49 results about "Theobromine" patented technology

The invention provides a compound organic fertilizer as well as a preparation method and application thereof, and the compound organic fertilizer is prepared from the following raw materials in parts by weight: 40 to 50 parts of basic fertilizer, 5 to 10 parts of alkaloid compound preparation, 1 to 3 parts of dendrobium nobile stem extract, 2 to 4 parts of carnosic acid nutrient solution, 5 to 8 parts of compound fermentation liquor and 0.8 to 1.2 parts of antibacterial peptide, the alkaloid compound preparation is prepared from nicotine, caffeine, theobromine, sophocarpidine and colchicine according to the mass ratio of 1: (1 to 2): (0.8 to 1.2): (0.5 to 0.8): (1.2 to 1.5); the compound fermentation liquor is prepared from earthworm fermentation liquor and chitin fermentation liquor in a mass ratio of 1: (3-5). According to the compound organic fertilizer disclosed by the invention, the alkaloid compound preparation, the dendrobium stem extract, the carnosic acid nutrient solution, the compound fermentation liquor and the antibacterial peptide are mixed with the basic fertilizer, so that the compound organic fertilizer has a prevention and treatment effect on phomopsis areca leaf spot and banana wilt, the yield increasing effect of bananas is remarkable, and the compound organic fertilizer has relatively good popularization and application values.

The invention discloses a preparation method of burdock powder and chocolate. The preparation method of the burdock powder comprises the following steps: baking burdock at the temperature of 110-130 DEG C until the burdock generates scorched cocoa fragrance, so as to obtain a first material; and crushing the first material to obtain powder. The burdock powder prepared by adopting the method has a relatively high polysaccharide component retention rate and relatively strong scorch aroma and cocoa scorch aroma, and can be used as an auxiliary material of chocolate to replace caffeine and theobromine in traditional chocolate, so that the chocolate not only has remarkable health benefits, but also has good flavor and palatability.

The present invention discloses a method for utilizing [C 12 mim]Br / STC[4] aqueous two-phase system for selective extraction of theobromine. 12 The solution containing theobromine to be extracted was added to the aqueous biphasic system of mim]Br / 4 wt% STC[4]. After mixing, the mixture was allowed to stand and centrifuged to completely separate the two phases. The distribution coefficients of Van, Syr, MA, Trp, and Cep were less than 1, namely 0.23, 0.24, 0.43, 0.44, and 0.56, respectively. The distribution coefficients of Tyr, Phe, Theo, and TB were greater than 1, namely 2.78, 2.07, and 12.45, respectively. The selectivity of TB for Syr, Van, MA, Trp, Cep, Tyr, Theo, and Phe were 51.88, 54.13, 28.95, 28.30, 22.23, 4.48, 6.01, and 5.00, respectively, achieving efficient and selective extraction of theobromine.

The invention discloses a method for rapidly and quantitatively analyzing caffeine, theophylline and theobromine in a beverage. The method comprises the following steps: mixing a solution containing caffeine, theophylline and theobromine with an MALDI matrix, and carrying out qualitative and quantitative analysis on a target object through MALDI primary mass spectrometry detection or combination of MALDI primary and secondary mass spectrometry detection. The quantitative analysis method provided by the invention is simple, convenient and rapid to operate, and the whole experimental process can be completed within 2 minutes. According to the method, absolute quantitative analysis of the pair of isomers of theophylline and theobromine can be realized, and the rapid and high-throughput detection requirements of caffeine, theophylline and theobromine in a beverage sample can be met.

The invention belongs to the field of cocoa extract tobacco flavors, and particularly relates to a preparation method and application of a high-theobromine cocoa extract and a style-enhanced cocoa extract. The high-theobromine cocoa extract is used for tobacco perfuming independently or after being blended with the cocoa extract tobacco flavor, so that the sensory effect of the cocoa extract tobacco flavor is improved; the preparation method of the high-theobromine cocoa extract comprises the following steps: preparing a cocoa powder water extract or a cocoa extract water diluent, and enriching theobromine in the cocoa extract by using macroporous adsorption resin column chromatography. Compared with pure theobromine, the high-theobromine cocoa extract has no obvious influence on the sensory quality of cigarettes, and compared with untreated cocoa extracts, the high-theobromine cocoa extract has the advantages that the aroma, richness, stimulation reduction, offensive odor covering, characteristic aroma intensity and the like are improved to different degrees; especially, the style-enhanced cocoa extract obtained by blending the high-theobromine cocoa extract and the untreated cocoa extract has a better effect.

This application relates to the technical field of biomedical detection, and specifically discloses a method for detecting the content of the genotoxic impurity 6-chloro-2-hexanone in pentoxifylline raw materials and injection solutions. The detection method disclosed in this application uses gas chromatography-mass spectrometry (GC-MS) to detect samples; the gas chromatography parameters are: injection port temperature 190 - 210 °C; temperature programming: initial temperature 75 - 85 °C, heated to 150 - 170 °C at a rate of 15 - 25 °C / min, held for 1.5 - 2.5 min, then heated to 210 - 230 °C at a rate of 55 - 65 °C / min, held for 1.5 - 2.5 min; the mass spectrometry parameters are: solvent delay 3 - 4 min; transfer line temperature 240 - 260 °C; quadrupole temperature 140 - 160 °C; ion source temperature 240 - 260 °C. The method of this application is simple to operate, has a fast detection speed, and has the advantages of high sensitivity, high precision, and high repeatability.

For the purpose of determination for the selection of intravesical BCG instillation therapy, the present invention comprises measuring 2-ethylhydracrylic acid-2, arabinonic acid-2, carnitine, lauric acid, myristic acid, octanoylcarnitine, paraxanthine, S-methylcysteine, S-methylcysteine-S-oxide, SDMA, theobromine, indole-3-acetic acid, pentanoic acid, 1-methyl-4-imidazoleacetic acid, ADMA, alanine, argininosuccinic acid, choline, citrulline, creatinine, guanidoacetic acid, lysine, methionine sulfoxide, myristic acid, N-(1-deoxy-1-fructosyl)leucine, N-acetylneuraminic acid, N6,N6,N6-trimethyllysine, propionylcarnitine, threonine, gamma-glutamyl-glycine, gamma-glutamyl-tyrosine, and gamma-glutamyl-valine in blood, serum, or plasma.

The present application relates to the field of tea tree biotechnology, in particular to Fangcheng tea low caffeine related molecular markers based on liquid chip and application thereof. The present application detects 16 different types of tea tree resources including Fangcheng tea and related alkaloid index content by using the liquid chip developed in the early stage, identifies 6 sense SNPs distributed on the CfTCS1 gene of Fangcheng tea caffeine synthesis enzyme, and uses the 6 mutations to accurately, efficiently and low-cost identify Fangcheng tea germplasm resources. The mutations are closely related to the caffeine and theobromine content of tea tree, and the genotypes can be used to quickly screen low caffeine and high theobromine germplasm resources. The results of the specific embodiments of the present application show that when the genotypes of the 6 SNP molecular markers are AA / AA / TT / GG / TT / GG in turn, the tea tree resources correspond to Fangcheng tea germplasm resources with high theobromine and low caffeine content.

Disclosed is a composition comprising photodynamic therapy photosensitizer and a composition comprising theobromine for treatment of a disorder of a mammalian, preferably human, subject; a composition comprising both photodynamic therapy photosensitizer and theobromine, for treatment of disorder of a mammalian, preferably human, subject; a method of making said composition; and a method of treating a disorder of a mammalian, preferably human, subject, using the composition / s of the invention.

The present disclosure relates to compositions of biocompounds derived from cacao, mainly aromatic compounds such as flavanols and methylxanthines in the form of suspended particles, and to methods for producing the compositions from cacao beans, in particular unfermented cacao beans. The disclosed compositions have high concentrations of epicatechin, procyanidin B2 and theobromine and demonstrate high bioavailability in in vitro tests. These results suggest that the compositions developed are potentially useful for producing functional foods.

The invention relates to the use of an extract of Phaeodactylum tricornutum alone or in combination with an extract chosen from a guarana (Paullinia cupana) extract, a ginseng (Panax ginseng) extract, a Ginkgo biloba extract, a Nelumbo nucifera extract, a Centella asiatica extract, a Piper nigrum extract, a Bacopa monnieri extract or any combination thereof and / or a compound chosen from arginine, creatine, caffeine, theanine, vitamin C, vitamin E, vitamin B, theophylline, paraxanthine, theobromine, rosmarinic acid, ellagic acid, cinnamaldehyde or any combination thereof, for maintaining and / or increasing data processing speed and / or concentration in healthy mammals. The combination of the extract of P. tricornutum and one of these extracts or one of these compounds is also described. The invention also relates to a composition comprising the combination according to the invention.

The invention belongs to the field of food processing, and particularly relates to a method for efficiently alkalizing cocoa powder, which specifically comprises the following steps: completely mixing cocoa powder with water to obtain a cocoa powder aqueous solution, adding a NaOH solution to adjust the pH value of the system to 6.8-9.2 for alkalization, then immediately heating by using microwaves at the microwave heating power of 380-700W for 5-15min, and cooling to room temperature to obtain the cocoa powder. And after heating is completed, immediately putting the cocoa powder into an ice-water bath for cooling, and then performing freeze drying to finally obtain alkalized cocoa powder. The alkalized cocoa powder prepared by the method is brown in color, more phytochemicals (epicatechin, catechin, theobromine and the like) are reserved, the oxidation resistance is higher, the flavor is better, and the alkalized cocoa powder can be widely applied to the food processing fields of drinks, baking, desserts, candy making and the like.

The invention relates to the technical field of tea tree biology, in particular to a Qingcheng tea low-caffeine related molecular marker based on a liquid phase chip and application of the molecular marker. According to the invention, 16 different types of tea tree resources including the defensive tea are detected by using a liquid phase chip developed at an early stage, and the content of related alkaloid indexes is detected at the same time, so that 6 sense SNP mutations distributed on the defensive tea caffeine synthetase CfTCS1 gene are identified, and the germplasm resources of the defensive tea can be accurately and efficiently identified at low cost by using the 6 mutations, so that the method has a wide application prospect. The mutations are closely related to the caffeine content and the theobromine content of the tea trees, and low-caffeine and high-theobromine germplasm resources can be rapidly screened according to the genotypes of the tea trees. The result of the specific embodiment of the invention shows that when the tea tree resource of which the genotypes of the six SNP molecular markers are AA / AA / TT / GG / TT / GG in sequence corresponds to the Guangcheng tea germplasm resource with high theobromine-low caffeine content.

The invention relates to the technical field of crystallization control of chemical bulk drug intermediates, and particularly provides a crystallization method of a pentoxifylline intermediate, which comprises the following steps: adding an acetic acid solution into a 3, 7-dimethylxanthine neutralization reaction solution at 80-85 DEG C until crystals are separated out, carrying out heat preservation and stirring for a first preset time, filtering, washing, and drying to obtain the pentoxifylline intermediate. And continuously adding an acetic acid solution to adjust the pH value of the system to be neutral, carrying out heat preservation stirring for a second preset time, slowly cooling to 45-55 DEG C, carrying out heat preservation stirring for a third preset time, and carrying out solid-liquid separation to obtain the pentoxifylline intermediate. According to the crystallization method provided by the invention, the problems of difficulty in centrifugal separation, easiness in blockage of filter cloth and redness of a wet product caused by high viscosity of a solid-liquid mixture in an existing staged cooling and crystal growing process are solved, the yield of the prepared 3, 7-dimethylxanthine product reaches 65% or above, the purity can reach 99.9% or above, the production efficiency is improved, and the crystallization method is suitable for large-scale industrial production.

The invention belongs to the technical field of medicines, and particularly relates to combined application of nicotine and theobromine in relieving bipolar affective disorder as well as a product and a preparation method of the product. The problems that traditional western medicines are large in curative effect fluctuation, have addiction risks, are obvious in side effects and the like are solved, the anti-anxiety characteristic of nicotine and the analgesic and sedative effects of theobromine are used for synergistically exerting a multi-dimensional intervention effect, and curative effect superposition is achieved. The invention also determines the ratio of nicotine to theobromine (the mass ratio of nicotine to theobromine is 1: 100-1000), provides a reliable basis for clinical application, and is beneficial to improving the treatment effect. According to the scheme, the technical blank that natural components are combined to be used for treating bipolar affective disorder is filled, a brand new path is provided for intervention of the disease, and important theoretical exploration value and practical application significance are achieved.

The present invention relates to relates to a non-alkalized, boiled and roasted cocoa solids comprising below 0.14 wt. % of caffeine and below 1.2 wt. % theobromine, preferably below 0.9 wt. % theobromine. The invention also relates to cocoa beverage liquid and powder with these characteristics. Furthermore, the invention relates to a method of making non-alkalized, boiled and roasted cocoa solids, the method comprising: providing cocoa nibs, boiling the cocoa nibs under pressure at a pressure of 1.5-4 bar for a period of 10-60 min, filtering the boiled cocoa nibs to a moisture content of 30-80 wt. %, preferably 50-75 wt. %, roasting the boiled nibs to a moisture content below 4 wt. % and grinding the roasted nibs to provide cocoa liquor, pressing to obtain a cocoa cake, preferably having a fat level 10-12 wt. % or 20-22 wt. % fat, and grinding the cocoa cake to cocoa solid.

Disclosed are stable dosage forms for oral administration of active pharmaceutical ingredients in which any unpleasant taste sensation, caused by release of the active pharmaceutical ingredient and / or of the excipients in the oral and pharyngeal cavity of the patient, is masked by the use of theobromine-free cocoa.

The present formulation provides a toothpaste or dentifrice that contains Nano-Hydroxyapatite, Micro-Hydroxyapatite, and Theobromine (with or without Xylitol) to provide a multifaceted approach to prevent caries development, promote caries remineralization (improving the mechanical strength of teeth), and treat tooth hypersensitivity.

A fermentation process for the preparation of xanthine and xanthine derivatives. The disclosure generally relates to a fermentation process for the preparation of xanthine or xanthine derivatives such as 7-methylxanthine (7-MX), theobromine, theophylline, 3-methylxanthine or mixtures thereof. The process results in improved yield and increased efficiency on industrial scale compared to batch process of preparation.

The purpose of the present invention is to provide a novel composition for increasing the efficiency of consumption of cognitive resources. The present invention provides a composition for increasing the efficiency of consumption of cognitive resources, said composition containing at least one substance selected from the group consisting of cacao polyphenol, theobromine, and caffeine as an active ingredient. The composition may be in a unit intake form, and one or more of the unit intake forms may contain the daily effective intake amount of cacao polyphenol, theobromine, and / or caffeine for a human. The composition is preferably a food.

A method for preparing tea lozenges by mixed - strain fermentation of summer and autumn tea and a compound fermenting agent used therein, including Aspergillus cristatus FT128 and Monascus purpureus HQ128. Aspergillus cristatus FT128 was deposited at the China Center for Type Culture Collection on November 9, 2023, with the deposit number CCTCC NO: M20232176; Monascus purpureus HQ128 has been deposited at the China Center for Type Culture Collection, and the deposit date is January 29, 2024, and the strain deposit number is CCTCC NO: M2024269. In the present invention, Aspergillus cristatus FT128 and Monascus purpureus HQ128 are respectively beneficial dominant fungal microorganisms in Fuzhuan tea and dominant fungal microorganisms in red yeast rice. By inoculating them into the extract of summer and autumn tea for mixed - strain liquid fermentation and concentration to prepare the fermented summer and autumn tea extract, and then preparing summer and autumn tea lozenges, the contents of soluble sugar, theobromine, total volatile compounds, monacolin k, and γ - aminobutyric acid are all significantly higher than those of ordinary green tea lozenges; the results show that the mixed - strain fermented summer and autumn tea lozenges have a richer flavor, a more mellow taste, and a higher overall quality.

The present invention provides a composite organic fertilizer and its preparation method and application. The composite organic fertilizer includes the following raw materials according to weight: 40-50 parts of basic fertilizer, 5-10 parts of alkaloid compound preparation, 1-3 parts of Dendrobium nobile stem extract, 2-4 parts of carnosic acid nutrient solution, 5-8 parts of composite fermentation liquid and 0.8-1.2 parts of antimicrobial peptide; the alkaloid compound preparation is nicotine, caffeine, theobromine, matrine and colchicine in a mass ratio of 1:1-2:0.8-1.2:0.5-0.8:1.2-1.5; the composite fermentation liquid is earthworm fermentation liquid and chitin fermentation liquid in a mass ratio of 1:3-5. The composite organic fertilizer of the present invention is mixed with basic fertilizer by alkaloid compound preparation, Dendrobium nobile stem extract, carnosic acid nutrient solution, composite fermentation liquid and antimicrobial peptide, and has a preventive and therapeutic effect on Phomopsis areca leaf spot disease and banana wilt disease, wherein the banana yield-increasing effect is remarkable, and has good promotion and application value.

To provide a novel agent for reducing intraocular pressure.SOLUTION: (A) Theobromine and / or (B) hesperidins selected from the group consisting of hesperidin, glucosyl hesperidin, and hesperetin are effective as active ingredients in an oral composition for intraocular pressure reduction, in a ROCK inhibitor, and in an autophagy enhancer.SELECTED DRAWING: None

An aerosol generating material comprising at least two non-tobacco botanical materials, the aerosol generating material produces an aerosol when heated, the aerosol comprising: a first compound selected from the list consisting of: 2-methoxy- phenol, 2-methoxy-4-vinylphenol, vanillin, benzeneacetic acid, phenylethyl alcohol, maltol, and combinations thereof; and a second compound selected from the list consisting of: D-limonene, alpha-terpineol, levomenthol, menthol, 3-methyl butanoic acid, 2-methoxy phenol, terpinene-4-ol, 6-methyl-5-hepten-2-one, 1H-pyrrole-2- carboxaldehyde, alpha-methyl-benzenemethanol, theobromine, octadecanoic acid, n- hexadecanoic acid, methyl-ester-hexadecanoic acid, butyrolactone, caffeine, 9- octadecenoic acid, furfural, 2-methyl butanoic acid, 2,3-dihydrobenzofuran, 2- heptadecanone, and combinations thereof.

The application discloses a theobromine-containing composition and a preparation method and application thereof. The application provides the theobromine-containing composition which comprises the following raw materials in mass fractions: 10-50 parts of microcrystalline cellulose, 0.5-5 parts of inorganic salt, 5-30 parts of theobromine, 1-20 parts of vitamin, 0.2-10 parts of sweetening agent, 1-10 parts of inorganic base, 2-20 parts of sugar alcohol, 2-20 parts of essence, 2-20 parts of humectant and 0.1-2 parts of cooling agent, with the total weight of all the raw materials being 100 parts. The theobromine-containing composition has good taste, rapid absorption, long-lasting effect, convenient carrying and good bioavailability. The theobromine-containing composition has a good application prospect in refreshing and blood pressure reducing products.

It is provided a composition comprising phytic acid or a pharmaceutically acceptable salt thereof, for use in reducing or preventing microorganisms' proliferation and / or encrustations caused by a urinary tract device implanted in a subject, thereby preventing or treating clinical complications related to microorganisms' proliferation and / or encrustations. The composition can further comprise a urine acidifier such as methionine, a crystallization inhibitor such as theobromine and / or other agents.

The invention discloses a synthesis method and application of theobromine-derived carbon quantum dots, belongs to the technical field of biological material preparation and application, and discloses a synthesis method and application of theobromine-derived carbon quantum dots. The theobromine-derived carbon quantum dots are prepared by performing centrifugal precipitation, dialysis and freeze-drying on raw materials theobromine, citric acid and ethylenediamine under a hydrothermal reaction condition. The carbon dots can significantly inhibit aging of zebrafish and show an anti-aging effect. The compound has good activity of removing active oxygen, and can reduce MDA (malondialdehyde) and inflammatory factors. Therefore, the compound has great application potential in the aspects of skin care product repair, anti-oxidation and anti-aging development.

The invention relates to the technical field of medicine preparation, in particular to a preparation method of high-purity pentoxifylline. Adding sodium hydroxide and potassium iodide into the methanol solution at room temperature, and adding theobromine for complete reaction; dropwise adding a 6-bromo-2-hexanone solution, cooling after reaction, filtering, reducing pressure, distilling, extracting, separating liquid, concentrating, recrystallizing, filtering and drying to obtain a crude product; pulping and filtering to obtain a finished product. Compared with the prior art, the method has the main differences that the reaction temperature and time are strictly controlled, the generation of side reaction impurities is reduced, the quality is good, 95% isopropanol is used for crystallization, the crystal is excellent, the appearance is good, the stability is high, the safety is good, the PH value and the osmotic pressure are basically consistent with those of the original research, the yield is high, and the quality is good.

The present invention relates to a composition comprising at least one psychedelic non-phosphorylated tryptamine, preferably derived from psychedelic psilocybin mushrooms, more preferably derived from psychedelic psilocybin mushrooms belonging to the Psilocybe genus, at least one antioxidant, wherein the antioxidant is at least one carotenoid, and at least one supplement selected from an amino acid, a vitamin, theobromine, caffeine, resveratrol, gamma aminobutyric acid and combinations thereof. The invention relates also to the pharmaceutical uses of the composition of the invention.