3 results about "Aporphine" patented technology

The application belongs to the technical field of medicines, and relates to an N-H aporphine nitrogen-containing heterocyclic derivative, a preparation method and application thereof.The N-H aporphine nitrogen-containing heterocyclic derivative comprises a compound shown in a general formula M, isomers thereof and pharmaceutically acceptable salts or hydrates thereof.The application introduces a nitrogen-containing heterocyclic ring into an aporphine derivative, and the disclosed N-H aporphine nitrogen-containing heterocyclic derivative can be applied in the preparation of medicines for preventing and / or treating obesity, urinary incontinence, depression, anxiety, obsessive-compulsive disorder, epilepsy, schizophrenia, pain, diabetes and drug addiction.

The invention discloses application of aporphine alkaloid Tinopaine A in hemsleya amabilis ox gall in preparation of a medicine for treating bone destruction related diseases, and belongs to the technical field of biological medicine. Experiments prove that the Tinpaine A monomer has an inhibition effect on osteoclast differentiation formation in vivo and in vitro; by regulating and controlling key factors for osteoclast formation, the compound has an inhibiting effect on in-vitro osteoclast formation under the concentration of 1-10 mu M and on in-vivo osteoclast formation of mice under the dosage of 2-20 mg / kg, can effectively reduce the number of osteoclasts and protect bone trabecula structures, and has an excellent treatment effect on bone destruction related diseases. The invention relates to a medicine for inhibiting osteoclast differentiation in vivo and in vitro and treating diseases related to bone destruction, which takes Tinopaine A as an active ingredient and can relieve bone destruction by regulating and controlling bone metabolism balance so as to achieve the purpose of treating the diseases related to bone destruction.

The application discloses a use of an aporphine alkaloid shown in formula III in preparation of an antidepressant, wherein R1 and R2 are independently selected from alkoxy and methylenedioxy, R3 and R4 are independently selected from H, OH, alkoxy and methylenedioxy, but R3 and R4 cannot be H at the same time or R1 and R2 are both selected from methoxy, and R3 cannot be OH and R4 cannot be H. Pharmacological experiments show that the aporphine alkaloid shown in formula III has better antidepressant effect, higher response rate and faster effect than fluoxetine.