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55 results about "High uptake" patented technology
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Induction of antigen specific immunologic tolerance
InactiveUS7485314B2Improve tolerancePromote absorptionBiocideSnake antigen ingredientsEpitopeRegimen
Antigen specific immune tolerance is induced in a mammalian host by administration of a toleragen in combination with a regimen of immunosuppression. The methods optionally include a preceding conditioning period, where immunosuppressive agents are administered in the absence of the toleragen. After the tolerizing regimen, the host is withdrawn from the suppressive agents, but is able to maintain specific immune tolerance to the immunogenic epitopes present on the toleragen. Optimally, the toleragen will have high uptake properties that allow uptake in vivo at low concentrations in a wide variety of tolerizing cell types.
Owner:RES & EDUCATION INST HARBOR - UCLA MEDICAL CENT
Active black dye
The invention relates to active black dye which essentially comprises fuchsine component A, orange yellow component B and navy component C, and is based on the component A, the component B and the component C; the weight percentage of the component A is 1 to 25 percent, the weight percentage of the component B is 1 to 25 percent, and the weight percentage of the component C is 50 to 95 percent; and the component A comprises at least a dye shown as formula (I) and a dye shown as formula (II), the component B comprises at least a dye shown as formula (III) and a dye shown as formula (IV), and the component C comprises at least a dye shown as formula (V). The active black dye has the advantages of high product solubility, strong salt and alkali resistance, high uptake date and color fixing rate, excellent dyeing fastness and environmental protection.
Owner:ZHEJIANG LONGSHENG GROUP +1
Metallocene complex and polymerization method of olefin
ActiveUS20110230622A1High molecular weightHigh melting pointSilicon organic compoundsMolecular sieve catalystsPolymer scienceOlefin polymerization
Owner:JAPAN POLYPROPYLENE CORP
Technetium-99m labeled isonitrile-containing FAPI derivative and preparation method and application thereof
ActiveCN112409414AReduce intakeExcellent anti-tumor performanceOrganic chemistry methodsRadioactive preparation carriersMouse tumorPerylene derivatives
The invention discloses a technetium-99m labeled isocyanide-containing FAPI derivative with a structural general formula of [99mTc-(CN-FAPI) 6] < + > and a preparation method and an application thereof. The [99mTc (CNFAPI) 6] < + > complex is obtained through two steps of synthesis of a ligand CN-FAPI and preparation of [99mTc-(CNFAPI) 6] < + >. The complex is simple and convenient to prepare, high in radiochemical purity and good in stability, has relatively high uptake and good retention at tumor parts of tumor-bearing mice, has specificity in tumor uptake, and is a novel tumor imaging agentwith popularization and application values.
Owner:BEIJING NORMAL UNIVERSITY
Method of producing monodisperse chelate resins
ActiveUS20090045137A1High degree of substitutionImprove separation efficiencyWaste water treatment from quariesGas treatmentNitrogenCrosslinked polymers
The present invention relates to a method of producing novel monodisperse chelate resins based on crosslinked polymer beads containing aminomethyl groups and / or aminomethyl nitrogen heterocyclic groups that have a high uptake capacity for heavy metals and rapid kinetics.
Owner:LANXESS DEUTDCHLAND GMBH
Imino acid PET imaging agent, and preparation method and application thereof
ActiveCN103333079AHigh tumor uptakeImprove featuresOrganic compound preparationRadioactive preparation carriersFiberImaging agent
The invention discloses an amino acid positron emission tomography (PET) imaging agent, and a preparation method and application thereof. The imaging agent belongs to the field of N-substituted positron nuclide labeled glutamic acid compound and has a structure as shown in the specification; and the L*represents -11CH3, CH2CH218F, and -COCH (18F) CH3. The novel imaging agent N-(2-18F-fluoropropionyl)-glutamic acid shows good tumor PET imaging sensitivity and specificity, has high uptake on tumor (such as S180 fibrosarcoma), and no obvious uptake on other tissues and organs (except for bladder) in the body, and indicates high tumor to background ratio. In vitro-in vivo experiments show that N-(2 - 18F -fluoropropionyl)-glutamic acid is stable in vitro and in vivo and shows good pharmacokinetic properties.
Owner:GUANGDONG HUIXUAN PHARMA TECH
Volume-differential assay using hydrophilic gel
InactiveUS7354768B1Less repulsionLess water to be absorbedComponent separationSpecific gravity using centrifugal effectsSediment FilterSuperabsorbent polymer
Systems and methods for measuring the moisture and sediment content of a petroleum sample. In one embodiment, a sample to be tested is collected in a field bottle. The sample from the field bottle is then transferred from the field bottle, and into and through a measurement column containing a high-uptake gelling agent, such as a superabsorbent polymer. The sample's moisture is determined by measuring the expanded volume of the high-uptake gelling agent. The measurement column also contains a sediment measurement section having a sediment filter and a sight glass with graduations to measure the sediment content of the sample.
Owner:PHASE DYNAMICS
Technetium-99m labeled hydrazine-based nicouramido-containing FAPI derivative as well as preparation method and application thereof
PendingCN112625065AReduce intakeConcentrated obviouslyRadioactive preparation carriersIsotope introduction to organic compoundsTPPTSTricine
The invention discloses a compound with a general formula of 99mTc (HYNIC-FAPI) (tricine / TPPTS) technetium-99 m labeled FAPI derivative containing hydrazino-nicotinamide, and a preparation method and application thereof. By two steps of synthesis of ligand HYNIC-FAPI and 99mtc (HYNIC-FAPI) (tricine / TPPTS) preparation, the 99mTc (HYNIC-FAPI) (tricine / TPPTS) complex is obtained. The complex has the advantages of simple preparation, high radiochemical purity and good stability, has high uptake and good detention at tumor parts of tumor-bearing mice, has specific uptake in tumors, and is a novel tumor radiopharmaceutical with clinical application value.
Owner:BEIJING NORMAL UNIVERSITY
TcN(DGDTC)2 complexes as well as preparation method and use thereof
The invention discloses a <99m> TcN(DGDTC)2 complex, a preparation method and application thereof. Taking the [<99m>Tc 3N] <2+> core as a central core, the complex has an irregular geometric configuration of square pyramid, wherein the N atom in the Tc3N triple bond is located at the acme, and the four sulphur atoms provided by two ligand CPFXDTC molecules are located at the four points on the bottom surface. The complex has the advantages of high radiochemical purity, good stability, simple preparation and low price, a higher uptake value and good residence in a tumor, and good target organ / non-target organ ratio such as tumor / blood ratio and tumor / muscle ratio. The complex is a novel tumor developer with high popularization and application value.
Owner:BEIJING NORMAL UNIVERSITY +1
D-glucose dithiocarbamate complex marked by TcO, preparation method and applications thereof
The invention discloses a D-glucose dithiocarbamate complex marked by TcO, a preparation method and applications thereof; the formula of the complex is TcO(DGDTC)2, takes Tc(V)O as a central nucleus and has a geometric configuration with the shape of an irregular square pyramid, wherein O atom in Tc=O bond is positioned at the top point and four sulphur atoms provided by two DGDTC ligand molecules are positioned at the four points of the bottom surface. By the technical steps of synthesis of ligand DGDTC and preparation of TcO (DGDTC)2 complex, the TcO (DGDTC)2 complex is obtained. The D-glucose dithiocarbamate complex has high radiochemical purity and good stability, has higher uptake value and good detention in tumor and higher ratio of tumor / muscle, and is suitable for being promoted and applied as a novel tumor imaging agent.
Owner:BEIJING NORMAL UNIVERSITY +1
Nitro imidazole xanthogenate complex marked by TcO, preparation method and applications
InactiveCN101555229ARadioactive preparation carriersGroup 7/17 element organic compoundsNitroimidazoleHuman body
The invention discloses a nitro imidazole xanthogenate complex marked by TcO with the formula of TcO (NMXT)2; in the formula, NMXT represents a compound containing nitro imidazole xanthogenate. The complex adopts Tc(V)O as a central nucleus and has a geometric configuration with the shape of an irregular square pyramid, wherein O atom in Tc=O bond is positioned at the top point and four sulphur atoms provided by two xanthogenate ligand molecules are positioned at the four points of the bottom surface. By the technical steps of synthesis of ligand NMXT and preparation of TcO (NMXT)2 complex, the TcO (NMXT)2 complex is obtained. The nitro imidazole xanthogenate complex has high radiochemical purity and good stability, has higher uptake value and good detention through in tumor and higher ratio of tumor / muscle, is widely applied to tumor imaging of human body and animal organs and is a novel tumor hypoxia imaging agent which is conveniently promoted and applied.
Owner:BEIJING NORMAL UNIVERSITY +1
Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
ActiveUS20180133146A1Sufficient amountHigh CmaxOrganic active ingredientsNervous disorderMorphineApomorphine
Methods and pharmaceutical unit dosage forms for treating Parkinson's disease in a subject (e.g., an “off” episode in a subject having Parkinson's disease) are described. The pharmaceutical unit dosage forms are films having a first portion including particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent. The pharmaceutical unit dosage forms can be flexible and have toughness greater than 100 g×mm. The methods can involve administering to a subject having Parkinson's disease a therapeutic dose sufficient to produce an apomorphine plasma concentrate of at least 2.64 ng / mL within 45 minutes after the administration. The subject may be identified as having low uptake, medium uptake, or high uptake of apomorphine administered via oral mucosa.
Owner:SUNOVION PHARMA INC
Induction of antigen specific immunologic tolerance
Antigen specific immune tolerance is induced in a mammalian host by administration of a toleragen in combination with a regimen of immunosuppression. The methods optionally include a preceding conditioning period, where immunosuppressive agents are administered in the absence of the toleragen. After the tolerizing regimen, the host is withdrawn from the suppressive agents, but is able to maintain specific immune tolerance to the immunogenic epitopes present on the toleragen. Optimally, the toleragen will have high uptake properties that allow uptake in vivo at low concentrations in a wide variety of tolerizing cell types.
Owner:KAKKIS EMIL D +4
Volume-differential water assay system using hydrophilic gel
InactiveUS7407625B1The process is fast and accurateEasy to measureAnalysis using chemical indicatorsComponent separationSediment FilterSuperabsorbent polymer
Systems and methods for measuring the moisture and sediment content of a petroleum sample. In one embodiment, a sample to be tested is collected in a field bottle. The sample from the field bottle is then transferred from the field bottle, and into and through a measurement column containing a high-uptake gelling agent, such as a superabsorbent polymer. The sample's moisture is determined by measuring the expanded volume of the high-uptake gelling agent. The measurement column also contains a sediment measurement section having a sediment filter and a sight glass with graduations to measure the sediment content of the sample.
Owner:PHASE DYNAMICS
Sorbent and Devices for Capturing, Stabilizing and Recovering Volatile and Semi-volatile Compounds
ActiveUS20200033236A1Promote recoveryIncrease uptakeGas treatmentOther chemical processesOrganic solventMesoporous silica
The present invention provides an improved sorbent and corresponding device(s) and uses thereof for the capture and stabilization of volatile organic compounds (VOC) or semi-volatile organic compounds (SVOC) from a gaseous atmosphere. The sorbent is capable of rapid and high uptake of one or more compounds and provides quantitative release (recovery) of the compound(s) when exposed to elevated temperature and / or organic solvent. Uses of particular improved grades of mesoporous silica are disclosed.
Owner:XPLOSAFE LLC
Metallocene complex and polymerization method of olefin
ActiveUS8461365B2High molecular weightHigh melting pointSilicon organic compoundsMolecular sieve catalystsPolymer scienceAlpha-olefin
Owner:JAPAN POLYPROPYLENE CORP
Positively-charged superparamagnetic iron oxide nanoparticle, contrast agent using the same and method of preparing the same
InactiveUS20120045399A1Ultrasonic/sonic/infrasonic diagnosticsMaterial nanotechnologySuperparamagnetic iron oxide nanoparticlesIron oxide nanoparticles
Provided are a positively-charged superparamagnetic iron oxide nanoparticle (SPION), a contrast agent using the same, and a method of preparing the same. The positively-charged SPION includes a SPION, a polymer layer including a polymer containing many carboxyl groups coated on a surface of the SPION, and a cationic material coupled via an amide bond to a surface of the polymer layer. Therefore, the SPION may be prepared in a simple and reproducible process to have hydrophilicity and a strong positive charge. The prepared positively-charged SPION may have high uptake into a cell and stability, and be used in various applications as an effective contrast agent through non-invasive in vivo imaging.
Owner:NAT CANCER CENT
Selective dendrimer delivery to brain tumors
ActiveUS20170173172A1Rapid clearanceHigh resolutionOrganic active ingredientsRadioactive preparation carriersImmunotherapeutic agentPolymer
A composition comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for the treatment or alleviation of one or more symptoms of a brain tumor have been developed. The dendrimers comprise one or more ethylene diamine-core poly(amidoamine) (PAMAM) hydroxyl-terminated generation-4, 5, 6, 7, 8, 9, or 10, most preferably generation 6 (G4-10-OH) dendrimers. The G6 dendrimers have demonstrated unexpectedly high uptake into the brain. The dendrimers provide a means for selective delivery through the blood brain barrier (“BBB”) of chemotherapeutic, immunotherapeutic and palliative agents. The dendrimers also have the advantage that two different classes of compounds, having one or more mechanisms of action can be bound to the dendrimers, providing simultaneous delivery. The dendrimers may be administered alone by intravenous injection, or as part of a multi-prong therapy with radiation.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
2-methyl-5-nitro glyoxaline compound, preparation and use thereof
InactiveCN101486707AHigh tumor uptakeHigh absolute tumor uptakeRadioactive preparation carriersGroup 7/17 element organic compoundsNitroimidazoleAbnormal tissue growth
The invention provides hydrophilic complexes marked by radioactive nuclide for hypoxic tumors; and the precursor of the complexes is a 1, 4, 8, 11-tetraazacyclotetradecane-contained 2-methyl-5-nitromidazole compound with the structural formula as shown on the right. The invention also provides preparation methods of the complexes and the precursor thereof, and the application of the complexes as potential tumor hypoxia imaging agents; and the complexes have good hydrophilic property and relatively high uptake value in tumors, especially the complexes such as TcO-MNIEC and TcN-MNIEC have high absolute uptake value in tumors, low L / NT value, relatively high tumor / muscle ratio and tumor / blood ratio, effectively solve the problem that the current tumor hypoxia imaging agent has the defects of low absolute uptake value and high L / NT value, thus being likely to become new tumor hypoxia imaging agents with better performance.
Owner:BEIJING NORMAL UNIVERSITY +1
Mini-gastrin analogue, in particular for use in CCK2 receptor positive tumour diagnosis and/or treatment
ActiveUS10130724B2Weak affinityEasy to oxidizePeptide/protein ingredientsIsotope introduction to peptides/proteinsDiseaseLow affinity
A gastrin analog shows high uptake in CCK-2 receptor positive tumors and simultaneously a very low accumulation in the kidneys. This is achieved by a mini-gastrin analog PP-F11 having the formula: PP-F11-X-DGlu-DGlu-DGlu-DGlu-DGlu-DGlu-Ala-Tyr-Gly-Trp-Y-Asp-Phe-NH2, wherein Y is an amino acid replacing methionine and X is a chemical group attached to the peptide for diagnostic and / or therapeutic intervention at CCK-2 receptor relevant diseases. Very suitable compounds with respect to a high tumor to kidney ratio are mini-gastrin analogs with six D-glutamic acids or six glutamines. These compounds still possess a methionine which can be oxidized easily which is a disadvantage for clinical application under GMP due to the forms which may occur. The elimination of the methionine leads to a lower affinity to oxidation which in general favors the tumor-kidney-ratio. Ideally, the methionine is replaced by norleucine. This PP-F11N mini gastrin exhibits currently the best tumor-kidney-ratio and is the most promising candidate.
Owner:PAUL SCHERRER INSTITUT
Compound for nanometer PET developer and its preparation method and use
ActiveCN105085617AImprove hydrophilicityImprove permeabilityRadioactive preparation carriersPeptide preparation methodsCompound aNanoparticle
The invention discloses a compound for a nanometer PET developer. The compound A is shown in the structural formula (I). The compound A is a small molecule and can undergo a condensation reaction under the action of furin to produce a polymer large molecule. The polymer large molecule has good blood vessel and cell permeability, has a high uptake rate, can actively target an imaging zone, can self-assemble to form nanoparticles in the tumor zone, has high imaging sensitivity and good imaging effects, can be prepared simply, allows mild reaction conditions and can be used for high-expression furin tumor PET development.
Owner:JIANGSU INST OF NUCLEAR MEDICINE
Induction of Antigen Specific Immunnologic Tolerance
Owner:BIOMARIN PHARMA INC
<99>Tc<m>N(NFXDTC)2 complex and preparation method and application thereof
ActiveCN101665520ARadioactive preparation carriersGroup 7/17 element organic compoundsSulfurInflammation imaging
The invention discloses a <99>Tc<m>N(NFXDTC)2 complex and a preparation method and an application thereof, the complex comprises an irregular square pyramid geometric configuration and takes a <99>Tc<m>N nucleus as a central nucleus, wherein, an N atom in a Tc equivalent to N triple bond is positioned in the vertex position, and four sulfur atoms provided by two ligand NFXDTC molecules are positioned at four points of the bottom surface. The <99>Tc<m>N(NFXDTC)2 complex has the advantages of high radiochemical purity, good stability, higher uptake value of inflammation and better target / non-target value and is convenient to popularize and apply as a novel inflammation imaging agent.
Owner:BEIJING NORMAL UNIVERSITY +1
Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
ActiveUS10449146B2High CmaxSufficient amountOrganic active ingredientsNervous disorderMorphinePharmaceutical drug
Methods and pharmaceutical unit dosage forms for treating Parkinson's disease in a subject (e.g., an “off” episode in a subject having Parkinson's disease) are described. The pharmaceutical unit dosage forms are films having a first portion including particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent. The pharmaceutical unit dosage forms can be flexible and have toughness greater than 100 g×mm. The methods can involve administering to a subject having Parkinson's disease a therapeutic dose sufficient to produce an apomorphine plasma concentrate of at least 2.64 ng / mL within 45 minutes after the administration. The subject may be identified as having low uptake, medium uptake, or high uptake of apomorphine administered via oral mucosa.
Owner:SUNOVION PHARMA INC
Sorbent and Devices for Capturing, Stabilizing and Recovering Volatile and Semi-volatile Compounds
Owner:XPLOSAFE LLC
Tc marked daunorubicin dithiocarbamate composition and preparation method and applications thereof
The invention discloses a Tc marked daunorubicin dithiocarbamate composition, including a composition consisting of TcN-DAUDTC and TcO-DAUDTC, and a preparation method and applications thereof. The composition uses a (Tc-N) nucleus or a (TcO) nucleus as a central nucleus, and has a geometrical configuration of irregular square pyramid, and four sulphur atoms provided by two DAUDTC ligand molecules are positioned at four points of the bottom of the irregular square pyramid. The composition is high in radiochemical purity, and good in stability. The composition of TcN-DAUDTC and TcO-DAUDTC has higher uptake value of tumors and good retention in tumors, and rational target-to-nontarget ratio of inflammation to muscle. Therefore, the composition is a new developer of tumors, with popularization and application values.
Owner:BEIJING NORMAL UNIVERSITY +1
Metallocene complex and olefin polymerization method
ActiveUS20150266914A1High uptake rateEasy to manufactureMolecular sieve catalystsGroup 3/13 element organic compoundsPolymer scienceAlpha-olefin
Provided are a metallocene complex that facilitates copolymerization of olefin monomers including propylene at a higher uptake rate of comonomers, i.e., ethylene and α-olefin, manufacture of a rubber component having a higher molecular weight, and manufacture of homopolypropylene having a higher melting point through homopolymerization of propylene, compared to traditional metallocene catalysts, and a method of olefin polymerization in the presence of such a metallocene complex. Also provided are, for example, a metallocene complex represented by general formula [I] (e.g., a metallocene complex having a substituent at position 6 of one or each indenyl ring and an optionally substituted furyl or thienyl group at position 2 of one or each indenyl ring), an olefin polymerization catalyst containing the metallocene complex, and a method of olefin polymerization involving olefin polymerization or copolymerization in the presence of the olefin polymerization catalyst.
Owner:JAPAN POLYPROPYLENE CORP
Sorbent and devices for capturing, stabilizing and recovering volatile and semi-volatile compounds
ActiveUS10866166B2Promote recoveryIncrease uptakeGas treatmentOther chemical processesOrganic solventMesoporous silica
Owner:XPLOSAFE LLC
A kind of high dye uptake polyester fiber fdy yarn and preparation method thereof
ActiveCN104499084BImprove dye uptakeGood flexibilityNew-spun product collectionMelt spinning methodsYarnFiber
Owner:JIANGSU HENGLI CHEM FIBER
4-nitro glyoxaline compound, preparation and use thereof
InactiveCN101486708ABiodistribution Advantages and AdvancesHigh tumor uptakeRadioactive preparation carriersGroup 7/17 element organic compoundsAbnormal tissue growthNitroimidazole
The invention provides hydrophilic complexes marked by radioactive nuclide for hypoxic tumors; and the precursor of the complexes is a 1, 4, 8, 11-tetraazacyclotetradecane-contained 4-nitromidazole compound with the structural formula as shown on the right. The invention also provides the preparation methods of the complexes and the precursor thereof, as well as the application of the complexes as potential tumor hypoxia imaging agents; and the tumor hypoxia imaging agent of the complexes have good hydrophilic property and relatively high uptake value in tumors, particularly the complexes such as TcO-NIEC and TcN-NIEC have high absolute uptake value in tumors, low L / NT value, relatively high tumor / muscle ratio and tumor / blood ratio, effectively solve the problem that the current tumor hypoxia imaging agent has the defects of low absolute uptake value and high L / NT value, thus being likely to become new tumor hypoxia imaging agents with better performance.
Owner:BEIJING NORMAL UNIVERSITY +1
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