171 results about "Contrast effect" patented technology

Performing image diagnosis in an easier and more appropriate manner by focusing on functional levels and segments of a liver. A segment function level calculation unit obtains, from liver function angiographic images obtained using a contrast agent that produces a contrast effect according to a functional level of a liver of diagnostic target, evaluation values representing functional levels of a plurality of liver segments in liver regions, a display image generation unit generates an image based on the evaluation values, and the image so generated is displayed on a display unit.

Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T₂ contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe₃O₄ nanoparticles having an interior space.

The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.

The invention discloses a load small interfering RNA (siRNA) nanoscale lipid microbubble ultrasonic contrast agent and a preparation method. The load siRNA lipid microbubble is formed by preparing DPPC (Dipalmitoyl Phosphatidyl Choline), DSPE (1, 2-distearoyl-sn-glycero-3-phosphoethanolamine) and DPPA (Diphenyl Phosphoryl Azide) into microbubbles (containing octafluoropropane) according to the weight part ratio of 18:1:1 and then assembling together with PEG-PLL (Polyethylene Glycol-Polylysne)-coated siRNA nanomicelle. The load siRNA nanoscale lipid is nanosclae, has an obvious ultrasonic contrast effect, and can generate obvious siRNA cell transfection efficiency under low-frequency ultrasonic irradiation, thereby further hopefully having important research values and application prospects in the fields of ultrasonic diagnosis and gene treatment.

The invention relates to a skin-touch polishing treatment agent for synthetic leather. The skin-touch polishing treatment agent consists of modified polyurethane resin, cyclohexanone, dimethylbenzene, butyl acetate, silica matting agent, amino-silicone oil and castor oil. The invention also relates to a method for preparing the skin-touch polishing treatment agent for the synthetic leather. Compared with the conventional common treatment agent for the synthetic leathe, the skin-touch polishing treatment agent for the synthetic leather has the advantages of extremely high haze and blackness and unique skin-touch handfeel; trenches are formed on the surface, and mist is formed at the bottom; the top layer is bright; the leather surface bright mist contrast effect is unique; and the leather made by the treatment agent is glossy, natural, clear in color, smooth in handfeel, high in real leather effect and good in comprehensive effect.

The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.

The invention discloses a pointing sand process of bullion jewelry, comprising pouring wax-drawing powder-roasting mold-reversing mold-holding mold-grinding-blowing sand-pointing sand-milling-shaping. The process combines with two technique of engraving and nailing sand. The product is subjected to nailing sand (pointing sand) using the surface density (fineness) of the diamond needle, therefore the contrast effect of the product is enhanced with more nicety and higher efficiency and the surface gloss of the product is very light and beautiful.

In order to provide an X-ray CT apparatus and a contrast enhanced scanning method that can obtain an image having a favorable contrast effect without re-injecting contrast medium even when a scanning position overtakes a position of the contrast medium during scanning using the contrast medium, the X-ray CT apparatus determines whether or not a current scanning position overtakes the contrast medium during main scanning, resets a scanning condition when overtaking the contrast medium, executes re-scanning under the reset scanning condition, and determines overtaking of the contrast medium based on differential data between measurement data acquired by non-contrast enhanced scanning to be performed before the main scanning and measurement data to be acquired by the main scanning. Hence, no image needs to be reconstructed during scanning to check whether or not there is a contrast effect, and the overtaking determination is performed at a high speed, which can swiftly shift to re-scanning.

The invention discloses a method for realizing two colors and two kinds of luster, a plastic casing and a terminal. The method comprises the following steps: electroplating so as to form a first non-conducting coating film layer, wherein the first non-conducting coating film layer is formed on a base material; performing laser etching on a part of regions of the first non-conducting coating film layer so as to form a first laser etching region, wherein the first laser etching region runs through the first non-conducting coating film layer; after the step of laser etching, spraying UV(ultra violet) surface paint so as to form a UV surface paint layer; performing laser etching on a part of regions of the UV surface paint layer so as to form a second laser etching region; not performing spraying or covering on the UV surface paint layer. Through the use of the method, two colors of the surface of the plastic casing of the terminal disclosed by the invention can be realized, a sharp contrast effect of a mill surface and a matt surface can be realized, and the texture of the plastic casing is better.

The invention discloses a CT imaging contrast agent and a preparation method thereof, relating to a contrast agent and providing a CT imaging contrast agent with higher chemical stability, better CT contrast effect and biocompatibility and controllable grains and a preparation method thereof. The CT imaging contrast agent contains nano gold and iohexol and is structurally characterized in that nano gold grains are cores, and the iohexol are packed on the peripheries of the nano gold grains. The preparation method comprises the following steps of: dissolving an iohexol solution in hyperpure water to prepare an iohexol solution the iohexol concentration of which is 1.2-6mg I/ml; adding a chloroauric acid solution in the iohexol solution to prepare a reaction precursor solution the chloroauric acid concentration of which is 0.2-2mM; pouring the reaction precursor solution into an agitated reactor for reaction, and cooling reaction system to the room temperature; and centrifuging the cooled system to enable the synthetized nano gold grains to be separated from the surplus iohexol in the solution and then cleaning to obtain the CT imaging contrast agent.

The present invention relates to a magnetic resonance imaging (MRI) contrast agent, particularly a metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent that can be used not only as a T1 MRI contrast agent but also as a T2 MRI contrast agent, and a method for producing the same. The metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent can provide more accurate and detailed information associated with disease than single MRI contrast agent by the beneficial contrast effects in both T1 imaging with high tissue resolution and T2 imaging with high feasibility on detection of a lesion.

The invention discloses a butt joint forgery prevention method based on the Moire pattern mechanism. The method comprises the following steps of establishing a background color block, separating a green C passage, a magenta M passage, a yellow Y passage and a black K passage, and respectively processing the four passages by use of a user-defined net setting function, wherein the net point is round; manufacturing a hidden pattern which has the same size and resolution ratio with the background color block; partitioning the hidden pattern into two hidden pattern layers; respectively embedding the two partitioned hidden pattern layers into a green version and a magenta version, and combining the four passages, thereby finally forming a digital pattern containing hidden information; manufacturing a matched butt joint grating; and superposing the manufactured butt joint grating on the digital pattern and extracting the hidden information. According to the method, a contrast effect is generated during hidden information extraction, so that the definition of the hidden information extraction is obviously improved.

The invention relates to an intestinal-tract targeted magnetic resonance contrast agent based on mesoporous silica and a preparation method thereof. The method takes mesoporous silica as a medium, mesoporous silica pore passages are loaded with gadolinium oxide nanoparticles, then the loaded mesoporous silica surface is coated with chitosan molecules, the intestinal-tract targeted contrast agent is prepared, and intestinal-tract targeted imaging is realized. The contrast agent takes mesoporous silica as the medium, and can regulate and control the content of gadolinium oxide, so as to realize different intensities of contrast effects; and at the same time, the mesoporous silica surface is coated with the chitosan, so that the contrast agent is allowed to have a targeting effect on intestinal tracts. The prepared contrast agent has the characteristics of stable performance, good biocompatibility, and adjustable magnetic resonance signals. The obtained product can meet the demand of clinical application. The preparation method is simple in process and strong in operability, and can further meet production and application.

The invention relates to a manufacturing method of bicolor wax-texture crack split leather and belongs to the technical field of leather. The manufacturing method of the bicolor wax-texture crack split leather comprises the following steps that processed and dyed split leather is obtained, dried, ground, milled, sprayed for the first time, roll-finished, sprayed for the second time, vibration-softened, rolled with oil wax and milled in sequence, and thus the bicolor wax-texture crack split leather is obtained. According to the manufacturing method of the bicolor wax-texture crack split leather, the processed and dyed split leather is dried, ground, milled, sprayed for the first time, roll-finished, sprayed for the second time, vibration-softened, rolled with the oil wax and milled, and the technological conditions of the steps and the chemical therapy ratio are strictly controlled and optimized, so that the low-level split leather is manufactured into the high-level crack leather with the wax texture, and the crack leather further has the strong bicolor contrast effect.

The invention discloses a dry-skid charred bright finishing agent for synthetic leather, which comprises the following components in parts by weight: 50-75 parts of resin, 20-30 parts of ethyl acetate, 20-30 parts of isopropanol, 1-3 parts of silicon dioxide delustering powder, 1-4 parts of modified siloxane, 1-3 parts of flatting agent and 1-3 parts of water-sprinkling agent. The invention also discloses a preparation method of the dry-skid charred bright finishing agent for the synthetic leather. The components of the dry-skid charred bright finishing agent for synthetic leather cooperate to perform combined actions, and thus, the dry-skid charred bright finishing agent has favorable matting effect and unique skid wax sensation; after lustre finishing, the surface has charred brightness, and the leather face has favorable bright matting contrast effect; and the preparation method is easy to realize and is suitable for industrial production.

The invention discloses a fluorine salt test system and a method based on a molten salt rector passive residual heat removal system. The fluorine salt test system comprises an argon gas assist systemformed of a argon gas bottle, a buffer tank, a argon gas pipe and a valve on the pipe, a storage tank used for storing fluorine salt for a long time, a simulated core tank used for simulating the relative position of the molten salt rector core, a heat pipe can with the quick heat radiation effect, a contrast tank used for playing a contrast effect on the heat pipe can and a fluorine salt pipe system connecting fluorine salt pipes of fluorine salt tank with the valve. The invention also provides the test method of the test system, which comprises the following steps: heating the fluorine saltin the storage tank into liquid state, entering the simulated core tank through the fluorine salt pipe under the pressure difference of the argon gas, flowing into the contrast tank or the heat pipe can to perform test under the action of the gravity, and finally flowing back to the storage tank along the fluorine salt pipes. The fluorine salt test system provided by the invention can bear high-temperature work condition, the test process operation is simple and the system loop is safe and reliable.

The invention relates to a preparation method of a targeted CT (computed tomography) contrast agent of a second generation polyamide-amine dendrimer stabilized gold nanoparticle based on folate modification, which comprises the following steps: preparing a gold nanoparticle under water bath conditions by using an amino-terminal second generation polyamide-amine dendrimer as a stabilizer; dialyzing, performing drying treatment, then modifying covalent bonds on amino groups of the dendrimer on the surface of the nanoparticle with targeted reagent folate, and subsequently performing full acetylation treatment on the residual amino groups on the surface of the dendrimer; dialyzing the solution subjected to the reaction, and performing freeze-drying treatment to obtain the final product; and evaluating the in-vitro and in-vivo CT contrast performance of the product. According to the invention, the cost of raw materials is relatively low; the preparation process is mild; the preparation method is simple and easy to implement; and the prepared folate-modified dendrimer stabilized gold nanoparticle has favorable stability, water solution dispersity and biocompatibility and reinforced targeted tumor CT contrast effect, thereby having potential targeted CT contrast application prospects.

The invention discloses a color-variable additive composition. The color-variable additive composition comprises the following components in parts by weight: 5.0-40.0 parts of a mixture, 0.2-10.0 parts of a compatibilizer and 50.0-94.8 parts of a carrier polymer, wherein the mixture comprises the following components in parts by weight: 60.0-85.0 parts of metal powder and 10.0-39.9 parts of a thermoplastic polymer. According to a novel color-variable additive composition, only one laser photosensitizer can be used for greatly improving the contrast effect of the color difference between a mark and a base material; particularly, dipentaerythritol phosphate and methyl ethyl phosphonic acid zinc are added and used as accelerants, and the contrast effect of the color difference is more obvious; meanwhile, the invention also provides a method for preparing the color-variable additive composition. The method is simple and convenient, easy to operate and high in product quality.

The invention discloses a hyaluronic acid-modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere ultrasonic contrast agent and a preparation method thereof. The hyaluronic acid modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere ultrasonic contrast agent prepared through an emulsification-silicon precipitation method has the particle size of approximately 274.5nm; the passive targeting can be realized through an EPR (Electron Paramagnetic Resonance) effect of a tumor site. Meanwhile, modifying hyaluronic acid can be also used for realizing the active targeting on a tumor cell; thus, the toxic and side effects of a preparation can be decreased; the curative effect of a drug is enhanced. On the other hand, compared with a phospholipid liquid fluorocarbon nanosphere, a hyaluronic acid modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere prepared by the method has favorable stability and a lasting ultrasonic contrast effect. The hyaluronic acid modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere ultrasonic contrast agent has the advantages of simple and convenient process, good biocompatibility of used materials, no use of a toxic surfactant, and wide application prospect.

The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (105) the substrate with hydrogen gas (H₂) enriched in para-hydrogen (p-¹H₂) to form a hydrogenated contrast agent and exposing (110: 705) the contrast agent to a magnetic field cycling profile adapted for enhancing the contrasting effects of the contrast agent. The magnetic field cycling profile comprises an initial decrease of the magnetic field followed by at least one increase of the magnetic field, which increase should be arranged as to give a non-adiabatic (diabatic) remagnetisation of the contrast agent.