The present invention provides, in one embodiment, a method of normalizing the timing of sexual response in a
mammal comprising the administration of an amount of a
central nervous system sexual response initiator in an amount sufficient to produce genital
vasodilation but less than the amount required to produce effective vasocongestive
arousal. The method is applicable not only to adjusting or normalizing the timing of sexual response in humans, but in the breeding of valuable commercial animals such as horses, cattle, sheep, swine and the like and domesticated pets such as dogs and cats. In an alternative embodiment, the present invention provides a method for the
prophylactic treatment of long-term
tissue degradation in the genital organs comprising the administration to a
mammal of a
central nervous system sexual response initiator in an amount sufficient to produce genital
vasodilation but less than the amount required to produce effective vasocongestive
arousal. The preferred
central nervous system sexual response initiator is
apomorphine or a pharmaceutically acceptable acid addition salt thereof.