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A method is disclosed for electrically stimulating a cranial nerve, especially a vagus nerve, to treat or alleviate angina pectoris. Pain is lessened or prevented by application of predetermined therapeutic electrical signal to a selected location on the cranial nerve of a patient using an implanted neurostimulating device. Such method employs selective application of electrical signals to a predetermined location on the nerve to alter the activity of the nerve and cause dilation of a coronary artery in the patient, which in turn provides complete or partial relief of chest pain or deters the onset of such pain.

Provided a toner including at least: toner particles each containing at least a binder resin, a release agent, and a colorant; and an inorganic fine powder, in which: a degree of aggregation Y1 at a time of compression (200 kpa) of the toner satisfies a relationship of 15≦Y1≦35, and a degree of aggregation Y2 at a time of non-compression of the toner satisfies a relationship of 7≦Y2≦15; and a highest endothermic peak of the toner is present in a temperature range of 30 to 200° C. in an endothermic curve measured with a differential scanning calorimeter (DSC), and a peak temperature Tsc (° C.) of the highest endothermic peak satisfies a relationship of 60≦Tsc≦130.

The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.

The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.

The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.

Swimming goggles includes lens assemblies and pad assemblies attached to peripheral frames of the respective lens assemblies. Each of the pad assemblies is formed by a first elastic member made of first elastic material which is relatively stiff and a second elastic member made of second elastic material which is relatively flexible wherein the second elastic member is in close contact with and bonded to the first elastic member in a radial direction of the lens assembly.

The invention features sublingual formulations of apomorphine that is a mucoadhesive polymer film or a strip having a first portion including an acid addition salt of apomorphine and a second portion including a pH neutralizing agent, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders by administering sublingually the film or strip.

Methods of treating an autoimmune disease such as rheumatoid arthritis, methods of increasing apoptosis of pro-inflammatory immune cells or synoviocytes, methods of increasing the quantity of the anti-inflammatory regulatory T cells, and methods of slowing the progression of inflammation in a subject include systemically administering to the subject a pharmaceutical composition including an effective amount of a TRAIL-conjugate. Preferably, the TRAIL-conjugate is effective for at least 3 days, more preferably at least 7 days, without being part of a nanocomplex that modulates the circulation half-life or release kinetics of the TRAIL-conjugate. Combination therapies including administering a second active agent, most preferably a TNF-α inhibitor, as well as pharmaceutical composition dosage units including a TRAIL-conjugate and a TNF-α inhibitor in an effective amount for a single once weekly dose for treatment of rheumatoid arthritis are also provided.

Provided is a flexible-circuit-board cable having a positioning structure. A connection zone is defined in a free end of the flexible-circuit-board cable and is provided with a plurality of conductive contacts. The connection zone has a first surface on which at least one projection section is formed and a second surface. A shielding layer overlaps the projection section and a portion of the first surface. The second surface of the connection zone is also bonded to a shielding layer. When the connection zone of the flexible-circuit-board cable is inserted into an insertion space defined in a connector, the first and second local zones of the connection zone formed by the shielding layers and the projection section are put into engagement with and thus positioned and retained by walls on opposite sides of the insertion space of the connector to thereby fix within the connector.

The present invention relates to a device for draining lymph into vein, which comprises: a storage chamber including a chamber wall, wherein a storage space formed by the chamber wall, and at least one first opening and a second opening are formed on the chamber wall; at least one osmosis membrane disposed at the first opening so that lymph can penetrate into the storage space, wherein the osmosis membrane is made of negative charged polymer molecules; a first conduit, of which one end connects to the storage space, and the other end connects with a vein so that the space can connect with the vein; and a pump provided in the storage chamber, wherein a negative pressure in the storage space is generated by the pump to drain lymph into the vein.

The invention relates to methods for the treatment of fibromyalgia and chronic fatigue syndrome by administration of a transdermally applied androgen composition. The treatment is both safe and effective for treating fibromyalgia-related pain and fatigue, as well as chronic fatigue syndrome.

The present invention is for a method of treatment for joint pain and other discomfort utilizing a brush applied to the skin of the patient. The brush is used to stimulate the skin in the area of pain or discomfort, thereby conditioning the nerves in the area to be less responsive to the aforementioned pain or discomfort.

The present invention relates to methods of alleviating pain with the administration of norketamine with a narcotic. More particularly, the invention provides a method of alleviating pain through the administration of a dose of norketamine, which, if administered alone would provide sub-optimal analgesic relief, yet provides analgesic relief when combined with a narcotic. In some embodiments, the combination of norketamine with a narcotic, further allows for the administration of a dose narcotic, which would be sub-optimal if used alone, but provides adequate pain relief in combination with norketamine. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine / opioid compositions effective to alleviate pain to a subject suffering from pain. Uses of norketamine / opioid compositions would also apply, to treating headaches, drug abuse, mood and anxiety disorders, as well as other, neuropsychiatric disorders, both motoric and cognitive, such as Alzheimer's disease, Parkinson's syndrome, which are thought to be caused by neurodegeneration.

The present invention discloses a method and a device for adjusting a display picture to solve a problem in the prior art that when Greenish phenomenon of a liquid crystal display screen is alleviated, aperture ratio of the display panel is decreased so that power consumption of the screen is increased. The method for adjusting the display picture includes the steps of: receiving a first clock signal for controlling a data line voltage signal for a pixel of the first color in the display picture and receiving a second clock signal for controlling data line voltage signals for pixels of the other colors; and making a pulse width at high level of the first clock signal smaller than a high level pulse width of the second clock signal, wherein the first color is closer to green than other colors.

Methods and compositions of AMP-18 derived peptides enablingly demonstrate that AMP-18 derived peptide compositions surprisingly reduce mucositis in mammals. Methods and peptide compositions treat mucositis, delays the onset or duration of mucositis, including cancer therapy-induced mucositis are disclosed. AMP 77-97 peptide derived from human AMP-18 protein alleviates cancer therapy-induced mucositis.

Methods and compositions of AMP-18 derived peptides enablingly demonstrate that AMP-18 derived peptide compositions surprisingly reduce mucositis in mammals. Methods and peptide compositions treat mucositis, delays the onset or duration of mucositis, including cancer therapy-induced mucositis are disclosed. AMP 77-97 peptide derived from human AMP-18 protein alleviates cancer therapy-induced mucositis.

Disclosed are non-immunosuppressive cyclophilin-binding cyclosporins, e.g., of formula (I, Ia or II) as defined herein, having useful properties in the prevention of Hepatitis C infections.

An attaching structure for a stabilizer of a utility vehicle includes: a pair of right and left independent suspension devices; the stabilizer which connects the pair of right and left independent suspension devices to each other; and a support member which is raised from a main frame and is configured to support a load from above. A through hole is defined in the support member such that the through hole penetrates the support member in a vehicle width direction, and the stabilizer passes through the through hole and is supported on the support member.

Provided is a knee support capable of correcting / alleviating an inner rotation or outer rotation of a knee joint.A knee support comprising a support main body for covering a knee joint, and a strap to be wound around and attached on an outer surface of the support main body helically while being pulled in the direction opposite to an inner rotation direction of the joint, wherein a projection to be contacted with an inner side of a shinbone below the knee when wearing is provided on the inner surface of the support main body or the inner surface of the strap.

A water-absorbing laminated protection film (1) including a hygroscopic resin layer 3 in which a desiccant is dispersed and a surface protection resin layer (5) provided on one surface of the hygroscopic resin layer (3). The surface protection resin layer (5) has a coefficient of moisture permeability of not more than 40 g / m2·day at 40° C. 90% RH, and the other surface of the hygroscopic resin layer (3) is a hygroscopically working surface (7).

The present invention discloses a method and a device for adjusting a display picture to solve a problem in the prior art that when Greenish phenomenon of a liquid crystal display screen is alleviated, aperture ratio of the display panel is decreased so that power consumption of the screen is increased. The method for adjusting the display picture includes the steps of: receiving a first clock signal for controlling a data line voltage signal for a pixel of the first color in the display picture and receiving a second clock signal for controlling data line voltage signals for pixels of the other colors; and making a pulse width at high level of the first clock signal smaller than a high level pulse width of the second clock signal, wherein the first color is closer to green than other colors.

Methods of treating an autoimmune disease such as rheumatoid arthritis, methods of increasing apoptosis of pro-inflammatory immune cells or synoviocytes, methods of increasing the quantity of the anti-inflammatory regulatory T cells, and methods of slowing the progression of inflammation in a subject include systemically administering to the subject a pharmaceutical composition including an effective amount of a TRAIL-conjugate. Preferably, the TRAIL-conjugate is effective for at least 3 days, more preferably at least 7 days, without being part of a nanocomplex that modulates the circulation half-life or release kinetics of the TRAIL-conjugate. Combination therapies including administering a second active agent, most preferably a TNF-α inhibitor, as well as pharmaceutical composition dosage units including a TRAIL-conjugate and a TNF-α inhibitor in an effective amount for a single once weekly dose for treatment of rheumatoid arthritis are also provided.

A method of controlling a liquid ejecting apparatus including a liquid ejecting head having a supply portion, an ejecting portion, a discharge portion, and a filter portion dividing an internal passage within the head into an upstream passage communicating with the supply and discharge portions and a downstream passage communicating with the ejecting portion, and further including pumps respectively connected to the supply and discharge portions, and a control portion configured to control the pumps so as to satisfy P1R4+P2R3<P3(R3+R4), and P1−P2>Q1(R3+R4), during a maintenance operation to discharge a supplied liquid from the discharge portion through the upstream passage, wherein P1: and P2 are pressures at the respective supply and discharge portions during the maintenance operation, P3 is a meniscus-withstanding pressure at the filter portion, R3 is a liquid flow resistance in a passage from the supply portion to the filter portion, R4 is a liquid flow resistance in a passage from the filter portion to the discharge portion, and Q1 is a minimum amount of liquid supplied through the supply portion and discharged through the discharge portion, which minimum amount is required to discharge foreign matters existing in the upstream passage during the maintenance operation.

Provided is a knee support capable of correcting / alleviating an inner rotation or outer rotation of a knee joint.A knee support comprising a support main body for covering a knee joint, and a strap to be wound around and attached on an outer surface of the support main body helically while being pulled in the direction opposite to an inner rotation direction of the joint, wherein a projection to be contacted with an inner side of a shinbone below the knee when wearing is provided on the inner surface of the support main body or the inner surface of the strap.

A cosmetic composition to prevent and / or ameliorate skin aging and applications thereof are provided in the present disclosure and the cosmetic composition comprises cyclic phosphatidic acid and citrus flavonoids which is hesperidin and / or hesperetin wherein the preventing and / or ameliorating skin aging include, without limitation, promoting moisture retention of stratum corneum, promoting skin elasticity, increasing presence or elasticity of collagens and elastins in fibroblasts, increasing transfers of fibroblasts, promoting anti-oxidation, increasing generation of hyaluronic acid, alleviating wrinkles and skin textures, moderating melanin, reducing skin oil and preventing transepidermal water losses.