerebral vascular diseases.

Description

technical field [0001] The present invention relates to an active ingredient of Panax notoginseng saponins extracted from Radix Notoginseng for the treatment of cardiovascular and cerebrovascular diseases. its application. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the three major diseases. According to the theory of traditional Chinese medicine, central retinal vein occlusion, internal eye hemorrhage, anterior chamber hemorrhage, cerebral thrombosis and other cerebrovascular diseases and their sequelae, etc., belong to the category of blood stasis and bleeding syndrome in traditional Chinese medicine. Currently, the injection preparations of Panax notoginseng total saponins used for the treatment of cardiovascular and cerebrovascular diseases include: Xuesaitong for injection, Xuesaitong injection, Xueshuantong for injection, Xueshuantong injection. [0003] Panax notoginseng is a unique multifunctional Chinese medicinal material, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/00A61K9/08A61K9/19A61K31/704A61P9/00
Inventor 黄生田陈明黄宇声刘冠萍
Owner GUANGXI WUZHOU PHARMA GRP
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