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Drug for treatment of ischemic cerebrovascular disease

A cerebrovascular disease and ischemic technology, applied in the field of pharmaceutical preparations, can solve the problems of no curative effect, adverse reactions, aggravation of the disease, etc., to reduce brain index and brain water content, inhibit thrombosis, and alleviate neurological deficits. Effect

Active Publication Date: 2010-06-23
HEBEI GOGIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic measures and drugs developed according to these theories have not achieved ideal curative effect, and some even have serious adverse reactions.
For example, most of the more than ten anti-stroke drugs approved by the FDA in the United States are thrombolytics and antithrombotics. Its biggest defect is that it is only suitable for use within 3 to 6 hours after the stroke occurs. If it exceeds 3 hours, thrombolysis may lead to Intracerebral hemorrhage and cerebral edema will aggravate the condition

Method used

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  • Drug for treatment of ischemic cerebrovascular disease
  • Drug for treatment of ischemic cerebrovascular disease
  • Drug for treatment of ischemic cerebrovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh 25kg of pig bile powder, add sodium hydroxide solution for saponification, adjust the pH value after letting it cool, precipitate and filter; the precipitate is washed to neutral with deionized water, and dried at low temperature to obtain the crude product of the extract; the crude product is washed with ethyl acetate The ester and an appropriate amount of activated carbon are heated to reflux, then dehydrated with anhydrous sodium sulfate, filtered, crystallized, and dried to obtain the fine product of hyocholic acid.

[0031] (2) Goat horns are removed and plugged, weighed 15kg; washed and dried, powdered, hydrolyzed with sulfuric acid reflux, let cool, adjusted pH with milk of lime until 4.0-4.5, stirred to stabilize pH; filtered, collected filtrate, Stir wash the precipitate with deionized water at 30-50°C, filter until the effluent is nearly colorless, combine the filtered and washing liquids; filter the combined liquid through a microporous filter membra...

Embodiment 2

[0038] Weigh 30kg of pig gall powder, 20kg of goat horns, 30kg of Scutellaria baicalensis, 30kg of gardenia, and 30kg of calamus. Extracts were prepared according to conventional methods. After the extract is mixed with 2kg of synthetic borneol, an appropriate amount of starch, dextrin, and magnesium stearate are added, mixed to make wet granules, and machine punched into tablets to make tablets each containing 2g of crude drug.

Embodiment 3

[0040]Weigh 60kg of pig gall powder, 30kg of goat horns, 50kg of scutellaria baicalensis, 60kg of gardenia, and 30kg of calamus. The extract was prepared according to the method described in Example 1. After mixing the extract with 2kg borneol, add distilled water and co-solvent to dissolve, filter and fill. Make the oral liquid that every 100ml contains crude drug 42g.

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Abstract

The invention discloses a drug for treatment of ischemic cerebrovascular disease, which is prepared with the following raw materials in parts by weight: 25-60 parts of pPig bile powder, 15-30 parts of cornu gorais, 25-50 parts of Baikal skullcap root, 25-60 parts of Gardenia, 25-30 parts of grass-leaved sweetflag and 1-2 part(s) of borneol or synthetic borneol. The drug can effectively inhibit the cascade reaction of the hypoxia-ischemia brain damage, improve the ischemical reperfusion injury of the cerebrovascular disease, and protect nerve cells.

Description

technical field [0001] The invention relates to a medicine preparation, specifically a medicine prepared from animal and plant medicinal materials and suitable for ischemic cerebrovascular disease. Background technique [0002] Cerebrovascular disease is a common and frequently-occurring disease that seriously endangers human health. It has become the first cause of disability and the third cause of death in the world, and the incidence of ischemic cerebrovascular disease accounts for about 75% of cerebrovascular diseases [Hou Xide. Neurology. People's Health Publishing House. Beijing. 1996: 197], there is an upward trend in recent years. With the acceleration of population aging in my country, there are about 1.5 million new cases of stroke (about 75% of which are cerebral infarctions) every year, and the number of patients is as high as 5 to 6 million. 4 Loss of labor force in different degrees, severe disability accounted for more than 40%, causing great harm to the famil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P9/10A61K31/045A61K35/32A61K35/413
Inventor 黄怀鹏高国领刘彩霞
Owner HEBEI GOGIN PHARMA
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