8 results about "Tanshinone IIA" patented technology

This invention discloses a Zhishu Yangwei tablet for chronic gastritis and its granule dry-compression tableting process, relating to the field of traditional Chinese medicine preparation technology. The Yangwei tablet is made from the following raw materials in parts by weight: Codonopsis pilosula 35-45 parts, stir-fried Atractylodes macrocephala 18-22 parts, Poria cocos 18-22 parts, Glycyrrhiza uralensis 8-12 parts, Amomum villosum 18-22 parts, Lindera strychnifolia 18-22 parts, Salvia miltiorrhiza 45-55 parts, roasted Aucklandia lappa 18-22 parts, Paeonia lactiflora 18-22 parts, stir-fried Citrus aurantium 18-22 parts, Magnolia officinalis 28-32 parts, Lilium brownii 35-45 parts, and stir-fried chicken gizzard lining 18- 22 parts, dried plum 45-55 parts, Coptis chinensis 8-12 parts, hawthorn 35-45 parts, magnesium stearate 5-7 parts, sucrose 28-32 parts; This invention uses low-temperature dynamic extraction technology to replace the traditional high-temperature decoction process, effectively reducing the decomposition loss of heat-sensitive active ingredients such as tanshinone IIA and ursolic acid, and improving the bioavailability of the drug. It also uses membrane concentration and spray drying technology to replace the traditional atmospheric pressure concentration and oven drying process, shortening the production cycle, reducing energy consumption, and avoiding the degradation of active ingredients caused by prolonged heating of materials.

This invention discloses a traditional Chinese medicine composition and its preparation method for treating liver, kidney, and cardiovascular diseases, relating to the field of traditional Chinese medicine preparations. It is made from the following raw materials in parts by weight: 10-30 parts of Gastrodia elata, 15-40 parts of Salvia miltiorrhiza, 10-25 parts of Panax quinquefolius, 10-30 parts of Panax notoginseng, 5-20 parts of Chrysanthemum morifolium, and 10-15 parts of Gecko. This traditional Chinese medicine composition and its preparation method for treating liver, kidney, and cardiovascular diseases features synergistic innovation in formulation, is suitable for specific populations, and achieves the therapeutic effects of clearing liver heat, promoting blood circulation, nourishing qi and yin, and tonifying the liver and kidneys. The process preserves the active ingredients, is suitable for absorption by middle-aged and elderly individuals, and maximizes the retention of heat-sensitive active ingredients such as gastrodin, total saponins of Panax notoginseng, tanshinone IIA, and total flavonoids of Chrysanthemum morifolium. The dosage form is flexible and adaptable, with a wide range of applications. Both the ultrafine powder and oral liquid preparations avoid irritating components. The application is clearly targeted, with significant differentiated advantages, especially suitable for middle-aged and elderly men around 70 years old and individuals with hyperglycemia and dizziness.

This invention discloses a method for inducing pluripotent stem cells to differentiate into skin keratinocytes and its culture medium, solving problems such as long differentiation cycles, low yields, insufficient purity, and animal-derived contamination in existing technologies. The first stage uses medium I containing FGF2 and tanshinone IIA to promote mesodermal differentiation. The second stage uses medium II containing BMP4, EGF, dexamethasone, and PVA to regulate and synergistically induce the BMP / ERK signaling pathway. The final stage uses medium III for expansion culture, obtaining fibroblasts with a purity >99% within 20 days. This method is non-invasive, simple, and low-cost, with potential for large-scale production. The obtained cells can be used for skin regeneration, disease modeling, drug screening, and clinical treatment, demonstrating significant medical application and industrial transformation value.

This invention discloses a brain-targeting neutrophil membrane-encapsulated tanshinone IIa PLGA nanoparticle formulation, its preparation method, and its uses. The brain-targeting tanshinone IIa nanoparticle formulation, Neu-Tan-IIa@PLGA, is characterized by comprising a PLGA-loaded tanshinone IIa nanoparticle core (Tan-IIa@PLGA) and an outer neutrophil membrane coating. This invention effectively overcomes the problems of poor water solubility, low oral bioavailability, and difficulty in crossing the blood-brain barrier associated with tanshinone IIa. This invention provides a tanshinone IIa with strong targeting and high drug stability, enabling delivery to lesions in ischemic brain regions and improving the safety and efficacy of stroke treatment.

The application discloses a kind of heart tonic tablet fingerprint spectrum detection methods, belong to traditional Chinese medicine detection technical field.The technical scheme includes: to system applicability solution, reference solution, medicinal material solution, test solution are detected by high performance liquid chromatography, obtain chromatogram;According to the chromatogram obtained in S5, determine the chemical composition of each chromatographic peak in the fingerprint spectrum, respectively 3 peaks of calycosin-7-glucoside, 4 peaks of 4-methoxy salicylaldehyde, 6 peaks of salvianolic acid B, 9 peaks of tanshinone I, 10 peaks of cryptotanshinone, 12 peaks of tanshinone IIA;According to the chromatogram obtained in S5, determine the source of each chromatographic peak in the fingerprint spectrum.The application is applied to heart tonic tablet detection aspect, solves the determination of only tanshinone IIA under the content item of existing heart tonic tablet current quality standard, control index is single, thus cannot comprehensively reflect the overall quality level of preparation problem, with the characteristics of accurate, stable and reliable detection result.

This invention discloses a traditional Chinese medicine composition for treating vascular cognitive impairment, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. It includes the following raw materials: stir-fried Atractylodes macrocephala, Fritillaria thunbergii, Ligusticum chuanxiong, Salvia miltiorrhiza, Curcuma longa, Acorus tatarinowii, Polygala tenuifolia, Cornus officinalis, Cistanche deserticola, Rehmannia glutinosa, Scrophularia ningpoensis, and borneol. Preparation method: First, the volatile oil is extracted by steam distillation and encapsulated with β-cyclodextrin; then, the lipid-soluble components in Salvia miltiorrhiza and Fritillaria thunbergii are extracted with ethanol; finally, the residue is combined with the remaining medicinal materials and decocted in water for extraction. Through the combination of Fritillaria thunbergii and borneol, the dual functions of "clearing inflammation + opening the blood-brain barrier" are achieved, increasing the brain concentration of lipid-soluble components such as tanshinone IIA. It significantly improves the learning and memory abilities of rats with vascular cognitive impairment, with efficacy superior to the Western medicine donepezil, and exhibits synergistic effects on multiple targets such as inhibiting NLRP3 inflammasomes and upregulating BDNF. This invention has a simple process, is suitable for industrial production, and has significant clinical application value.

This invention relates to the fields of biomedicine and health food, and particularly to a supercritical fluid-extracting, fat-soluble anti-aging soft capsule made from *Pteris vittata* (a type of insect) and its preparation method. The soft capsule has two formulation options, both using supercritical CO₂ extraction of *Pteris vittata* fat-soluble extract as the core ingredient. The first formulation combines curcumin and tanshinone compounds, supplemented with flaxseed oil, rosemary extract, and other components. The second formulation combines turmeric oil and tanshinone IIA, combined with wolfberry seed oil and licorice oil. The core active substances are obtained using supercritical CO₂ extraction, and after mixing according to the specified ratio, the mixture undergoes emulsification, filling, and drying to obtain the finished product. This invention's product exhibits significant antioxidant and anti-inflammatory effects, improves the absorption efficiency of fat-soluble components, is gentle and non-irritating to the gastrointestinal tract, and can improve chronic inflammation, skin aging, and cardiovascular-related risks. The preparation process is stable and controllable, possessing high industrial application value.

This invention relates to the field of biomedical dressings, specifically disclosing an exosome-loaded tanshinone hypertrophic scar dressing and its preparation method. The dressing comprises an exosome-tanshinone complex, methacrylamide gelatin, oxidized dextran, and a photoinitiator. The key to its preparation lies in: first, using DSPE-PEG-Maleimide as a bridge, covalently coupling the RGD targeting peptide to the exosome membrane via a Michael addition reaction to construct an active targeting carrier; then, efficiently loading tanshinone IIA using electroporation to form a complex; finally, mixing the complex with a gel precursor and cross-linking it under ultraviolet light. This invention solves the problem of easy detachment of the targeting ligand through chemical coupling, and utilizes a dual-network hydrogel to achieve responsive drug release to the MMP-2 enzyme in the scar microenvironment, thereby improving the local anti-fibrotic efficacy while reducing the single-drug dosage and toxic side effects.