187results about How to "Suppress death" patented technology

PCT No. PCT/JP97/01828 Sec. 371 Date Jan. 30, 1998 Sec. 102(e) Date Jan. 30, 1998 PCT Filed May 29, 1997 PCT Pub. No. WO97/45410 PCT Pub. Date Dec. 4, 1997The invention provides novel benzindole derivatives, processes for producing them, as well as a neuroprotective agent, an agent to prevent or treat diseases involving the degeneration, retraction or death of neurons, and an analgesic, each containing the benzindole derivatives as an active ingredient.

In accordance with the invention, a compound with a protective action for nerve cell can be reselected by adding PPARδ agonist to a culture cell system where toxic substances such as thapsigargin, MPP⁺ and staurosporine are preliminarily allowed to react and reselecting a compound improving the survival rate. The compound selected by such method can be used as an active ingredient of a therapeutic agent for neurodegenerative diseases such as cerebral infarction and Parkinson's disease. Thus, the invention is very useful for research works for creating novel pharmaceutical agent.

The invention discloses an expansion method of various lymphocyte subpopulations and application of the expansion method to preparation of an adoptive immunotherapy medicine for cancers. The expansion method comprises the following steps: S1, adding IFN gamma and zoledronic acid into a culture medium of PBMC collected in the blood of a tumor patient, and re-adding an OKT3 antibody and recombinant human interleukin-2 after culture to stimulate PBMC so as to finish preliminary expansion; S2, after finish of preliminary expansion, mixing immune lymphocytes with feeder layer cells, and after adding zoledronic acid, an OKT3 antibody and recombinant human interleukin-2, continually performing expansion. By adoption of the expansion method, after twice expansion, the sum of the immune cells can be 10,000 to 80,000 times by expansion, the expanded immune cells include alpha beta T cells, gamma delta T cells, NKT cells and NK cells, and tumor cells can be directly killed, or a cellular immunotherapy drug is prepared to kill the tumor cells.

A lactic acid bacteria fermented substance is characterized by being obtained by culturing lactic acid bacteria in a medium containing an extract of at least one food material selected from the group consisting of rice bran, persimmon leaf, Perilla frutescens, Houttuynia cordata, Eucommia ulmoides, turmeric, clove, cinnamon and Rubus suavissimus. Because the extract to be used in the production of the lactic acid bacteria fermented substance does not cause a flavor problem and can increase the number of living lactic acid bacteria easily by simply being added to and mixed in the medium, the lactic acid bacteria fermented substance containing many living lactic acid bacteria in which high activity is maintained and a food or a drink using the same can be obtained.

The invention discloses effector protein Avh87 derived from phytophthora cinnamomi, and a coding gene and application thereof. The protein has the amino acid sequence of SEQ ID No. 1 in the sequence table. The nucleotide sequence expressing the protein is represented by SEQ ID No. 2 in the sequence table. Experiments show that the gene can inhibit plant cell hypersensitive reactions induced by apoptotic precursor protein Bax, or inhibit plant cell death induced by pathogenic phytophthora elicitors INF1. The effector protein Avh87 is of great significance in enriching molecular mechanism information of the interaction between the phytopathogenic oomycetes and hosts, and in establishing a comprehensive prevention and control technology strategy for phytopathogenic oomycete diseases.

Compositions and methods for preventing fusarium head blight on target crop plants are disclosed.

The invention relates to a herbicide. The herbicide comprises following raw materials in parts by weight: 40-60 parts of acetochlor, 20-50 parts of glyphosate, 1-5 parts of polyvinyl alcohol, 3-10 parts of fluroxypyr-mepthyl, 3-8 parts of acetone and 2-10 parts of a surfactant. The glyphosate is used for enabling a ternary component to have the obvious synergistic effect by a pure stem and leaf uptake and translocation effect and the combination of fluoroglycofen-ethyl and the fluroxypyr-mepthyl through different mechanisms of stem and leaf touch and root inner uptake and translocation. The glyphosate and a salt thereof are of a low-toxin sterilant herbicide and can be used for preventing and removing all green plants.

The present invention relates to a pharmaceutical composition for the treatment and/or prevention of a neurodegenerative disease, comprising the following polypeptide shown in any of (a) to (c): (a) a polypeptide comprising the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1); (b) a polypeptide comprising an amino acid sequence having a deletion, substitution, insertion, and/or addition of one or several amino acids in the amino acid sequence consisting of Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death associated with neurodegenerative disease; and (c) a modified polypeptide from the polypeptide (a) or (b), or a pharmaceutically acceptable salt thereof, as an effective ingredient.

The invention discloses a tea leaf theanine health-care food composite. The tea leaf theanine health-care food composite comprises the following raw materials in part by weight: 50-100 parts of tea leaf theanine, 50-100 parts of gamma-aminobutyric acids, 300-380 parts of DHA (dihexyl adipate) algae oil, 30-70 parts of taurine and 1.0-2.5 parts of vitamin. The invention also discloses a preparation method of the tea leaf theanine health-care food composite. The tea leaf theanine health-care food composite is reasonable in formula; by the tea leaf theanine health-care food composition, effects of effectively alleviating physical and psychological stress, relaxing mood, improving memory and reducing blood pressure can be achieved; and the fatigue of a user can be relieved as soon as possible after the user takes a break after working. An animal function test shows that the tea leaf theanine health-care food composition has a function of improving memory and does not have any toxic or side effects.

The present invention provides medicinal or pharmaceutical compositions and preparations for administration, which are useful as cytoprotective agents and a remedy for neurotrauma, comprising ginseng, its extract, ginseng components, metabolites thereof or salts thereof (for example, red ginseng powder or components thereof). More particularly, the present invention provides medicinal or pharmaceutical compositions for inhibiting apoptosis or apoptosis-like cell death, medicinal or pharmaceutical compositions for promoting the expression of a cell death-suppressing gene product Bcl-x_L, or preparations for oral or intravenous administration, comprising ginseng, its extracts, ginseng components, metabolites thereof or salts thereof preferably at low concentrations. These medicinal or pharmaceutical compositions and/or preparations for administration are characterized by containing, as the active ingredient(s), ginseng, its extracts, ginseng components, metabolites thereof or salts thereof at low concentrations. These drugs are useful for therapy, prevention or treatment of brain and nervous diseases, heart diseases, etc.

The invention discloses a weather-proof, anti-corrosion and antibacterial processing process for rosewood fan frameworks, and belongs to the process field of folding fan bamboo material processing. The weather-proof, anti-corrosion and antibacterial processing process is characterized by including the steps of preparing antibacterial and anti-corrosion solvents and antibacterial and anti-corrosion boiled materials, and conducting material boiling, spraying and slurry wrapping. In addition, as surface active agents, purification dispersants and sodium carboxymethylcellulose are added to the antibacterial and anti-corrosion solvents for use, all anti-corrosion and antibacterial components can be integrated and coincident, and the antibacterial and anti-corrosion effect can be maximized and optimized under the synergistic effect. Pure natural materials are selected as the antibacterial and anti-corrosion solvents and the antibacterial and the anti-corrosion boiled materials, the purchase cost is economical and affordable, the weather-proof, anti-corrosion and antibacterial effects are good, no hazard is caused to the environment and human bodies, successes are made at the experimental stage and during batched small experiments, and the weather-proof, anti-corrosion and antibacterial processing process is suitable for industry popularization.

The invention discloses a planting method of Hongruyi pomegranate. By inter-planting orange trees, planting coriander, tomato, wintergreen, ginger, wormwood, or fennel among pomegranate rows, planting calamus yunnanensis at the edge of a planting area, and fertilizing reasonably during fertilizer and water management, diseases and insect pests of the pomegranate can be effectively inhibited, a food refusal effect is generated to insects, ova, larvae and adult insects can be killed, and the use of chemical insecticides is reduced, so that the edible safety of the pomegranate is improved; and photosynthesis is improved, fruit dropping of the pomegranate is prevented, the quality and yield of the pomegranate are improved, and land resources can be reasonably used to improve the economic value of lands.

A metal magnetic powder for a magnetic recording medium is provided whose particles have a metal magnetic phase, composed mainly of Fe or Fe plus Co, and an oxide layer, wherein the average major axis length of the powder particles is 10-50 nm, the average particle volume including the oxide layer is 5,000 nm³ or less, the atomic ratio (R+Al+Si)/(Fe+Co) calculated using the content values (at. %) of the elements contained in the powder particles is 20% or less, where R is rare earth element (Y being treated as a rare earth element). The metal magnetic powder is obtained by using a complexing agent and a reducing agent to elute nonmagnetic constituents after firing. The metal magnetic powder exhibits a large saturation magnetization σs for its particle volume while maintaining weatherability comparable to the conventional level and is suitable for a coated-type magnetic recording medium.

The invention belongs to the field of cosmetics and particularly relates to a hydrogen containing gel mask. The hydrogen containing gel mask comprises a powder agent A and a gel agent B. The powder agent A is prepared from, by weight, 0.01-5% of potassium carbonate, 0.1-10% of sunflower seed oil, 0.1-5% of magnesium salt, 0.0001-0.5% of hydrogen, 0.1-5% of silica, 0.0001-0.05% of a pH buffering agent and the balance corn starch, wherein the total weight percentage is 100%. The powder agent B is prepared from, by weight, 1-20% of a polyalcohol moisturizing agent, 0.05-2% of a thickening agent, 0.001-1% of active additives, 0.1-5% of a cosmetically acceptable carrier and the balance water, wherein the total weight percentage is 100%. The hydrogen containing gel mask gives play to remarkable skincare efficacies of hydrogen, has anti-oxidation, anti-inflammatory, anti-radiation and anti-ultraviolet functions and is capable of remarkably resisting skin injuries caused by radiation and ultraviolet while promoting fibrocyte collagen synthesis, clearing free radicals and inhibiting keratinocyte death so as to achieve efficacies of radiation resisting, ultraviolet resisting, beautifying, acne removing and wrinkle resisting.

The invention relates to an antagonistic polypeptide and application thereof in preparation of novel coronavirus resistant drugs, and belongs to the technical field of biopharmacy. The antagonistic polypeptide contains an amino acid sequence shown as SEQ ID NO: 1 from the N terminal to the C terminal, or the antagonistic polypeptide contains an amino acid sequence shown as SEQ ID NO: 1 from the Nterminal to the C terminal, and the N terminal or the C terminal of the amino acid sequence shown as SEQ ID NO: 1 is connected with an amino acid sequence shown as SEQ ID NO: 2 from the N terminal tothe C terminal; and the antagonistic polypeptide can be competitively combined with an endocytosis receptor and a receptor binding domain of a novel coronavirus or SARS virus. The antagonistic polypeptide has a strong antagonistic effect on SARS-CoV/SARS-CoV-2, can effectively block SARS-CoV/SARS-CoV-2 endocytosis, and inhibits SARS-CoV/SARS-CoV-2 induced renal epithelial cell death. The antagonistic polypeptide can be used for preparing drugs for antagonizing SARS-CoV/SARS-CoV-2, and can be applied to prevention and treatment of new coronavirus and SARS virus infection and renal complicationsthereof.

The invention discloses cloning and application of an R gene TN2 for regulating and controlling powdery mildew resistance of plants. The invention provides a method for regulating and controlling the resistance of plants on powdery mildew. An amino acid sequence of TN2 protein is a sequence 2 in a sequence table; premature translation termination is caused by single amino acid change of seven sites and mutation of two sites; and the resistance of an exo70B1 mutant on the powdery mildew and powdery mildew-induced cell death can be restrained, but no obvious effect is generated on growth and development of plants, thus, the TN2 can be applied to the technical field of genetic engineering, so as to regulate and control resistance reaction of the plants on the powdery mildew.

The invention discloses an effector protein Avh57 from phytophthora cinnamomi as well as a coding gene and an application thereof. The protein has an amino acid sequence shown in SEQ ID NO: 1 in a sequence table. Experiments prove that the protein controlled and expressed by the gene can participate in invasion process of phytophthora cinnamomi into nicotiana benthamiana, and the gene has the function of inhibiting plant cell death induced by proapoptotic protein Bax. The phytophthora cinnamomi effector protein of the present invention has important significance on enriching molecular mechanism data information about interaction of plant pathogenic oomycetes and hosts, and establishing a comprehensive prevention and control technical strategy against plant pathogenic oomycetes diseases.

The invention relates to a piperazine derivate and application thereof. The piperazine derivate takes N1-arylmethyl and N4-pyridyl piperazine as parent matrixes to modify the structure of pesticides of main pharmacophore of the N1-arylmethyl and N4-pyridyl piperazine, so as to obtain a type of novel compound. As shown by biological (insect disinfestation) activity determination: the novel compound designed and synthesized by the invention can effectively inhibit feeding and growth of crolepidopteron, and cause the crolepidopteron to die. The piperazine derivate not only is helpful to the further research of 5-hydroxytryptamine receptors of insects but also provides direction for creation of green pesticides with a novel functional mechanism.

The invention discloses a pests and disease prevention purposed planting method of soft-seed pomegranates. The pests and disease prevention purposed planting method mainly includes four prevention stages of preplanting, sapling, growing period and fruit period, for preplanting, performing deep plowing the land before planting, spraying a biogenic-source disinfectant, and disinfecting by a soil fumigation mode; for the sapling, growing period and fruit period, performing targeted prevention on different pathogenesis. With the method, to-be-cultivated soil can be kept clean, survival rate of the pomegranates is increased, pest and disease damage of later period is prevented, root, stem and leaf health is kept, photosynthesis of the pomegranates is improved, storage of nutrients is guaranteed, and growth quality of the pomegranates is improved; meanwhile, the disinfectant is the biogenic-source disinfectant, continuous pest killing effect is achieved, antibody cannot be produced to larva, and soil hardening, underground water pollution and harm to human beings cannot occur.

The invention discloses a processing technique for perfuming, corrosion preventing and bacteria inhibiting of a redwood fan framework, and belongs to the field of folding fan bamboo material processing techniques. The processing technique is characterized by including the steps of preparation of antibacterial and anticorrosive solvent and antibacterial and anticorrosive perfume, boiling, baking, spraying and paste wrapping. Surfactant, cleaning dispersant and sodium carboxymethylcellulose are added into the antibacterial and anticorrosive solvent, so that all antibacterial and anticorrosive elements are integrally blended, and antibacterial and anticorrosive effects can be achieved maximumly and optimally due to the synergistic effect. The pure natural plant perfume is used for baking and perfuming the redwood fan framework by stages, so that fragrances can slowly infiltrate the interiors of redwood fibers, smoke smell is avoided, and freshness lasts long. After high-oleic-acid redwood preservative solution is sprayed, the surface of the redwood fan framework is scrubbed by cotton cloth repeatedly until a glossy paste wrapping layer appears, so that compactness of a surface anti-oxidation layer can be achieved, and weather fastness can be improved effectively.

The invention relates to the field of molecular biology, and specifically discloses a fungus effector, a coding gene and application thereof. Through experimental researches, it is found that the effector RxLR129113 (nucleotide sequence as shown in SEQ ID No.1) from Phytophthora capsici can cause the hypersensitive reaction (HR) and inhibit Bax-induced programmed cell death (PCD) and inhibit INF1-induced cell death on nicotiana benthamiana. According to the structure of RxLR129113, RxLR129113 is truncated, and four truncated mutants (RxLRW1, RxLRW1-2, RxLRW1-3 and RxLRW1-4) are subjected to functional verification; and it is found that RxLRW1-3 is a key functional domain that inhibits cell death caused by Bax and INF1. The nuclear output and nuclear input functions of RxLR129113 and RxLRW1-3 are verified, and the result shows that when RxLR129113 is located in cytoplasm, HR can be caused and the ability of inhibiting Bax and INF1 is strong, and when RxLRW1-3 is located in cytoplasm, the ability of inhibiting Bax and INF1 is strong.

The invention belongs to the field of drug synthesis, and discloses a compound with a structure as shown in a formula I (See the specification) and pharmaceutically acceptable salt, tautomer, polymorphic substance, isomer and solvate thereof. Secondly, the invention discloses a method for preparing chiral chloroquine and hydroxychloroquine through chiral high performance liquid chromatography. Finally, the invention discloses application of chiral chloroquine, hydroxychloroquine and salt derivatives thereof in preparation of drugs for treating novel coronavirus pneumonia.