D-glucose dithiocarbamate complex marked by TcO, preparation method and applications thereof

A kind of ammoniacalate, 99mtco technology, applied in the field of radiopharmaceutical chemistry and clinical nuclear medicine, can solve the problems of high blood background, slow blood clearance, affecting imaging quality and so on
CN101555263AActive Publication Date: 2009-10-14BEIJING NORMAL UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Publication Date
2009-10-14

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Abstract

The invention discloses a D-glucose dithiocarbamate complex marked by TcO, a preparation method and applications thereof; the formula of the complex is TcO(DGDTC)2, takes Tc(V)O as a central nucleus and has a geometric configuration with the shape of an irregular square pyramid, wherein O atom in Tc=O bond is positioned at the top point and four sulphur atoms provided by two DGDTC ligand molecules are positioned at the four points of the bottom surface. By the technical steps of synthesis of ligand DGDTC and preparation of TcO (DGDTC)2 complex, the TcO (DGDTC)2 complex is obtained. The D-glucose dithiocarbamate complex has high radiochemical purity and good stability, has higher uptake value and good detention in tumor and higher ratio of tumor / muscle, and is suitable for being promoted and applied as a novel tumor imaging agent.
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Description

Technical field

[0001] The present invention relates to 99m The field of radiopharmaceutical chemistry and clinical nuclear medicine technology of TcO nuclear labeling, specifically relates to a 99m TcO core-labeled D-glucosaminolate complex, its preparation method and application. Background technique

[0002] Today, malignant tumors have become the main killer of human health. In the prevention and treatment of tumors, the treatment method is not the most important, but the early diagnosis of tumors is the key. Studies have shown that with early diagnosis and early treatment, 50% of tumor patients can be cured. Radionuclide imaging can reflect changes in the physiology, pathology, metabolism, and function of tumors, and radionuclide imaging is a non-invasive detection method with many advantages that make radionuclide imaging the mainstay of tumor diagnosis. method. Among the many tumor imaging drugs, 18 F-fluorodeoxyglucose ([ 18 F]FDG) is currently the most widely...

Claims

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