99 results about "Magnetic marker" patented technology

An implantable marker for imaging and surgical guidance by susceptometry comprising one or more pieces of a ferromagnetic material having a total length to diameter ratio of at least about 500, and a total volume of less than about 1×10−11 m3. The one or more pieces of ferromagnetic material may have a high initial relative permeability (μr,i)>about 1000. Also disclosed is a detection system for locating an implantable marker comprising such an implantable marker; at least one drive coil arranged to excite the marker with an alternating magnetic field, and at least one sense coil arranged to detect a signal received from the excited marker; a magnetic field generator arranged to drive an alternating magnetic field through the at least drive coil; and at least one detector arranged to receive the signal from the sense coil and detect one or more harmonics of the drive frequency in the received signal.

The invention provides a liquid leakage detection method and device for a liquid cooling device, and the method comprises the steps: obtaining the fluorescence intensity and magnetic field gradient of a surface detection region of the liquid cooling device; wherein the cooling liquid of the liquid cooling device contains a fluorescent marker and a magnetic marker; based on the fluorescence intensity and the magnetic field gradient, determining whether a liquid leakage risk exists in the detection area; in response to the liquid leakage risk of the detection area, obtaining the liquid leakage probability of each grid position of the detection area based on the fluorescence intensity and the magnetic field gradient; and determining a target grid position where liquid leakage occurs in the detection area based on the liquid leakage probability. According to the technical scheme of the invention, the detection precision and detection efficiency of liquid leakage of the liquid cooling device can be improved.

A driving assistance system and method is provided that includes a plurality of magnetic markers having a magnet component configured to generate a magnetic field on a road surface, together with a pavement marking material that includes a RFID tag that is readable by a RFID tag reader. The pavement marking material includes encoded information that is conveyed to a vehicle's on-board sensing system that is adapted to obtain data through wireless communications. The magnetic markers are conformable, polymeric materials having viscoelastic properties such that vehicles having magnetic sensors can detect magnetic fields from the magnetic markers when positioned on a road surface.

A method and apparatus for preparing tissue of interest in a patient for possible excision by surgery. In one embodiment, the method comprises the steps of: removing a biopsy sample from the tissue of interest; placing a magnetic marker at the biopsy site; performing a pathology analysis of the biopsy sample; and if the pathology analysis indicates that the tissue of interest should be removed, locating the tissue for surgery using a magnetic detection probe. In one embodiment, the marker comprises magnetic nanoparticles in a bioabsorbable matrix. A system for preparing tissue of interest in a patient for possible excision by surgery. In one embodiment, the system includes a magnetic marker and magnetic detection probe system.

A driving assistance system and method is provided that includes a plurality of magnetic markers having a magnet component configured to generate a magnetic field on a road surface, together with a pavement marking material that includes a RFID tag that is readable by a RFID tag reader. The pavement marking material includes encoded information that is conveyed to a vehicle's on-board sensing system that is adapted to obtain data through wireless communications. The magnetic markers are conformable, polymeric materials having viscoelastic properties such that vehicles having magnetic sensors can detect magnetic fields from the magnetic markers when positioned on a road surface.

A supplemental tool for installation that can achieve both high magnetic-marker installation efficiency and high magnetic-marker installation accuracy is provided. A supplemental tool for arranging a magnetic marker in an accommodation hole provided by being drilled in a road surface includes a columnar-shaped retaining member including a retaining surface for the magnetic marker at an end portion in an axial direction and a detaching member combined with the retaining member so as to be able to move to the axial direction as opposed to the retaining member. A combination of the retaining member and the detaching member is such that detaching member can abut on the magnetic marker retained on the retaining surface, and it is configured so that the retaining member can retreat in the axial direction to a side away from the magnetic marker keeping a state in which the detaching member abuts on the magnetic marker.

A point-of-care device and method for simultaneously and quantitatively assessing a magnetically-labelled analyte immobilised on a lateral flow test strip are provided. The method comprises the steps of sensing a magnetic signal from the magnetically-labelled analyte on the test strip and converting the magnetic signal into an electric signal; processing the electric signal to obtain a quantitative value of the amount of analyte; and processing the values to provide a differential assessment between the magnetically-labelled analyte. The device includes a magnetic reader with at least one magnetic sensor, such as a giant magnetoresistive sensor. The magnetic sensor can be directly or indirectly coupled to a lock-in amplifier configured to perform phase-sensitive detection and enhance the signal-to-noise ratio of weak magnetic signals. A system, microfluidics device, lateral flow immunoassay test strip and kit are also provided.

Methods and systems for detecting a magnetic marker for guiding a surgeon to a region of interest during a surgical procedure comprising generating a driving magnetic field having a cyclic pattern comprising two or more successive periods of time, the driving magnetic field having a substantially constant, non-zero amplitude during each of the successive periods of time, and the amplitude of the driving magnetic field during at least one of the periods of time being different from the amplitude of the driving magnetic field during at least one other of the periods of time; detecting a response magnetic field; selecting at least one signal from a plurality of sensed signals, each of which corresponds to the response magnetic field detected during a respective one of the successive periods of time of each cycle; determining a detection signal corresponding to the magnetic marker using the at least one selected signal; and generating an output signal (e.g. an audio or display signal) based on a strength of the detection signal.

A magnetic marker is embedded in a road, and is configured to be detected by a magnetic sensor provided in a vehicle. The magnetic marker is provided with a case accommodating a magnet and a protective material covering the magnet, and an anchor that is provided protruding downward from the case and that is configured to expand in diameter in a state of being embedded in the road.

A vehicular system has a database of position data of discrete points on a route, a first positioning circuit that measures an own vehicle position by using the magnetic markers, a second positioning circuit that measures the own vehicle position by autonomous navigation, and a control circuit that controls the vehicle by taking a deviation of the own vehicle position with respect to the route as a control target. In the database, marker position data with reference to any discrete point is recorded as linked to position data. The first positioning circuit identifies the detected magnetic marker by referring to the database. The control circuit identifies the deviation of the own vehicle position with respect to the route by referring to the database.

The invention provides an ultrasonic detection imaging method, system and device and a medium. The method comprises the steps that magnetic markers are arranged in an ultrasonic probe and in a target area; performing magnetic positioning on the ultrasonic probe, and tracking spatial information of the ultrasonic probe in real time; based on magnetic control, controlling the ultrasonic probe to carry out multi-angle shooting in the target area so as to obtain three-dimensional ultrasonic image data of the target area; synchronizing the space information of the ultrasonic probe with the ultrasonic image data, and performing real-time linkage on the contrast image and the ultrasonic image data to generate an ultrasonic fusion image; acquiring focus ultrasonic fusion information in the target area based on the ultrasonic fusion image; and performing PSA detection on the lesion ultrasonic fusion information, and determining a lesion treatment range based on a PSA detection result. The clinical application value of surgical ultrasonic imaging can be improved, and more accurate and safer diagnosis and treatment schemes are provided for patients.

A probe for locating a magnetic marker for use in surgery. The probe comprises at least two first coils (3a, 3b) and at least one second coil (5) which are arranged substantially coaxially on a longitudinal axis of the probe for measuring the proximity of a magnetic marker to the probe, and a baseline voltage taring device (7) comprising a first elongate conductor which defines a conducting path extending partially around the probe axis. The conducting path is configured and arranged such that in use the balancing magnetic field induces a balancing voltage in a sense coil that at least partially offsets the baseline voltage. Also disclosed is a method of manufacturing such a probe, a method of setting up such a probe for use in sensing a magnetic marker, and detection apparatus for locating a magnetic marker during surgery.

A method for detecting a magnetic marker comprises generating a driving magnetic field comprising first and second frequencies and detecting a response magnetic field comprising first and second response components. The magnetic marker provides a non-linear response to the driving signal. A primary portion of the response components is generated by the magnetic marker, and a secondary portion of the response components is generated by a secondary magnetic source. The method comprises determining a driving factor representing a ratio of the frequencies in the driving signal; determining a correction factor corresponding to the secondary portion of the second response component, based on the first response component and the driving factor; determining a detection signal corresponding to the primary portion of the second response component, based on the second response component and the determined correction factor; and generating an output signal based on a strength of the detection signal.

The invention provides a paramagnetic micro-nano magnetic particle magnetophoresis separation device and a paramagnetic micro-nano magnetic particle magnetophoresis separation method, and relates to the technical field of micro-nano magnetic particle separation and magnetic labeled biomolecule separation analysis. The separation device comprises a plurality of permanent magnets which have the same magnetism and the same size and are arranged above the separation channel at intervals in the direction of the separation channel, and a plurality of sets of mechanical structures which respectively drive each permanent magnet to move up and down in the vertical direction; the Hall sensor clings to the separation channel and is used for detecting the magnetic induction intensity at the separation channel; a liquid inlet device; a UV / Vis ultraviolet-visible light detector; a collection device and a computer. The magnetic induction intensity in the separation channel can be set, the critical diameter of the micro-nano magnetic particles capable of being captured by the magnetic field is determined, magnetophoresis separation of paramagnetic micro-nano magnetic particles is accurately achieved, the controllability of the magnetophoresis separation process is enhanced, and the separation effect of the micro-nano magnetic particles is improved.

The invention provides a drilling gas cut monitoring method and device based on a magnetic induction effect, and the method comprises the steps: pumping drilling fluid carrying magnetic particles marked by a magnetic marker into a shaft, and measuring the nearby magnetic field intensity through a magnetic signal induction short section arranged at the bottom of the shaft to obtain magnetic field data; and acquiring gas cut monitoring data according to the change condition of the magnetic field data in the preset period. Therefore, by monitoring the magnetic signal which responds to the gas cut very quickly, advanced early warning of the early trace gas cut is realized, and the response speed and sensitivity are superior to those of a sound wave or resistivity method; by actively introducing a magnetic marker and adopting a differential detection and temperature compensation algorithm, the problems that a resistivity method is greatly interfered by a stratum and a sound wave method is seriously influenced by well conditions and noise are effectively solved, the anti-interference capability is high, and the reliability is high.

The invention discloses an energy-releasing anchor rod extension displacement automatic measurement system based on magnetic mark positioning, and relates to the technical field of tunnel engineering supporting. A separated magnetic mark array is integrated on a damping cylinder in the energy-releasing anchor rod extension displacement automatic measuring system, and a magnetic field induction sensing head is integrated on a damping block. The separated magnetic mark array comprises a plurality of separated magnetic mark units which are arranged at equal intervals in the axial direction of the damping cylinder; the magnetic field induction sensing head is used for sweeping the separated array along with the damping block and generating a characteristic electric signal for indicating the scanned magnetic marking unit by sensing a magnetic field peak value or a magnetic field characteristic change generated by the magnetic marking unit, so that the number of the scanned units is determined according to the characteristic electric signal; and the extension displacement of the energy-releasing anchor rod is calculated according to the number and the arrangement distance, so that the relative displacement of the damping block and the damping cylinder in the energy-releasing anchor rod covered by the sprayed concrete can be accurately and reliably measured, an observation channel does not need to be reserved, and the method has the characteristic of low cost.

The embodiment of the invention relates to the technical field of positioning and navigation, and discloses a mileage correction method, device and equipment and a medium, and the mileage correction method comprises the following steps: reading a standard mileage value of an RFID tag installed on a driving path based on an RFID reader-writer, and meanwhile, obtaining an actual mileage value of mobile equipment on the driving path at present, scanning a magnetic marker mounted on the driving path based on a multi-channel magnetic sensor to obtain a plurality of magnetic signals; the position of the magnetic marker is the same as that of the RFID tag; calculating a mileage correction point according to the plurality of magnetic signals; the mileage correction point is a mileage correction position set on the driving path; judging whether a mileage error exists based on the actual mileage value and the mileage correction point; and if the mileage error exists, correcting the subsequent mileage of the mobile equipment based on the standard mileage value and the actual mileage value. According to the mileage correction method disclosed by the invention, high-precision and low-cost mileage correction in a complex environment is realized.

A vehicle system (1S) is provided with: a sensor unit (1) which is provided with magnetic sensors (Cn) for detecting magnetic markers, and also a contactless displacement sensor (15) which measures displacement relative to the road surface where the magnetic marker is installed; a processing circuit which executes detection processing for detecting magnetic markers by performing processing on a magnetic measured value measured by multiple magnetic sensors (Cn); and a switching circuit (103) which switches detection processing depending on the displacement measured value measured by the contactless displacement sensor (15). It is possible to highly reliably detect magnetic markers by switching detection processing depending on the displacement measured value measured by the contactless displacement sensor (15).

Disclosed is a device and method for retrieving a magnetic marker implanted in an individual. The device includes an introducer having a tip. An obturator is disposed within the introducer. The obturator has a magnetic end. The obturator is operable such that the magnetic end is enclosed within the introducer in a first position and the magnetic end extends at least partially beyond the tip of the introducer in a second position. A method for removing a magnetic marker from a location within an individual includes inserting an introducer into an individual. The introducer has an obturator with a magnetic end. A magnetic marker is magnetically attracted using the obturator such that the magnetic marker attaches to the obturator. The obturator is retracted into the introducer such that the magnetic marker is at least partially within the introducer.

This invention provides a CT and SERF-based magnetic resonance imaging (MRI) registration system and method, including a MRI registration module and a CT registration module. The MRI registration module includes a multi-turn circular positioning coil and an adjustable patch limiting device; the positioning coil can be fixed to a protrusion of the limiting device. The CT registration module includes a non-magnetic marker with an appearance consistent with the arc-shaped reference object of the MRI registration module. CT scans acquire the image structure of the human torso, perform segmentation and 3D reconstruction; the relative positional relationship between the human body and the magnetometer can be obtained based on the positioning coil. The arc-shaped reference objects of the MRI registration module and the CT registration module are registered using a nearest neighbor algorithm, thereby completing the conversion between the CT coordinate system and the magnetometer coordinate system. This system is unaffected by human respiration, improving registration accuracy, making MRI equipment more complete, and advancing subsequent 3D imaging applications.

The invention discloses a double-phase composite structure magnetic core and a preparation method thereof, an orthogonal fluxgate probe, a magnetic sensing test system and a molecular test method. Taking a silver wire with the purity of 4N as a substrate, and depositing amorphous-phase CoP; and carrying out current heating annealing on the magnetic core to enable CoP to react with air to form partial crystallization. The orthogonal fluxgate probe comprises a U-shaped double-phase composite structure magnetic core, a voltage signal pickup coil, two glass tubes and a PCB (printed circuit board), and mutual conduction is avoided by penetrating different glass tubes. According to the magnetic sensing test system, a reaction channel chip is used for bearing a biological sample to be tested, a magnetic marker is contained in the biological sample to be tested, and a voltage signal picks up a coil magnetic field signal. The molecular test method comprises the steps of surface functionalization treatment, magnetic marker capture and signal detection, and concentration gradient detection and quantitative analysis. The probe and the system provided by the invention have the advantages of low noise, high sensitivity, good stability, controllable structure and the like, and realize single-particle-size magnetic bead detection and low-concentration biomolecule detection.

The invention discloses a reconfigurable magnetic mark tracking system and method for structural deformation monitoring, and relates to the technical field of engineering structural deformation monitoring. The system comprises a magnetic marking module which is used for providing displacement information generated by a to-be-monitored structure marking point in a deformation process; the magnetic sensing array module is used for recording a real-time magnetic field signal in a target area during a monitoring period through a magnetic sensing array; and the magnetic particle mark coordinate inversion module is used for analyzing the acquired magnetic field signals based on the space coordinates of the magnetic sensing array by using a no-load calibration magnetic particle mark coordinate inversion method, and calculating to obtain the three-dimensional coordinate change of the magnetic particle mark of the to-be-monitored structure in the monitoring period. According to the invention, a reconfigurable magnetic sensor array is designed by adopting a strip-shaped modular extension architecture, and long-term monitoring of structural deformation can be realized in combination with a no-load calibration magnetic particle marking coordinate inversion method, so that the method is particularly suitable for real-time monitoring of structural deformation under the conditions of high temperature, high pressure, invisible environment and the like.

A detection system (1) whereby a vehicle, which comprises a sensor array (11) having magnetic sensors arranged in the width direction, detects a magnetic marker disposed on a travel route. The detection system includes: a differential circuit (121) that obtains the difference between magnetic measurement values for each combination of two separated magnetic sensors that are separated by a prescribed interval; an arithmetic circuit (123) that executes processing for detecting the position of a magnetic marker by processing the difference for each combination; and a settings circuit (125) that selectively sets a prescribed interval for obtaining the magnetic measurement value differences. Magnetic markers arranged on a travel route can be detected with high reliability, regardless of differences in installation height of the magnetic sensors on the vehicle side.

A catheter for an ultrasound system can a marker disposed on the hub. The marker is optically or magnetically readable and, when read, identifies the catheter. A drive unit can include an optical or magnetic marker reader. Alternatively or additionally, a catheter may include an active memory arrangement that can be read by an appropriate reader on the drive unit.

The invention relates to a microfluidic device. Said device has at least one magnetic marker, which is designed to bind to surface proteins of cells (30, 31), at least one mixing region, which is designed to bring the at least one magnetic marker into contact with the cells (30, 31), and at least one separating region (14), into which the cells (30, 31) can be introduced and which has at least one magnet (15), preferably on an upper side (16). A method for separating cells by means of the microfluidic device comprises bringing cells (30, 31) into contact with at least one magnetic marker in the mixing region, sedimenting the cells (30, 31) in the separating region (14), applying a magnetic field in the separating region (14), and discharging cells (31) marked with the marker from the separating region by means of a fluid flow (61).

A probe for locating magnetic markers used in surgery. The probe includes: at least two first coils (3a, 3b) and at least one second coil (5), which are arranged substantially coaxially on the longitudinal axis of the probe for measuring the proximity of the magnetic marker to the probe; and a reference voltage balancing device (7) comprising a first elongated conductor defining a conductive path extending partially around the probe axis. The conductive path is configured and arranged such that, in use, a balancing magnetic field induces a balancing voltage in the sensing coil that at least partially cancels out the reference voltage. Methods for manufacturing such a probe, methods for setting such a probe for sensing magnetic markers, and detection devices for locating magnetic markers during surgery are also disclosed.

The present invention relates to methods for detecting target compounds in a sample quickly. A method for detecting one or more target compounds in a sample is provided. The method comprises mixing a sample with a solution that contains magnetic labels covered with one or more capturing probes; forming complexes of the one or more target compounds and the one or more corresponding capturing probes; washing the magnetic labels in a solution; applying a magnetic field to bring the magnetic labels in proximity with one or more detecting probes to form one or more super-complexes of detecting probe and corresponding existing complexes of capturing probe and target compound; isolating the super-complexes; and detecting the presence of the super-complexes.

Provided is an orally administered substance provided with a magnetic marker that can be detected easily by a magnetic sensor even with a small amount applied. The orally administered substance contains a composition for oral administration and a magnetic marker provided on the composition for oral administration. The magnetic marker contains a magnetic powder and a binder and has a squareness ratio of 0.40 or more.

The invention relates to a microfluidic device. Said device has at least one magnetic marker, which is designed to bind to surface proteins of cells (30, 31), at least one mixing region, which is designed to bring the at least one magnetic marker into contact with the cells (30, 31), and at least one separating region (14), into which the cells (30, 31) can be introduced and which has at least one magnet (15), preferably on an upper side (16). A method for separating cells by means of the microfluidic device comprises bringing cells (30, 31) into contact with at least one magnetic marker in the mixing region, sedimenting the cells (30, 31) in the separating region (14), applying a magnetic field in the separating region (14), and discharging cells (31) marked with the marker from the separating region by means of a fluid flow (61).