A traditional Chinese medicine lipid-lowering composition and its preparation method and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine lipid-lowering composition and preparation thereof, can solve problems such as long-term application of side effect drugs, and achieve the effects of improving phlegm turbidity block, improving blood lipid status, and reducing TCH

Active Publication Date: 2021-10-15
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the treatment of hyperlipidemia still relies on drug therapy, and the drugs used can be mainly divided into five categories: statins, fibrates, nicotinic acid, bile acid chelating agents, and cholesterol absorption inhibitors. The main reasons for the long-term use of drugs

Method used

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  • A traditional Chinese medicine lipid-lowering composition and its preparation method and application
  • A traditional Chinese medicine lipid-lowering composition and its preparation method and application
  • A traditional Chinese medicine lipid-lowering composition and its preparation method and application

Examples

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Effect test

Embodiment 1

[0029] Prescription: a traditional Chinese medicine lipid-lowering composition made of the following traditional Chinese medicines: Polygonatum 400g, Coptidis 100g, Jiaogulan 300g, Pueraria 300g, Hawthorn 260g;

[0030] Preparation method: Weigh the above five traditional Chinese medicines in proportion, take Coptis chinensis and add 6 times its mass of water to decoct twice, each decocting time is 1h; ~1.30 thick ointment for later use; add 5 times the amount of water to the remaining four traditional Chinese medicines each time and decoct twice, filter and combine the filtrate and concentrate at 55°C to form a relative density of 1.25~1.30 thick ointment; mix the above two thick ointments Vacuum drying method is used to dry the dry paste respectively, the drying temperature is 60°C, and the vacuum degree is -0.07Mpa; then the dry paste is respectively pulverized, and the dry paste powder is obtained after mixing, and the paste is added to the above dry paste powder Refined, ...

Embodiment 2

[0032] Prescription: a traditional Chinese medicine lipid-lowering composition made of the following traditional Chinese medicines: Polygonatum 500g, Coptidis 200g, Jiaogulan 400g, Pueraria 400g, Hawthorn 360g.

[0033] Preparation method: Weigh the above five traditional Chinese medicines in proportion, take Coptis chinensis and add 12 times its mass of water to decoct twice, and the decoction time is 2 hours; 1.30 thick ointment for later use; add 10 times the mass of water to the other four traditional Chinese medicines each time and decoct twice, filter and combine the filtrate and concentrate at 65°C to form a thick ointment with a relative density of 1.25-1.30; separate the above two kinds of thick ointments Vacuum drying is used to dry the paste, the drying temperature is 80°C, and the vacuum degree is 0.08Mpa; the dry paste powder is mixed after crushing, and then the dry paste powder is directly filled into capsules to obtain capsules.

Embodiment 3

[0035] Prescription: a traditional Chinese medicine lipid-lowering composition, made of the following traditional Chinese medicines: Polygonatum 420g, Coptidis 120g, Jiaogulan 320g, Pueraria 320g, Hawthorn 300g.

[0036]Preparation method: Weigh the above five traditional Chinese medicines in proportion, take Coptis rhizome and add water to decoct twice. 8 times, and the decoction time is 1.5h; after filtering and combining the filtrates, concentrate at 60°C to form a thick paste with a relative density of 1.25-1.30 for later use; the remaining four traditional Chinese medicines are combined and decocted twice, and the amount of water added for the first decoction is its mass 8 times of its mass, and the decocting time is 2 hours; the amount of water added for the second decoction is 6 times its mass, and the decocting time is 1.5 hours; after filtering and combining the filtrates, it is concentrated at 60°C to a thick paste with a relative density of 1.25-1.30; The above two ...

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Abstract

The invention provides a traditional Chinese medicine lipid-lowering composition and its preparation method and application. The composition is made of the following traditional Chinese medicines in parts by weight: Polygonatum 400-500 parts, Coptidis 100-200 parts, Jiaogulan 300-400 parts, Pueraria 300 parts ~400 parts, hawthorn 260~360 parts; its preparation method comprises as follows: Weigh the above five traditional Chinese medicines in proportion, take Coptidis Rhizome and add water to decoct, filter, combine the filtrate and concentrate into a thick paste for later use; the remaining four traditional Chinese medicines are decocted in water, filtered , concentrating into a thick paste after merging the filtrates; drying and pulverizing the above two thick pastes respectively to obtain a dry paste powder, and then adding dextrin, stevioside, and aspartame to prepare molding. The effect of dispelling turbidity, promoting blood circulation and unblocking veins is clinically effective in the treatment of hyperlipidemia of qi stagnation and blood stasis type.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine lipid-lowering composition and its preparation method and application. Background technique [0002] Over the past 20 years, with the improvement of people's living conditions, the prevalence of hyperlipidemia has increased year by year. According to the latest data from the survey of "Chinese Resident Nutrition and Health Status", the prevalence of hyperlipidemia among adults in my country is 18.6 %, about 160 million people. Changes in cholesterol levels and mortality in the Chinese population have increased by 6 times in the past 15 years, especially for men aged 35 to 45, when they are in their prime of life, the mortality rate of acute myocardial infarction has increased by 154%. It can be seen that hyperlipidemia has become a major problem threatening human health. [0003] Abnormal fat metabolism or operation makes one or more li...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P3/06
CPCA61K36/424A61K36/488A61K36/718A61K36/734A61K36/8969A61K2236/331A61K2236/39A61P3/06A61K2300/00
Inventor 向大雄罗世林刘新义李文群李健和朱运贵胡雄彬杨永玉
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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