131 results about "Ginsenoside Rb1" patented technology

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

The invention provides a cobalt monatomic nano-enzyme system modified by phospholipid polyethylene glycol carboxyl. The cobalt monatomic nano-enzyme system comprises a cobalt monatomic nano-enzyme composite core and phospholipid polyethylene glycol carboxyl compounded on the surface of cobalt monatomic nano-enzyme, the cobalt monatomic nano-enzyme composite core comprises a cobalt monatomic nano-enzyme and ginsenoside loaded on the cobalt monatomic nano-enzyme. The invention also provides a bifidobacterium synergetic cobalt monatomic nano-enzyme system which is formed by combining cobalt monatomic nano-enzyme with ginsenoside Rb1 and further delivering the cobalt monatomic nano-enzyme and ginsenoside Rb1 through bifidobacterium bifidum for targeted therapy of enteritis. The combination of Co SA and Rb1 can enhance the anti-inflammatory efficacy by adjusting a key immune signal pathway, and bifidobacterium bifidum can ensure targeted delivery of microbiota and promote intestinal barrier repair. The synergistic three-component strategy integrating monatomic nano-enzyme antioxidation, natural drug immunoregulation and probiotic targeting is provided, and a promising treatment platform is provided for accurate intervention of IBD.

An aureobasidium pullulans P1 and application thereof in rare saponin conversion, and belongs to the technical field of microorganisms and biological medicines. The strain preservation number is CGMCC No.23227. The Aureobasidium pullulans P1 can be used for preparing rare ginsenoside Rg3 and CK by converting ginsenoside Rb1 by beta-glycosidase through fermentation, the target products are various and definite, other impurities have small interference, the products are easy to generate, the conversion specificity is high, the efficiency is high, the product recovery rate is over 60%, and the method has obvious advantages in the process of producing Rg3 and CK by mass fermentation.

The present invention relates to a functional cosmetic composition comprising plant exosomes derived from ginseng as an active ingredient and a functional cosmetic containing the same. Ginseng exosomes have a bilipid layer structure and are rich in ginsenosides Rb1 and Rg1, which influence skin improvement and whitening. It has been proven that these powerful functional materials, ginsenosides Rb1 and Rg1, are absorbed in large quantities through ginseng exosomes into skin cells, enhance the synthesis of collagen and hyaluronic acid in skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosomes rich in ginsenosides Rb1 and Rg1, presented in the present invention, can be beneficially used in functional cosmetic compositions for skin aging prevention, skin whitening, wrinkle improvement and skin cell regeneration.

The present invention relates to a functional cosmetic composition comprising plant exosome derived from ginseng as an active ingredient thereof and a functional cosmetic comprising the same. Ginseng efflux has a dual lipid layer structure and is rich in ginsenosides Rb1 and Rg1 that affect skin improvement and whitening. The powerful functional substances ginsenosides Rb1 and Rg1 have been proved to be massively absorbed into skin cells through ginseng exosomes, enhance the synthesis of collagen and hyaluronic acid in the skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosome rich in ginsenosides Rb1 and Rg1, as presented in the present invention, can be advantageously used in a functional cosmetic composition for skin aging prevention, skin whitening, wrinkle reduction, and skin cell regeneration.

The invention relates to a strain of Lactobacillus coryniformis ZS-07 and an application of the Lactobacillus coryniformis ZS-07 in preparation of rare ginsenoside through fermentation, and belongs to the field of microbial fermentation, the Lactobacillus coryniformis ZS-07 is preserved in China Center for Type Culture Collection on January 4, 2026, and the preservation number of the Lactobacillus coryniformis ZS-07 is CCTCC NO: M 2026009. According to the invention, ginsenoside Rb1 is used as a raw material, and the rare ginsenosides 20 (S)-Rg3, 20 (R)-Rg3, Rk1 and Rg5 are prepared by fermentation and conversion of Lactobacillus coryniformis ZS-07. The preparation method comprises the following steps: preparing the rare ginsenosides 20 (S)-Rg3, 20 (R)-Rg3, 20 (R)-Rg3, Rk1 and Rg5; the ginsenoside Rb1 can be converted into 20 (S)-Rg3, 20 (R)-Rg3, Rk1 and Rg5 after fermentation, and different from conventional methods depending on alkaline hydrolysis, high temperature and high pressure or steam treatment, the process shows the advantages of excellent mild characteristic, environmental friendliness and low cost, and the content of converted products can be effectively increased. The invention constructs a new strategy for directional synthesis of rare ginsenosides 20 (S)-Rg3, 20 (R)-Rg3, Rk1 and Rg5, thereby widening the application prospect and industrialization potential of the rare ginsenosides 20 (S)-Rg3, 20 (R)-Rg3, Rk1 and Rg5.

The invention relates to the technical field of food, in particular to a composition for relieving anxiety and improving sleep and a preparation method and application thereof, and the composition is composed of jujuboside, anthocyanin, gamma-aminobutyric acid and ginsenoside Rb1. The jujuboside is derived from spina date seeds, the anthocyanin is derived from at least one of lycium ruthenicum, blueberry purple epidermis, aronia melanocarpa and mulberries, and the ginsenoside Rb1 is derived from at least one of ginseng roots, ginseng stems and leaves, ginseng flowers, panax notoginseng roots, panax notoginseng stems and leaves, panax notoginseng flowers, panax notoginseng fibrous roots and American ginseng. According to the invention, a plurality of components are synergistic, the efficacy is comprehensive and the pertinence is strong, the effective components are not simply mixed, but form a highly synergistic action system, and the efficacy covers multiple dimensions of improving sleep, relieving anxiety and improving the overall state.

The invention discloses application of notoginsenoside in preparation of a wound repairing medicine, and particularly discloses application of notoginsenoside in preparation of the wound repairing medicine. The notoginsenoside comprises ginsenoside Rb1, ginsenoside Re, ginsenoside Rg1 and notoginsenoside R1. The specific action mechanism of notoginsenoside in promoting wound healing is explored, and notoginsenoside is effectively applied to clinical practice, so that the current technical blank can be filled, and a new treatment way can be provided for wound repair, thereby benefiting the majority of patients.

The present invention relates to the technical field of determination of ingredients in Chinese patent medicines, and in particular to a method for detecting ginsenoside content and an application thereof. The present invention utilizes a multiple heart-cutting two-dimensional liquid chromatography tandem charged aerosol detector method to detect the content of ginsenosides including notoginsenoside R1, ginsenoside Rg1, ginsenoside Re, 24(R)-pseudoginsenoside F11, ginsenoside Rf, ginsenoside Ra2, ginsenoside Rb1, ginsenoside Rg2, ginsenoside Rh1, ginsenoside Rc, ginsenoside Ro, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rd, ginsenoside Rg3(S), and ginsenoside Rg3(R). The method has the advantages of accuracy, high sensitivity, and strong specificity, is suitable for determining the content of ginsenosides in different Chinese patent medicines containing Panax genus Chinese medicines, and can be used reliably, comprehensively, and accurately for quality control of ginsenosides in Chinese patent medicines containing Panax genus Chinese medicines.

The invention relates to the technical field of gene engineering and enzyme engineering, in particular to a beta-glucosidase mutant with high catalytic activity and application of the beta-glucosidase mutant. The sequence of the beta-glucosidase mutant is obtained by carrying out any one of the following mutations on an amino acid sequence as shown in SEQ ID No.1: respectively mutating proline at the 95th site and arginine at the 178th site into cysteine; phenylalanine at the 98th site and arginine at the 178th site are respectively mutated into cysteine. The obtained mutants P95C / R178C and F98C / R178C have high enzyme activity, ginsenoside Rb1 can be converted into CK, the conversion efficiency is respectively improved by 83.52% and 105.79% compared with that of wild beta-glucosidase, and the industrial application of enzymatic conversion of rare ginsenoside CK is promoted.

The invention discloses a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease as well as a preparation and application thereof, and belongs to the technical field of chronic obstructive pulmonary disease medicines. The traditional Chinese medicine composition consists of a qi tonifying component, a blood activating component and a phlegm reducing component, or consists of the qi tonifying component and the blood activating component, or consists of the qi tonifying component and the phlegm reducing component, wherein the qi-tonifying component is selected from any one or a combination of more of ginsenoside Rg1, ginsenoside Rb1, astragaloside and schizandrin; the blood activating component is selected from any one or combination of more of ligustrazine and ferulic acid; the phlegm reducing component is selected from any one or combination of more of glucosinolate and quercetin. The compatibility and combination of the medicines have obvious effects in the aspects of improving lung inflammatory response and inhibiting pathological remodeling of pulmonary blood vessels.

Compositions useful for delaying reproductive aging in an individual comprise L-ergothioneine and ginsenoside Rb1. Methods of delaying reproductive aging, such as methods of treating age-related ovarian granulosa cell injury.

The invention discloses Dubosiella Newyorkens TZF-001 capable of producing beta-glucosidase and application of the Dubosiella Newyorkens TZF-001 in preparation of ginsenoside through fermentation and conversion, and belongs to the field of probiotic fermentation. The Dubosiella Newyorkens TZF-001 is preserved in the China Center for Type Culture Collection on December 15, 2025, and the preservation number of the Dubosiella Newyorkens TZF-001 is CCTCC (China Center for Type Culture Collection) NO: M20252889. According to the invention, ginsenoside Rb1 is used as a raw material, and Dubosiella Newyorkens TZF-001 with high yield of beta-glucosidase is used for fermentation and conversion of ginsenoside so as to prepare ginsenoside Rd. The ginsenoside Rb1 can be completely converted into Rd after fermentation, the dependence of a traditional method on acid-base hydrolysis, high temperature and high pressure and steam treatment is avoided, the reaction condition is mild, and the method has the advantages of being environmentally friendly, low in cost, high in product purity and the like. The method opens up a brand new technical path for green and low-cost preparation of ginsenoside Rd, and has remarkable innovativeness and popularization value in the field of industrialization of active ingredients of natural medicines.

The present invention relates to a method for manufacturing a black ginseng probiotic essence and a black ginseng probiotic essence beverage manufactured using same, wherein the probiotic essence has a significantly increased content of ginsenosides Rb1, Rg1, and Rg3, helping probiotic generation in the body and helping to improve gastrointestinal functions in the human body, and the probiotic essence is easily ingested in a beverage form, making it possible to provide a beverage having an increased absorption rate in the body.

The invention provides a nerve soothing and mind stabilizing pill and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: cleaning, infiltrating, cutting, drying, performing high-pressure steam sterilization on genuine medicinal materials such as poria cocos, poria with hostwood, ginseng, polygala tenuifolia, rhizoma acori graminei and the like in a formula of the mind-tranquilizing and mind-tranquilizing pill, mixing and crushing at low temperature to obtain fine powder, adding refined honey to prepare pills, and finally coating with cinnabar powder to obtain the mind-tranquilizing and mind-tranquilizing pill. The contents of polygala-ketone III, 3, 6 '-dimustard acyl sucrose, ginsenoside Rb1, beta-asarone, dehydrotumoic acid, pachymic acid and calcium salt in the prepared nerve-soothing and mind-stabilizing pill are high, the loss of index components in the pelleting process is small, and the dissolution time limit and microbial limit of the pill meet the requirements of Chinese Pharmacopoeia of 2025 edition. The preparation process of the mind-tranquilizing and mind-stabilizing pill is stable, and the prepared mind-tranquilizing and mind-stabilizing pill can effectively improve cognitive impairment, inflammation and oxidative stress injury caused by insomnia.

The invention discloses application of combination of ginsenoside Rb1 and luteolin in prevention and treatment of male reproductive toxicity caused by organophosphorus pesticides, and belongs to the field of medicines. A high-toxicity organophosphorus pesticide glyphosate is used as a representative, the reproductive toxicity effect of the glyphosate on male mice and the relieving effect of the ginsenoside Rb1 and the composition of the ginsenoside Rb1 and the luteolin on the male reproductive toxicity of the glyphosate are observed through tests, and the result shows that the ginsenoside Rb1 and the luteolin composition have the effect of inhibiting the reproductive toxicity of the glyphosate. The ginsenoside Rb1 and the composition of the ginsenoside Rb1 and the luteolin have a remarkable relieving effect on male reproductive toxic diseases caused by organophosphorus pesticides, wherein the male reproductive toxic diseases comprise testis diseases and sperm malformation rate increase, and antioxidant index GSH decrease and T-SOD increase caused by the organophosphorus pesticides. Effective drugs and treatment strategies are provided for preventing and treating organophosphorus pesticide induced male reproductive toxicity and diseases induced by organophosphorus pesticide induced male reproductive toxicity.

The present disclosure provides a medicament for treating brain diseases. Specifically, provided is a pharmaceutical composition. The active ingredient of the pharmaceutical composition comprises: (a) a first active ingredient, wherein the first active ingredient is a pharmaceutically acceptable salt of salvianolic acid; and (b) a second active ingredient, wherein the second active ingredient is ginsenoside or a pharmaceutically acceptable salt thereof. The pharmaceutically acceptable salt of salvianolic acid is selected from the following group: magnesium salvianolate B, calcium salvianolate B, magnesium salvianolate A, sodium rosmarinate, and a combination thereof. The ginsenoside is selected from the following group: ginsenoside Rg1, ginsenoside Rh2, ginsenoside Rb1, and a combination thereof. The mass ratio of the first active ingredient to the second active ingredient is 1:(0.1-10), wherein the mass ratio is based on the pharmaceutically acceptable salt of salvianolic acid and ginsenoside. Also provided is use of the pharmaceutical composition in preventing or treating brain diseases.

The invention belongs to the technical field of food processing and biological medicines, and relates to a ginsenoside Rb1-lactoferrin composite emulsion with an anti-inflammatory effect and a preparation method thereof. The emulsion is prepared from the following components in parts by weight: 0.1 part of ginsenoside Rb1-lactoferrin complex, 7.5 to 8.5 parts of peanut oil and 1.4 to 2.4 parts of water. The emulsion disclosed by the invention has better stability, bioaccessibility and anti-inflammatory activity, does not have unstable phenomena such as layering and the like after being stored at room temperature for 35 days, and has a wide application prospect in food and pharmaceutical industries.

The application discloses Jianyang capsule fingerprint spectrum and a construction method and application thereof, and relates to the technical field of quality detection. The construction method of the Jianyang capsule fingerprint spectrum comprises the following steps: preparing a control solution by using ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1, ganoderic acid A, primulaverin and 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside; preparing a test solution by using powders of Jianyang capsules of different batches; and performing high performance liquid chromatography analysis on the control solution and the test solution respectively to generate the Jianyang capsule fingerprint spectrum. The main peak and each chromatographic peak of the Jianyang capsule fingerprint spectrum obtained by the application are well separated, the Jianyang capsule fingerprint spectrum is applied to quality control detection of Jianyang capsules, the quality of the products can be comprehensively monitored, the consistency, controllability and stability of the product quality are ensured, and therefore, the quality of the Jianyang capsule products can be more comprehensively monitored.

The invention discloses a method for detecting notoginsenoside R1, ginsenoside Rg1 and ginsenoside Rb1 in a heart-stabilizing composition.The method comprises the steps of preparation of a reference solution, preparation of a test solution and determination through a high performance liquid chromatography. The notoginsenoside R1, the ginsenoside Rg1 and the ginsenoside Rb1 can be detected at the same time, the separation effect of the notoginsenoside Rb1 is good, and a new alternative method is provided.

The invention discloses a method for extracting ginsenosides Rb1 and Rd from pseudo-ginseng. The method comprises the following steps: step 1, extracting raw materials; step 2, recovering ethanol; step 3, preparing crude extraction column loading liquid; step 4, crude extraction; step 5, re-dissolving; step 6, separating a single component; step 7, refining a single component of ginsenoside Rb1; and step 8, refining a single component of ginsenoside Rd. According to the method disclosed by the invention, the non-polar macroporous adsorption resin and the moderately polar macroporous adsorption resin are combined for use, gradient elution is performed, and a high-content and batch-level single-component product can be obtained; on the basis, a high-content product is further obtained through the steps of crystallization and chromatography. The method disclosed by the invention is easy to operate and implement, can be repeatedly used and is relatively high in yield.

The application provides a composition for improving intestinal digestive enzyme activity and application thereof, and belongs to the technical field of animal medicine. The composition is composed of double-kidney polysaccharide, ginsenoside Rb1 and ginsenoside Rg1. In the composition, the mass ratio of the double-kidney polysaccharide, the ginsenoside Rb1 and the ginsenoside Rg1 is 90:5:5 or 95:2.5:2.5, preferably 90:5:5, and the intestinal digestive enzyme is specifically duodenal trypsin and amylase. Experimental results show that the composition can significantly synergistically improve the activities of the duodenal trypsin and amylase of laying hens, improve the feed utilization rate, thereby improve the egg production rate, improve the egg weight and the eggshell strength, and effectively improve the breeding benefit of the laying hens.

The invention provides application of pediococcus acidilactici and red ginseng fermented by the pediococcus acidilactici in oral anti-aging efficacy, and relates to the technical field of biological fermentation, the pediococcus acidilactici is pediococcus acidilactici, the strain number of the pediococcus acidilactici is KMHD9-314, the registration number of the pediococcus acidilactici in the China General Microbiological Culture Collection Center is CGMCC No.32357, and the preservation number of the pediococcus acidilactici is KMHD9-314. According to the pediococcus acidilactici KMHD9-314, ginsenosides Rb1, Rb2, Rc, Rf and Re can be converted into rare ginsenosides 20 (S)-Rg3, 20 (R)-Rg3, Rk1, Rg5, Rh1, Rg6, Rh4 and Rk3, and the total amount of the rare ginsenosides is increased. The technical problem that in the prior art, the efficiency of converting rare ginsenoside through microbial fermentation is low is solved.

The invention relates to the field of probiotic fermentation of Pediococcus acidilactici N6‑3 and its application in fermenting and transforming ginsenoside Rb1 to prepare rare ginsenosides. Pediococcus acidilactici N6‑3 was deposited in the China Center for Type Culture Collection on September 18, 2024, with a deposit number of CCTCC NO:M 20241999. The self-isolated and identified high-yielding β-glucosidase Pediococcus acidilactici N6‑3 of the present invention can be used for fermenting and transforming ginsenoside monomer Rb1. In the process of preparing rare ginsenosides, the present invention does not need to be combined with alkaline hydrolysis, high temperature and high pressure, steam treatment and other treatment methods, and has the advantages of mild reaction, green environmental protection, low cost and short fermentation time. After fermentation, ginsenoside monomer Rb1 can be completely converted into rare ginsenosides 20(R)‑Rg3, 20(S)‑Rg3, Rk1 and Rg5, providing a new way for Pediococcus acidilactici to ferment and transform ginsenoside Rb1 to prepare rare ginsenosides.

The invention relates to the technical field of health-care food, in particular to a pseudo-ginseng oral liquid and a preparation method and application thereof, and the pseudo-ginseng oral liquid comprises the following components in percentage by weight: 20-40% of pseudo-ginseng root extract, 3-8% of pseudo-ginseng stem and leaf extract, 0.5-2% of pseudo-ginseng flower extract and the balance of purified water. The total saponin is not less than 1200 mg / 100 mL in terms of ginsenoside Re, the ginsenoside Rb1 is not less than 30 wt%, the ginsenoside Rg1 is not less than 25 wt%, and the notoginsenoside R1 is not less than 5 wt%. The pH value of the product is 4.5-7.5, the product meets strict physicochemical and microbial standards, the product is packaged by a sodium-calcium glass bottle, and the shelf life is 24 months. The preparation method comprises the following steps: exclusively extracting, purifying, preparing, sterilizing and the like, and realizing quality controllability through an HPLC (High Performance Liquid Chromatography) characteristic chromatogram. The preparation is reasonable in dosage form, the problems of moisture absorption, low bioavailability and the like of a solid preparation are solved, and the active components are easy to absorb and convenient to take. Through research, the health-care tea has the health-care functions of improving hypoxia tolerance and relieving physical fatigue, and is suitable for people with related requirements.

The present invention provides an application of a nano zero-valent iron catalyst in the conversion of rare ginsenosides. The nano zero-valent iron catalyst is prepared by the following steps: S1, taking dried Sophora japonica powder and adding a certain proportion of ethanol solution to a reaction vessel, heating and refluxing for extraction for a certain period of time, and then filtering the mixed solution to obtain a Sophora japonica extract; S2, taking the Sophora japonica extract prepared above, adding a certain mass of ferric chloride hexahydrate to a container, and performing hydrothermal synthesis for a certain period of time, centrifugal washing, and vacuum drying to obtain nano zero-valent iron particles; the nano zero-valent iron catalyst is used to convert ginsenoside Rb1 into rare ginsenoside derivatives 25-OH-Rg3. The advantages of the present invention are: the synthesis method of preparing a nano zero-valent iron catalyst by reducing trivalent iron ions with Sophora japonica extract is simple in process, low in energy consumption, and has a wide range of raw material sources. It has high specificity when used to catalyze the conversion of ginsenoside Rb1 into rare ginsenoside Rg3 derivatives, can be efficiently and quickly catalyzed, and has a high conversion rate.

The invention discloses a natural compound composition as well as a preparation method and application thereof, and relates to the technical field of medicines, effective components of the natural compound composition are ginsenoside Rb1 and periplocin, the compound composition has an obvious protection effect on mouse nerve microglial cells BV2 damaged by MPP +, zebrafish PD-like dyskinesia caused by MPTP can be obviously improved, and the effect of preventing and treating MPP + is achieved. The compound combination is expected to be used for preventing and treating Parkinson's disease.

The application discloses a bovine viral diarrhea virus inactivated vaccine containing ginsenoside Rb1 / Rg5-PLGA nanoparticles, and relates to the technical field of biological medicines.The bovine viral diarrhea virus (BVDV) inactivated vaccine comprises inactivated bovine viral diarrhea virus and a vaccine adjuvant; the vaccine adjuvant comprises ginsenoside Rb1 / Rg5-PLGA nanoparticles.The application effectively enhances the application effect of the vaccine by combining the use of PLGA, ginsenoside Rb1 and Rg5, and can cause better humoral immunity and cellular immunity levels, thereby laying a foundation for the development of the BVDV inactivated vaccine for deer.

A method for producing a plant-based extract composition having the effect of enhancing nutrition and immunity comprises the following steps: (i) preparing materials; (ii) creating a base mixture; (iii) creating a foundation mixture; (iv) creating a first temporary mixture; (v) creating a second temporary mixture; (vi) creating a uniform mixture; (vii) creating a post-incubation mixture; and (viii) concentrating the post-incubation to obtain the plant-based extract composition having the effect of enhancing nutrition and immunity. This composition includes the following components: Ngoc Linh ginseng (Panax vietnamensis) extract; jiaogulan (Gynostemma pentaphyllum) powder; maingay's tree (Cratoxylum maingayi) powder; nodding clubmoss (Lycopodiella cernua) powder; red ginseng (Radix Ginseng Rubra) powder; codonopsis root (Codonopsis pilosula) powder; angelica root (Angelica sinensis) powder; rice bran oil, legume powder; coenzyme Q10; ginsenoside Rb1 extract; and honey.