The invention relates to the technical field of fertilizer, and in particular, relates to a paris polyphylla special fertilizer and a preparation method thereof. The paris polyphylla special fertilizer comprises the raw materials: fresh livestock and poultry manure, wheat bran, straw, corn flour, malt, oyster shells, a shrimp shell powder, pitaya peel, aerial root of banyan, and semen pharbitidis. The preparation method comprises the steps: firstly, fully mixing the corn flour with gibberellin and indoleacetic acid, and then carrying out ultrasonic treatment, to obtain a mixture for standby application; respectively powder-grinding the malt, aerial root of banyan, semen pharbitidis and pitaya peel, mixing with the shrimp shell powder, adding water, decocting for one time, filtering, to obtain a filtrate, mixing the filtrate with the straw, and placing the mixture at the environment of the temperature of 35-45 DEG C, carrying out sealed heating, adding the livestock and poultry manure and the wheat bran, mixing evenly, and naturally fermenting to obtain a fermentation product; sending the fermentation product and the standby-application mixture into a granulator, granulating, then sprinkling the surface of the granules with the oyster shell powder, and thus obtaining the granular fertilizer. The fertilizer has balanced nutrition, has lasting fertilizer efficiency, also has the desinsectization ability, and improves the disease resistance ability of paris polyphylla and comprehensive utilization rate of plants.