6results about How to "Various dosage forms" patented technology

The invention provides a plant-derived active polypeptide and application thereof in prevention or treatment of Parkinson's syndrome, and belongs to the technical field of polypeptide bioengineering. The amino acid sequence of the active polypeptide is MKGASSIMYALG, and the active polypeptide is prepared from Fuding white tea raw materials through a directional two-step enzymolysis process. According to the polypeptide, the damage of 6-OHDA induced BZ555 nematode dopaminergic neurons can be remarkably reduced, and the dyskinesia of Parkinson's syndrome model animals can be remarkably improved; meanwhile, the expression level of proinflammatory factors such as IL-1beta and IL-18 in serum of a model mouse can be lowered, the content of dopamine in a nigra area of brain tissue of the model mouse can be increased, and the activity of monoamine oxidase B can be reduced. The results show that the Fuding white tea-derived active polypeptide has exact prevention and treatment effects on Parkinson's syndrome, and has important development value and wide application prospects in the field of medicines.

The present invention discloses a sorghum black rice nutritious food and a preparation method and application thereof, and relates to the technical field of functional nutritious food, the sorghum black rice nutritious food comprises the following components by weight: 30%-60% of sorghum black rice polysaccharide, 15%-40% of compound prebiotics, 10%-25% of a cereal matrix, 3%-8% of a natural adhesive and 0.5%-5% of a flavor regulator. Through the synergistic effect of the sorghum black rice polysaccharide in a specific ratio and the composite prebiotics composed of the xylooligosaccharide and the inulin, the regulation capability on intestinal flora and the improvement effect on the intestinal barrier function are remarkably improved; the technical bottlenecks of low extraction efficiency, large component loss and single product taste and dosage form in the prior art are solved, and the finally prepared nutritional food not only has various dosage forms and high absorption and utilization rate, but also shows remarkable multifunctional application value in the aspects of prevention and adjuvant treatment of metabolic syndrome.

The invention discloses application of piperlongumine in treating and preventing lung injury, and belongs to the technical field of medicines. Aiming at the technical bottlenecks of limited treatment means and high case fatality rate of the existing acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), the invention discovers that piperlongumine can specifically inhibit cGAS-STING signal channel activation for the first time, and expression release of inflammatory factors IFN-beta, IL-6 and TNF-alpha is reduced by regulating phosphorylation of a downstream interferon regulatory factor 3 (IRF3). In-vitro experiments prove that piperlongumine inhibits ISD-induced inflammatory response in a dose-dependent manner, and in-vivo experiments show that piperlongumine can significantly relieve LPS-induced mouse acute lung tissue inflammatory cell infiltration, reduce serum IL-6 and TNF-alpha levels, and improve lung tissue pathological injury. According to the invention, the medicinal application of piperlongumine is expanded, a new lung injury treatment scheme based on natural active compounds is provided, and the piperlongumine can be widely applied to prevention and treatment of acute lung injury and related inflammatory lung diseases.

This invention belongs to the field of biomedicine, specifically relating to the application of caffeine in the preparation of a composition for improving liver inflammation and oxidative stress damage associated with high red meat intake. This invention is the first to discover that caffeine can significantly inhibit liver inflammation and oxidative stress phenotypes and improve liver function indicators in the context of high HLC exposure. Caffeine is a mature raw material with abundant dosage forms, easily forming oral formulations or food compositions, suitable for rapid intervention or long-term risk management after short-term high red meat intake, and has good operability. Caffeine can be combined with gut microbiota modulatory components to form compositions that balance short-term effects with long-term microecological improvement. In the application provided by this invention, through caffeine intake, animal experiments have shown that it can comprehensively improve abnormal lipid metabolism and liver histological damage, demonstrating systemic metabolic protective potential.

The invention belongs to the technical field of biological medicines, and particularly relates to a method for promoting proliferation of immature bone marrow-derived macrophages and polarization of the immature bone marrow-derived macrophages to M1 through stress application culture and application of the method. The in-vitro stress application culture method of the macrophages from the immature bone marrow has the characteristics of high stability, high amplification efficiency, polarization controllability, high purity, flexibility in application, low production cost and the like; the problems that a traditional cell factor induction method is low in amplification efficiency, poor in polarization controllability, insufficient in purity and the like are solved, the purity of the obtained M1 type macrophage reaches 90% or above, stability is high, and cost is low. The method can be applied to preparation of macrophage drugs for immunoregulation, anti-fibrosis, metabolism regulation, anti-tumor CAR-M and the like, tissue regeneration biological materials, anti-inflammatory drugs, in-vitro diagnosis products and the like, dosage forms are diversified, and a standardized cell preparation scheme is provided for the related biological medicine field.

This invention provides a plant-derived bioactive polypeptide and its use in the prevention or treatment of Parkinson's syndrome, belonging to the field of polypeptide bioengineering technology. The amino acid sequence of the bioactive polypeptide is MKGASSIMYALG, and it is prepared from Fuding white tea raw materials through a directed two-step enzymatic hydrolysis process. This polypeptide can significantly alleviate 6-OHDA-induced damage to dopaminergic neurons in BZ555 nematodes and significantly improve motor dysfunction in Parkinson's syndrome model animals. Simultaneously, it can downregulate the expression levels of pro-inflammatory factors such as IL-1β and IL-18 in the serum of model mice, upregulate dopamine content in the substantia nigra region of brain tissue in model rats, and reduce monoamine oxidase B activity. These results indicate that the Fuding white tea-derived bioactive polypeptide of this invention has definite preventive and therapeutic effects on Parkinson's syndrome, and has significant development value and broad application prospects in the pharmaceutical field.