38results about How to "Improve pathological condition" patented technology

The invention provides Fu moxibustion traditional Chinese pharmaceutical oil and a preparation method thereof. The traditional Chinese pharmaceutical oil is prepared from the following raw materials in parts by weight: 2 to 8 parts of cortex cinnamomi oil, 5 to 10 parts of wintergreen oil, 5 to 10 parts eucalyptus oil, 1 to 5 parts of mint oil, 1 to 5 parts of rose oil, 1 to 5 parts of lavender oil, 2 to 8 parts of rhizoma acori graminei oil, 2 to 8 parts of clove oil, 1 to 5 parts of ginger oil, and 2 to 8 parts of ethyl alcohol. The Fu moxibustion traditional Chinese pharmaceutical oil has the effects of dispelling the wind, invigorating the blood circulation, dispelling cold, diminishing inflammation, relieving pain, quieting the heart, soothing the nerves and calming. Based on the yin-yang theory in the traditional Chinese medicine theory, the drug effects can be quickly played through exhaling, exterior syndrome relieving and warming of the externally applied drug. Due to the action of the ethyl alcohol, the drug can quickly penetrate through skin and permeate into muscular striae, and the effects of dispelling the wind, invigorating the collateral, diminishing inflammation and relieving pain can be obtained. The kind of medium medicine can dispel cold through warmness to achieve the effects of dispelling the wind, removing cold, clearing heat, diminishing inflammation, invigorating the blood circulation, activating meridians and relieving pain.

The invention discloses an application of chlorogenic acid in preparation of medicines for treating a parkinson disease. The chlorogenic acid is beneficial to reduction of the toxicity of substantia nigra and striatum neurons and activation of the autophagy activity of substantia nigra and striatum neurons in a midbrain, beneficial to adjustment of blood ketone content of a parkinson disease mice model, and beneficial to inhibition of apoptosis of substantia nigra cells in the parkinson disease mice model, and plays positive improvement and treatment roles in symptoms, pathology and the like of the parkinson disease.

The present invention relates to a composition and particularly discloses the blood-sugar-lowering composition prepared from lucid ganoderma, grifola frondosa and bitter gourds as main raw materials,a preparation method and a use thereof. The composition comprises the following raw materials in weight percentages: 20-40% of lucid ganoderma, 40-60% of grifola frondosa and 10-30% of bitter gourds.Beneficial effects are as follows: (1) the blood-sugar-lowering composition has characteristics of being natural and safe; and at the same time, edible fungi are mixed with natural hypoglycemic substances, effects of each of the various raw materials on hypoglycemic effects are fully exerted, and the composition has a good hypoglycemic coordination function; (2) microfiltration and ultrafiltrationretention technology used in the preparation method has characteristics of simple operation, low energy consumption, short production cycle, etc., maximally separates and protects the active ingredients in an extract of grifola frondosa, and removes less effective ingredients; and (3) animal experiments show that the composition is significant in hypoglycemic effect.

The present invention provides an application of angelica peony powder in preparation of drugs for treating cirrhosis ascites. With the angelica peony powder of the present invention, indicators of TBIL, ALT and AST of cirrhosis ascites rats can be significantly reduced, ALB can be increased, A/G ratio inversion is improved, liver cell metabolism is improved, liver function is improved, and liver protection is achieved; and a liver fibrosis pathological state is improved, and pseudolobule formation is slowed so as to prevent cirrhosis formation. With combination of the angelica peony powder and V2 receptors of distal convoluted tubules and collecting ducts of kidney, water reabsorption of kidney collecting ducts is inhibited. In addition, with the angelica peony powder of the present invention, AQP4 expression in liver tissues is unregulated, ascites transportation is prompted, and cirrhosis ascites generation is reduced so as to provide treatment effects for cirrhosis ascites.

The present invention belongs to the field of medicine, and particularly relates to uses of cycloastragenol in preparation of chronic renal failure treatment drugs. According to the present invention, cycloastragenol is the aglycone of astragaloside A, and has advantages in biological membrane permeation and gastrointestinal tract absorption compared to astragaloside A due to the relatively small molecular weight and the strong lipophilicity, and the test results show that cycloastragenol can change various physiologic indexes of chronic renal failure rates so as to provide great application prospects in the treatment of chronic renal failure.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a radix astragali, radix notoginseng and radix astragali dampness-clearing formula and application thereof, and the radix astragali, radix notoginseng and radix astragali dampness-clearing formula comprises the following raw material medicines in parts by weight: 15-60 parts of radix astragali, 5-10 parts of radix notoginseng, 5-15 parts of rhizoma curcumae, 5-15 parts of radix paeoniae rubra, 5-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of cordyceps sobolifera and 10-30 parts of rhizoma smilacis glabrae. The invention also provides application of the Sanqi dampness-eliminating formula. Clinical tests show that the Sanqi dampness-clearing prescription can significantly improve the remission rate of a patient with membranous nephropathy, and when the Sanqi dampness-clearing prescription is combined with an immunosuppressive agent to treat membranous nephropathy, the curative effect is obvious, and the safety is good. Animal experiments show that the Sanqi dampness-clearing formula can improve general conditions such as appetite, body weight, activity, mental state, hair, hair color, urination and defecation of doxorubicin-induced nephrotic syndrome rats; the urine protein level of rats can be reduced to a certain extent; the pathological state of the rat kidney tissue is improved.

The invention provides an injection injected into an acupoint Houhai to treat piglet diarrhea. Every 100ml of the injection contains the following raw medicines: 2% procaine*(18-22)mL, ceftiofur sodium (0.5g/bottle)*(22-28) bottles, Newcastle disease IV (1000 feathers), dexamethasone (2mg/mL)*(18-22)mL and the balance of physiological saline. Compared with the existing treatment medicines, the injection injected into the acupoint Houhai of piglets to treatment diarrhea has higher cure rate and reduces the treatment cost by 20%.

The invention discloses a control method of a physiotherapy instrument. The control method comprises the following steps: the physiotherapy instrument receives a starting instruction; the physiotherapy instrument outputs a first physiotherapy instruction and inputs a first physiotherapy signal to a first output end and inputs a second physiotherapy signal to a second output end; the physiotherapy instrument outputs a second physiotherapy instruction, inputs the first physiotherapy signal to the second output end and inputs the second physiotherapy signal to a third output end; and so on; the physiotherapy instrument outputs a (n-1)th physiotherapy instruction, inputs the first physiotherapy signal to a (n-1)th output end and inputs the second physiotherapy signal to an nth output end. The control method of the physiotherapy instrument is suitable for meridian therapy, controls the physiotherapy instrument with multiple output ends to circularly and orderly inputs the physiotherapy signals to the output ends so as to dredge main and collateral channels of a physiotherapy object, so that the physiotherapy efficiency can be improved, the dredging and physiotherapy effect of the main and collateral channels can be improved, and the human body function of the physiotherapy object can be effectively regulated and controlled.

The present invention relates to a high-affinity anti-cyclic citrullinated peptide single-chain variable region tetravalent micro-molecule antibody. The invention proves that an anti-CCP antibody is not only a serologic marker for RA diagnosis, but also plays an important role in RA pathogenesis, and provides a test basis for RA targeted therapy with a citrullinated antigen as a target. In the present invention, a CCP epitope is used as a therapeutic target and an entry point. The research content involves multiple levels at which the CCP may be involved in the RA pathogenesis, so as to systematically and comprehensively reveal the role of the anti-CCP antibody in the RA pathogenesis. The peptide chain of an anti-CCP- ScFv antibody and a tetramer antibody with a P53 framework used in the invention are completely humanized sequences, acted on and targeted to an initiation of the RA pathogenesis and chronic process of inflammation, so as to have more pertinence. Different from existing downstream inflammatory response mediators and inflammatory signaling pathway mediators that antagonize the RA pathogenesis, the high-affinity anti-cyclic citrullinated peptide tetravalent micro-molecule antibody of the invention has more leading and accurate targetability of the target, and has better potential for transformation of technological achievements and prospect for biopharmaceutical development. In addition, an anti-CCP+RA and an anti-CCP-RA targeted by the high-affinity anti-cyclic citrullinated peptide tetravalent micro-molecule antibody of the invention may be two different disease subtypes of the RA, so that the antibody may become a new hope for accurately targeted therapy for such patients.

The invention discloses a traditional Chinese medicine composition for treating hypertensive heart failure and belongs to the field of traditional Chinese medicine. Active pharmaceutical ingredients of the traditional Chinese medicine composition include caulis spatholobi, pseudo-ginseng, root of red-rooted salvia, radix astragali and exocarpium. The traditional Chinese medicine composition conforms to theories of modern systematic pharmacology, and selected medicine has clear ingredients and can act on disease targets of hypertension and heart failure at the same time; the composition also accords with conventional traditional Chinese medicine dialectical theory systems and monarch, minister, assistant and guide combination principles of traditional Chinese medicine. In-vivo experiment results show that the composition can effectively lower systolic pressure of spontaneously hypertensive rats SHR and is slightly less than positive control medicine captopril in effect; the compositioncan increase ejection fraction and shortening fraction of SHR hearts and is better than captopril in treatment effect. The composition is few in herbal medicine, accurate and reliable in treatment effect and clear in main medicinal ingredient, non-medicinal factors in traditional Chinese medicine compound preparations can be reduced, and preparation level is improved.

The invention discloses an application of glucogalactooligosaccharide in preparation of a medicine for treating and/or preventing ischemia-reperfusion injury. The glucogalactooligosaccharide disclosed by the invention can be used for remarkably relieving postoperative liver injury, kidney injury, brain injury and the like of ischemia reperfusion mice, is safe and non-toxic, has a strong drug effect, and has a very good medicinal prospect in prevention and treatment of ischemia reperfusion injury.

The invention discloses application of a radix ampelopsis extract in preparation of a medicine for preventing and/or treating polycystic ovarian syndrome. The polyovarian syndrome (PCOS) is an endocrine metabolic disease, and the clinical main manifestations are menorrhea or amenorrhea, hyperandrogenesis, polycystic ovarian alteration and the like. On the human body, menstruation can show the ovulation condition of a woman; on the rat body, the ovulation condition of the rat is displayed by the mood cycle. Rats are taken as experimental subjects, a PCOS group, an ampelopsis japonica group and a normal group are set, and the influence of the ampelopsis japonica extract on the PCOS rat physical state is researched by representing the estrus cycle, the ovary state, the sex hormone level, the body mass, the ovary weight, the uterus weight and the like of the rats.

The invention discloses dampness-clearing tea and a preparation method thereof, and relates to the field of health-care food. The dampness-clearing tea comprises the following raw materials in parts by weight: 2-5 parts of jasmine flowers; 15 to 20 parts of lotus leaf; 10-14 parts of pericarpium citri reticulatae; 5-8 parts of hyacinth bean flower; 6 to 10 parts of wrinkled gianthyssop herb; 3-7 parts of plum blossom; 12 parts to 17 parts of semen sojae germinatum; and 6-8 parts of fortune eupatorium herb. The formula provided by the invention has an exact curative effect on conditioning the damp-heat constitution, also has a certain effect on treating damp-heat symptoms of diseases such as diarrhea, distention and fullness, hyperlipidemia and hyperglycemia, is easy to prepare, improves the pathological state of the biased constitution on the whole compared with other clinical preparations, and is exact in curative effect, relatively good in taste and free of obvious side effects; and clinical requirements can be well met.

The invention discloses a traditional Chinese medicine composition for treating primary biliary cirrhosis and a preparation method, dosage form and application of the composition and belongs to the technical field of traditional Chinese medicine and preparations. The traditional Chinese medicine composition is prepared from, by weight, 1,000-3,000 parts of radix rubiae, 800-3,000 parts of herba siegesbeckiae, 800-2,000 parts of radix gentianae macrophyllae, 500-3,000 parts of radix salviae miltiorrhizae, 1,000-2,000 parts of poria cocos and 500-1,500 parts of radix liquiritiae. The traditionalChinese medicine composition has the advantages that the traditional Chinese medicine composition has the main functions of invigorating spleen-stomach, replenishing qi, promoting blood circulation,removing stasis, clearing damp and promoting diuresis and is mainly applied to primary biliary cirrhosis of liver and gall stasis, syndrome of interior dampness-heat and qi stagnation and blood stasis, the human body of a patient with primary biliary cirrhosis can be subjected to overall immune adjustment at the same time, the PBC pathological symptoms can be remarkably improved, and the composition has the advantages of being remarkable in treatment effect, free of toxic or side effect, simple in composition, convenient to prepare, low in cost and the like.

The invention discloses an orthopedic central machine acupuncture treatment assembly which comprises a central machine needle and a central machine hammer which are matched with each other; the central machine needle comprises a needle body, an end head and a cutting edge, wherein the end head and the cutting edge are located at the top and the bottom of the needle body respectively; the central machine hammer comprises a hammer head and a hammer handle fixedly connected with the hammer head, and the two ends of the hammer head can knock the end head. The orthopedic central machine acupuncture treatment assembly is easy to operate, low in dependence on the operation technology of doctors, extremely high in safety, good in treatment effect, short in needed treatment time and capable of effectively improving the treatment efficiency and reducing the treatment cost.

The invention relates to a senior silkworm excrement external ironing packet for treating diabetes gastroparesis as well as a preparation and use method of the senior silkworm excrement external ironing packet. The preparation method comprises the following steps: S1, frying senior silkworm excrement with rice wine so as to obtain a senior silkworm excrement product; S2, uniformly mixing the senior silkworm excrement product with crude salt so as to obtain a senior silkworm excrement mixture; S3, putting the senior silkworm excrement mixture into a cloth bag, thereby obtaining the senior silkworm excrement external ironing packet. The senior silkworm excrement is fried with rice wine and is mixed with the crude salt to make the external ironing packet, the packet is heated for external ironing, absorption of medicinal effects by bodies is promoted through heat, and meanwhile, partial blood vessel expansion and lymphangiectasis of skin can be adjusted and circulation of blood and lymph can be promoted through heat stimulation, so that nutrition metabolism of the bodies can be improved, inflammation reactions can be eliminated, body immunity can be improved, functions of whole bodies can be adjusted, and a function of promoting disease treatment can be achieved. The external ironing packet has the effects of harmonizing stomach and reducing turbidity, activating blood and removing meridian obstruction as well as expelling wind and drying dampness, and with a traditional Chinese medicine instructed massage method, transportation and transformation of spleens and stomachs can be promoted, and catharsis functions of livers can be adjusted.

The invention belongs to the field of application of a traditional Chinese medicine in treating diseases caused by the influence of the expression level of an oncogene mutant p53 and an oncogene MDM2 on the gastric mucosa of a patient, and particularly relates to specific application of the traditional Chinese medicine in the diseases caused by the mechanism, such as chronic atrophic gastritis. According to the technical scheme, the traditional Chinese medicine composition capable of influencing the oncogene expression level of the gastric mucosa is prepared from the following components in parts by weight: 400 to 3000 parts of radix astragali seu hedysari, 500 to 1500 parts of lucid ganoderma, 300 to 4000 parts of semen coicis, 500 to 1500 parts of pericarpium citri reticulatae, 300 to 4000 parts of herba salviae chinensis and 300 to 4000 parts of herba hedyotidis diffusae. Immunohistochemical analysis shows that by inhibiting expression correlation of oncogene mutant p53 and MDM2, the medicine has a good curative effect on patients with chronic atrophic gastritis, and particularly has a better curative effect on improving gastral cavity fullness or dull pain, stomach pressing or warming, thin stool, lassitude and weakness, short breath and laziness to speak and the like compared with a gold standard medicine morhodamine; the pathological states of gastric mucosa atrophy, intestinal metaplasia, chronic inflammation, activity and the like can be effectively improved, and the atrophy process is delayed.