46 results about "Yohimbine" patented technology

The present invention relates to spray dried hydrophobic phytochemical (i.e., yohimbine and ibogaine) compositions, a process for making such compositions and a method of using such compositions for, e.g., the promotion of weight loss. Typically, the hydrophobic dietary compositions of the present invention exhibit enhanced absorptivity when taken orally.

Inhibition of RNA function, and treatment or control of diseases or conditions, e.g. infectious diseases such as viruses and viral infections (including HIV) and microbial infections, by the contacting of the RNA with a compound having a central or core structure comprising three fused rings containing from 12 to 15 ring atoms, the central ring including at least one heteroatom selected from nitrogen, oxygen and sulfur, the atoms of the three-ring core structure being optionally substituted with substituents such as halogens, cyano, and/or various substituted or unsubstituted aliphatic and/or heteroaliphatic moieties, or contacting the RNA with yohimbine, usnic acid or N-{4-[2,5-Dioxo-1-(4-trifluoromethoxy-phenyl)-pyrrolidin-3-yl]-phenyl}-2,2,2-trifluoro-acetamide. Preferred compounds are various phenothiazines, including both known and novel compounds.

The present invention provides compositions and methods that assist in providing weight control. Compositions comprise Caffeine, an adrenergic amine (e.g. synephrine, hordenine, octopamine, tyramine and N-methyltyramine,) forskolin, Guggulsterones, an alpha-2 receptor antagonist (e.g. Yohimbine) and a vinca alkaloid (e.g. vinpocetine.) Black pepper extract may be added as well in various alternative embodiments. Methods utilizing administration of nutrient compositions are disclosed as well.

A nutritional composition and method is provided for promoting weight loss or weight maintenance in an individual by supporting and enhancing thermogenesis and lipid oxidation comprising therapeutically effective amounts of yohimbine or derivatives thereof, an effective amount of Evodia rutaecarpia extract and a source of an effective amount of L-carnitine or derivatives thereof.

The invention discloses a combiner capable of promoting the movement function and the sexual function. The combiner comprises 4-48 parts by weight of yohimbine hydrochloride, 5-150 parts by weight of icariin, 20-300 parts by weight of tribulus terrestris protodioscin, 10-600 parts by weight of eurycoma longifolia extract, 10-600 parts by weight of maca extract, 10-500 parts by weight of taurine, 10-100 parts by weight of zinc aspartate, 150-1350 parts by weight of magnesium aspartate and 0.1-5 parts by weight of vitamin B6.

It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine.

The present invention relates to a pharmaceutical or food composition for α₂ receptor blockage comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof:

(wherein R¹ represents a hydrogen, alkyl group, alkenyl group, alkynyl group, aromatic group, aralkyl group, acyl group, arylsulfonyl group, alkylsulfonyl group, or hydroxyl group; R² represents a hydrocarbon group; R³, R⁴, R⁵, R⁶, and R⁷ are the same or different and represent a hydrogen, halogen, alkyl group, or alkoxy group; R⁸ represents a hydrogen or acyl group; n represents an integer of 1 to 6; and a and b are the same or different and represent 1 or 0).

The invention provides maintaining gel capable of strengthening yang and nourishing kidney, for male sexual dysfunction, and a production method of the maintaining gel, and relates to the technical field of medical health. The production method comprises the steps of firstly dissolving Chinese herbal medicine extract in water so as to obtain a Chinese herbal medicine extract mixed solution; dissolving xanthan gum in water, performing puffing, performing uniform stirring so as to obtain xanthan gum liquid; and mixing the xanthan gum liquid with the Chinese herbal medicine extract mixed solution, and performing uniform stirring so as to obtain gel, wherein the Chinese herbal medicine extract comprises eurycoma longifolia, ginseng, prepared rehmannia roots, herba epimedii, radix morindae officinalis, herba cistanches, flatstem milkvetch seeds, leek seeds, radix angelica sinensis, radix astragali and a yohimbine extract. The gel disclosed by the invention can increase the male hormone level, so that the purposes of reinforcing sexual desire, promoting sexual capacity and fundamentally treating sexual dysfunction of impotence, prospermia and the like can be achieved, and the maintaininggel does not have any toxic or side effects.

The present invention relates to the development of a virtual screening model for predicting antipsychotic activity using quantitative structure activity relationship (QSAR), molecular docking, oral bioavailability, ADME and Toxicity studies. The present invention also relates to the development of QSAR model using forward stepwise method of multiple linear regression with leave-one-out validation approach. QSAR model showed activity-descriptors relationship correlating measure (r²) 0.87 (87%) and predictive accuracy of 81% (rCV²=0.81). The present invention specifically showed strong binding affinity of the untested (unknown) novel compounds against anti-psychotic targets viz., Dopamine D2 and Serotonin (5HT_2A) receptors through molecular docking approach. Theoretical results were in accord with the in vitro and in vivo experimental data. The present invention further showed compliance of Lipinski's rule of five for oral bioavailability and toxicity risk assessment for all the active Yohimbine derivatives. Therefore, use of developed virtual screening model will definitely facilitate the screening of more effective antipsychotic leads/drugs with improved antipsychotic activity and also reduced the drug discovery cost and duration.

The invention discloses a functional food helping improve male sexual function and the effective components thereof are prepared with materials with the following weight proportion: 10 to 60g of aweto, 10 to 60g of yohimbine extracts, 200 to 400g of prepared rhizome of rehmannia , 300 to 900g of epimedium, 100 to 400g of raspberry, 100 to 400g of sealwort and100 to 400g of endothelium corneumgigeriae galli. Hence, the functional food can rapidly show effect, is effective in treatment, can completely cure male erectile dysfunction and effectively improve male sexual function.

The invention discloses a method for extracting multiple alkaloids from rauvolfia vomitoria. The method comprises the following steps of: adding acid-containing ethanol aqueous solution into root powder of the rauvolfia vomitoria, stirring and filtering to obtain leach liquor; concentrating the leach liquor, adsorbing with non-polar macroporous adsorption resin, washing and eluting with 40 percent ethanol and 80 percent ethanol; collecting eluate respectively, concentrating and then adsorbing with weakly acidic cation exchange resin, washing and eluting with 50 percent ethanol; collecting eluate respectively, adjusting pH to be 3 by using concentrated acid, concentrating and then adsorbing with a C18 reversed phase chromatography medium and eluting with the ethanol aqueous solution with gradually increasing concentration; and collecting the eluate in stages respectively, combining the parts with higher single alkaloid purity in the eluate respectively, concentrating to obtain solid, adding an organic solvent to crystallize to obtain crystals of yohimbine, ajmaline, reserpoid, reserpine and rescinnamine. According to the method, five alkaloids can be extracted from a plant at most at one time; and the method has the advantages of few steps, less dosage of the used organic solvent, low pollution and simple required equipment.

The invention discloses an external preparation for preventing and treating male sexual dysfunction. The external preparation comprises mesenchymal stem cell supernatant, water-soluble laurocapram, arginine, taurine, peppermint oil, small molecular oyster peptide, ginsenoside extract, yohimbine extract, lubrajel and double distilled water. Every 200ml of finished product comprises the following components in percentage by volume/volume: 15% of mesenchymal stem cell supernatant, 2% of water-soluble laurocapram, 2% of peppermint oil and 6% of lubrajel. The external preparation further comprisesthe following components in percentage by mass/volume: 5% of arginine, 5% of taurine, 2.5% of small molecular oyster peptide, 2% of a ginsenoside extract and 2% of a yohimbine extract, and the balanceof double distilled water which is quantified to 200ml. The external preparation can promote the blood sinus filling of the cavernous body of the penis, has a direct effect on the aspects of erectionassistance, time delay, thickening and the like, and has the advantages of quick response, good curative effect and high safety. The externally-applied smearing formula reduces the risk caused by oral administration and penis local drug injection.

Yohimbine derivatives are disclosed having modification of the C-16 carboxyl group to include a sidechain and where the resulting derivative does not possess a second yohimbine pharmacophore (i.e., the compound is not a yohimbine dimer). The yohimbine derivatives of the present invention are preferably characterized by selective activity as α_2c-AR antagonists. Use of the compounds, or pharmaceutical composition containing them, for treating or preventing an α_2c adrenergic receptor mediated condition or disorder, and for antagonizing activity of an α_2c adrenergic receptor are also disclosed.

A method for creating the animal model of rat, which is used for screening the related medicine and evaluating the related therapy for restless syndrome, features that the specific antagonist "Yohimbine" for alpha-2 receptor is injected into the local region of the prefrontal lobe of rat with a micro-quantity to block the function of apha-2 receptor and directly induce the restless syndrome of the rat.

The invention provides a capsule for treating male sexual dysfunction and a preparation method thereof. In the capsule, intermediates and monomers of natural plant extracts are taken as raw materials. The capsule comprises the following components in parts by weight: 100-200 parts of damiana extract, 50-120 parts of L-arginine, 50-100 parts of ginseng root saponin, 5-10 parts of yohimbine and 50-100 parts of gorgon euryale seed extract. By taking the capsule, erectile dysfunction can be repaired, the growth and development as well as erection hardness of penis are promoted, the effects of nourishing essence and reinforcing kidney to secure essence are achieved, and the length of encounter is prolonged.

The invention discloses a yohimbine hapten YHA, an artificial antigen and an antibody thereof as well as preparation and application thereof. The preparation method comprises preparing a yohimbine hapten YHA, wherein the structural formula of the yohimbine hapten YHA is shown as a formula (I); preparing a yohimbine artificial antigen and a yohimbine antibody YHA-IgG by using the hapten. The antibody YHA-IgG has high detection sensitivity and strong specificity for yohimbine, the half inhibition concentration is 0.50 mu g/kg, the detection range for yohimbine is 0.12-2.18 mu g/kg, the lowest detection limit is 1.13 mu g/kg, and the detection requirements are met; besides, the preparation methods of the yohimbine hapten YHA, the yohimbine artificial antigen and the yohimbine antibody YHA-IgGare simple and low in cost, and a core raw material is provided for establishing an immunological detection method of specific yohimbine; therefore, the yohimbine antibody YHA-IgG has a wide application prospect in detection of yohimbine.

This invention discloses a nutritional composition of matter that effectively reduces and stabilize glucose levels in the blood of mammals by deliberately inducing ketosis. The compositions comprise, Sodium Beta-Hydroxybutyrate, Potassium Beta-Hydroxybutyrate, Magnesium Beta-Hydroxybutyrate, Calcium Beta-Hydroxybutyrate, Ketone Esters, Medium Chain Triglycerides (MCT) with at least one or more from L-Leucine, L-Lysine, L-isoleucine, Caffeine, Yohimbine, Yohimbe, Berberine and Creatine or its derivatives (such as creatine salt, and Creatyl-L-leucine).

Nutritional supplement compositions for mood enhancement are disclosed. A nutritional supplement composition can include one or more of plant material from pine bark, plant material from a species of the genus Ephedra, caffeine, green tea, octopamine, quercetin, trimethylglycine, yohimbine, and niacin. Some nutritional supplement compositions may affect heart rate, blood pressure, and/or resting metabolic rate when ingested. Related processes are also disclosed.

The invention provides a capsule for treating male sexual dysfunction and a preparation method of the capsule. The capsule comprises the following raw materials of intermediates and monomers of natural plant extracts in parts by weight: 90-200 parts of a maca extract, 50-120 parts of L-arginine, 50-100 parts of ginseng root saponin, 5-10 parts of yohimbine and 50-100 parts of a gorgon fruit extract. The capsule for treating male sexual dysfunction is capable of remedying penis erectile dysfunction, promoting growth and development and erectile stiffness of penises, nourishing vital essence and tonifying kidney and securing essence.