The invention is applicable to the field of medical chemistry and provides a natural and edible composition with healthcare functions, application of composition, makeup cosmetics and a preparation method of the makeup cosmetics. The composition comprises multiple active molecular tanshinone IIA, a ginseng extract and soybean lecithin which are natural, all the components have an effect synergistic superposition function, have significant therapeutic effects, are natural, edible, safe and free of side effects, can be applied to preparation of makeup cosmetics with multi-molecular, multi-target, multi-layer, multi-link and multi-way functions, including but not limited to lipsticks, lip cream, lip gloss, colored lip cream, lip balm, lip moisturizing gel, lip protection oil, lip glaze, lip dying liquids, lip liners, rouge, eye shadow, blusher, pressed powder, liquid foundation, BB cream, air cushion cream, eye liner, eye shadow cream, eyebrow pencils and finishing powder, and can endow the cosmetics with multiple skin care and healthcare effects so as to enrich functions of the cosmetics.