Medicinal composition for preventing and treating cardiovascular diseases and application thereof

A kind of technology for preventing and treating cardiovascular disease and composition, applied in the field of pharmaceutical composition

Inactive Publication Date: 2012-07-04
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research is mainly focused on the research and clinical application of compound preparations. The research and development of effective fractions of traditional Chinese medicines are still in the exploratory stage in terms of ideas, technologies and methods, and there are still many problems to be solved extensively. , in-depth and comprehensive research

Method used

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  • Medicinal composition for preventing and treating cardiovascular diseases and application thereof
  • Medicinal composition for preventing and treating cardiovascular diseases and application thereof
  • Medicinal composition for preventing and treating cardiovascular diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] A. Extraction: Take 1 kg of Salvia miltiorrhiza, crush it into 18 meshes, add 6 times the amount of deionized water and decoct it at 90°C for extraction, extract 3 times, and the extraction time for each time is 0.8h, combine the extracts for three times, and concentrate under reduced pressure to 2ml / 1g of Danshen medicinal material to obtain the water-extracted concentrated solution of Danshen.

[0119] B. Purification: Take the concentrated liquid of Danshen in A and use HPD450 macroporous resin to purify (about 7kg, column volume about 10L). 1BV / 6h), and then eluted with 2BV of 40% ethanol (the elution flow rate is 1BV / 6h), the eluate was concentrated to a relative density of 1.05g / ml, and spray-dried to obtain the total phenolic acids of Salvia miltiorrhiza.

[0120] After testing, the proportion of salvianolic acid B in the total phenolic acids of the salvia miltiorrhiza is 72%, and the rest are other salvianolic acids and non-salvianolic acid substances.

Embodiment 2

[0122] A. Extraction: Take 1 kg of Danshen medicinal material, crush it into 10 meshes, add 8 times the amount of deionized water to decoct and extract at 80°C, extract 3 times, and the extraction time for each time is 0.5h, combine the extracts for three times, and concentrate under reduced pressure to 2ml / 1g of Danshen medicinal material to obtain the water-extracted concentrated solution of Danshen.

[0123] B. Purification: Take the Danshen water extract concentrate in A and use HPD450 macroporous resin to purify (about 7kg, column volume about 10L). After loading the sample, use 2BV of pure water to elute and remove impurities (flow rate is 1BV / 6h), and then Elute with 2BV of 40% ethanol (the elution flow rate is 1BV / 8h), concentrate the eluate until the relative density of the drug solution is 1.05g / ml, and spray-dry to obtain the total phenolic acid of salvia miltiorrhiza.

[0124] After testing, the proportion of salvianolic acid B in the total phenolic acids of the sa...

Embodiment 3

[0126]A. Extraction: Take 1 kg of Danshen medicinal material, crush it into 24 meshes, add 10 times the amount of deionized water and decoct it at 100°C for extraction, extract 3 times, and the extraction time for each time is 1 hour, combine the extracts of the three times, and concentrate under reduced pressure to 2ml / 1g of Danshen medicinal material to obtain the water-extracted concentrated liquid of Danshen.

[0127] B. Purification: Take the Danshen water extract concentrate in A and use HPD450 macroporous resin to purify (about 7kg, column volume about 10L). After loading the sample, use 2BV of pure water to elute and remove impurities (flow rate is 1BV / 6h), and then Elute with 2BV of 40% ethanol (the elution flow rate is 1BV / 4h), concentrate the eluate until the relative density of the drug solution is 1.05g / ml, and spray-dry to obtain the total phenolic acid of salvia miltiorrhiza.

[0128] After testing, the proportion of salvianolic acid B in the total phenolic aci...

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Abstract

The invention discloses a medicinal composition for preventing and treating cardiovascular diseases, belonging to the technical field of Chinese medicines. The medicinal composition is prepared from salvianolic acids, total tanshinone and a notoginsenoside mixture in a certain weight ratio, wherein the notoginsenoside mixture is prepared by mixing ginsenoside Rb1, ginsenoside Rg1 and notoginsenoside R1; and the notoginsenoside mixture can be replaced by an equivalent amount of arasaponin. The medicinal composition has remarkable treatment effects on a coronary heart disease, angina and myocardial infarction.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application, in particular to a traditional Chinese medicine composition for preventing and treating cardiovascular diseases such as coronary heart disease, angina pectoris and myocardial infarction and its application, which belongs to the field of traditional Chinese medicine. Background technique [0002] Coronary atherosclerotic heart disease, referred to as coronary heart disease for short, is a common clinical disease and frequently-occurring disease, and its incidence rate shows an increasing trend year by year. The main clinical manifestations of coronary heart disease are angina pectoris and arrhythmia caused by myocardial ischemia and hypoxia. In severe cases, myocardial infarction may occur, and various complications may be life-threatening. Primary disease occurs in people over 40 years old, and men are more than women. People with high blood pressure, hyperlipidemia, diabetes a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61P9/00A61K31/704
Inventor 王阶郭丽丽崔翰明吴萍陈雯
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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