7results about How to "Suppress death" patented technology

The present invention relates to a triazole compound having a novel ring structure, a preparation method therefor, and a use thereof. The triazole compound having a novel ring structure according to the present invention exhibits excellent ASK1 inhibiting ability and inhibits apoptosis of neurons, and thus can be used for the prevention or treatment of ASK1-related diseases, including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and liver diseases.

This application discloses the use of USP15 inhibitors in the preparation of medicaments for the treatment and / or prevention of renal cell carcinoma, as well as pharmaceutical compositions and kits thereof.

The invention discloses a phytophthora pini effector protein PpinAvh23 as well as a coding gene and application thereof, and belongs to the technical field of molecular biology. The amino acid sequence of the protein is as shown in SEQ ID NO. 1. Experiments show that the protein can specifically inhibit programmed death of plant cells induced by pathogenic bacteria elicitors, and it is proved that the protein can promote pathogen infection as a toxic effector in plants. The invention also provides a gene (SEQ ID NO.2) for coding the protein. The protein and the coding gene thereof can be used as a key molecular tool and a screening target for researching a plant-pathogen interaction mechanism, and a basis is provided for developing a new strategy for preventing and controlling plant diseases.

This application provides a biomimetic mineralized hydrogel, relating to the field of medical polymer materials. The biomimetic mineralized hydrogel provided in this application uses a biodegradable polymer containing carboxylate groups as a mineralization template, and phosphate-containing small molecules as strong ligands and phosphate donors, inducing Fe... 3+ In-situ mineralization forms stable iron-bearing mineralized crystals, achieving Fe³⁺ + Long-term, low-dose sustained release, thereby delivering Fe 3+ The concentration is maintained within a safe window to allow it to exert its positive bioregulatory effects while avoiding the risks of iron overload-induced oxidative damage and ferroptosis. Simultaneously, it slows the release of Fe³⁺. + It can regulate cellular iron metabolism and activate antioxidant stress-related pathways, inhibit ferroptosis, and create a favorable repair microenvironment for osteochondral regeneration. Experimental results show that this hydrogel not only has excellent flexibility, biocompatibility, antibacterial properties, and angiogenesis-promoting properties, but also promotes osteogenic and chondrogenic differentiation of cells, thereby achieving an integrated osteochondral repair effect.

This invention belongs to the field of targeted drug technology, and specifically relates to the application of PRDX3 protein as a drug target in screening drugs for the prevention and / or treatment of COPD induced by cigarette smoke. This invention demonstrates that the expression level of PRDX3 protein is increased in COPD mouse models and in cigarette smoke-induced MLE-12 alveolar epithelial cells, and also explores the effect of PRDX3 on COPD disease progression. Overexpression of PRDX3 in alveolar epithelial cells significantly improves lung function and lung tissue damage in COPD mice, while knockdown of PRDX3 exacerbates COPD symptoms in COPD mice. This invention provides a novel drug target and candidate compound for the treatment of COPD, and has significant clinical application value.

The application belongs to the field of clinical drug toxic side effects, and particularly relates to the use of phenazine-1-carboxylic acid in treating cisplatin-mediated acute kidney injury. The application first discovers and proves that phenazine-1-carboxylic acid can effectively alleviate cisplatin-induced acute kidney injury. In a cisplatin-induced acute kidney injury model of mice, intraperitoneal injection of phenazine-1-carboxylic acid can effectively protect kidney function, which is specifically manifested as follows: significantly reducing urea nitrogen and creatinine levels in serum of model mice; reducing pathological injury of kidney tissue and reducing tubular injury score; and inhibiting expression of inflammatory factors and injury markers in kidney tissue. The treatment effect is equivalent to that of a classic ferroptosis inhibitor, Ferrostatin-1, and a new candidate drug for solving the dose-limiting toxicity of cisplatin in clinical application is provided.

The invention relates to the technical field of films, and discloses an antibacterial PE film and a preparation method thereof. The PE film prepared by the invention comprises the following raw materials in parts by weight: 35-45 parts of low-density polyethylene, 15-25 parts of high-density polyethylene, 10-20 parts of metallocene linear low-density polyethylene, 5-10 parts of maleic anhydride grafted POE, 5-10 parts of a composite antibacterial agent, 2-5 parts of a lubricant and 1-3 parts of an antioxidant. The PE film not only has the barrier property of the traditional PE film, but also is endowed with excellent antibacterial property by adding the composite antibacterial agent.