34 results about "Magnetic marker" patented technology

A point-of-care device and method for simultaneously and quantitatively assessing a magnetically-labelled analyte immobilised on a lateral flow test strip are provided. The method comprises the steps of sensing a magnetic signal from the magnetically-labelled analyte on the test strip and converting the magnetic signal into an electric signal; processing the electric signal to obtain a quantitative value of the amount of analyte; and processing the values to provide a differential assessment between the magnetically-labelled analyte. The device includes a magnetic reader with at least one magnetic sensor, such as a giant magnetoresistive sensor. The magnetic sensor can be directly or indirectly coupled to a lock-in amplifier configured to perform phase-sensitive detection and enhance the signal-to-noise ratio of weak magnetic signals. A system, microfluidics device, lateral flow immunoassay test strip and kit are also provided.

The invention provides a paramagnetic micro-nano magnetic particle magnetophoresis separation device and a paramagnetic micro-nano magnetic particle magnetophoresis separation method, and relates to the technical field of micro-nano magnetic particle separation and magnetic labeled biomolecule separation analysis. The separation device comprises a plurality of permanent magnets which have the same magnetism and the same size and are arranged above the separation channel at intervals in the direction of the separation channel, and a plurality of sets of mechanical structures which respectively drive each permanent magnet to move up and down in the vertical direction; the Hall sensor clings to the separation channel and is used for detecting the magnetic induction intensity at the separation channel; a liquid inlet device; a UV / Vis ultraviolet-visible light detector; a collection device and a computer. The magnetic induction intensity in the separation channel can be set, the critical diameter of the micro-nano magnetic particles capable of being captured by the magnetic field is determined, magnetophoresis separation of paramagnetic micro-nano magnetic particles is accurately achieved, the controllability of the magnetophoresis separation process is enhanced, and the separation effect of the micro-nano magnetic particles is improved.

The invention provides a drilling gas cut monitoring method and device based on a magnetic induction effect, and the method comprises the steps: pumping drilling fluid carrying magnetic particles marked by a magnetic marker into a shaft, and measuring the nearby magnetic field intensity through a magnetic signal induction short section arranged at the bottom of the shaft to obtain magnetic field data; and acquiring gas cut monitoring data according to the change condition of the magnetic field data in the preset period. Therefore, by monitoring the magnetic signal which responds to the gas cut very quickly, advanced early warning of the early trace gas cut is realized, and the response speed and sensitivity are superior to those of a sound wave or resistivity method; by actively introducing a magnetic marker and adopting a differential detection and temperature compensation algorithm, the problems that a resistivity method is greatly interfered by a stratum and a sound wave method is seriously influenced by well conditions and noise are effectively solved, the anti-interference capability is high, and the reliability is high.

A vehicle system (1S) is provided with: a sensor unit (1) which is provided with magnetic sensors (Cn) for detecting magnetic markers, and also a contactless displacement sensor (15) which measures displacement relative to the road surface where the magnetic marker is installed; a processing circuit which executes detection processing for detecting magnetic markers by performing processing on a magnetic measured value measured by multiple magnetic sensors (Cn); and a switching circuit (103) which switches detection processing depending on the displacement measured value measured by the contactless displacement sensor (15). It is possible to highly reliably detect magnetic markers by switching detection processing depending on the displacement measured value measured by the contactless displacement sensor (15).

Disclosed is a device and method for retrieving a magnetic marker implanted in an individual. The device includes an introducer having a tip. An obturator is disposed within the introducer. The obturator has a magnetic end. The obturator is operable such that the magnetic end is enclosed within the introducer in a first position and the magnetic end extends at least partially beyond the tip of the introducer in a second position. A method for removing a magnetic marker from a location within an individual includes inserting an introducer into an individual. The introducer has an obturator with a magnetic end. A magnetic marker is magnetically attracted using the obturator such that the magnetic marker attaches to the obturator. The obturator is retracted into the introducer such that the magnetic marker is at least partially within the introducer.

The invention discloses a double-phase composite structure magnetic core and a preparation method thereof, an orthogonal fluxgate probe, a magnetic sensing test system and a molecular test method. Taking a silver wire with the purity of 4N as a substrate, and depositing amorphous-phase CoP; and carrying out current heating annealing on the magnetic core to enable CoP to react with air to form partial crystallization. The orthogonal fluxgate probe comprises a U-shaped double-phase composite structure magnetic core, a voltage signal pickup coil, two glass tubes and a PCB (printed circuit board), and mutual conduction is avoided by penetrating different glass tubes. According to the magnetic sensing test system, a reaction channel chip is used for bearing a biological sample to be tested, a magnetic marker is contained in the biological sample to be tested, and a voltage signal picks up a coil magnetic field signal. The molecular test method comprises the steps of surface functionalization treatment, magnetic marker capture and signal detection, and concentration gradient detection and quantitative analysis. The probe and the system provided by the invention have the advantages of low noise, high sensitivity, good stability, controllable structure and the like, and realize single-particle-size magnetic bead detection and low-concentration biomolecule detection.

A catheter for an ultrasound system can a marker disposed on the hub. The marker is optically or magnetically readable and, when read, identifies the catheter. A drive unit can include an optical or magnetic marker reader. Alternatively or additionally, a catheter may include an active memory arrangement that can be read by an appropriate reader on the drive unit.

The present invention relates to methods for detecting target compounds in a sample quickly. A method for detecting one or more target compounds in a sample is provided. The method comprises mixing a sample with a solution that contains magnetic labels covered with one or more capturing probes; forming complexes of the one or more target compounds and the one or more corresponding capturing probes; washing the magnetic labels in a solution; applying a magnetic field to bring the magnetic labels in proximity with one or more detecting probes to form one or more super-complexes of detecting probe and corresponding existing complexes of capturing probe and target compound; isolating the super-complexes; and detecting the presence of the super-complexes.

The invention particularly relates to a track state holographic detection system based on magnetic sensing and a use method thereof. The track state holographic detection system comprises a magnetic sensing detection module and a magnetic marking module, the magnetic force sensing detection module comprises a sensing array adjusting mechanism, a closed-loop linear Hall sensing array, multi-channel sensors, a magnetic force detection module and a magnetic force detection module, wherein the tail end of the sensing array adjusting mechanism is symmetrically provided with sensor mounting seats along the two sides of a steel rail, and the sensing array adjusting mechanism moves in multiple directions; the multi-channel sensors are arranged on the sensor mounting seats, are distributed along the profile of the section of the steel rail and comprise a rail head area, a rail waist area and a rail bottom area; the sensor array adjusting mechanism adjusts the spatial position and posture of the sensor array through multi-directional movement. The magnetic marking module comprises a magnetic marking unit, the magnetic marking unit comprises permanent magnets arranged at the rail bottom of the rail and at the end of the sleeper, and the magnetic marking unit and the magnetic sensing detection module generate signal detection reaction. The method has the advantages that the multi-dimensional holographic detection capability of a track state monitoring system is improved, and the problem of magnetic interference in a complex environment is solved.

To provide a method for installing magnetic markers that can shorten the time the road surface needs to be closed during installation, allowing the road surface to be reopened sooner. [Solution] In the construction method for laying a sheet-shaped magnetic marker 1 on a road surface 53, the magnetic marker 1 is placed on the road surface 53 with an adhesive layer 21 made of modified silicone adhesive in between. Then, before the modified silicone adhesive forming the adhesive layer 21 hardens, a load is applied to the construction site 5A while restricting the position of the magnetic marker 1 on the road surface 53 to compact it and make the magnetic marker 1 adhere tightly to the road surface 53.

The application discloses a two-phase composite structure magnetic core and a preparation method thereof, a normal magnetic flux gate probe, a magnetic sensing test system and a molecular test method. The two-phase composite structure magnetic core comprises a silver wire with a purity of 4N as a substrate and amorphous CoP deposited on the substrate; current annealing is performed on the magnetic core to make the CoP react with air to form partial crystallization. The normal magnetic flux gate probe comprises a U-shaped two-phase composite structure magnetic core, a voltage signal pickup coil, two glass tubes and a PCB printed circuit board, and the two glass tubes are penetrated to avoid mutual conduction. The magnetic sensing test system uses a reaction channel chip to carry a biological sample to be tested, and the biological sample to be tested has a magnetic marker and a voltage signal pickup coil magnetic field signal. The molecular test method comprises surface functionalization treatment, magnetic marker capture and signal detection, concentration gradient detection and quantitative analysis. The probe and the system have the advantages of low noise, high sensitivity, good stability and controllable structure, and realize single particle level magnetic bead detection and low concentration biological molecule detection.

A vehicular system includes a measuring unit attached to a vehicle to detect a magnetic marker laid along a traveling road, a database storing position information of the magnetic marker, and a control unit that acquires the position information of the magnetic marker by referring to a storage area of the database. The database has stored therein position information of each magnetic marker to which a distance from a reference point on the traveling road as a starting point to each magnetic marker is linked. By referring to the database by using a distance traveled until the magnetic marker is detected after the vehicle passes over the reference point, position information of newly detected magnetic marker is acquired.

The present application relates to geological exploration technical field, specifically, it relates to a kind of with the precision positioning system and method of advanced detection abnormal body of excavation, it includes magnetic field fusion correction unit, for tunnel inside net magnetic field;Magnetic resonance detection unit is used to combine tunnel inside net magnetic field and detects the water content characteristics and porosity characteristics of target stratum position in front of excavation face;Bio-magnetic marker unit injects tracer to target stratum position and continuously monitors, when target stratum position reaches target tracer concentration, generates bio-magnetic signal;Magnetic anomaly positioning feedback unit outputs abnormal body center coordinates, while triggering early warning.The precision positioning system and method of advanced detection abnormal body of excavation, realize the high-precision, low false alarm rate positioning of abnormal body such as water-bearing structure, simultaneously through dynamic integral area adjustment and closed-loop feedback mechanism, significantly improve the real-time and reliability of advanced detection of excavation under complex geological conditions.

The invention provides an electrocardiogram detection method and device based on a magnetoresistive sensor. The electrocardiogram detection method based on the magnetoresistive sensor comprises the following steps: arranging a magnetic marker in a pre-cardiac region body surface preset region of a detected object; a magnetoresistive sensor array is arranged at a preset distance of a precardiac region of a measured object, and magnetoresistive sensor signals including ballistocardiogram signals and noise signals are collected in real time through magnetic field coupling between the magnetoresistive sensor array and a magnetic marker; preprocessing the magnetoresistive sensor signal, and extracting a ballistocardiogram signal from the preprocessed magnetoresistive sensor signal; and inputting the ballistocardiogram signal into the reconstruction model to output an electrocardiogram waveform. By collecting ballistocardiogram signals in real time and converting the ballistocardiogram signals into electrocardiogram signals through a model algorithm, the accuracy and stability of measurement are improved, and the method is suitable for early prevention and long-term monitoring of cardiovascular diseases.

Systems and methods of detecting magnetic markers for surgical guidance. Methods and systems of detecting magnetic markers to guide a surgeon to a region of interest during a surgical procedure include generating a driving magnetic field having a cyclic pattern comprising two or more consecutive time periods, the driving magnetic field having a substantially constant non-zero amplitude during each of the consecutive time periods, and the amplitude of the driving magnetic field during at least one of the time periods being different than the amplitude of the driving magnetic field during at least one other of the time periods; detecting a response magnetic field; selecting at least one signal from the sensed plurality of signals, wherein each signal corresponds to the response magnetic field detected during a respective one of the consecutive time periods of each cycle; using the selected at least one signal to determine a detection signal corresponding to the magnetic marker; and generating an output signal (e.g., an audio or display signal) based on the strength of the detection signal.

The present disclosure may be embodied as a probe for determining a position and pose of an anisotropic magnetic marker having a known size, shape, and magnetization. The probe has a substrate having a first side, a second side, a longitudinal axis, and a transverse axis. A first magnetic sensor is on the first side of the substrate. A second magnetic sensor is on the first side of the substrate and spaced apart from the first magnetic sensor along the longitudinal axis of the substrate and spaced apart from the first magnetic sensor along the transverse axis of the substrate. A third magnetic sensor is on the second side of the substrate. Each of the first magnetic sensor, the second magnetic sensor, and the third magnetic sensor is a multidimensional magnetic sensor. A processor is configured to determine a disposition of the magnetic marker in five degrees of freedom.

In a vehicle-oriented system (1) for providing information to a vehicle (5) side by using an information providing area (11) provided on a plane where a vehicle (5) moves, a magnetic distribution indicating the information by a plurality of N-pole magnetic markers (10N) is formed in the information providing area (11), and a sign (100) for identifying a position and orientation of the information providing area (11) is provided in the information providing area (11). Therefore, information can be provided by a magnetic method irrespective of a forwarding direction of the vehicle (5).

A method of detecting a magnetic marker includes generating a driving magnetic field including a first frequency and a second frequency, and detecting a response magnetic field including a first response component and a second response component. The magnetic marker provides a nonlinear response to the driving signal. A primary portion of the response component is generated by the magnetic marker, and a secondary portion of the response component is generated by a secondary magnetic source. The method includes determining a driving factor representing a ratio of the frequencies in the driving signal, determining a correction factor corresponding to the secondary portion of the second response component based on the first response component and the driving factor, determining a detection signal corresponding to the primary portion of the second response component based on the second response component and the determined correction factor, and generating an output signal based on an intensity of the detection signal.

The present disclosure provides a magnetoresistive sensor-based electrocardiogram detection method and device. The magnetoresistive sensor-based electrocardiogram detection method comprises: setting a magnetic marker on a predetermined region of the precordial region of the measured object; setting a magnetoresistive sensor array at a predetermined distance of the precordial region of the measured object, and collecting magnetoresistive sensor signals containing ballistocardiogram signals and noise signals in real time through the magnetic field coupling between the magnetoresistive sensor array and the magnetic marker; preprocessing the magnetoresistive sensor signals, and extracting the ballistocardiogram signals from the preprocessed magnetoresistive sensor signals; and inputting the ballistocardiogram signals into a reconstruction model to output electrocardiogram waveforms. The method of collecting ballistocardiogram signals in real time and converting the ballistocardiogram signals into electrocardiogram signals through a model algorithm improves the accuracy and stability of the measurement, and is suitable for early prevention and long-term monitoring of cardiovascular diseases.

A cell destruction method includes providing an anionic biomarker that comprises a magnetic material such as an iron or an iron compound. The anionic biomarker is introduced into an organism having pathogen cells with a negative charge. The anionic biomarkers are attracted to the negative charges of the pathogen and couple thereto. The anionic biomarker may also have a coupler portion that further aids in the anionic biomarker coupling to and being bound to the pathogen cell and / or cell wall. An electric field may be produced to cause the anionic biomarkers and / or the negative charges of the pathogen cell to polarize on or along the pathogen cell. A magnetic field is directed to cause the anionic biomarker, or magnetic material thereof to move and damage the cell. The magnetic field may be an alternating magnetic field that causes the magnetic material to oscillate and damage the cell wall.

A 3D input apparatus including a first object, a second object movable relative to the first object, and at least one sensor unit for detecting displacements and / or angular rotations of the objects relative to each other. Each sensor unit includes a magnetoresistive sensor, a magnetic field element, and a magnetic marker element. The magnetoresistive sensor and the magnetic field element of respectively one sensor unit are connected to one of the objects, and the marker element of said sensor unit is connected to the other object. For each sensor unit the magnetoresistive sensor of said sensor unit detects a magnetic field emitted by the magnetic field element of said sensor unit and influenced by the marker element of said sensor unit.

A magnetic marker for marking a site in tissue in the body. In one embodiment, the marker comprises a magnetic metallic glass. In another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 9. In yet another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 6. In yet another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 3.

A process for magnetically sorting biological objects includes the steps of applying a magnetic field generated by a magnetic assembly to a flexible conduit; flowing a sample fluid containing magnetically labeled biological objects through the flexible conduit to collect the magnetically labeled biological objects on a conduit wall; removing the magnetic field from the flexible conduit; and mechanically deforming the flexible conduit to loosen the magnetically labeled biological objects collected on the conduit wall.

The invention relates to the technical field of positioning and righting of underground oil pipes, in particular to a positioning and righting device and method for an underground oil pipe. The method comprises the following steps: firstly, acquiring a first magnetic signal when a cable connected with a centralizer passes through a first magnetic reader in a lowering process and a second magnetic signal when the cable passes through a second magnetic reader; and then the cable lowering speed at each moment is obtained, the lowering depth of the centralizer at each moment is obtained by further combining the total number of the second magnetic signals, and then the cable lowering speed is adjusted in real time until the centralizer is lowered to the preset target depth, and positioning and centralizing are stopped. According to the method, magnetic mark points are continuously marked in the cable descending process based on a magnetic mark measurement method so as to measure and calculate the descending depth, the cable descending speed is evaluated by means of the dislocation magnetic reading duration between different magnetic readers, the descending depth of the cable which is already descended but cannot be accurately measured by magnetic marks is complementarily calculated, a centralizer is accurately positioned, and the accuracy of cable descending is improved. Therefore, the positioning and righting accuracy of the underground oil pipe is improved.

Disclosed herein are joint implants and methods for intra-operatively detecting joint implant gap. A method for detecting a joint implant gap may include coupling a first implant to a first bone of a joint, coupling a second implant to a second bone of the joint, measuring an amplitude of a magnetic flux density using a magnetic sensor to determine a gap between the first and second implants. The first implant may include at least one magnetic marker. The second implant may be configured to contact the first implant. The second implant may include at least one magnetic sensor to detect the magnetic flux density of the magnetic marker. The gap between the first and second implant may be intra-operatively determined using the measured amplitude of the magnetic flux density.

The invention relates to the technical field of flatness detection, in particular to a building flatness detection system and technology. Each detection mechanism comprises a push frame and a pressure plate, a detection table is hinged to the inner wall of the push frame, a group of detection mechanisms are slidably connected to the inner wall of the detection table, and a group of pressure push rods are fixedly mounted between the opposite surfaces of the pressure plate and the detection table. A magnetic mark assembly matched with the pressure applying plate, a horizontally-arranged piston cylinder and a linkage assembly are installed in the detection frame, the inner wall of the piston cylinder is slidably connected with a piston seat, and a calibration rod and a guide rod are fixedly installed on the two side faces of the piston seat respectively. The universal steel ball cleaning device has the beneficial effects that when the universal steel ball cleaning device works, the soft bristles can perform physical brushing on a to-be-detected area, and the influence of impurities on the surface of the detected area on the universal steel ball is effectively avoided by realizing the gas cleaning and physical brushing effects, so that the detection precision of the universal steel ball cleaning device is improved in an auxiliary manner.

The application is a track state holographic detection system based on magnetic force sensing and a method thereof, comprising a magnetic force sensing detection module and a magnetic marker module; the magnetic force sensing detection module comprises a sensing array adjusting mechanism, a sensor mounting seat symmetrically arranged at the two sides of the end of the steel rail and capable of moving in multiple directions, a closed-loop linear Hall sensing array arranged on the sensor mounting seat and distributed along the sectional profile of the steel rail, and a multi-channel sensor including a rail head area, a rail waist area and a rail bottom area, the sensing array adjusting mechanism adjusting the spatial position and attitude of the sensor array by moving in multiple directions; the magnetic marker module comprises a magnetic marker unit including a permanent magnet arranged at the rail bottom and the sleeper end of the track, and the magnetic marker unit and the magnetic force sensing detection module have a signal detection reaction; the application has the advantages of improving the multi-dimensional holographic detection capability of the track state monitoring system and solving the magnetic interference problem in complex environments.

A vehicle system includes a sensor unit including magnetic sensors for detecting a magnetic marker and non-contact displacement sensors which measure a displacement relative to a road surface where the magnetic marker is laid, a processing circuit which performs detection process for detecting the magnetic marker by processing a magnetic measurement value by the plurality of magnetic sensors, and a switching circuit which switches the detection process in accordance with displacement measurement values by the non-contact displacement sensors. By switching the detection process in accordance with the displacement measurement values by the non-contact displacement sensors, the magnetic marker can be detected with high reliability.