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Medicinal composition containing kudzu root or its extract and mongolian snakegourd or its extract

A technology of kudzu root extract and composition, which is applied in the field of medicine to achieve the effects of accelerating blood flow, enhancing drug efficacy, and a clear dose-effect relationship

Inactive Publication Date: 2011-02-09
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, using the interaction of Pueraria root or its extract and Trichosanthes or its extract to prepare prescriptions for treating cardiovascular and cerebrovascular diseases has not been reported yet.

Method used

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  • Medicinal composition containing kudzu root or its extract and mongolian snakegourd or its extract
  • Medicinal composition containing kudzu root or its extract and mongolian snakegourd or its extract
  • Medicinal composition containing kudzu root or its extract and mongolian snakegourd or its extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] The preparation and assay of embodiment 1 kudzu root extract

[0092] 1. Preparation of kudzu root extract

[0093] Take the Pueraria root medicinal material, crush it, add 70% ethanol to heat and reflux to extract twice, add 12 times the amount of alcohol for the first time, extract for 2 hours, add 10 times the amount of alcohol for the second time, extract for 1 hour, combine the extracts, filter, and filtrate Concentrate until there is no alcohol smell, filter, and elute with water and 70% ethanol respectively in the AB-8 macroporous resin that has been treated on the filtrate, and the elution volume is 4 times the volume of the column. Deliquify, recover ethanol, concentrate under reduced pressure to a relative density of 1.1-1.3 (50°C), and dry to obtain the product.

[0094] Three batches of kudzu root extract were prepared respectively, and the yields are shown in Table 5.

[0095] 2. Determination of Pueraria root extract content

[0096] Determination of ...

Embodiment 2

[0104] Preparation and content determination of embodiment 2 Trichosanthes quince extract

[0105] Preparation of Fructus Trichosanthes Extract

[0106] Take Trichosanthes medicinal material, dry, crush into coarse powder, add water to reflux and extract twice, add 10 times the amount of water each time, reflux extract for 2 hours, filter, combine filtrates, concentrate to a relative density of 1.10-1.15 (60°C ) concentrated solution, add ethanol until the alcohol content reaches 80%, leave it overnight, take the supernatant, recover the ethanol until it has no alcohol smell, reduce the pressure to a thick paste, and dry it in vacuum to obtain Trichosanthes extract 1.

[0107] Three batches of Fructus Trichosanthes extract 1 were prepared respectively, and the yields are shown in Table 6.

[0108] Preparation of Trichosanthes quince extract II

[0109] Take Trichosanthes medicinal material, dry, crush into coarse powder, add water to reflux and extract twice, add 10 times ...

Embodiment 3

[0118] The preparation of embodiment 3 pharmaceutical composition tablet of the present invention

[0119] Prescription 1:

[0120] Pueraria root extract 21.4g (equivalent to 500g of raw medicinal materials)

[0121] Trichosanthes extract 1 76g (equivalent to 1000g of raw medicinal materials)

[0122] Starch 65g

[0123] Microcrystalline Cellulose 45g

[0124] 2% HPMC aqueous solution appropriate amount

[0125] Magnesium Stearate 6g

[0126] Carboxymethyl Starch Sodium 20g

[0127] A total of 1000 tablets were prepared

[0128] Prescription 2:

[0129] Pueraria root extract 10.7g (equivalent to 250g of raw medicinal materials)

[0130] Trichosanthes extract 1 114g (equivalent to 1500g of raw medicinal materials)

[0131] Starch 65g

[0132] Microcrystalline Cellulose 45g

[0133] 2% HPMC aqueous solution appropriate amount

[0134] Magnesium Stearate 6g

[0135] Carboxymethyl Starch Sodium 20g

[0136] A total of 1000 tablets were prepared

[0137] Prescripti...

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Abstract

The invention belongs to the field of medicine technology, particularly relating to a medicine composition used for treating cardiovascular disease, the preparation method and usage thereof as well as the preparations containing the medicine composition. The composition of the raw materials of the effective components of the medicine composition is: 125-2000 portions of kudzuvine root and 100-2000 portions of snakegourd fruit, or 4-100 portions of kudzuvine root extract and 2-160 portions of snakegourd fruit extract. The medicine composition can be prepared into any preparation formulation acceptable in pharmacy, but injection or oral preparation is preferred. The medicine composition of the invention has the functions of dilatating coronary, increasing the flow rate of coronary, inhibiting platelet aggregation, decreasing blood viscosity, reducing the formation of thrombus through improving hemorheology and microcirculation, improving the blood supply function of the heart, reducing cerebral vascular resistance, increasing cerebral vascular blood flow, improving the microcirculation of the brain, etc.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for cardiovascular and cerebrovascular diseases, a preparation method thereof, and a preparation containing the pharmaceutical composition. [Background technique] [0002] Cardiovascular and cerebrovascular diseases are the number one disease that threatens middle-aged and elderly people. Its high incidence, high disability rate, high mortality rate and many complications are typical "three highs and one many" diseases, which bring great harm to patients, families and society. Great harm. It is also one of the major diseases that endanger human health and life at present. In China, the number of deaths due to this disease accounted for 10.07% of the total death toll in the country in 1957, and this number rose to 39% in 1997, and it is currently reported that the death toll of cardiovascular and cerebrovascular diseases accounted for 1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P9/10A61P9/00
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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