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Medicine composition of Panax notoginseng saponins

A technology of Panax notoginseng saponins and Panax notoginseng saponins, which is applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., and can solve the problems of not selecting saponin components with different pertinence and insufficient research

Inactive Publication Date: 2009-03-25
HEILONGJIANG ZBD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, the total saponins of Panax notoginseng are usually used as an overall component in medicine, or only a small number of components are detected or limited.
For the influence of the content and ratio relationship between each component on the therapeutic effect, there is no sufficient research in the prior art
Moreover, in practical applications, the total saponins of Panax notoginseng are usually used directly to treat various cardiovascular and cerebrovascular diseases, and saponins with different pertinence are not selected according to different diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Macroporous Adsorption Resin Column for Group Separation

[0021] Grind 1000g of Sanqi raw medicinal material into coarse powder, reflux extract with 2, 1.5, 1.5 times the amount of ethanol respectively for 3 times, each time for 1.5h, filter, combine the filtrate, recover the ethanol until dry; or add the notoginseng coarse powder to Add 2.3 times the amount of 90% ethanol to the multi-functional heat reflux extraction concentrator, heat and reflux extraction and concentration for 10 hours, then move the concentrated solution to a single-effect external circulation concentrator and concentrate under reduced pressure until there is no alcohol smell. The residue was dissolved with an appropriate amount of methanol. Through the macroporous adsorption resin column, it was sequentially eluted with 25%, 40%, 80% and 95% (volume ratio) ethanol gradient, the flow rate was 10ml / min, and each part was collected in 500ml. The eluate was analyzed by silica gel H thin-layer chroma...

Embodiment 2

[0023] Notoginsenoside R 1 , Ginsenoside Rg 1 , Ginsenoside Rb 1 , Ginsenoside Re, Ginsenoside Rd, Ginsenoside Rb 3 and ginsenoside Rb 2 separation and extraction.

[0024] The concentrated solution containing the above-mentioned components separated by the macroporous adsorption resin in Example 1 was respectively put on the chromatographic silica gel column, and the "chloroform-methanol-water" was used successively as 83:16:1, 76:22:2, 68.5:27.5 :4, 65:30:5, 61:33:6, 54:38.5:7.5 solvent elution, flow rate 10ml / min, collected in 500ml each. The eluate was analyzed by silica gel H thin-layer chromatography, and the developing solvent was the same as above. The same components of the chromatographic spots were combined, and the solvent was recovered under reduced pressure to obtain the above-mentioned components with high purity.

[0025] Elution with acetonitrile-water binary gradient, acetonitrile: 0-30min, 18%-19% (volume ratio); 30-35min, 19-35% (volume ratio); 35-60m...

Embodiment 3

[0034] Preparation of the composition

[0035] Take the above-mentioned separated components, mix them in proportion, dissolve them in an appropriate amount with water for injection, decolorize them with activated carbon for injection, filter, add water for injection to the total amount, adjust the pH value to 6.5-7.0, filter, and freeze-dry to obtain .

[0036] According to the above method, the following composition is prepared:

[0037] Composition 1-1: 7 parts of R 1 , 31 parts of Rg 1 , 31 parts of Rb 1 , 3 parts of Re, 6 parts of Rd and 0.05 parts of Rb 3 . And in the above composition, the total content of the above components is 96.53%.

[0038] Compositions 1-2: 9 parts of R1 , 39 parts of Rg 1 , 35 parts of Rb 1 , 6 parts of Re, 11 parts of Rd and 1.0 parts of Rb 3 . And in the above composition, the total content of the above components is 96.40%.

[0039] Composition 2-1: R 1 :Rg 1 :Rb 1 :Re:Rd:Rb 2 It is 7:31:31:3:6:15, and in the above composition,...

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Abstract

The invention relates to panax notoginseng saponins medicine combination and the application thereof, which are characterized in that the active ingredient is composed of panax notoginseng saponins which contains notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, ginsenoside Rd, ginsenoside Rb3 and ginsenoside Rb2; the combination with different contents and ingredients of saponins are prepared; the combinations have different treatment effects.

Description

technical field [0001] The invention relates to a pharmaceutical composition of Panax notoginseng saponins and its application. Background technique [0002] Panax notoginseng, ginseng, and American ginseng are collectively referred to as the three major ginseng in the world, among which panax notoginseng is the least well-known among the people, but the latest research has found that panax notoginseng has the highest content of medicinal ingredients, so panax notoginseng is called the "king of ginseng", especially for blood It has a very good curative effect on such diseases and is known as the blood guard. Panax notoginseng is a perennial herb of Araliaceae ginseng. It grows in low latitude and high altitude areas. It is used as medicine with dry roots. Ginseng notoginseng, Yunnan notoginseng. Panax notoginseng has a long history of being used to treat diseases, and it has been recorded in the "Secrets of Medicine" and "Wonderful Prescriptions for Falling Damage" before ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P3/06A61P7/02A61P9/10A61K31/704
Inventor 方同华项彦华周雪峰岳大彪周广红
Owner HEILONGJIANG ZBD PHARMA
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