The invention discloses a medicine for treating middle and terminal hypertension. The medicine is prepared from the following raw materials in parts by weight: 20-30 parts of prepared rehmannia root, 10-15 parts of Chinese yam, 10-15 parts of dogwood, 8-12 parts of moutan bark, 8-12 parts of rhizoma alismatis, 8-12 parts of poria coco, 10-15 parts of fruits of Chinese wolfberries, 8-12 parts of chrysanthemum flowers, 10-15 parts of the root of bidentate achyranthes, 10-20 parts of tortoise plastron, 8-12 parts of gastrodia elata, and 10-15 parts of folium mori. The medicine is prepared from 12 natural traditional Chinese medicines through mixing, the traditional Chinese medicines synergistically act to achieve the efficacies of enriching the blood and nourishing, tonifying deficiency and resisting aging, benefiting qi and nourishing blood, strengthening body resistance and eliminating pathogenic factors, activating blood circulation to dissipate stasis, reducing blood pressure, reducing blood vessel resistance, contracting blood vessels slightly, increasing the flow of coronary arteries, and the like, the medicine can treat both causes and symptoms of diseases, and is good in effect in treating middle and terminal hypertension, and free of toxic or side effect. A preparation is simple, the course of treatment is short, the administration is convenient, the cost is low, and the effective rate achieves 90% or above.