96results about How to "Alleviate pathological changes" patented technology

Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.

The invention discloses compounds having virus resistance and a composition thereof. The composition comprises one or more of the 13 compounds comprising 6'-O-caffeoyl deacetyl asperulosidic acid methyl ester. The compounds having virus resistance and the composition thereof can be extracted from plants and can also be prepared by synthesis. The composition comprising the compounds having virus resistance can prevent and treat viral infection-caused diseases such as influenza, myocarditis, conjunctivitis, viral pneumonia, encephalitis, leukemia, hepatitis B, hepatitis C, AIDS, genitourinary system infection, EB virus infection, human papillomavirus infection and cytomegalovirus infection. The composition can be prepared into an oral preparation, an injection, a spray, a subcutaneous injection and an anus suppository.

The invention relates to a medicine for treating rheumatic heart disease, in particular to a traditional Chinese medicine composition for treating rheumatic heart disease which is made from plant Chinese herbal medicine. It is characterized in that, the raw material medicine that makes active ingredient is according to the following weight: Wujiapi 20-30 grams each, Radix Astragali 20-30 grams, Atractylodes macrocephala 20-30 grams, Poria cocos 15-25 grams, Radix Paeoniae Alba 15-25 grams , 5-15 grams of schisandra, 5-15 grams of licorice, 5-15 grams of salvia miltiorrhiza, 4-12 grams of cassia twig, 4-12 grams of sunburned aconite and 2-8 grams of asarum. All medicines of the present invention are compatible, complement each other, bring out the best in each other, have heat-clearing and toxic substances removing, expelling wind and relieving pain, regulating blood circulation and promoting blood circulation to remove blood stasis, eliminating stagnation and relieving pain etc., the synergistic action of drug effect can treat both symptoms and root causes, can reduce pathological integral, free radical, Reduce the autoimmune reaction of the heart, nourish the myocardium, improve blood supply and oxygen supply, and repair the lesion, thereby alleviating the pathological changes of the heart valve.

The invention discloses a method for producing a nutritious soybean milk which is made from major ingredients including soybean, vitamin B12, vitamin D, taurine and calcium and adjuvant ingredients including pueraria root, cinnamon bark, folic acid, beta-cyclodextrin and flavoring agent. The method comprises the following steps: soaking soybean and draining or soaking soybean, dehulling and draining; freezing at low temperature; mixing with other ingredients; blending to obtain a slurry with bean cake particle size less than or equal to 50 micrometers and protein content more than or equal to 2%; homogenizing; boiling to obtain nutritious soybean milk; and optionally further concentrating and drying to obtain nutritious soybean milk powder. The product can relieve the adverse effect of hypoglycemic drugs and prevent diabetes complications.

The medicine for treating cardiac and cerebral vascular diseases is prepared with astragalus root and notoginseng as material, and is Chinese medicine injection, including injection liquid, transfusion liquid and freeze dried powder for injection, prepared through extraction, purification and addition of proper amount of medicinal supplementary material. The medicine has high stability and long effective period, and may be used in intramuscular injection, intravenous injection and intravenous instillation. Pharmacodynamic test shows that the medicine can protect brain against oxygen lack and cardiac muscle damage, raise anaerobic resistance, lower serum LDH and CK activity and reduce myocardial infarction range. The medicine is used in treating cardiac and cerebral vascular diseases and has fast acting, determined curative effect and no toxic side effect.

The present invention discloses one kind of medicine for treating rhinitis, and the medicine is prepared with centipeda herb 100-500 weight portions, rhubarb 50-300 weight portions, lily magnolia 50-300 weight portions, cocklebur fruit 50-300 weight portions, mint 50-300 weight portions and borneol 1-10 weight portions. The medicine has obvious systemic and local antiallergic effect and antiphlogistic effect, and is used in treating allergic rhinitis, chronic rhinitis, etc. It has fast acting, determined curative effect, high safety and less toxic side effect. The present invention also discloses the preparation process of the medicine.

A Chinese medicine is prepared from peony root and liquorice root through decocting, filtering, collecting the filtrate, adsorbing by macroreticular adsorptive resin, eluting with alcohol, collecting the eluting liquid, recovering alcohol, concentrating and drying. It can be used to treat chronic viral hepatitis B. Its advantage is high curative effect.

The invention discloses application of cobra venom in preparation of a medicament for treating lung inflammatory disease and pulmonary fibrosis. Animal experiment proves that Chinese cobra venom can alleviate acute endotoxin poisoning symptom within a range of 10-3000mug/kg, particularly has obvious therapeutic action on lung inflammatory disease caused by endotoxin, and can be used for alleviating inflammatory cell infiltration, alveolar septum thickening, and focal atelectasis and emphysema. Repeated small dose of endotoxin can result in pulmonary fibrosis, the cobra venom can significantly alleviate pulmonary fibrosis symptom and reduce alveoli damage and collagen hyperplasia. Naturally-modified Chinese cobra venom and physically-modified Chinese cobra venom have similar actions, but the physically-modified Chinese cobra venom has better action. Used for treating lung inflammatory disease, the Chinese cobra venom has the advantages of low dose, safety, capability of being orally administrated, injected, and administered through oral mucous membrane and skin and the like.

The invention relates to a traditional Chinese medicine pill for curing amenorrhea resulted from psychotropic drugs and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following bulk drugs in parts by weight: 80-100 parts of salvia miltiorrhiza bunge, 80-100 parts of peach kernel, 80-100 parts of safflower, 30-40 parts of cinnamon, 30-40 parts of fennel, 40-60 parts of folium artemisiae argyi, 40-60 parts of rhizoma cyperi, 40-60 parts of radix linderae, 40-60 parts of angelica sinensis, 40-60 parts of szechuan lovage rhizome, 40-60 parts of twotooth achyranthes root, 40-50 parts of rhizoma corydalis, 40-60 parts of bighead atractylodes rhizome and 40-60 parts of poria. The preparation method is as follows: weighting and processing 900g of the bulk drugs in parts by weight; taking 600g of the processed bulk drugs, adding 1200ml of water in the 600g of the processed bulk drugs, decocting for 40 minutes, removing dregs, decocting once again until the decoction liquid boils, decocting by slow fire and concentrating until the volume of the decoction solution is 400ml for later use; and grinding the rest 300g of the bulk drugs into fine powder, and placing the fine powder in a pelleting container, spraying the concentrated liquid in the pelleting container to prepare into water pills, taking the water pills out of the container and drying to obtain the concentrated pills. The traditional Chinese medicine pill is a pure traditional Chinese medicine preparation, has no toxic or side effect, is convenient to take and has low price.

The invention relates to pregnane glycoside compounds with orthoester groups, medical compositions with the compounds and applications of the medical compositions in the preparation of immunosuppressive agents, and in particular relates to pregnane glycoside compounds which are extracted from Periploca plants and contain the orthoester groups, medical compositions with the compounds, and applications of the medical compositions in the preparation of the immunosuppressive agents which are used to prevent and/or treat immunological rejection after cell/organ transplantation, or autoimmune diseases which contain rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis, etc.

The invention relates to a drug for treating chronic kidney disease proteinuria, which is a capsules prepared as follows: the materials are astragalus, Oriental Waterplantain Rhizome, Chinese Magnolivine Fruit, fried foxnut and node of lotus rhizome, which are added to water to be decocted, and the decoction solution is concentrated and dried. The drug has the advantages of kidney invigorating, diuresis inducing and stranguria treating, blood activating and stasis removing, swelling reducing and pain alleviating, heat-clearing and detoxifying, body fluid regenerating and thirst quenching, darrhea relieving, cough relieving and bleeding stopping, which has the function of body immunity regulation and reinforcing, and is suitable for the patient with chronic kidney disease and chronic renal failure proteinuria; the drug can effectively reduce proteinuria, increase plasma albumin, reduce the pathological changes of kidney and improve hemorheology indexes, which has a certain controlling effect on hematuria and proteinuria. In clinical verification, the drug has the advantages of fast therapeutic effect, good efficacy and small side effect.

The medicine for treating chronic bronchitis is compound medicine comprising fermented aweto powder, Sichuan fritillary bulb and loquat leaf with the functions of invigorating lung and kidney, benefiting vital energy, nourishing Yin, clearing away heat, eliminating phlegm, and relieving cough and asthma. It may be prepared into any pharmaceutically acceptable orally taken preparation forms. The medicine, pharmacodynamics test shows, has the functions of relieving cough, eliminating phlegm, resisting anoxia, resisting fatigue, resisting cold, diminishing inflammation and raising immunity, and has total effective rate on chronic bronchitis of 90.59 %,

The invention relates to a Chinese medicine for treating the systemic lupus erythematosus, particularly the lupus nephritis and a method for preparing the same. The medicine consists of the following components of oldenlandia diffusa, barbat skullcap, redroot gromwell, glutinous rehmannia, root of red-rooted salvia, motherwort and scorpion. The medicine has effects of clearing away the heat-evil and expelling superficial evils and activating blood circulation to dissipate blood stasis and is mainly used to treat the systemic lupus erythematosus, particularly the lupus nephritis; moreover, by matching Western medicines such as glucocorticoid and immunodepressant, etc., the medicine can be used to jointly treat the systemic lupus erythematosus, which can improve the effect of the hormone and the immunodepressant in curing the systemic lupus erythematosus, lower the incidence rate of infecting the complication, lower the recurernce rate and the death rate and have the important clinical meaning. The medicine of the invention can be made in all medicament forms for clinical use, including the powder, the medicinal broth, the mixture, the oral taking liquid, the capsule, the pelletized granule and the concentrated pill, etc.

The invention belongs to the field of medicine preparation, and particularly relates to application of N-acetylcysteine in preparing a medicament for preventing decompression sickness caused by fast buoyant ascent escape. N-acetylcysteine is dissolved in normal saline to prepare a 50-500mg/mL injection for use. The dosage of an N-acetylcysteine intraperitoneal injection is 150-1000mg/kg, and the dosage of an N-acetylcysteine intravenous injection is 200-500mg/kg. The N-acetylcysteine is used 16-60 minutes before fast buoyant ascent escape. Experiments prove that the N-acetylcysteine can be used for remarkably inhibiting heart failure caused by myocardial fiber fracture due to air bubbles, improving heart functions and reducing lung injury and inflammation, thus reducing pathologic changes caused by decompression sickness. Experimental data is provided to clinically more reasonable application of N-acetylcysteine to prevention of decompression sickness caused by fast buoyant ascent escape.

The invention provides application of Src kinase inhibitor in preparing medicaments for treating acute kidney injury. Further, the acute kidney injury is caused by renal ischemia. Further, the Src kinase inhibitor is PP1 (4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine). The invention proves that PP1 inhibition of Src can relieve the pathobiological change of kidney after I/R, so as to improve kidney function. The treatment mechanism of the Src kinase inhibitor includes procedures of inhibiting apoptosis of renal tubule cells, protecting multiple connexins and adhesive proteins, and inhibiting cell death and inflammation signal pathway.

The invention discloses application of fucoidan to preparing products for preventing and/or treating lower limb peripheral artery vascular diseases.The fucoidan is applied to preparing the products for preventing and/or treating the lower limb peripheral artery vascular diseases.The application has the advantages that the low-molecular-weight fucoidan (LMWF) comes from the naturally available thallus laminariae, is easily available and is safe; certain improvement effects can be realized for the lower limb peripheral artery vascular diseases; the products with the low-molecular-weight fucoidan can be absorbed if the products are orally administered, and have a potential application significance on preventing and treating the lower limb peripheral artery vascular diseases, side effects rarely can be realized, and the like.

The invention relates to a method for preparing a mycobecterium tuberculosis gene vaccine used for curing drug-resistant tuberculosis, and is characterized in that the mycobacterium tuberculosis gene vaccine against the drug-resistant tuberculosis clones a coding gene sequence of the mycobacterium tuberculosis Ag85A to the eukaryotic expression vector pVAX1, or clones coding gene sequences of the Ag85A and the ESAT6 together to the eukaryotic expression vector pVAX1 to form the ESAT6-Ag85A chimeric gene vaccine. Separated immunity or combined chemotherapy can obviously relieve pathology change in lungs of mice with drug-resistant tuberculosis and can obviously reduce bacteria numbers in lungs and spleens of little mice.

The invention relates to Chinese medicine used for treating chronic kidney disease, especially for treating kidney inflammation, invisible kidney inflammation and nephritic syndrome, and a preparation method of the Chinese medicine. The medicine is made of yerbadetajo, Ligustrum lucidum, Leonurus japonicus, Salvia, Rehmanniae, Lonicera confuse, Madder, Lycium Chinese Mill and Scorpion. The medicine has the efficacy of replenishing vital essence, tonifying kidney-yin, activating blood and dissolving stasis. The medicine is mainly applicable to treating kidney deficiency as well as the chronic kidney disease, the invisible kidney inflammation and the nephritic syndrome and also can be used for treating the nephritic syndrome in conjunction with western medicine such as Glucocorticoid. The medicine can improve curative effect, put off recurrence and reduce the times of recurrence. The medicine of the invention can be made into any formulation which is suitable for clinical treatment, including powders, decoction, mixture, oral liquor, capsule, granular formulation and a condensed pill and so on.

The invention discloses a traditional Chinese medicine composition for treating egg drop disease of laying hen and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following medcinal raw materials in parts by weight: 15 to 20 parts of salvia miltiorrhiza, 10 to 12 parts of safflower carthamus, 10 to 15 parts of leonurus, 5 to 7 parts of rhizoma sparganii, 5 to 7 parts of curcuma zedoary, 15 to 20 parts of herba epimedii, 15 to 20 parts of fructus cnidii, 15 to 20 parts of rhizoma curculiginis and 10 to 13 parts of polygonum cuspidatum. The traditional Chinese medicine composition for treating egg drop disease of laying hen and the preparation method and application thereof are mainly used for treating the egg drop disease of the laying hen with a clear target; the traditional Chinese medicine composition is reasonable in compatibility of medicinal raw materials, and simple to process, used in a way of being mixed with feed, and has an remarkable effect of preventing and treating the egg drop disease of the laying hen.

An application of astragalus saponin A in preparing the medicines for preventing and treating the diabetic peripheral neuropathy is disclosed. Said medicine applied orally is prepared from the astragalus saponin A and proper additive.

The invention discloses ferroferric oxide nanoparticles as well as a preparation method and the application of the ferroferric oxide nanoparticles in inhibiting proliferation of Salmonella. The ferroferric oxide nanoparticles are added to a feed for resisting Salmonella infection in poultry. According to the invention, the ferroferric oxide nanoparticles are used for resisting the Salmonella infection of the poultry for the first time; the ferroferric oxide nanoparticles are added in the feed during the brooding period, so that the bacteria loading amount of the Salmonella in broiler bodies infected with the Salmonella can be significantly reduced, and the ferroferric oxide nanoparticles have favorable effects on liver tissues, do not produce side effects and have lower use cost, and further are convenient in use and simple in production process. According to the ferroferric oxide nanoparticles and the preparation method and the application of the ferroferric oxide nanoparticles in inhibiting the proliferation of the Salmonella, a new way for treating the Salmonella is opened, and a new research idea for the development of medicines resisting the Salmonella is further provided.

The invention belongs to the medicine field and particularly discloses application of benzoyl aconine in preparation of rheumatoid arthritis therapeutic drugs, the benzoyl aconine is taken as a natural medical material extractive, remarkable multi-acting target, low toxicity and high-efficiency therapeutic effects to the rheumatoid arthritis can be realized through multiple action mechanisms of anti-inflammation and detumescence, ankle pathologic change reduction, immune visceral organ pathologic change reduction and/or serum cell factor reduction, the cure rate of the rheumatoid arthritis patients is increased, the possibility of the medicine kinds and the dosage is reduced, and the benzoyl aconine has a remarkable and advanced meaning in the preparation of the rheumatoid arthritis therapeutic drugs.

The invention discloses a traditional Chinese medicine preparation for curing migraine, which is prepared by extracting 1 proportion of rhizoma ligustici wallichi, 0.45-1.2 proportions of cinnamomum migao H.W.Li, 0.40-1.1 proportions of raphani, 0.005-0.15 proportion of artificial musk, 0.002-0.03 proportion of borneol and additives, in addition, nasal cavity spraying agents and nose drops can also be prepared. According to the traditional Chinese theory of 'the brain is linked with the nose', the medicine is taken through the nasal cavity, which has rapid pain relieving effect, high potency and no toxicity and side effects.

The invention belongs to the field of medicine preparation, and particularly relates to applications of ammonium pyrrolidine carbodithioic salt in preparation of a drug for preventing decompression sickness caused by fast buoyant ascent escape. The ammonium pyrrolidine carbodithioic salt is dissolved in normal saline to prepare 25-125mg/mL of injection for use. The dose of ammonium pyrrolidine carbodithioic salt intraperitoneal injection is 80-120mg/kg, and the dose of ammonium pyrrolidine carbodithioic salt intravenous injection is 30-50mg/kg. The ammonium pyrrolidine carbodithioic salt is used at 20-35 minutes before fast buoyant ascent escape. The experiments show that the ammonium pyrrolidine carbodithioic salt can obviously inhibit the heart failure caused by myocardial fiber fracture due to bubbles so as to improve the cardiac function and lighten the injury and inflammation of the lung, so that the pathologic change caused by the decompression sickness can be lightened. Furthermore, the applications can provide experimental data for clinically more reasonably applying the ammonium pyrrolidine carbodithioic salt onto the decompression sickness caused by the fast buoyant ascent escape.