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Preparation method of roxburgh anoectochilus terminal bud extracts containing kinsenoside and application of extracts

A technology of clematis glycosides and extracting solution, applied in the field of medicine, can solve the problems of reduced utilization rate, easy decomposition and low bioavailability of clematis glycosides, and achieves alleviation of pathological changes of liver tissue, good repeatability, and improved utilization rate. Effect

Inactive Publication Date: 2018-12-18
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional methods of taking clematis clematis are making tea, simmering soup, decocting, etc. In recent years, people have improved the processing technology of clematis clematis. Patent No. CN102697748B discloses a clematis clematis buccal tablet and its preparation method. In this method, the dried clematis is crushed and sieved and directly used as medicine without extracting the active ingredients, so the bioavailability is low; CN105106653A (a method for preparing clematis granules), CN105288190A (a clematis Extraction tablet and preparation method thereof), CN107822134A (clematis buccal tablet and manufacturing process) and CN107929543A patent (a kind of clematis concentrated powder and its preparation method) in the extracting method of clematis using hot water or steam Leaching, auroside is soluble in water and ethanol, but due to the influence of the lactone ring structure and glycoside structure, it is easy to decompose in a water environment, resulting in a decrease in the utilization rate of auroside

Method used

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  • Preparation method of roxburgh anoectochilus terminal bud extracts containing kinsenoside and application of extracts
  • Preparation method of roxburgh anoectochilus terminal bud extracts containing kinsenoside and application of extracts
  • Preparation method of roxburgh anoectochilus terminal bud extracts containing kinsenoside and application of extracts

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Experimental program
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Effect test

Embodiment 1

[0038] Embodiment 1: the preparation method and transfer rate of Clematis clematis dry cream powder

[0039] A. After the clematis is purified, add 12 times of 50% ethanol to reflux for extraction for 1.5 hours, collect the filtrate, add 10 times of water to the filter residue, decoct and extract twice, each time for 1.5 hours, and filter in the same way. The first and second filtrates were combined, and the third filtrate was collected separately. The clematis extract was concentrated under reduced pressure and heated to recover ethanol, and the filtrate was concentrated to a thick paste with a relative density of 1.25 (50°C), and combined. Dry under reduced pressure at 55°C to obtain a dry paste. Pulverize and pass through an 80-mesh sieve to obtain dry cream powder.

[0040]B. After cleaning the clematis, add 15 times of 70% ethanol to reflux for extraction for 1 hour, collect the filtrate, add 12 times of water to the filter residue, decoct and extract twice, 1 hour each...

Embodiment 2

[0047] Embodiment 2: Preparation of granules containing auroside

[0048] A health food containing auroglutin, in the form of granules, consisting of the following components by weight:

[0049]

[0050] The filler, such as for chemical liver damage or assisting in lowering blood lipids, can be lactose, sucrose, mannitol, sorbitol, and maltitol, and can be used for assisting in lowering blood sugar, such as mannitol, sorbitol, and maltitol. The wetting agent is 80%-90% ethanol. Lubricants can be magnesium stearate, talcum powder, polyethylene glycol, silicon dioxide; sweeteners can be aspartame, stevioside, sucralose; flavoring agent is natural fruit essence.

[0051] Preparation method: dry the filler at 80°C for 4 hours, pass through a 100-mesh sieve, weigh it according to the prescription amount, and set aside; put the filler in a granulator, add the dry cream powder of Clematis clematis, mix well, and spray into the moistening Wet agent, mix well, pass through 14-24 m...

Embodiment 3

[0053] Embodiment 3: Tablet preparation containing auroglutin

[0054] A health food containing auroglutin, in the form of a tablet, consisting of the following components by weight:

[0055]

[0056] The filler, if used to treat chemical liver damage or assist in lowering blood lipids, can be lactose, sucrose, mannitol, sorbitol, maltitol, starch, maltodextrin, dextrin, microcrystalline cellulose, such as using To assist in lowering blood sugar, mannitol, sorbitol, maltitol, starch, and maltodextrin can be used. The wetting agent is 80%-90% ethanol; the lubricant can be magnesium stearate, talcum powder, polyethylene glycol, silicon dioxide and the like.

[0057] Preparation method: dry the filler at 80°C for 2 to 6 hours, pass through a 100-mesh sieve, weigh according to the prescription amount, and set aside; granulation: put the filler and the dry cream powder of Clematis clematis into a granulator, and mix well , spray into the wetting agent, dry, the temperature is ...

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Abstract

The invention provides a preparation method of a roxburgh anoectochilus terminal bud extracts containing kinsenoside and application of the extracts. The roxburgh anoectochilus terminal bud extracts are is prepared from roxburgh anoectochilus terminal bud extraction liquid, roxburgh anoectochilus terminal bud thick paste, roxburgh anoectochilus terminal bud dry paste and roxburgh anoectochilus terminal bud dry paste powder. The preparation method comprises the work procedures of medical material alcohol extraction, water extraction, reduced pressure concentration, drying, crushing and the like. The method has the advantages that the transfer rate of the effective ingredient of the kinsenoside can be improved by 50 percent or higher through being comparedin comparison with a conventional water extraction process; the utilization rate of the rare medicinal materials is obviously improved; the process operability is high; the repeated performance is good; the equipment requirement is low;the preparation method is applicable to industrialized production. The roxburgh anoectochilus terminal bud extracts prepared by the method can be used for preparing health care food; the taking and the carrying of the finished product are is convenient to take and carry; the quality is stable; the auxiliary protection effect is achieved on the chemical liver damage; the effects of assistance in reducing the blood fat in an auxiliary way and reducing the blood sugar in an auxiliary way areis obvious.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a herbal drug extract and an extraction method, in particular to a preparation method of an extract of Auranthus clematis and an application of the extract. Background technique [0002] Anoectochilus roxburghii (Wall.) Lindl. is a perennial herbaceous plant of the Orchidaceae genus Anoectochilus roxburghii (Wall.) Lindl., which is used as a whole herbal medicine. This strain is a rare and precious herbal medicine in Fujian, Taiwan and other provinces. It is known as the "King of Medicine". Its nature is flat and sweet; Children with convulsions and other symptoms. Modern pharmacological research shows that this product has pharmacological activities such as liver protection, anti-HBV, lowering blood fat, lowering blood sugar, anti-inflammation, anti-oxidation, and anti-osteoporosis. [0003] Clematis glucoside is the main active ingredient of Clematis clematis, with a content o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/06A61K9/14A61K9/16A61K9/28A61P1/16A61P3/06A61P3/10A23L33/105
CPCA23V2002/00A61K9/06A61K9/14A61K9/1623A61K9/28A61K36/898A61K2236/331A61K2236/333A61K2236/39A61K2236/51A23L33/105A61P1/16A61P3/06A61P3/10A23V2200/30A23V2200/3262A23V2200/328A23V2250/21A23V2300/14
Inventor 张勇慧
Owner HUAZHONG UNIV OF SCI & TECH
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