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Medicinal preparation for treating nerve-root cervical spondylopathy, and preparation method and quality detection method thereof

A technology for nerve root and cervical spondylosis, which can be applied to nervous system diseases, drug combinations, and pharmaceutical formulations, and can solve problems such as single dosage forms

Inactive Publication Date: 2015-09-09
SHANDONG MINGREN FURUIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The object of the present invention is to solve the problem of single dosage form of Jingtong granule, the only Chinese patent medicine for treating nerve root type cervical spondylosis, and provide a kind of overcoming granule Disadvantages of bitter taste, easy to take and carry tablets and capsules

Method used

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  • Medicinal preparation for treating nerve-root cervical spondylopathy, and preparation method and quality detection method thereof
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  • Medicinal preparation for treating nerve-root cervical spondylopathy, and preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] 250g of Panax notoginseng is crushed into fine powder; 1000g of notopterygium and 1000g of Clematis extract the volatile oil, and the volatile oil is wrapped with beta-cyclodextrin (1ml: 3.3g) to form inclusions, and the decoction is filtered; the dregs of the medicine are added with water and decocted for 1 hour , filtered, combined with the second filtrate, and set aside; add 750g of pueraria root and 750g of Radix Paeoniae Alba to water and decoct twice, for 1.5 hours for the first time, and 1 hour for the second time, combine the decoction, filter, combine the filtrate with the above-mentioned filtrate, and concentrate to The relative density is 1.12 (50°C), add ethanol to make the alcohol content reach 60%, stir well, refrigerate overnight, filter, wash the filter residue once with 60% ethanol, filter the washing liquid, combine with the above filtrate, recover ethanol, concentrate To a clear paste with a relative density of 1.26 (50°C); 750g of Rhizoma Chuanxiong, ...

Embodiment 2

[0099] 250g of Panax notoginseng is crushed into fine powder; 1000g of notopterygium and 1000g of Clematis extract the volatile oil, and the volatile oil is wrapped with beta-cyclodextrin (1ml: 3.3g) to form inclusions, and the decoction is filtered; the dregs of the medicine are added with water and decocted for 1 hour , filtered, combined with the second filtrate, and set aside; add 750g of pueraria root and 750g of Radix Paeoniae Alba to water and decoct twice, for 1.5 hours for the first time, and 1 hour for the second time, combine the decoction, filter, combine the filtrate with the above-mentioned filtrate, and concentrate to The relative density is 1.14 (50°C), add ethanol to make the alcohol content reach 60%, stir well, refrigerate overnight, filter, wash the filter residue once with 60% ethanol, filter the washing liquid, combine with the above filtrate, recover ethanol, concentrate To a clear paste with a relative density of 1.27 (50°C); 750g of Rhizoma Chuanxiong, ...

Embodiment 3

[0101] 250g of Panax notoginseng is crushed into fine powder; 1000g of notopterygium and 1000g of Clematis extract the volatile oil, and the volatile oil is wrapped with beta-cyclodextrin (1ml: 3.3g) to form inclusions, and the decoction is filtered; the dregs of the medicine are added with water and decocted for 1 hour , filtered, combined with the second filtrate, and set aside; add 750g of pueraria root and 750g of Radix Paeoniae Alba to water and decoct twice, for 1.5 hours for the first time, and 1 hour for the second time, combine the decoction, filter, combine the filtrate with the above-mentioned filtrate, and concentrate to The relative density is 1.15 (50°C), add ethanol to make the alcohol content reach 60%, stir well, refrigerate overnight, filter, wash the filter residue once with 60% ethanol, filter the washing liquid, combine with the above filtrate, recover ethanol, concentrate To a clear paste with a relative density of 1.29 (50°C); 750g of Rhizoma Chuanxiong, ...

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Abstract

The invention relates to a medicinal preparation for treating nerve-root cervical spondylopathy, and a preparation method and a quality detection method thereof. The invention is an extension of an original invention. The medicinal preparation comprises a granule, a tablet and a capsule, the preparation method is an optimized and screened production technology based on the original invention, a modern new device, a new process and a new technique are adopted to realize industrial production; and quality standard researches are completed and improved on the basis of original standards, HPLC is adopted to simultaneously determine the content of ginsenoside Rg1, ginsenoside Rb1 and notoginsenoside R1 in a finished product, and thin layer discrimination of all medicines is carried out to comprehensively control the quality, so the clinic curative effects are guaranteed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a medicinal preparation for treating cervical spondylotic radiculopathy, a preparation method and a quality detection method thereof. Background technique [0002] Cervical spondylosis is a common and frequently occurring clinical disease. With the accelerated pace of life in modern society, changes in work styles, and the widespread use of computers and air conditioners, people suffer from wind-cold-damp evils and the probability of neck flexion has increased significantly, and its incidence has continued to rise (3.8 % rose to 10%), and the age of onset continued to advance (from 55 to 39), which has replaced low back and leg pain as the main clinical orthopedic disease. Cervical spondylotic radiculopathy is the most common type of cervical spondylosis, accounting for 60-70% of all cervical spondylosis types. At present, except for severe patients, surgery...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/716A61K47/48A61P19/00A61P25/00G01N30/88G01N30/90
Inventor 张玲凌沛学殷成强
Owner SHANDONG MINGREN FURUIDA PHARMA
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