53 results about "Morus Alba Root" patented technology

The application discloses an active polypeptide and application thereof in treating diabetic peripheral neuropathy, and belongs to the technical field of biological polypeptide drugs. An amino acid sequence of the active polypeptide is QVWPDGFVGLAKLWI, which is obtained by step-by-step enzymatic extraction and purification from Morus alba L. which is a homology of medicine and food. The polypeptide can significantly inhibit oxidative stress, inflammatory infiltration and cell apoptosis of Schwann cells induced by a high-sugar environment, and repair the function of damaged nerve cells. Meanwhile, the polypeptide can effectively improve abnormal sciatic nerve conduction function of a diabetic model mouse. The active polypeptide can be used for preparing a drug for treating diabetic peripheral neuropathy, and provides a new candidate drug and research and development direction for the targeted treatment of diabetic peripheral neuropathy.

The invention belongs to the field of food nutrition and pharmacy, and particularly relates to folium mori crude polysaccharide and application thereof. An extract rich in mulberry leaf polysaccharide is extracted from mulberry leaves through a specific extraction process, and it is found through an in-vitro antibacterial experiment that the crude mulberry leaf polysaccharide has the direct inhibiting and killing effect on helicobacter pylori (Helicobacter pylori). In-vitro intestinal flora fermentation research shows that the folium mori crude polysaccharide can effectively correct intestinal flora disorder caused by triple antibiotics for treating helicobacter pylori, meanwhile, the short-chain fatty acid level is remarkably improved, and the helicobacter pylori abundance in intestinal flora is reduced. The application field of mulberry leaf polysaccharide is widened, and important reference is provided for developing products for adjuvant therapy of H.pylori infection and intestinal microecology regulation based on natural polysaccharide.

The invention provides application of loranthus parasiticus in preparation of a lipid-lowering medicine. The application has the advantages that the loranthus parasiticus extract can effectively improve HFD-induced obesity and glucose and lipid metabolism disorder; the loranthus parasiticus extract can relieve adipose tissue enlargement and liver fatty degeneration.

The present application belongs to the technical field of biological medicine, and particularly relates to a pharmaceutical composition for treating pulmonary fibrosis and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 12-18 parts of Astragalus membranaceus, 6-12 parts of Ophiopogon japonicus, 4-10 parts of Poria cocos, 1-3 parts of Radix Glycyrrhizae, 10-16 parts of Salvia miltiorrhiza, 6-12 parts of Scutellaria baicalensis, 4-10 parts of Morus alba, 2-6 parts of Pericarpium Citri Reticulatae Viride, 1-4 parts of Sophora flavescens and 1-4 parts of Fritillaria cirrhosa. The present application is a three-phase and fixed-ratio compound of polysaccharides, phenolic acids and flavonoids. The polysaccharides are obtained by water extraction and alcohol precipitation, and are used as a mucosal retention adhesion carrier. The phenolic acids and flavonoids are extracted by low-degree ethanol refluxing, so as to ensure the structural integrity and maintain stability. The alkaloids are extracted by ethanol and then mildly salified, so as to reduce irritation and adsorption loss. The polysaccharides are then subjected to selective light fermentation to build a slightly acidic environment. In the compounding process, a buffer system is used to adjust pH, and cyclodextrin is used to stably bind the components. The three phases synergistically intervene in oxidation-inflammation-fibrosis.

This invention relates to the field of health products or food technology, and more specifically to a composition and its application in removing dampness and controlling blood sugar, balancing blood pressure, and regulating blood lipids. The invention provides a composition for removing dampness and controlling blood sugar, balancing blood pressure, and regulating blood lipids, comprising Poria cocos extract, Astragalus membranaceus extract, hirudin, and at least one or more of Eucommia ulmoides extract, Gynostemma pentaphyllum extract, and Morus alba twig extract. The composition provided by this invention utilizes extracts from at least four precious Chinese medicinal herbs to exert a synergistic effect, jointly achieving the effects of lowering blood pressure, removing dampness and lowering blood sugar, and lowering blood lipids.

The invention relates to the technical field of instant food production, and discloses a making process of a convenient mushroom hotpot, which comprises the following steps of: firstly, selecting basic mushrooms of which the first type is shiitake mushroom, coriaria sinica, pleurotus citrinopileatus, black fungus, pleurotus cornucopiae, velvet antler mushroom, cordyceps flower and hericium erinaceus, and the second type is tremella aurantialba and bamboo fungus; cleaning and removing impurities, adding water into the first type of mushrooms, heating at 100-120 DEG C for 30 minutes, adding the second type of mushrooms, and continuously heating for 20 minutes to obtain a mixed system containing cooked mushrooms and mushroom stock; and after solid-liquid separation, adding seasonings into the mushroom stock soup, heating to prepare a mushroom soup bag, sealing the cooked mushrooms to form a mushroom bag, and packaging the mushroom soup bag and the mushroom bag together to obtain the product. According to the scheme, the problems that basic mushroom combination of an existing convenient mushroom hotpot is not clear, the taste and the umami are insufficient due to the fact that heating is not conducted according to characteristics differentially, and the flavor is poor due to the fact that mushroom soup is not original soup are solved, and the product is convenient to eat and stable in quality.

The present invention relates generally to methods and compositions useful for treating skin, and in particular to improve the appearance of droopy, loose, sagging, and / or flaccid skin and / or to improve facial contouring. In some aspects, disclosed are methods comprising topically applying to the skin an effective amount of a topical composition comprising escin, Ascophyllum nodosum extract, caffeine, Coleus barbatus extract, Hedychium coronarium root extract, Argania spinosa oil, Rosmarinus officianalis leaf extract, and / or Morus alba fruit extract.

The invention belongs to the technical field of cosmetics, and particularly relates to a composition with effects of improving skin color and resisting oxidation as well as a preparation method and application of the composition. The composition with the effects of improving the skin color and resisting oxidation, provided by the invention, is prepared by compounding an ormosia henryi bark extract, a mulberry root bark extract, a raspberry fruit extract, 4-butylresorcinol and ascorbyl tetraisopalmitate; wherein in the preparation method of the ormosia henryi bark extract, the ormosia henryi bark is extracted by adopting a mode of combining eutectic emulsion standing extraction with micro-jet secondary extraction, the stability of active substances in the obtained ormosia henryi bark extract is good, and the extraction efficiency is high; the extraction method is low in production cost and easy to operate, and conforms to the green chemistry principle. The composition provided by the invention has excellent effects of improving skin color and resisting oxidation and is mild and non-irritant, the preparation method is simple and easy to operate, and industrial actual large-scale production and application are facilitated.

The invention discloses a traditional Chinese medicine medicated bath medicine bag for treating wind-cold-dampness arthralgia, and belongs to the technical field of traditional Chinese medicines. The medicine bag is prepared from 10-20 parts by mass of broussonetia papyrifera roots, pine roots, albizia roots, Chinese redbud roots, maidenhair roots, mulberry roots, banyan roots, camphor tree roots, paulownia roots and willow roots, preferably 15 parts. The preparation method comprises the steps of raw material weighing, drying treatment, mixing and subpackaging into an air-permeable fiber medicine bag, the medicine bag is a 20 cm * 15 cm rectangular cloth bag, three sides are sealed, and one side is provided with an opening and closing structure. Broussonetia papyrifera roots and camphor tree roots are used as monarch drugs together, and synergistically expel wind, remove cold, remove dampness and activate blood, and aim at the core pathogenesis of wind-cold-dampness arthralgia; the root medicinal materials of the whole formula walk through lower jiao and directly reach muscles and bones, are externally applied through fumigation medicated bath, avoid burdens of gastrointestinal tracts, livers and kidneys caused by oral administration, have the advantages of strengthening body resistance and harmonizing, quick response, direct action, high safety and the like, are convenient to use, and are suitable for family health care and clinical popularization.

This invention provides a traditional Chinese medicine composition for treating ulcerative colitis, belonging to the field of traditional Chinese medicine pharmaceutical technology. The composition is obtained through rational formulation based on the principles of syndrome differentiation and treatment in traditional Chinese medicine, specifically composed of Forsythia suspensa, Lilium brownii, Lysimachia christinae, Sesamum indicum, Prickly ash, Pueraria lobata, Centella asiatica, Viola yedoensis, Houttuynia cordata, Portulaca oleracea, Litsea cubeba, Cirsium japonicum, Schizonepeta tenuifolia, Morus alba root, Lophatherum gracile, Lygodium japonicum, and Capsella bursa-pastoris. This invention's composition exhibits significant anti-inflammatory and de-inflammatory effects, and can repair and improve the integrity of colonic tissue structure, enhance intestinal barrier function, and achieve both symptomatic and root-cause treatment of ulcerative colitis. Simultaneously, this invention's composition has a high efficacy and cure rate in treating ulcerative colitis, and significantly alleviates symptoms such as diarrhea, bloody stools, abdominal pain, abdominal distension, anal burning, and tenesmus, greatly reducing patient suffering.

The present invention relates to a composition for improving cardiovascular calcification using a mulberry tree extract and a method for preparing the same. The composition is prepared by collecting the fruit (mulberry), leaves (mulberry leaves), branches (mulberry branches), and root bark (mulberry bark) of the mulberry tree, extracting the fruit and freeze-drying it to produce a mulberry extract, hot-air drying the leaves, branches, and root bark, adding 20-70% ethanol corresponding to 5-50% by weight of each, extracting at 50-90°C for 2-10 hours, filtering and concentrating the extract, and freeze-drying the extract to obtain a mulberry tree extract, and dissolving each extract in distilled water at a concentration of 10-50 mg / ml to provide a composition for improving cardiovascular calcification using a mulberry tree extract and a method for preparing the same, thereby enabling relatively safe and effective improvement of cardiovascular calcification, including vascular calcification.

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for promoting hair growth and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from raw materials including notopterygium root, pawpaw, wine-processed ligusticum wallichii, angelica sinensis, prepared rehmannia root, prepared polygonum multiflorum, wine-processed glossy privet fruit, eclipta, mulberry, herba epimedii, gastrodia elata, barbary wolfberry fruit and Chinese yam according to a specific weight ratio. The preparation method comprises the following steps: preparing pills by using tender honey and honey water as adhesives by adopting a generic or plastic process, and carrying out covering treatment to obtain the traditional Chinese medicine honeyed pill preparation. The composition aims at the pathogenesis of liver and kidney deficiency and blood deficiency and wind dryness type alopecia, and through triple compatibility of nourishing liver and kidney to treat root causes, nourishing blood and activating blood to charge its source, and dispelling wind and dredging collaterals to open its way, the composition not only supplements the material basis of hair growth, but also improves the nutritional status of hair follicles and dredges stasis of hair orifices; the traditional Chinese medicine composition effectively solves the problems that an existing traditional Chinese medicine compound is tonified but not smooth, takes effect slowly, does not have an obvious curative effect on patients with wind pathogen or blood stasis syndromes and is high in relapse rate.

The invention provides a traditional Chinese medicine composition with an effect of treating chronic pharyngitis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 30-50 parts of phyllanthus emblica, 20-40 parts of oroxylum indicum, 15-25 parts of terminalia chebula, 40-60 parts of roughhaired holly root, 15-35 parts of radix ophiopogonis, 5-15 parts of subprostrate sophora, 25-45 parts of selfheal, 10-30 parts of folium mori, 15-35 parts of chrysanthemum, 5-15 parts of radix scrophulariae, 8-18 parts of scaphium scaphigerum, 150-200 parts of wild chrysanthemum and 40-50 parts of honeysuckle. The preparation method comprises the following steps: (1) pretreatment and enzymolysis of rhizome raw materials; (2) whole-formula mixed extraction; (3) two-stage concentration; and (4) drying. Wild chrysanthemum focuses on clearing away heat and toxic materials and relieving swelling and pain The honeysuckle can help the wild chrysanthemum flower to clear away heat and toxic materials and dispel wind and heat. The two components are matched with the phyllanthus emblica and the like, and are prepared through an ultrasonic enzymolysis-gradient alcohol precipitation process, so that the curative effect is improved, and the recurrence rate is reduced.

This invention relates to a strain of *Sanghuang* fungus suitable for making fermented barley tea and its applications, belonging to the field of biotechnology. The *Sanghuang* fungus strain described in this invention was deposited on April 3, 2024, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 41280. This strain is suitable for solid-state fermentation of barley grains for making barley tea. The mycelium of this strain can penetrate the interior of barley grains, fully converting and utilizing the nutrients in the barley grains, exhibiting characteristics such as rapid growth and good appearance. The roasted *Sanghuang* barley tea has a yellow and lustrous color, overcoming the drawback of traditional barley tea being prone to causing "heatiness," possessing both the mellow aroma of barley tea and the unique refreshing aroma of *Sanghuang* fungus, and containing medicinal components of *Sanghuang* fungus. The *Sanghuang* fungus mycelium formed by fermentation and culture of this strain using barley grains as nutrients effectively solves the shortcomings of *Sanghuang* fungus being difficult to cultivate and expensive, while greatly increasing the added value of traditional barley tea.

The application discloses a gene BpMIXTA01 for regulating and controlling initial development of Broussonetia papyrifera epidermal hair as well as an expression protein and application thereof, and belongs to the technical field of plant genetic engineering. The nucleotide sequence of the gene is shown in SEQ ID NO. 1, and the amino acid sequence is shown in SEQ ID NO. 2. The gene belongs to the ninth sub-group MIXTA gene of the R2R3 MYB transcription factor family. Function verification shows that overexpression of BpMIXTA01 in Arabidopsis thaliana can significantly increase the number of epidermal hairs, and can restore the epidermal hair loss phenotype of the Arabidopsis thaliana hairless mutant, proving that BpMIXTA01 is a positive regulation factor of epidermal hair formation. The application first discloses a key regulation gene for initial development of Broussonetia papyrifera epidermal hair cells, provides an important gene resource for analyzing the molecular mechanism of epidermal hair development of woody plants, and can cultivate a hairless forage Broussonetia papyrifera new variety through genetic engineering means, and has important theoretical value and application prospect.

This invention relates to the field of traditional Chinese medicine and health food preparation technology, and discloses a selenium-enriched medicinal and edible compound preparation for improving diabetic encephalopathy, as well as its preparation and application. The preparation is made from a specific weight ratio of Codonopsis pilosula, Astragalus membranaceus, Polygonatum sibiricum, selenium-enriched Corydalis yanhusuo, and Morus alba leaves. The preparation method includes raw material pulverization, constant-temperature reflux extraction with water, filtration and purification using a 0.22μm microporous membrane, vacuum low-temperature concentration to extract, and addition of excipients to form granules, capsules, or tablets. This invention constructs a multi-target synergistic network integrating qi replenishment, blood sugar control, and nerve protection through scientific formulation. It utilizes the strong antioxidant properties of organic selenium to efficiently scavenge free radicals in the brain, improving cognitive impairment caused by diabetic encephalopathy and lowering blood sugar. Combined with a mild closed-loop process and microfiltration technology, it ensures the stability and dissolution rate of heat-sensitive active ingredients, improving the purity, safety, and batch-to-batch consistency of the preparation.

The invention discloses mulberry cytochrome P450 monooxygenase MaCYP73A16 as well as a coding gene and application thereof, and belongs to the technical field of plant genetic engineering. The amino acid sequence of the mulberry cytochrome P450 monooxygenase CYP73A16 is as shown in SEQ ID NO: 2. The nucleotide sequence of the coding gene is as shown in SEQ ID NO: 1. According to the invention, a VIGS technology is used for MaCYP73A16, so that the expression quantity of MaCYP73A16 in mulberry leaves is reduced, functional research in synthesis of mulberry flavonoids is carried out, and a regulation and control network of a synthesis pathway of mulberry flavonoids and application of the regulation and control network are improved. Important theoretical support is provided for cultivation and screening of mulberry varieties rich in flavonoid.

The application discloses a traditional Chinese medicine composition for reducing blood sugar, which is prepared from the following traditional Chinese medicinal materials in parts by weight: 20-60 parts of Astragalus membranaceus, 10-40 parts of Morus alba, 20-60 parts of Pueraria lobata, 20-50 parts of Polygonatum odoratum, 2-5 parts of bee glue and 2-5 parts of beeswax. The traditional Chinese medicine composition embodies the traditional Chinese medicine theory of syndrome differentiation and treatment, and is skillfully formulated. The traditional Chinese medicine composition plays the role of tonifying qi and nourishing yin and reducing blood sugar, and embodies the unique advantages of traditional Chinese medicine in reducing blood sugar.

The invention discloses multi-herb hair-blacking, hair loss-preventing, eye-nourishing and skin-care powder and a preparation method of the multi-herb hair-blacking, hair loss-preventing, eye-nourishing and skin-care powder. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of radix polygoni multiflori preparata, 10-20 parts of semen sesami nigrum, 8-15 parts of fructus ligustri lucidi, 8-15 parts of herba ecliptae, 10-20 parts of fructus lycii, 5-12 parts of radix angelicae sinensis, 5-10 parts of rhizoma chuanxiong, 8-15 parts of fructus mori, 5-10 parts of semen cuscutae, 5-10 parts of fructus rubi, 5-10 parts of folium mori, 5-10 parts of flos chrysanthemi, 5-8 parts of radix paeoniae alba and 3-6 parts of pearl powder. Dendrobium officinale and herba ecliptae extracts are innovatively added to form synergistic interaction with an original formula, the yin nourishing and heat clearing effects of dendrobium officinale enhance the overall oxidation resistance of the raw materials, and polysaccharide components of dendrobium officinale can promote hair follicle cell proliferation; the herba ecliptae extract enriches effective components and strengthens the adjusting effect on the scalp microenvironment, the problems that a traditional formula is mild in effect and slow in effect taking are solved, meanwhile, the product integrates the multiple effects of blackening hair, preventing hair loss, nourishing eyes and protecting skin, and the defect that an existing product is single in function is overcome.

The present invention relates to a composition based on plant extracts for improving female fertility and / or treating female infertility. It uses a mixture of extracts of Cuscuta chinensis, Lycium barbarum, Morus alba, Rehmannia glutinosa and Carthamus tinctorius. This composition is available in various forms, such as tablets, capsules or drinkable solutions, and the efficacy thereof has been demonstrated in studies carried out on mice and zebrafish. Toxicity tests indicate that this composition is non-toxic. It improves indicators of female fertility, such as ovarian coefficient, and reduces oocyte malformations.

The preparation method comprises the following steps: (1) ultrasonic-assisted hot water extraction, (2) micro-filtration membrane rough filtration, (3) concentration, (4) alcohol precipitation, (5) ethanol decoloration, (6) polysaccharide redissolution, (7) Sevag method deproteinization, (8) rotary evaporation, (9) ultrafiltration and (10) freeze-drying. The MSCP prepared by the preparation method of the present application inhibits excessive secretion of NO and IL-1beta (plt; 0.05) plays an anti-inflammatory role, and the potential application value of the compound as a natural anti-inflammatory agent is prompted.

The application discloses a safe traditional Chinese medicine eye-care hydrogel eye patch with antioxidant activity and a preparation method and application thereof. The preparation of traditional Chinese medicine extract includes the following steps: taking semen astragali complanati, chamaemelum nobile, morus alba, prunella vulgaris, rhizoma acori graminei and chrysanthemum according to a proportion, adding 6-10 times of 60%-80% ethanol solution, constant temperature extraction for 12 hours, filtration, vacuum concentration of the filtrate to relative density of 1.10-1.25 of the extract, and preparation for use; the preparation of a hydrogel matrix includes the following steps: taking half of the extract and adding a small amount of sodium polyacrylate for multiple times, stirring until completely dissolved; taking the other half of the extract and heating to 90 DEG C, adding agar powder and stirring until completely dissolved, cooling to 55 DEG C, then adding aluminum glycyrrhizinate, continuously stirring for 10 minutes, finally mixing and stirring the two to form a crosslinked gel matrix; eye patch forming: adding glycerol and propylene glycol into the crosslinked gel matrix, uniformly mixing, vacuum defoaming, then pouring the gel liquid into a customized mold, cooling and forming, and packaging, and the eye patch is obtained.

The application provides a traditional Chinese medicine preparation for ischemic cerebral stroke, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Gentiana macrophylla Pall, Saposhnikovia divaricata, Morus alba, Scrophularia ningpoensis, red ocher, Fritillaria delavayi Franch, bamboo juice, Prunella vulgaris, Hericium, and Melia toosendan. The traditional Chinese medicine preparation has the functions of calming liver and hiding yang, calming wind and stopping convulsion, and removing phlegm and opening orifices. The traditional Chinese medicine preparation has a significant improvement effect on the nerve function of a cerebral ischemia-reperfusion injury model rat, can effectively reduce the brain tissue water content and cerebral infarction volume of the rat, significantly increase the GSH and SOD levels in the brain tissue of the rat, and reduce the MDA level, and has an effect of improving the oxidative stress induced by cerebral ischemia-reperfusion. The traditional Chinese medicine preparation can effectively relieve the nerve function loss of a patient with ischemic cerebral stroke, help restore the life function of the patient, and reduce the clinical symptoms of the patient, and has a definite and significant curative effect, and can be used as a new drug for treating ischemic cerebral stroke.

The invention discloses a traditional Chinese medicine hemagglutination rehabilitation composition for treating aplastic anemia and a preparation method thereof, and is characterized in that the traditional Chinese medicine hemagglutination rehabilitation composition is synthesized from extracts of morinda officinalis, angelica sinensis, American ginseng, rhizoma polygonati, astragalus membranaceus, cistanche, mulberry, raspberry, fructus alpiniae oxyphyllae, hawthorn, Chinese yam, fructus perillae, jujube, semen cassiae and cordyceps sinensis. Compared with the prior art, the traditional Chinese medicine composition for treating aplastic anemia disclosed by the invention has the advantages that a compound compound of a traditional Chinese medicine extract enters blood cells of a human body, mitochondria in the cells converts the compound into ATP (adenosine triphosphate) to supply energy of cell nucleuses (gene DNA), and the cell nucleuses start to split and start and stimulate bone marrow cell regeneration; the traditional Chinese medicine composition can be used for activating body dormant cells, supplementing hemoglobin and recombining stem cells, providing new blood after cell recombination for human body functions, and restarting a basic hematopoietic function of bone marrow, so that the aim of treating aplastic anemia is fulfilled.

The invention relates to a composition containing i) a DPP-4 inhibitor selected from an extract of dandelion (Taraxacum officinale), an extract of white mulberry (Morus alba), an extract of bitter melon (Momordica charantia), a hydrolysate of yeast (Saccharomyces cerevisiae), an extract of garlic (Allium sativum), an extract of grape (Vitis vinifera), an extract of turmeric (Curcuma longa), an extract of horseradish tree (Moringa oleifera) and an extract of fenugreek (Trigonella foenum-graecum); and ii) a GLP-1 analogue selected from a hydrolysate of yeast (Saccharomyces cerevisiae), a white mulberry (Morus alba) extract, a yerba mate (Ilex paraguariensis) extract, an Arabica coffee (Coffea arabica) extract, a purslane (Portulaca oleracea) extract, a bitter melon (Momordica charantia) extract, a lager flower (Lagerstroemia speciosa) extract, an apple (Malus domestica) extract, a cinnamon (Cinnamomum verum) extract and a fenugreek (Trigonella foenum-graecum) extract; and iii) a GLP-1 secretion enhancer selected from inulin, gum arabic, an extract of bitter melon (Momordica charantia), an extract of purslane (Portulaca oleracea), an extract of common barberry (Berberis vulgaris), an extract of Arabica coffee (Coffea arabica), an extract of Siberian angelica (Angelica dahurica), an extract of turmeric (Curcuma longa) and an extract of fenugreek (Trigonella foenum-graecum), where at least one ingredient is selected from each group i)-iii) and a total of at least three different ingredients are selected.

The invention discloses a Wuzi kidney-tonifying pill and a preparation method thereof. The Wuzi kidney-tonifying pill is prepared from the following raw materials in parts by weight: 100g of longspur epimedium, 100g of actinolite, 100g of fructus psoraleae, 100g of rhizoma curculiginis, 150g of sweet potato pulp, 150g of radix morindae officinalis, 150g of radix rehmanniae preparata, 100g of fructus lycii, 100g of mulberry, 100g of semen cuscutae, 100g of rhizoma coptidis, 100g of semen euryales, 100g of semen ginkgo, 200g of herba cistanche and 100g of Chinese chive seeds. Therefore, a traditional formula is upgraded and optimized through the modern pharmacology and process technology, and the whole-process improvement of refined medicinal material treatment, scientific compatibility and intelligent pelleting process is realized. Specifically, longspur epimedium, morinda officinalis, radix rehmanniae preparata, actinolite and other warm kidney-yang-tonifying medicines are introduced into the preparation, meanwhile, Chinese wolfberry fruits, mulberries, semen cuscutae, gordon euryale seeds and other essence-enriching and marrow-filling medicines are matched, the formula covers multiple vitamin paths of tonifying yang, nourishing yin and inducing astringency, and the preparation can better cope with modern sub-health states such as kidney deficiency, immunocompromise and endocrine disorder.

This invention discloses a traditional Chinese medicine compound composition for protecting sperm DNA integrity, its preparation method, and its application. The composition comprises the following components by mass: 10-30 parts Codonopsis pilosula, 10-20 parts Citrus reticulata, 10-30 parts Taraxacum mongolicum, 10-30 parts Agrimonia pilosa, 10-30 parts Astragalus membranaceus, 10-30 parts Rhodiola rosea, 6-10 parts Astragalus complanatus, 6-10 parts Morus alba, 6-10 parts Schisandra chinensis, 6-10 parts Curcuma zedoaria, 6-10 parts Carthamus tinctorius, and 6-10 parts Citrus reticulata seed. This traditional Chinese medicine compound composition can tonify the spleen and kidneys, clear heat and detoxify, invigorate blood circulation and regulate qi, and balance the yin and yang of kidney essence. It effectively protects sperm DNA integrity and reduces the increase in sperm DNA fibrillation (DFI) caused by sperm DNA damage, demonstrating definite clinical efficacy. The traditional Chinese medicine compound composition of this invention is convenient to take in clinical use, has good patient tolerance, and no adverse reactions have been found with long-term oral administration. After being made into a standardized traditional Chinese medicine preparation, it can further promote the standardized treatment and use of traditional Chinese medicine.

This invention discloses a traditional Chinese medicine composition for regulating sub-health conditions and its preparation method, belonging to the technical field of traditional Chinese medicine compositions. This composition is made from a specific weight ratio of raw materials including Asparagus cochinchinensis, Lilium brownii, Poria cocos, Triticum aestivum, Polygonatum sibiricum, Morus alba, Black sesame, Walnut, Ginseng, Lycium barbarum, Angelica dahurica, Rose, Jujube, Honey, Citrus medica, Tangerine peel, Lotus seed, Prunus persica, Amomum villosum, Chrysanthemum morifolium, Hawthorn, Dioscorea opposita, Pueraria lobata, and Coix lacryma-jobi, with optional addition of natural Vitamin C. Based on the principles of traditional Chinese medicine (TCM) theory of monarch, minister, assistant, and guide herbs, this invention has the effects of invigorating Qi and nourishing Yin, strengthening the spleen and removing dampness, soothing the liver and regulating Qi, nourishing blood and calming the mind, and moisturizing the skin and beautifying the complexion. It effectively improves sub-health symptoms such as insomnia, fatigue, loss of appetite, and excessive dampness. This invention is suitable for people with difficulty swallowing and those requiring rapid onset of action. All dosage forms maintain the characteristics of mild medicinal properties, safety without side effects, simple preparation, and convenient administration, making it suitable for long-term daily conditioning and showing good application prospects.

This invention provides a fast-dissolving compound microcapsule powder of traditional Chinese medicine and its preparation method, belonging to the field of health food technology. The microcapsule powder preparation method includes: sequentially extracting a mixture of Epimedium powder, Hovenia dulcis powder, Cornus officinalis powder, Pueraria lobata root, Morus alba fruit, and Citrus reticulata peel with 55-60% ethanol for a first extraction, followed by a second extraction with water to adjust the ethanol concentration to 45-50%, obtaining a mixed extract; concentrating and drying to obtain a powder of the traditional Chinese medicine extract; mixing this powder with maltodextrin, citric acid, and stevia to prepare a core material powder; preparing a capsule material solution with gum arabic, β-cyclodextrin, and konjac gum; and coating the core material surface with the capsule material using a fluidized bed, followed by solidification to obtain the final product. This invention achieves efficient extraction of components with different polarities through a combination of gradient alcohol extraction and fluidized bed microencapsulation technology, significantly improving product stability, hygroscopic resistance, and solubility, effectively masking unpleasant odors. The resulting microcapsule powder has synergistic effects of anti-fatigue and kidney tonification, is convenient to take, and is suitable for the health product field.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating upper digestion type diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 25 to 35 parts of herba eupatorii, 25 to 35 parts of radix codonopsis, 25 to 35 parts of radix rehmanniae recen, 25 to 35 parts of radix puerariae, 25 to 35 parts of radix trichosanthis, 20 to 30 parts of radix ophiopogonis, 15 to 25 parts of rhizoma coptidis, 15 to 25 parts of radix adenophorae, 15 to 25 parts of rhizoma anemarrhenae, 15 to 25 parts of rhizoma polygonati, 15 to 25 parts of poria with hostwood, 15 to 25 parts of corn stigma, 15 to 25 parts of folium mori, 5 to 15 parts of fructus schizandrae and 5 to 10 parts of liquorice root. The traditional Chinese medicine composition provided by the invention can be used for effectively treating the upper-digestion diabetes mellitus on the basis of the main pathogenesis of the upper-digestion diabetes mellitus according to medication experience and traditional Chinese medicine theories.