6 results about "Apomorphine" patented technology

The present invention relates to a compound of formula (I), which is a phosphate ester of apomorphine, or a pharmaceutically acceptable salt thereof. The apomorphine phosphate ester according to the invention exhibits remarkably advantageous properties as a therapeutic, including a favorable tolerability, an improved side effect profile, particularly a reduced occurrence of skin nodule formation and panniculitis when administered subcutaneously, as well as pharmacokinetic and metabolic properties rendering it particularly well-suited as an apomorphine prodrug. The invention further relates to the compound of formula (I) for use as a medicament, particularly for use in the treatment of Parkinson's disease.

Medical garment for Parkinson's patients using an apomorphine pump. The invention of this vest model allows Parkinson's patients to wear their apomorphine treatment device in a garment specifically designed for their comfort, replacing the elastic belt usually supplied with the medication. The apomorphine pump device comes with a pouch and a belt, made of synthetic material and generally worn directly against the skin, which causes heaviness and discomfort for the patient, as well as a risk of the tubing detaching.The solution I propose involves manufacturing a vest made of hypoallergenic material, equipped with pockets and an opening system adapted to the apomorphine pump. This allows for: easier handling of the device by both the patient and the nurse; an improved dressing process thanks to a separating zipper opening on the front of the vest; enhanced security for the medical device, which is thus protected under the vest; and discreet clothing. This medical garment, according to the invention, is specifically designed to improve the comfort and quality of life of Parkinson's patients using an apomorphine pump. The attached drawing sheet contains sketches illustrating the vest design and its functionalities.[Fig. 1] shows the vest from the front (1), equipped with a separating zipper allowing for full front opening (2), and two rectangular zippered pockets sized to accommodate the apomorphine pump (3). The pockets have vertical zippers to facilitate insertion and removal of the pump when it is necessary to check the flow rate or administer a bolus (4). The tubing is thus secured inside. [Fig. 2] shows the vest open. The entire medical device connected to the catheter—syringe, tubing, and pump—is inserted into the pocket through a slit in the vest fabric, just behind the pocket. (1) [Fig. 3] shows a close-up of the device on the right pocket. This is a cross-section of the pocket viewed from the inside (1). An opening (slit) is made on the inside of the vest, at the back of the pocket, to allow the passage of the device: pump + syringe + tubing (2).The device is connected to the catheter (3). The entire device is then placed at the bottom of the zippered pocket. [Fig 4] shows the position of the medical device on the male body when placed in the pocket of the POMPIPOCHE vest. [Fig 5] shows the position of the medical device on the female body when placed in the pocket of the POMPIPOCHE vest. [Fig 6] shows an image of the medical device as it is positioned.

The application discloses a preparation method of arbutin, and the preparation method comprises the following steps: (1) C5-halogenated ester (II) is reacted with 2-mercaptobenzothiazole (MBT) to generate C5-BT (III), and C5-BT (III) is further oxidized to prepare C5-BTS (IV); and (2) C5-BTS (IV), C15-BTS (V) and C10-dialdehyde (VI) are coupled to prepare arbutin (I), and the specific route can be C5+C10→C15, C15+C15→C30, or C15+C10→C25, C25+C5→C30; the method has low raw material cost, avoids the use of phosphorus salt in a traditional synthesis route, and provides an efficient, economical and environmentally-friendly solution for large-scale clean production of arbutin.

Provided herein are apomorphine compositions comprising an excipient particle and apomorphine nanoparticles, wherein the surface of the excipient particle is coated by Vapor-phase-deposition with the apomorphine nanoparticles. Also provided herein are methods of their preparation and use for treating, preventing, or ameliorating one or more symptoms of a neurological disorder.

Provided are very slightly soluble salts of apomorphine, sustained-release pharmaceutical compositions including the slightly or very slightly soluble salts of apomorphine, and their uses in treating a neurological disease, sexual dysfunction, neuroleptic (-like) malignant syndrome, or an alcohol-related disorder. The very slightly soluble salts of apomorphine are an apomorphine hydroxynaphthoate salt or an apomorphine pamoate salt in a crystal or amorphous form. Also provided are methods for preparing the very slightly soluble salt of apomorphine and its crystal or amorphous form.

The invention relates to a method of treating a neurological disorder in which an increase in dopaminergic turnover is beneficial, the method comprising intranasal administration of an encapsulated apomorphine composition to a subject in need thereof.