68 results about "Iron oxide nanoparticles" patented technology

The invention discloses a preparation method and application of a high-density iron-nitrogen-carbon monatomic catalyst. The method specifically comprises the following steps: S1, uniformly mixing nitrogen-doped carbon and ferrous oxalate; s2, in an inert atmosphere, carrying out a first pyrolytic reaction at 340-360 DEG C to obtain an intermediate, and meanwhile, carrying out etching on the carbon carrier by using CO2 gas generated by the reaction, so that a plurality of microporous structures are formed on the carbon carrier; s3, the intermediate continues to be subjected to a second pyrolytic reaction in the inert atmosphere at the temperature of 850-950 DEG C, the FeOx nano-particles are converted into Fe-N4 active sites, and a pyrolytic product is obtained; and S4, naturally cooling to room temperature to obtain the high-density iron-nitrogen-carbon monatomic catalyst. Superfine ferric oxide (FeOx) nano-particles are generated through a precursor to serve as intermediates, carbon defects are created through CO2 gas released in the decomposition process of the FeOx nano-particles, and therefore the oxygen reduction reaction performance of the catalyst is remarkably improved, and the catalyst is applied to fuel cells.

The invention discloses iron oxide nanoparticles capable of responding to particle size change in a tumor microenvironment and a preparation method of the iron oxide nanoparticles, and belongs to the technical field of biomedical nano materials. The nano-particle comprises an iron oxide nano-crystal core with the particle size of 3-5nm and a tumor microenvironment response layer coating the surface of the iron oxide nano-crystal core. The response layer contains groups, such as disulfide bonds, enzyme digestion peptide fragments and the like, which can respond to acidic pH, high-concentration reduced glutathione or matrix metalloproteinase and other tumor characteristic stimuli to generate structural changes. In a tumor microenvironment, the hydration particle size of the nanoparticles can be directionally and controllably converted from 3-20 nm to 20-100 nm (or reversely). The preparation method mainly comprises two steps of preparing the core by a thermal decomposition method and modifying the surface response layer. The technical problems of insufficient tumor targeted enrichment capacity, limited imaging contrast and difficulty in balancing permeation and retention caused by fixed particle size of the existing iron oxide nanoparticles are solved, and the accuracy and efficiency of tumor diagnosis and treatment can be remarkably improved.

The application discloses iron oxide coated silica core-shell nanoparticles and a preparation method and application thereof. The iron oxide coated silica core-shell nanoparticles comprise silica nanoparticles as an inner core and iron oxide nanoparticles as an outer shell coated on the inner core surface of the silica nanoparticles; the particle size is 22-112 nm; and the particle uniformity is 0.08-0.3. The preparation method of the iron coated silica nanoparticles provided by the application adopts the measure of adjusting the pH of slurry for multiple times, avoids the agglomeration of nanoparticles in a solution near the isoelectric point, and is thus favorable for finally obtaining core-shell nanoparticles with uniform monodispersity. No surfactant is used in the preparation process, and there is no complicated post-treatment process, thereby reducing the production cost. The uniformly monodispersed nanoparticles prepared by the method have great potential in the field of chemical mechanical polishing.

The invention discloses a visual efficient chloride ion removal adsorbing material and a preparation method and application thereof.The adsorbing material is prepared by the steps that hollow glass microspheres serve as a carrier, and hollow glass porous particles are synthesized from a mixture of hollow glass microsphere powder and a pore forming agent through a sol-gel method; the preparation method comprises the following steps: modifying the surface of a porous adsorption material through a low-temperature plasma bombardment technology to enhance the adsorption performance on chloride ions, and loading magnetic iron oxide nanoparticles on the porous adsorption material to prepare the chloride ion adsorption material; the adsorption material has the characteristic of environmental friendliness, not only can efficiently adsorb chloride ions in a water body, but also can realize the visualization of the adsorption process through the density difference before and after adsorption, has the characteristics of repeated use and easiness in regeneration, and has relatively high market application prospect and economic value.

The application discloses a seminal plasma metabolic biomarker combination for male infertility spermatogenesis obstacle typing diagnosis, and relates to the field of biological science and technology.The application records the metabolic fingerprints of 475 seminal plasma samples by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry, and constructs a seminal plasma metabolic fingerprint database related to spermatogenesis obstacle (SPGF). Then, through machine learning and statistical analysis, six metabolic biomarkers for SPGF typing diagnosis are screened and identified in the seminal plasma, and the six metabolic biomarkers can realize accurate typing of SPGF (AUC=0.814). The application has the advantages of simple sample pretreatment, fast analysis speed and low cost by means of recording the metabolic fingerprints of seminal plasma by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry. Through the synthesized iron oxide nanoparticles as a matrix, small molecule metabolites in the seminal plasma can be efficiently captured and ionized, and complex pretreatment steps such as deproteinization and chromatographic separation are not needed, so that super-fast analysis, super-high sensitivity, extremely low sample consumption and excellent repeatability detection are realized.

The invention provides an iron-based nano material, a preparation method and application, the material comprises magnetic iron oxide nano particles and a functional modification layer on the surface, the magnetic iron oxide nano particles are Fe3O4, the particle size is 10-30 nm, and the magnetic iron oxide nano particles have specific oxygen vacancy concentration, 337 nm laser absorptivity and saturation magnetization; the functional modification layer is an amino-containing polymer layer, such as a polydopamine or cysteine-polyethyleneimine copolymer, and can reduce salt ion interference. The material solves the problems of low molecular weight region background interference, non-uniform crystallization, low ionization efficiency, poor salt tolerance and the like during detection of 100-400Da small molecular metabolites in trace samples such as tears and the like by optimizing magnetic responsiveness, photo-thermal conversion capability and salt resistance of an existing matrix; the method realizes high sensitivity and high repeatability (detection), and is suitable for metabonomics analysis of trace biological samples.

This disclosure relates to a method for improving the colonization efficiency of rhizosphere growth-promoting bacteria using nanomaterials and a magnetic interaction system. The method includes: S1, mixing modified iron oxide nanoparticles with a suspension of rhizosphere growth-promoting bacteria and then conducting a first culture to obtain modified rhizosphere growth-promoting bacteria; S2, applying a dispersion of magnetic iron oxide nanoparticles to the roots of a plant for a second culture to obtain modified plants; S3, applying the suspension of the modified rhizosphere growth-promoting bacteria to the roots of the modified plants for a third culture; wherein the modified iron oxide nanoparticles are cationic polymer-modified iron oxide nanoparticles. This method constructs a plant-microorganism magnetic interaction system, improving the colonization ability of rhizosphere growth-promoting bacteria in plant roots, and also enhancing the nitrogen-fixing ability of the rhizosphere growth-promoting bacteria, effectively promoting plant growth.

The invention discloses a preparation method of a bionic magnetic nano-motor mixed and wrapped by a neutrophile granulocyte membrane and a stem cell exosome. The bionic magnetic nano-motor comprises the neutrophile granulocyte membrane, the stem cell exosome, a polylactic acid-glycolic acid copolymer and an anti-inflammatory drug. According to the method, a layer of polylactic acid-glycolic acid copolymer is wrapped outside magnetic ferroferric oxide nanoparticles and an anti-inflammatory drug by utilizing an ultrasonic emulsification method, and finally the polylactic acid-glycolic acid copolymer is wrapped by utilizing a neutrophile granulocyte membrane and a stem cell exosome, so that the bionic magnetic nano motor is obtained, and the motor has good biocompatibility. Meanwhile, the motor has an immune escape function and can resist phagocytosis of macrophages in blood. And under the control of an external alternating magnetic field, the medicine can accurately reach a spinal cord injury part, and the effects of inflammation inhibition and neuron recovery can be achieved under the mixed action of neutrophile granulocyte membranes, stem cell exosomes and anti-inflammatory drugs.

This invention belongs to the field of skin-like tissue preparation technology, and relates to a method for constructing ordered skin-like tissue with magnetic field assistance. The method involves directional cryo-casting to prepare a layered ordered hydrogel, providing skin-like seed cells, and culturing and expanding these cells in large quantities using a complete culture medium to obtain skin-like cells. The cultured skin-like cells are then co-cultured with iron oxide nanoparticles to prepare magnetized skin-like cells. These magnetized skin-like cells are then co-cultured with the layered ordered hydrogel, and magnetic fields are applied to both sides to induce the magnetized skin-like cells to enter the layered ordered hydrogel, resulting in a hydrogel scaffold. After washing the obtained hydrogel scaffold, it is transferred to a complete culture medium, and keratinocytes are seeded on the surface of the hydrogel scaffold and cultured to prepare an ordered skin-like tissue. This invention can effectively regulate the migration and arrangement of fibroblasts, providing a physical basis for the arrangement of the extracellular matrix, especially collagen.

This invention discloses a method for preparing cationic and amphiphilic quaternized composite magnetic nanoparticles, comprising the following steps: Step S1, preparing magnetic iron oxide nanoparticles using a hydrothermal method; Step S2, preparing silica-coated magnetic iron oxide nanoparticles using the Stober method; Step S3, preparing cationic and amphiphilic quaternized composite magnetic nanoparticles using an electrostatic self-assembly method. This invention uses low-cost alkane quaternary ammonium salts as functional monomers to achieve a three-layer core-shell structure comprising an iron oxide magnetic core, a silica intermediate bridging layer, and an alkane quaternary ammonium salt functional outer layer. The alkane quaternary ammonium salt is stably loaded onto the silica surface through a non-covalent grafting mechanism of electrostatic self-assembly, thereby achieving mild and efficient grafting. The resulting composite magnetic nanoparticles can achieve efficient separation of emulsified oily wastewater at room temperature and exhibit excellent recyclability, salt tolerance, and wide pH adaptability.

The invention discloses a composition with a tumor mitochondrial dual regulation effect, temperature-sensitive hydrogel and application, and belongs to the technical field of biological medicine, the composition is composed of a peroxide initiator and a mitochondrial autophagy inhibitor, the peroxide initiator is used for causing mitochondrial damage, and the mitochondrial autophagy inhibitor is used for causing mitochondrial autophagy. The mitochondrial autophagy inhibitor is used for inhibiting mitochondrial The peroxide initiator is indocyanine green, chlorin, iron oxide nanoparticles or Fe-MOFs (Metal-Organic Frameworks); the mitochondrial autophagy inhibitor is chloroquine, 3-methyladenosine or bajulomycin A1; the tumor is specifically melanoma; the combination of the peroxide initiator and the mitochondrial autophagy inhibitor can better inhibit the energy metabolism of tumor cells and inhibit the occurrence and development of tumors, and after the composition is delivered through the temperature-sensitive hydrogel carrier, the treatment effect of the composition on tumors is further improved.

The present application relates to the technical field of water treatment, in particular to a preparation method of a confined carbon film electrode and application thereof. The advanced oxidation technology is a free radical oxidation system mainly with hydroxyl radicals and sulfate radicals. When degrading persistent organic pollutants, the hydroxyl radicals and sulfate radicals are easily consumed by chain reaction with anions in water and also produce toxic byproducts. In view of the above problems, the present application provides a confined carbon film electrode which is formed by depositing Fe2O3 / CNTs composite material on the surface of a microporous filter membrane to form a membrane electrode. The Fe2O3 / CNTs composite material is to confine iron oxide nanoparticles on the sidewall of the hollow pipe of carboxyl functionalized CNTs. The present application combines electrocatalysis technology and membrane separation technology, can more efficiently remove harmful substances such as persistent organic pollutants and heavy metals in water, and has higher water purification efficiency compared with the single electrocatalysis technology and membrane separation technology.

The application discloses a kind of multistage size response type iron-based nano preparation and its preparation method and application, the iron-based nano preparation includes responsive iron-based nanomaterial and the protein drug of load, the responsive iron-based nanomaterial is by magnetic iron oxide nanoparticles surface complex dopamine and dopamine phenylboronic acid ligand, the molar ratio of two ligands is 1:0.52~2.57;Preparation method: magnetic iron oxide nanoparticles is dispersed in solvent, dopamine hydrochloride and dopamine phenylboronic acid are added, and under the condition of 40~80 DEG C reaction, obtain responsive iron-based nanomaterial;Protein drug is mixed with the responsive iron-based nanomaterial obtained in aqueous solvent, and evenly dispersed to obtain target nano preparation.The multistage size response type iron-based nano preparation of the application realizes microenvironment response delivery, deep penetration, lysosome enrichment, efficient iron death trigger and the cascade synergistic effect of immune activation, provides a kind of safe and efficient new strategy for tumor synergistic treatment.

The invention relates to a safe scavenger for inflammable and virulent hydrogen sulfide and a preparation method thereof, and belongs to the technical field of hydrogen sulfide adsorption materials. The preparation method comprises the following steps: by taking a carbon nanotube as a matrix, growing iron oxide nanoparticles on the carbon nanotube in situ, so that the dispersion and distribution uniformity of the iron oxide nanoparticles can be improved, and then carrying out Michael addition reaction on a vinyl group on the vinyl modified iron oxide loaded carbon nanotube and a secondary amino group in a hexahydro-s-triazine grafted compound, so as to obtain the composite material. Amine groups containing a large number of hexahydrotriazine groups, piperazine groups and the like can be further cross-linked and coated on the surface of the scavenger, and a hexahydrotriazine-piperazine cross-linked network polymer is formed on the surface of the scavenger; the tubular carbon nanotubes, the ferric oxide particles loaded on the surfaces of the tubular carbon nanotubes and the piperazine-hexahydro-s-triazine cross-linked network-shaped polymer coated on the surface of the hydrogen sulfide scavenger work together, so that the removal effect of hydrogen sulfide in a gas phase and a water phase is effectively improved.

The present invention relates to an apparatus for softening a crystalline lens nucleus (100) in a cataract phacoemulsification treatment comprising an electric current pulse generator (11) to supply a pulse current to a handpiece (12), wherein the pulse current generates a pulsatile magnetic field, and to hydrodissect the lens nucleus with iron oxide nanoparticle solution to loosen the lens nucleus as well as to infiltrate the lens nucleus (14) with the iron oxide nanoparticles (13), characterised in that the needle tip (24) of the handpiece (12) conducts the generated pulsatile magnetic field to the lens nucleus which causes vibration of iron oxide nanoparticles which emanates a mechanical force to break interdigitating bonds between lens fibers, leading to a controlled softening and fragmenting of the lens nucleus, wherein the electric current pulse generator (11) is configured to produce pulse currents with adjustable voltage and frequency parameters, and the iron oxide nanoparticle solution (13) further comprises a superparamagnetic property functionalised with a biocompatible coating.

Disclosed herein are compositions and methods for deploying interventional agents into constrained biological states using non-crystalline amorphous iron oxide nanoparticles (NAIONPs). The NAIONPs comprise coordination-stabilized, aqueous colloidal dispersions lacking long-range crystalline order and presenting surface-accessible coordination sites for reversible or covalent association with one or more interventional agents. The compositions are configured to modify the biological context in which an interventional agent is presented, enabling functional engagement of agents whose deployment is limited when administered in isolation due to factors including impaired biodistribution, reduced stability, stress sensitivity, immune-mediated clearance, altered cellular responsiveness, or non-optimal exposure conditions. Interventional agents may include polynucleotides, peptides, proteins, small molecules, targeting moieties, radiologic agents, or combinations thereof. The disclosed compositions and methods are applicable to in vivo, ex vivo, and in vitro biological systems, including oncologic disease states such as primary tumors, metastatic disease, hematologic malignancies, and treatment-refractory cancers.

This invention relates to the field of electromagnetic wave absorbing materials, specifically to a Fe@Fe / SiO2 gradient impedance electromagnetic wave absorbing material and its preparation method. The specific technical solution involves coating the surface of iron oxide nanoparticles with a SiO2 shell and performing high-temperature reduction heat treatment to transform the iron oxide core into a Fe magnetic core. Simultaneously, Fe single atoms, iron oxide, and Fe nanoparticles are loaded onto the inner wall of the SiO2 shell. This structure utilizes the SiO2 shell to block the continuous conductive network and suppress the skin effect, while the gradient impedance structure optimizes impedance matching to facilitate the entry of electromagnetic waves into the particle interior. The magnetic losses of the Fe magnetic core and the Fe magnetic particles on the inner wall of the SiO2 shell, as well as the dielectric losses of the Fe single atoms, iron oxide, and Fe magnetic nanoparticles, synergistically and efficiently dissipate electromagnetic waves. Furthermore, after reflection from the Fe magnetic core, the electromagnetic wave undergoes continuous reflection within the hollow cavity between the yolk and shell due to the gradient impedance structure, achieving efficient attenuation of electromagnetic wave energy.

The application relates to the technical field of magnetic particle imaging, and more particularly to an iron oxide nanoparticle and application of the iron oxide nanoparticle in magnetic particle imaging. The nanoparticle is an octahedral superparamagnetic ferroferric oxide nanoparticle, the nanoparticle is synthesized by adding a surfactant and controlling a reaction rate through a high-temperature thermal decomposition method, the surfactant includes oleic acid and oleylamine, the octahedral superparamagnetic ferroferric oxide nanoparticle is coated with an amphiphilic polymer, the amphiphilic polymer includes polymaleic anhydride-1-octadecenoic acid and polystyrene maleic anhydride copolymer, and the outer layer of the amphiphilic polymer includes biological membranes such as macrophage membranes, red blood cell membranes, neutrophil membranes and tumor cell membranes according to biological application requirements. The surface of the octahedral magnetic particle is a crystal face, the crystal face has low spin disorder and low anisotropy, so that the octahedral magnetic particle has the advantages of low coercivity and high initial magnetic susceptibility, and thus becomes a high-sensitivity magnetic particle imaging tracer.

The invention discloses a multi-layer modified magnetic nanoparticle, a preparation method thereof and a method for extracting precious metal from electronic waste, and belongs to the technical field of precious metal extraction.The multi-layer modified magnetic nanoparticle comprises the following structures that a core layer is composed of iron oxide nanoparticles and provides magnetism; the inner layer is composed of silicon dioxide and coats the surface of the core layer, so that the chemical stability and the biocompatibility of the particles are improved; the outer layer is composed of polyethylene glycol-sulfydryl, coats the surface of the inner layer, provides specific adsorption sites and is used for adsorbing precious metal nanoparticles. According to the method, the precious metal can be effectively extracted, interference of other metal ions on extraction of the precious metal is avoided in the extraction process, and gold, silver nanoparticles and platinum nanoparticles can be independently separated.

The application discloses a kind of for in-vivo tumor microenvironment magnetic heat immune closed loop system and control method, belong to biomedical engineering and nanotechnology cross field.For the existing magnetic heat therapy technology cannot carry out real-time self-adaptive regulation according to the dynamic change of GAL-1, IFN-gamma, IL-4 and Th1 / Th2 ratio in tumor microenvironment, easy to cause the problem that immune marker deviates from window, a kind of magnetic heat immune closed loop regulation system is proposed.Firstly, baseline value is obtained and target concentration window is set;Control alternating magnetic field to activate vortex magnetic iron oxide nanoparticles to generate heat and active oxygen;Real-time acquisition of immune marker concentration fed back by implantable electrochemical sensor, dynamically adjust field strength and / or frequency;With single effective activation window, maximum single time length, temperature as stop criterion;After stop, standby and pulse reset.Real-time self-adaptive regulation of in-vivo immune state is realized, immune activation deficiency or immune marker deviation from window is avoided, and normal tissue thermal damage is prevented by multi-level thermal safety constraint.

The technology is based on a conducting, ferromagnetic ink made from, in an aqueous suspension: conducting nanopolymers, ferromagnetic nanoparticles, an adhesion promoter and optionally, a surfactant and / or stabilizer. The ink is used to form reversible physical and electrical connections between e.g., rigid and flexible devices. In some aspects, the conducting nanopolymers are PEDOT:PSS (poly(3,4-ethylenedioxythiophene) polystyrene sulfonate) nanopolymers and the magnetic nanoparticles are iron oxide nanoparticles. The ink, which may be magnetic, is used to form solid, flexible, ferromagnetic conducting designs or nodes which may also be magnetic. The flexible, ferromagnetic conducting designs or nodes are used to form reversible magnetic electrical connections with devices such as potentiostats and data telemetry devices.

Disclosed is a multi-functional nanoparticle delivery system comprising a biodegradable core of poly(lactic-co-glycolic acid) (PLGA) or calcium phosphate (CaP), encapsulating a nicotinamide adenine dinucleotide (NAD+) precursor and a sirtuin activator. Surrounding the core is a liposomal or polymeric layer containing one or more senolytic agents, and an outer layer of magnetic iron oxide nanoparticles for targeted delivery, external manipulation, and imaging. In some embodiments, the nanoparticle surface is functionalized for conjugation with autologous mesenchymal stem cells to enhance homing and regenerative potential. The system is pH-responsive, releasing its payload in acidic microenvironments typical of senescent or diseased cells, while remaining stable at physiological pH. This integrated design supports NAD+ restoration, sirtuin activation, senescent cell clearance, and tissue regeneration. Applications include treatment of age-related diseases, regenerative medicine, cardiovascular and neurodegenerative disorders, and cosmetic skin rejuvenation.

A preparation method of a particle hydrogel includes: mixing a gelatin nanoparticle, a calcium carbonate nanoparticle, an iron oxide nanoparticle, and a sodium alginate solution under alkaline conditions, and adding GDL to produce the particle hydrogel with improved mechanical properties, which is abbreviated as Ca-Alg / MCG. The present disclosure endows the hydrogel system with properties such as catheter injectability, vascular deliverability, and intravascular hardenability. The particle hydrogel can be delivered to fine blood vessels of tumors. The mechanical properties of the particle hydrogel can be gradually enhanced over time, which further improves the embolization efficacy of the particle hydrogel in blood vessels. Magnetic nanoparticles endow the particle hydrogel with magnetothermal responsiveness. Thus, the particle hydrogel can undergo a rapid temperature rise under an alternating magnetic field to further kill tumor cells. The particle hydrogel demonstrates improved embolization efficacy in rabbit renal embolization models and rabbit liver cancer-embolization models.

This invention discloses a supramolecular carrier-free self-delivery system, its preparation method, and its application in tumor treatment, belonging to the field of biomedical technology. The supramolecular carrier-free self-delivery system is prepared by non-covalent self-assembly of mitoxantrone, dihydroporphyrin (Ce6), and ultrasmall iron oxide nanoparticles in an aqueous phase. This invention utilizes the co-assembly of mitoxantrone (MTX), dihydroporphyrin (Ce6), and ultrasmall iron oxide nanoparticles (IONP) to form a supramolecular carrier-free self-delivery system CMIOs. This system is simple to prepare, stable in performance, and highly biosafety. It can synergistically inhibit cancer through multiple mechanisms, achieving highly efficient inhibition of breast cancer, providing a new strategy for tumor treatment, and has broad application prospects in solving clinical problems.

The present invention relates to glycyrrhizin-glycol chitosan conjugate-coated nanoparticles, islet cells, prepared using same, for transplantation, and an MRI imaging composition comprising same. If transplanted, the islet cells comprising the nanoparticles can suppress a post-transplantation immune response. The present invention can provide islet cells for transplantation that can be transplanted to a certain region by magnetic force induction and can be tracked by MRI.

A method of making an array of vertically-aligned CNT bundles includes dispersing iron oxide nanoparticles in a solvent to form a suspension. The method further includes dipping a TiN-coated substrate in the suspension and removing to form a suspension-coated substrate. The method also involves drying the suspension-coated substrate by evaporating the solvent from the suspension-coated substrate to form a first sample. Furthermore, the method includes treating the first sample by microwave plasma under hydrogen flow at 500 degrees centigrade (° C.) to 700° C. to form a pre-treated sample followed by treating the pre-treated sample by microwave plasma under methane flow at 500° C. to 700° C. to form the vertically-aligned carbon nanotube bundles.

Disclosed herein are embodiments of a nanoparticle suitable for use in providing hyperthermia treatment. The nanoparticle may be a cubical bipyramid cobalt-doped iron oxide nanoparticle. Also disclosed are compositions comprising the nanoparticle. The composition may further comprise a polymer and / or a targeting moiety. Further disclosed and methods for making the nanoparticle and the composition, and embodiments of a method for using the nanoparticle or a composition thereof. The nanoparticle may be useful for treating cancer, endometriosis, or ectopic pregnancy.

The present application relates to the technical field of biological medicine, and particularly relates to a tumor microenvironment responsive iron overload hydrogel, a preparation method and application thereof. The hydrogel anchors deferoxamine conjugate in the hydrogel network through thiol-maleimide click chemistry, does not affect intracellular Fe 2+ The Fenton reaction process occurs, and the excreted Fe 3+ is specifically captured and locked, iron ion loss and systemic diffusion are effectively prevented, and a long-acting iron overload microenvironment is constructed locally in the tumor; iron oxide nanoparticles release Fe 2+ in response to a weak acid microenvironment, hydroxyl radicals are catalytically generated, and the effect of the iron death inducer on the antioxidant pathway is synergistic, effectively inducing tumor cell ferroptosis and overcoming treatment resistance; the hydrogel has excellent biocompatibility, blood compatibility and targeted tumor inhibition activity, inhibits the growth of solid tumors while reducing systemic toxic side effects, and thus realizes efficient and safe local treatment of tumors.

The application discloses a preparation method of a pressure-resistant high-flux polyvinylidene fluoride nanofiltration membrane, which comprises the following steps: preparation of a polyvinylidene fluoride ultrafiltration base membrane, preparation of a polyvinylidene fluoride and hydrophilic inorganic nanoparticle blended membrane, in-situ growth of hydroxyl iron oxide nanoparticles on the surface of the blended membrane and the like. The method can solve the technical problems of conventional commercial nanofiltration membranes, such as low flux, poor pressure resistance and easy peeling of a separation layer, expand the application field of fluorine-containing high polymer materials, and overcome the problem of poor pressure resistance of polyvinylidene fluoride and other fluorine-containing materials used in nanofiltration base membranes. The existence of inorganic nanoparticles overcomes the problem of poor pressure resistance of the polyvinylidene fluoride base membrane; the existence of the intermediate layer of the hydroxyl iron oxide nanoparticles makes the membrane exhibit excellent permeability and ensures the stable adhesion of the separation layer obtained through interfacial polymerization on the surface of the polyvinylidene fluoride membrane. The application provides a novel and reliable method for the preparation of the pressure-resistant high-flux polyvinylidene fluoride base nanofiltration membrane and provides an effective method for the application of the pressure-resistant high-flux polyvinylidene fluoride base nanofiltration membrane to different nanofiltration processes.

The application discloses a kind of photo-thermal regulation's anaerobic sclera crosslinking nano-composite material and its preparation method and application, for the technical bottleneck of lacking anaerobic crosslinking agent for the inhibition of myopia development of sclera collagen crosslinking technology, develop a kind of not dependent on oxygen, photo-thermal regulation's nano-composite crosslinking agent PHIONs-GQDs-AIBI nano system.Based on the good photo-thermal performance and synergistic effect of mesoporous iron oxide nanoparticles (PHIONs) and graphene quantum dots (GQDs), the near-infrared excitation light energy is efficiently converted into heat energy, and the heat energy is efficiently transmitted to the free radical initiator (AIBI) through the excellent thermal conductivity of GQDs. Make AIBI decompose to produce an anaerobic radical under high heat excitation, that is, alkyl radical, for the crosslinking of sclera collagen.