The invention provides traditional Chinese medicine colon dialyzate treating chronic renal failure. The traditional Chinese medicine colon dialyzate comprises, by weight, 10-30 parts of astragalus membranaceus, 15-45 parts of angelica sinensis, 10-30 parts of codonopsis pilosula, 5-15 parts of ligusticum wallichii, 12-30 parts of raw rhubarb, 12-30 parts of raw oyster shell, 15-30 parts of dandelion, 5-15 parts of ganoderma lucidum, 6-10 parts of herb of snow of june, 3-9 parts of resina draconis, 3-9 parts of ternate buttercup root and 3-6 parts of ambrette musk mallow. The clinic experiment proves that the traditional Chinese medicine colon dialyzate has an obvious curative effect on treating the chronic renal failure. The traditional Chinese medicine colon dialyzate has a small number of adverse reactions, has the advantages of being high in safety, low in cost, convenient to operate and the like and is a safe and effective new method for treating the chronic renal failure.