Extract of panax notoginseng saponins and preparation method thereof

A technology of Panax notoginseng saponins and Panax notoginseng saponins, which is applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve problems such as hidden safety hazards, high toxicity, and clinical application of Panax notoginseng saponins, and achieve high safety , The effect of less extraction process steps

Inactive Publication Date: 2010-09-15
北京中海康医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Secondly, in the prior art, there are many extraction and purification process steps, or the use of highly toxic organic solvents, which poses a safety hazard for the subsequent clinical application of Panax notoginseng saponins

Method used

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  • Extract of panax notoginseng saponins and preparation method thereof
  • Extract of panax notoginseng saponins and preparation method thereof
  • Extract of panax notoginseng saponins and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] Take the crude extract of Panax notoginseng total saponins, put it on a macroporous adsorption resin column; elute with deionized water, discard the eluent; elute with 15% ethanol solution, discard the eluent; elute with 40% ethanol solution , collecting the eluent, concentrating under reduced pressure, and drying to obtain the saponins of the notoginsengtriol group; continuing to elute with 70% ethanol solution, collecting the eluent, concentrating the eluent under reduced pressure, and drying to obtain the saponins of the notoginsengdiol group;

[0126] The detection of notoginseng saponin R 1 , Ginsenoside Rg 1 , the content of ginsenoside Re accounted for 15.0%, 69.0% and 6.4% of the saponins of the notoginsenoside group respectively, and the ginsenoside Rb 1 and ginsenoside Rd accounted for 70.0% and 18.4% of the saponins in the notoginsengdiol group, respectively.

[0127] The saponins of the notoginseng triol group and the saponins of the notoginseng-diol group...

Embodiment 2

[0134] Take the crude extract of Panax notoginseng total saponins, put it on a macroporous adsorption resin column; elute with deionized water, discard the eluent; elute with 5% ethanol solution, discard the eluent; elute with 30% ethanol solution , collect the eluate, concentrate under reduced pressure, and dry to obtain the saponins of the notoginseng triol group; continue to elute with 80% ethanol solution, collect the eluate, concentrate the eluent under reduced pressure, and dry to obtain the saponins of the notoginseng triol group.

[0135] The detection of notoginseng saponin R 1 , Ginsenoside Rg 1 , the content of ginsenoside Re accounted for 13.8%, 66.7% and 9.7% of the saponins of the notoginseng triol group respectively, and recorded ginsenoside Rb 1 The contents of ginsenoside Rd and ginsenoside accounted for 64.0% and 21.1% of the saponins in the notoginsengdiol group, respectively.

[0136] The saponins of the notoginseng triol group and the saponins of the not...

Embodiment 3

[0138] Take the crude extract of Panax notoginseng saponins, put it on a macroporous adsorption resin column; elute with deionized water, discard the eluent; elute with 10% ethanol solution, discard the eluent; elute with 50% ethanol solution , collect the eluent, concentrate under reduced pressure, and dry to obtain the saponins of the notoginseng triol group; continue to elute with 60% ethanol solution, collect the eluate, concentrate the eluent under reduced pressure, and dry to obtain the saponins of the notoginseng triol group.

[0139] The detection of notoginseng saponin R 1 , Ginsenoside Rg 1 , the content of ginsenoside Re accounted for 20.5%, 61.7% and 12.7% of the saponins of the notoginseng triol group respectively, recorded ginsenoside Rb 1 The contents of ginsenoside Rd and ginsenoside accounted for 67.5% and 13.1% of the saponins in the notoginsengdiol group, respectively.

[0140] The saponins of the notoginseng triol group and the saponins of the notoginseng...

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Abstract

The invention relates to an extract of panax notoginseng saponins, a preparation method thereof, a preparation prepared from the total saponins and a method for preparing the preparation. The extract comprises panaxtriol saponins (PTS) and panaxadiol saponins (PDS), wherein the PTS mainly comprises notoginsenoside R1 and ginsenoside Rg1; the PDS mainly comprises the ginsenoside Rb1 and the ginsenoside Rd; the extract is characterized in that the weight ratio of the PTS to the PDS is 1:0.5-2; and the total content of the notoginsenoside R1, the ginsenoside Rg1, the ginsenoside Rb1 and the ginsenoside Rd accounts for over 80 weight percent of the extract of the panax notoginseng saponins. The preparation of the extract of the panax notoginseng saponins comprises the therapeutically effective amount of the panax notoginseng saponins and pharmaceutically acceptable adjuvant.

Description

technical field [0001] The invention relates to a Panax notoginseng saponin extract and a preparation method thereof, a preparation containing the Panax notoginseng saponin extract and a preparation method thereof. Background technique [0002] Panax notoginseng is the dry root of Panax notoginseng (Burk.) F.H.Chen. It is mainly produced in Wenshan, Yunnan, Yanshan, Guangnan, Maguan and Jingxi, Mubian, Baise and other places in Guangxi. Sweet in nature, slightly bitter, warm. Return through the stomach meridian. Function cures mainly for removing blood stasis and stopping bleeding, reducing swelling and relieving pain. For hemoptysis, hematemesis, hematochezia, uterine bleeding, traumatic bleeding, chest and abdomen tingling pain, tumbling and swelling pain. [0003] Panax notoginseng contains saponins, flavonoids, amino acids, polysaccharides, fatty acids, peptide compounds and other components, among which, dammarane-type tetracyclic triterpenoid saponins (total saponi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/10A61P7/02A61K125/00
Inventor 黄海宋华先马红萍张占军程宇刘启悦
Owner 北京中海康医药科技发展有限公司
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