63results about How to "Reduce the size of cerebral infarction" patented technology

This invention relates to ilexin, drug combination of ilexin and its extraction method, which is used to treat CHD, angina pectoris, stroke, cardiac infarction and other cerebral vascular diseases. It uses ethanol for extraction, adds water into the extract, centrifuges to get the sediments and supernatant. Sediments are added 50-95% ethanol for extraction and filtration, the liquid is concentrated, placed and filtrated, and the sediments are dried to get a part of total saponin, the saponin is crystallized by ethanol to get a part of ilexin. The supernatant is enriched and centrifuged for the sediments, which is washed with appropriate water and crystallized by ethanol after dried to get another part of ilxin. Two parts of ilxin are put together and recrystallized for several times to get the pure ilxin, which content can be more than 98.0%.

The present invention relates to an iron holly bark total saponin for curing cardio-cerebral vascular system diseases of coronary heart disease, angina pectoris, apoplexy and cerebral infarction, medicine composite containing iron holly bark total saponin and its extraction separation method. Said method includes the following steps: using ethyl alcohol to extract iron holly bark to obtain extract, adding water, centrifugal separation, concentrating supernatant fluid, centrifugal separation, washing precipitate, drying so as to obtain the iron holly bark total saponin whose content can be up to above 50%; mixing said iron holly bark total saponin with oral preparation auxiliary material or injection preparation auxiliary material so as to obtain various oral preparations and injection preparation containing iron holly bark total saponin.

A Chinese medicine for preventing and treating cardiac and cerebral ischemia and fatty liver is prepared from arasaponin extracted from notoginseng, the ginkgolide and ginkgetin extracted from ginkgo leaf, and the polydanshinolic acid and danshinon extracted from red sage root.

The present invention relates to total ovateleaf holly saponin for treating coronary heart disease, angina, apoplexy and other cardiac and cerebral vascular diseases, its medicine composition and extracting process. Ovateleaf holly bark is extracted with alcohol, and the extract is added with water and centrifuged to obtain precipitate and supernatant. The precipitate is alcohol reflux extracted, and the extract is treated through filtering, filtrate concentrating, drying and other steps to obtain the first part of total saponin. The supernatant is treated through concentrating, centrifuging, water washing of the precipitate and drying to obtain the second part of total saponin. These two parts of total saponin are merged to obtain the total ovateleaf holly saponin, which may be added with supplementary material and further treated to obtain various kinds of oral preparations and injection.

The invention relates to application of a salvianolic acid A composition in preparing medicines for protecting ischemic brain tissue damage. The composition is prepared from 94-97% of salvianolic acid A, 0.1-1.5% of alkannic acid, 0.1-1.5% of rosmarinic acid, 0.1-1.5% of salvianolic acid B and 0.1-2.0% of salvianolic acid C.

The present invention relates to an ilex pedunculosa glycoside for curing cardio-cerebral vascular system diseases of coronary heart disease, angina pectoris, apoplexy and cerebral infarction, medicine composite containing ilex pedunculosa glycoside and its extraction separation method. Said extraction separation method includes the following steps: using ethyl alcohol to extract ilex pedunculosa to obtain extract, adding water into said extract, making centrifugal separation, concentrating supernatant fluid, making centrifugalization, washing precipitate by using proper quantity of water, drying and using ethyl alcohol to make crystallization so as to obtain the ilex pedunculosa glycoside pure product whose content can be up to above 98.0%.

The invention relates to a compound for treating cerebral infarction. The invention further relates to a preparation method of the compound and an application of the compound for preparing a drug for treating the cerebral infarction. The compound can significantly reduce thrombosis generated after rat vein ligation, and can obviously reduce an area of the cerebral infarction of a rat with middle cerebral artery occlusion. Therefore, the compound can prevent the thrombosis, can facilitate thrombolysis, and can be used in prevention and treatment of the cerebral infarction such as cerebral thrombosis and cerebral embolism.

This invention discloses a new drug used to cure coronary disease, hypertension, hyperlipemia, viral myocarditis, myocardiopathy ischemia, arrhythmia, cerebral infarction, hepatitis, poisoning liver injury, liver fibrillated, epilepsy, convulsion, heating, pain and eyesight descent--- taurine ampuls and its making method. The drug is composed of 0.4-1.2g taurine, medicine findings and water for injection, and it can be made to small injection for vein administering drug, transfusion agent or freeze dried agent. Its preparation technique is: add water for injection to boiling dissolve taurine and medicine findings, adjust pH value, add adsorbent, filter to remove adsorbent, add water for injection to total amount, fine filter and clarify, embed, disinfect, cool, check; and the freeze dried agent has the procedures of freezing out, equation, cap rolling, label or lettering, finished product inspection and packing. Its virtues are biology usage high and drug effect action fast. It is available to emergency and serious patients.

The invention discloses a drug for treatment of ischemic cerebrovascular disease, which is prepared with the following raw materials in parts by weight: 25-60 parts of pPig bile powder, 15-30 parts of cornu gorais, 25-50 parts of Baikal skullcap root, 25-60 parts of Gardenia, 25-30 parts of grass-leaved sweetflag and 1-2 part(s) of borneol or synthetic borneol. The drug can effectively inhibit the cascade reaction of the hypoxia-ischemia brain damage, improve the ischemical reperfusion injury of the cerebrovascular disease, and protect nerve cells.

The invention belongs to the medical technical field and discloses a drug combination for the cardiovascular disease and the preparation method of the drug combination. The drug combination contains the pharmacodynamic components of the raw materials of drugs of danshen root, Szechwan lovage rhizome, panax notoginseng, milkvetch root and storax. In order to achieve a better curative effect, a leech, tonka beans and peach nuts can also be added into the drug combination; in order to further improve the curative effect, rosewood, axillary choerospondias fruit and earthworms can be added into the drug combination. The drug combination of the invention has the efficacies of promoting the circulation of qi to induce resuscitation, activating blood circulation for removing blood stasis, dredging channels for alleviating pain etc. and is used for preparing the drugs for remedying the cerebral infarction convalescence of the coronary heart disease, the angina pectoris or the arteriosclerosis, the syndrome of which belong to the qi stagnation and blood stasis with the symptoms of chest pain, oppression in the chest, shortness of breath, heart throb, inefficaciousness of limbs, inarticulacy etc. The drug combination of the invention can be made into any preparation type, which is acceptable in the clinic and the pharmacy, and the oral preparation is preferential.

The invention relates to application of syringin in preparing drug combination for treating cardiovascular and cerebrovascular diseases. The syringin preparation is safe and nontoxic and has strong pharmacological action and good drug effect, thereby indicating bright prospect in drugs; the syringin preparation is simple in preparing process, has no toxic side effects and can be in oral forms such as tablets, pills, capsules and the like, or in injectable forms such as powder-injection, instillations and the like; the drugs prepared by the syringin can evidently lessen the degree and scope of myocardial ischemia caused by the anterior descending branch of canine coronary artery, reduce the myocardial oxygen consumption index, obviously withstand barium chloride induced arrhythmia in rats and reduce the cerebral infarct area of focal cerebral ischemia in rats; the above effects show that the drugs have obvious effects against arrhythmia, myocardial ischemia and cerebral ischemia. The drugs can be clinically used for preventing and treating coronary diseases, angina, stroke and cerebral infarct, etc.

The invention discloses a traditional Chinese medicine composition for treating dementia and a preparation method thereof. The composition is characterized by consisting of the following traditional Chinese medicine raw materials in parts by weight: 1-30 parts of rhizoma corydalis decumbentis, 1-30 parts of rhizoma curcumae longae and 1-30 parts of flos caryophylli. According to the traditional Chinese medicine composition and the preparation method thereof, the active ingredients of the composition are extracted by a reasonable process; the composition is made into multiple dosage forms and is good in safety; moreover, the composition can effectively reduce the brain tissue injury caused by cerebral ischemia and obviously alleviate the dementia symptoms, and realizes a remarkable effect in a process of preventing and treating vascular dementia.

The invention relates to the technical field of dental pulp stem and fine treatment, in particular to a method for treating cerebral ischemia reperfusion injury by using a dental pulp stem cell exosome. The method comprises the steps: extraction of exosomes from dental pulp stem cells, extraction of third molars without dental caries and periodontal lesions from healthy volunteers at age of 18 to 30 years-disinfection of tooth surface with 75% alcohol-removal of dental pulp from dental drill-cutting into pieces of 1 mm3-flushing three times with PBS containing 2.5% antibiotic-placement of pulp tissue in 1.5 ml EP tube with digestion of 3 mg/ml type I collagenase-placement in dispase of 4 mg/mL for 30 minutes at 37 DEG C-cell resuspension- and culturing in a 5% CO2 incubator at 37 DEG C; brain tissue is an organ most sensitive to ischemia and hypoxia of the body, irreversible brain injury occurs after blood flow supply is interrupted for several minutes, animal experiments find that the exosome from the dental pulp stem cells can reduce the cerebral infarction area after cerebral ischemia-reperfusion injury of a mouse, and a key technology is provided for clinical application of the dental pulp stem cell exosome in treatment of cerebral ischemia-reperfusion injury.

The invention provides a leonurine borneol derivative, the leonurine borneol derivative is a compound shown as B1 or B2 or a stereoisomer or a pharmaceutically acceptable salt form thereof, and the invention also provides a preparation method of the derivative and an application of the derivative in a medicine for preventing and treating nervous system diseases or cardiovascular and cerebrovascular diseases. The leonurine borneol derivative provided by the invention has a remarkable neuroprotective effect, can repair nerve cell injury, and also can play a role in obviously reducing lipid, so that the leonurine borneol derivative has remarkable pharmacological activity for treating and preventing nervous system and cardiovascular and cerebrovascular diseases, has important significance for developing novel drugs for preventing or treating nervous system and cardiovascular and cerebrovascular diseases.

The invention relates to a nasal spray for treating acute cerebral apoplexy and a preparation method thereof, and the nasal spray is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 6-9 parts of musk, 20-40 parts of radix curcumae, 20-40 parts of cape jasmine and 0.5-2 parts of borneol.

The invention provides an application of mitiglinide (MGN) in preparation of a medicine for treating the cerebral arterial thrombosis. An experiment shows that under the condition that the dosage of blood sugar is not reduced, the MGN can obviously improve the neurological disorder of a mice model or a rat model suffering from the cerebral arterial thrombosis and reduce the volume of the cerebral infarction; and the MGN inhibits the reduction of the survival rate of SH-SY5Y cells of a neuron cell strain caused by the oxygen-glucose deprivation (OGD), so that release of lactic dehydrogenase (LDH) is reduced, and the neuronal apoptosis caused by the OGD is improved. A result shows that the MGN has pharmacological effects of treating the cerebral arterial thrombosis and reducing the neuron damage caused by the OGD; and the treatment effect is bidirectional. The invention aims to prepare the medicine for treating the cerebral arterial thrombosis by taking the MGN as an active component.

The invention provides a Chinese medicinal preparation of acanthopanax root leaf extract for treating and preventing cardiovascular and cerebrovascular diseases and its preparing process, wherein the acanthopanax root leaf extract comprises quercetin, quercetin, globularicitrin, hyperin, chlorogenic acid and dicaffeoylquinate. Based by hyperin, the content of phenol constituents in the extract is not lower than 50%.