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Intestinal-tract targeted magnetic resonance contrast agent based on mesoporous silica and preparation method thereof

A technology of mesoporous silica and magnetic resonance contrast agent, applied in the field of nano-biomedical materials, can solve the problems of Gd-DTPA inaccessibility, Gd-DTPA retention, loss of enhancement effect, etc., to meet production and application, magnetic resonance The effect of adjustable signal and stable performance

Inactive Publication Date: 2014-09-17
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the currently used contrast agent, such as Gd-DTPA, is a non-specific extracellular contrast agent, Gd-DTPA cannot be retained in the intestinal mucosa and absorbed by the intestinal mucosa through oral or colonic enema, so that Gd-DTPA cannot Reach or stay in diseased tissue, loss of enhancing effect

Method used

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  • Intestinal-tract targeted magnetic resonance contrast agent based on mesoporous silica and preparation method thereof
  • Intestinal-tract targeted magnetic resonance contrast agent based on mesoporous silica and preparation method thereof
  • Intestinal-tract targeted magnetic resonance contrast agent based on mesoporous silica and preparation method thereof

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Embodiment 1

[0024] 1. Preparation of gadolinia-supported mesoporous silica:

[0025] A certain amount of cetyltrimethylammonium bromide (CTAB) was dissolved in 180 mL of water, and after stirring for 15 minutes, 6 mmol of NaOH was added. With vigorous stirring, TEOS was added dropwise. The molar ratio of CTAB to TEOS is 0.1:1. At the same time adding Gd(NO 3 ) 3 ·6H 2 O, making gadolinium ions (Ga 3+ ) to TEOS in a molar ratio of 0:05:1. The reactant was stirred slowly for 10 hours at 25°C, and the obtained reaction product was aged at room temperature for 12 hours, washed with twice distilled water, dried in vacuum at 80°C for 12 hours, and finally calcined in air at 550°C for 6 Hour.

[0026] 2. Surface-coated chitosan and its derivatives:

[0027] Dissolve chitosan with a degree of deacetylation of 95% in 2% acetic acid solution, stir slowly at room temperature for 0.5 hours, add 0.1 g of mesoporous silica loaded with gadolinium oxide, and chitosan with a degree of deacetylatio...

Embodiment 2

[0030] 1. Preparation of gadolinia-supported mesoporous silica:

[0031] A certain amount of Triton X-100 was dissolved in 180 mL of water, and after stirring for 15 minutes, 6 mmol NaOH was added. With vigorous stirring, TEOS was added dropwise. The molar ratio of Triton X-100 to TEOS is 0.15:1. Add GdCl at the same time 3 ·6H 2 O, making gadolinium ions (Ga 3+ ) to TEOS in a molar ratio of 0:2:1. The reactant was stirred slowly for 10 hours at 25°C, and the obtained reaction product was aged at room temperature for 12 hours, washed with twice distilled water, dried in vacuum at 80°C for 12 hours, and finally calcined in air at 550°C for 6 Hour.

[0032] 2. Surface-coated chitosan and its derivatives

[0033] Hydroxypropyl chitosan was dissolved in 2% acetic acid solution, and after stirring slowly at room temperature for 0.5 hour, 0.5 g of gadolinium oxide-loaded mesoporous silica and 1 g of hydroxypropyl chitosan were added. Adjust the pH of the system to 5 and stir...

Embodiment 3

[0036] 1. Preparation of gadolinia-supported mesoporous silica:

[0037] A certain amount of Pluronic F127 was dissolved in 180 mL of water, and after stirring for 15 minutes, 6 mmol NaOH was added. With vigorous stirring, TEOS was added dropwise. The molar ratio of Pluronic F127 to TEOS is 0.05:1. At the same time adding Gd(NO 3 ) 3 ·6H 2 O, making gadolinium ions (Ga 3+ ) to TEOS in a molar ratio of 0:5:1. The reactant was stirred slowly for 10 hours at 25°C, and the obtained reaction product was aged at room temperature for 12 hours, washed with twice distilled water, dried in vacuum at 80°C for 12 hours, and finally calcined in air at 550°C for 6 Hour.

[0038] 2. Surface-coated chitosan and its derivatives

[0039] Dissolve N-hydroxypropyl trimethyl quaternized chitosan in 2% acetic acid solution, stir slowly at room temperature for 0.5 hours, add 1 g of gadolinium oxide-supported mesoporous silica, N-hydroxypropyl trimethyl 0.5 g of quaternized chitosan. Adjust...

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Abstract

The invention relates to an intestinal-tract targeted magnetic resonance contrast agent based on mesoporous silica and a preparation method thereof. The method takes mesoporous silica as a medium, mesoporous silica pore passages are loaded with gadolinium oxide nanoparticles, then the loaded mesoporous silica surface is coated with chitosan molecules, the intestinal-tract targeted contrast agent is prepared, and intestinal-tract targeted imaging is realized. The contrast agent takes mesoporous silica as the medium, and can regulate and control the content of gadolinium oxide, so as to realize different intensities of contrast effects; and at the same time, the mesoporous silica surface is coated with the chitosan, so that the contrast agent is allowed to have a targeting effect on intestinal tracts. The prepared contrast agent has the characteristics of stable performance, good biocompatibility, and adjustable magnetic resonance signals. The obtained product can meet the demand of clinical application. The preparation method is simple in process and strong in operability, and can further meet production and application.

Description

technical field [0001] The invention relates to a preparation method of a magnetic resonance dual-mode contrast agent, in particular to a technology for preparing intestinal magnetic resonance imaging by using mesoporous silicon dioxide as a medium, loading gadolinium oxide and wrapping chitosan. The invention belongs to the field of nano biomedical materials. Background technique [0002] With the development of the economy and the changes in people's diet and living habits, the health problems caused by gastrointestinal diseases have gradually increased, and they have increasingly become the main problems affecting human health. Globally, the incidence of inflammatory bowel disease is on the rise, and the incidence of colorectal cancer has risen from the sixth in the 1970s to the third now, second only to lung cancer and gastric cancer. Therefore, the diagnosis of gastrointestinal diseases is particularly important. However, the existing imaging examination methods requi...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/08
Inventor 何丹农朱君程杰军周涓
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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